A study led by UC San Diego researchers identifies the root cause of lithium metal battery failure as bits of lithium metal deposits that break off from the anode during discharging. These deposits get trapped in the solid electrolyte interphase (SEI) layer, lowering Coulombic efficiency and causing batteries to fail. The findings coul...
A survey of over 1,800 participants found that more than 67% were willing to share all items with researchers from their home institution, while fewer shared with other institutions. The way preferences are elicited also affects sharing, with opt-out forms resulting in greater sharing per item.
Researchers at UC San Diego have developed a new therapeutic approach to convert tumor-associated macrophages (TAMs) into cancer killers. The antibody, LM609, induces ADCC and kills drug-resistant tumors, prolonging response to standard treatments.
Researchers developed an app called Bluetana that uses Bluetooth signature detection to identify gas pump skimmers. It has been shown to discover more skimmers and have a lower false positive rate than existing apps, allowing inspectors to quickly locate the devices without manual inspections.
Researchers will use human pluripotent stem cells, CRISPR and human organoids to dissect beta cell defects and create a human cell model of type 1 diabetes. The goal is to identify the cellular actions leading to disease onset and potentially rescue surviving beta cells.
Researchers at University of California San Diego School of Medicine found that removing the enzyme PHLPP1 improves outcomes in a mouse model of sepsis. The study introduces the possibility of inhibiting PHLPP1 as a new treatment for sepsis.
Researchers at the University of California San Diego have developed a groundbreaking system for determining gene expression based on machine learning. The new method leverages chromatin biology and molecular features to identify expressible genes with high accuracy, providing a genetic 'Rosetta Stone' for biologists.
Engineers at the University of California San Diego have developed the world's thinnest optical device, a waveguide consisting of three layers of atoms thin. The waveguide channels light in the visible spectrum and supports electron-hole pairs, generating a strong optical response.
A new drug called volanesorsen has been shown to significantly reduce blood fat levels in people with a rare genetic disorder. In a Phase III clinical trial, participants experienced a 77% reduction in triglyceride levels, while those receiving a placebo saw a 18% increase.
Researchers found that adding MS drug teriflunomide to targeted cancer therapy significantly shrinks glioblastoma tumors and improves mouse survival. The treatment targets cancer stem cells, which are responsible for tumor recurrence.
A genome-wide association study found specific genetic links to re-experiencing trauma symptoms in US veterans with PTSD, highlighting the role of brain cells in stress response. The study identified eight distinct genetic regions associated with PTSD vulnerability, providing potential targets for drug treatments.
Researchers reconstruct 3D image of group II introns to uncover large-scale molecular movement associated with RNA catalysis. This discovery provides key insights into the evolutionary origins of RNA splicing and its impact on human disease.
Researchers at UC San Francisco identified functionally distinct composite clusters of genes corresponding to synaptic transmission, metabolism, cell cycle, and immune response. These changes occurred extensively in AD patients and may help streamline clinical trials recruitment efforts.
Researchers suggest a genetic mutation two to three million years ago led to a heightened risk of cardiovascular disease in all humans, while also setting up a further risk for red meat-eating humans. Human-like mice modified to lack the CMAH gene showed a significant increase in atherogenesis compared to control mice.
Researchers discovered that reactive oxygen species, once thought to cause cellular damage, actually protect phytoplankton cells from overproducing a compound used for photosynthesis. This finding challenges conventional wisdom and may have implications for understanding ocean resilience to climate change.
Researchers from UC San Diego successfully embedded complex sensors inside robotic limbs and grippers using commercial 3D printing. However, the performance of these sensors is limited by the use of non-conductive polymers, which require additional post-processing for optimal functionality.
Researchers have identified an enzyme called LPCAT1 that plays a key role in tumor growth by changing the phospholipid composition of cancer cells' plasma membranes. When genetically depleted in mice, malignancies shrank dramatically, suggesting LPCAT1 as a potential new drug target for various cancer types.
Researchers developed an AI-based system, SpoilerNet, to flag spoilers in online book and TV show reviews. The tool achieved 89-92% accuracy in detecting spoilers, with most errors caused by distracting words.
Researchers at UC San Diego are creating the world's first high-intensity twisted laser beams, also known as corkscrew light pulses. This achievement has potential applications in nuclear physics, astrophysics, and non-invasive tumor therapies.
Adolescents exposed to high levels of pesticides are at increased risk of depression, according to a new study. The study found that lower levels of the enzyme acetylcholinesterase, which measure pesticide exposure, were associated with more symptoms of depression in teens.
Researchers found that protein clumps in ALS neurons can be triggered by cellular stress and may provide a potential target for new therapies. Chemical compounds have been identified to prevent this stress-induced accumulation, offering a promising starting point for treating the disease.
Researchers at the University of California - San Diego have developed a new cold-tolerant electrolyte for lithium-metal batteries, improving cycling efficiency and reducing dendrite growth. The breakthrough could lead to lighter batteries capable of storing more charge, extending electric vehicle range and lowering battery costs.
A new study published in the Proceedings of the National Academy of Sciences found that cultural environment influences early diversity in abstract thought. Chinese children demonstrated superior relational reasoning skills compared to US children, with significant differences emerging around age 3.
Researchers at UC San Diego discover a gel-like state of DNA that enables stability and responsiveness in the nucleus. The study suggests a physical principle of chromosomal organization with implications for gene expression and cell fate.
Researchers at the University of California San Diego discovered a complex process where viral components are transported along filaments within bacterial cells. This 'treadmill-like' structure allows for efficient movement of cargo, similar to human cell mechanisms, and has significant implications for understanding phage therapy.
Nanoengineers developed new graph network-based models that accurately predict material properties, outperforming existing AI technology in complex tasks. The MEGNet models can learn relationships between elements and overcome data limitations in materials science, enabling rapid discovery of transformative materials.
A team of researchers found that the unique nanostructure of deep-sea dragonfish teeth is responsible for their transparency. The findings provide insights into this adaptation and could lead to the development of new transparent ceramics.
Researchers discover that progesterone triggers the mineralocortoid receptor in elephant sharks, while aldosterone and cortisol do not. This finding provides new insights into the evolution of human physiology.
A joint study by University of California San Diego School of Medicine and CALCASA found California's reported sexual harassment rates are 5% higher for women and 10% higher for men compared to the national average. Immigrant-born men, as well as gay and lesbian Californians, are also at increased risk.
A study published in Environmental Research found higher blood pressure and pesticide exposures in children associated with a heightened pesticide spraying period around the Mother's Day flower harvest. Children examined sooner after the harvest had higher pesticide exposures and higher systolic and diastolic blood pressures.
Researchers developed a computational approach to design new hybrid halide semiconductors, discovering 13 new material candidates for solar cells and 23 for LEDs. The study used large-scale quantum mechanics calculations to identify novel materials with excellent optoelectronic properties.
A new study reveals that specific brain regions, including executive function areas and sensory monitoring zones, moderate both depressive mood and physical pain. The research found that individuals with higher levels of depressive mood exhibited increased sensitivity to pain and heightened activation in these brain regions.
Researchers at UC San Diego found that neonatal nicotine exposure changes the biochemistry of the reward circuitry in mice brains, increasing their preference for nicotine in later adulthood. This study suggests a potential mechanism for how early life exposure to nicotine may contribute to addiction later in life.
Researchers discovered a plant virus capable of delivering pesticide molecules deep into the soil, targeting pests like nematodes. The breakthrough could help farmers reduce pesticide use and minimize environmental harm.
Researchers used zebrafish and human cells to determine how blood stem cells receive Wnt signaling, discovering the crucial role of the epidermal growth factor receptor. This finding may advance laboratory development of blood stem cells, potentially leading to off-the-shelf treatments for patients with blood diseases.
Researchers developed a wearable patch that cools or warms a user's skin to a comfortable temperature, reducing the need for heating and cooling systems. The patch is powered by a flexible battery pack and can be integrated into clothing, promising to save energy on personal thermal comfort.
A multidisciplinary team at UC San Diego unraveled the mechanisms controlling cell size through a fundamental process known as 'the adder.' The process relies on balanced synthesis of biological ingredients and a critical threshold to initiate cell division. This discovery sheds light on the origins of precise cellular reproduction.
A recent study found that women's gut microbiomes are more diverse and mature earlier than men's, with a positive association between age and bacterial diversity. The research suggests that sex hormones may play a role in the development of the female gut microbiome.
A recent study published in Clinical Gastroenterology and Hepatology found a significant association between glyphosate exposure and nonalcoholic fatty liver disease (NAFLD) in human subjects. The study, led by Paul J. Mills, PhD, examined urine samples from patients with NAFLD and healthy individuals, revealing higher levels of glypho...
Using stem cells from six people, researchers recreated retinal cells in the lab and found a specific genetic variation that contributes to AMD. The study suggests that reducing VEGFA expression may be a key factor in the development of AMD.
Researchers identified the retrosplenial cortex as the brain region responsible for value-based decision-making, which is crucial for neurological conditions such as schizophrenia and dementia. The study used data from tens of thousands of neurons to show that the RSC maintains subjective value information until the next experience.
A study by University of California San Diego researchers found that optimism, wisdom, and social connections protect against declining cognitive and physical health. Conversely, loneliness increases the risk of mental decline. The findings can inform new interventions for aging populations.
Marine invertebrates' vision is highly sensitive to oxygen levels, with reduced oxygen causing 60-100% vision loss. Most species recover visual function when oxygen levels are restored.
Research reveals men treated for benign prostatic hyperplasia (BPH) with 5-α-reductase inhibitors experienced a two-year delay in prostate cancer diagnosis and were twice as likely to have advanced disease. PSA suppression from these medications led to delays in diagnosis, potentially resulting in worsened clinical outcomes.
A study published in JAMA Pediatrics found that autism diagnoses become stable starting at 14 months, with a mean age of diagnosis being significantly lower than previously reported. This suggests that accurate screening and earlier treatment can result in improved therapeutic benefits for children with ASD.
Researchers have uncovered a new set of rules that predict how the tissue of origin influences tumor genetic makeup, with potential implications for targeted cancer therapies. The study found that cancer cells are addicted to specific NAD synthesis pathways, making them vulnerable to targeted interventions.
Researchers found a significant reduction in strokes and heart attacks with low-dose blood thinner use in patients with worsening heart failure or coronary artery disease. The study, published in JAMA Cardiology, suggests that this strategy may improve outcomes for patients at risk of subsequent issues.
Researchers found that treating patients with personalized, combination therapies improved response rates and overall survival in patients with therapy-resistant cancers. Highly matched patients showed a 50% response rate compared to unmatched or less well-matched patients.
Researchers developed FitRec, a deep learning tool that analyzes past performance to predict speed and heart rate. The tool identifies important features affecting workout performance and recommends alternate routes for runners to achieve specific target heart rates.
A new recycling process regenerates degraded cathodes from spent lithium-ion batteries, restoring their original capacity and cycle performance. The method uses eutectic lithium salts to dissolve degraded materials without adding pressure, reducing costs and safety concerns.