Researchers at University of California, San Diego School of Medicine developed a way to chemically disguise RNAi drugs so they can enter cells. The technique converts disguised drug precursors into active RNAi drugs that selectively block target protein production in a cell.
Researchers found that cirmtuzumab induces senescence in cancer stem cells, degrading their ability to grow and metastasize. Ovarian cancer patients with high levels of ROR1 experienced more aggressive forms of the disease, highlighting the potential of this antibody therapy as a targeted treatment.
Researchers at UC San Diego School of Medicine implicated a new gene in non-syndromic autism, suggesting similar molecular pathways among different types of autism. The study used mouse models, induced pluripotent stem cells and the 'Tooth Fairy' project to identify TRPC6 as a novel predisposing gene for ASD.
Researchers connect ancient clay tablet data to climate records, suggesting that drought and overpopulation weakened the empire's economy and destabilized its political system. The study draws parallels between the Assyrian Empire's collapse and contemporary issues in the region, highlighting the importance of considering long-term sus...
Researchers at University of California, San Diego, have removed the brain area responsible for spatial navigation in rats, showing that other memory abilities remain intact. The study provides insights into Alzheimer's disease and stroke effects on the brain's navigational system.
Researchers found significant safety flaws in popular flight tracking systems, including firmware manipulation and tampering with real-time information. The team recommends securing communication, pairing devices properly, signing firmware updates, and using HTTPS or digitally signed data.
Researchers at the University of California, San Diego, propose a new surgical intervention that combines the first and second steps of single-ventricle heart surgery. This approach aims to reduce the workload on the patient's heart, increase blood flow to the lungs, and improve oxygen delivery.
Scientists identify tumor necrosis factor alpha (TNFα) as a key player in the emergence of hematopoietic stem cells, a breakthrough that could aid in developing induced pluripotent stem cell replacements for blood disorders. The discovery sheds light on the complexities of HSC genesis and paves the way for further research.
The TREDS program trains doctors and law enforcement officers to assess older drivers' abilities and identify warning signs of impaired driving. Researchers aim to prolong seniors' safe driving time by educating people about aging effects on driving skills.
A recent study published in Neural Computation found that CoQ10 supplements improved physical function in 80% of treated veterans with Gulf War illness. The study suggests that CoQ10 may be beneficial for those suffering from this chronic condition, which is linked to chemical exposures and mitochondrial damage.
Researchers at UC San Diego invented a new method of lithography using self-propelled nanorobots to create complex surface patterns on devices. The technology provides a framework for autonomous writing of nanopatterns at a fraction of the cost and difficulty of current state-of-the-art methods.
Researchers developed a novel ultrasound technology to screen for heart conditions, enabling earlier diagnosis and more effective treatment. The technology helps identify blood flow patterns in the heart, which is crucial for diagnosing hypertrophic cardiomyopathy and non-ischemic dilated cardiomyopathy.
Researchers developed an EEG test to help diagnose persons at risk of developing mental illness and measure the effectiveness of treatment options. The test measures auditory processing deficits in schizophrenia patients, suggesting potential improvement with cognitive exercises.
A new nanoparticle-based material developed by the University of California, San Diego, can absorb and convert over 90 percent of sunlight into heat. This breakthrough aims to improve concentrating solar power plants' efficiency, making them more competitive with traditional energy sources.
Researchers at the University of California, San Diego, have developed a new process for self-driving phospholipid membrane assembly, similar to those found in living cells. This non-enzymatic technique can be used for artificial cell studies and potentially for drug delivery packets.
Researchers have discovered that multiple viruses share an L-shaped switch in their RNA genomes, which can be flipped to prevent replication. The discovery has implications for developing new drugs to inhibit viral replication, particularly for hepatitis C virus.
Researchers have developed CNiFERs cells to track dopamine signaling, providing a real-time readout of neurochemical activity associated with learning, memory and reward. The study reveals that dopamine release is linked to classical conditioning and anticipatory behavior.
UC San Diego has been designated as one of three 'alpha clinics' by the California Institute for Regenerative Medicine to accelerate clinical development of emerging stem cell therapies. The designation will support the establishment of a comprehensive regenerative medicine clinical hub and attract patients, funding agencies, and study...
The POLARBEAR collaboration has made the most sensitive measurements yet of the cosmic microwave background's polarization, revealing telling twists called B-modes that indicate cosmic history imprints. These findings suggest a new regime in precision cosmology, paving the way for solving mysteries about matter and energy at the Big Bang.
Researchers used mathematical models to explain how moths locate mates over hundreds of meters, integrating pheromone signals and adapting to turbulent airflow. The study has implications for agriculture, robotics, and understanding animal navigation.
Researchers have discovered a fusion protein in approximately 15% of secondary glioblastomas, offering insights into the disease's cause and potential therapeutic targets. The PTPRZ-MET fusion may be exquisitely sensitive to existing MET inhibitors, allowing for personalized oncologic care.
Researchers found that moderate levels of free radicals are necessary for proper skin wound healing in laboratory roundworms. Increased ROS can even accelerate wound closure, suggesting a potential therapeutic target for improving wound healing in humans, particularly the elderly and those with diabetes.
A $9.2 million grant from the NIH will help researchers share, use and cite biomedical datasets more efficiently. The project, led by UC San Diego, aims to create a searchable online digital library for health-related datasets.
A team of researchers uncovered how Protein Kinase A II-beta changes shape in response to cAMP, revealing its internal architecture and ability to regulate energy consumption and hormone interactions.
A new study defines the epidemiology of gastrointestinal stromal tumors (GIST), identifying Asian descent patients as at-risk groups. Patients from this population are 1.5 times more likely to be diagnosed with GIST than others, highlighting a higher incidence rate and survival disparity.
Researchers at UC San Diego identified microRNA let-7 as a key player in managing cell survival and growth. The molecule controls autophagy through the amino acid sensing pathway, which has emerged as the most potent activator of mTORC1 complex activity.
Two UC San Diego professors, David Braff and Gregory Light, have been recognized for their contributions to schizophrenia research. They developed innovative methods to identify biomarkers and create new psychosocial and pharmaceutical therapies for the disorder.
Researchers at the University of California, San Diego School of Medicine have discovered that T-cells are activated by a pain receptor called TRPV1 channel. The study shows that this receptor helps regulate intestinal inflammation in mice, suggesting a potential new target for treating certain autoimmune disorders.
Researchers at the University of California - San Diego developed SeedMe to convert labor-intensive data sharing processes into streamlined automatable ones, promoting interdisciplinary collaboration. The platform aims to provide significant time-saving benefits for researchers by enabling easy integration into existing scientific appl...
A new map of the world's seafloor has been created using satellite data, revealing thousands of previously uncharted sea mountains and providing new clues about deep ocean structures. The map, which is twice as accurate as the previous version, also reveals details of continental connections across South America and Africa.
Researchers at UC San Diego aim to bioengineer the irregularly shaped patches of the pancreas called Islets of Langerhans in a dish. This could lead to studying the events that trigger beta cell destruction and developing new drug therapies, as well as understanding the genetic component of the disease.
A new genetic operating system enabled the emergence of bilateral animal body plans by facilitating the formation of a mesoderm layer, which is absent in radial organisms. This 'operating system' was linked to an ancient protein called TRF2, found in bilateral animals but not non-bilaterian animals.
Researchers at UC San Diego used mesh-free simulation to analyze skeletal muscle tissue, finding loss of force exceeds loss of volume with aging. The method cuts back on processing time and can be applied to study injuries from extreme events.
Alpha-synuclein regulates neuronal communication by self-association, clustering synaptic vesicles and restricting neurotransmission to manage communication. This newfound understanding may be critical for therapeutic interventions targeting alpha-synuclein levels and activity in Parkinson's disease.
Scientists at UC San Diego and Hebrew University found that nitrogen fingerprints in biomolecules can be explained by chemistry within the solar system. By generating ammonia with skewed ratios of nitrogen-15, they recreated the conditions that produce life's fundamental molecules.
Researchers present a bioregional guide that combines place-based city planning and ecosystem management to address wide-ranging human health challenges along the US-Mexico border. The approach aims to promote healthy placemaking, taking into account environmental exposures, stress, diet, urban design, and behavior.
Researchers at University of California, San Diego aim to develop a whole eye transplant technique that can reconnect the eye's neuronal wiring to the brain. The goal is to treat patients with vision restoration due to structural or functional problems in the eye.
Researchers have developed a program that predicts the placement of chemical tags controlling gene activity based on DNA sequences. The analysis identified specific DNA patterns associated with epigenomic modifications, revealing new insights into gene regulation and potential therapeutic targets.
A new technique uses perfluorocarbon tracers in combination with MRI to track therapeutic immune cells injected into patients with colorectal cancer. The study found that only half of the delivered cell vaccine remained at the inoculation site after 24 hours, but the technology shows promise for tracking other cell types and diseases.
Scientists have identified a control mechanism for the brain's processing of disappointment, which may be a key to treating depression. In experiments with rodents, researchers found that a small region above the thalamus secretes both excitatory and inhibitory neurotransmitters, allowing for a more subtle control of signaling.
The team's innovative approach allows for the separation between electric vehicle purchase and battery pack costs, potentially lowering prices by $10,000. Swappable modules also enable users to recharge batteries at home, expanding access to electric vehicles in cities without wall outlets.
The team used LiDAR technology to create a detailed map of the site, capturing structures that were previously inaccessible due to dense jungle canopy. By exploring these uncharted areas, researchers gained a better understanding of ancient Maya city-states and their interactions.
Researchers found that cancer cells decorate their surfaces with glycans that can promote or inhibit cancer progression depending on the stage of the disease. The immune system may be a double-edged sword in cancer, with certain immune cell receptors binding to these glycans producing opposite outcomes.
Researchers found that neurons from schizophrenia patients secrete higher amounts of dopamine, norepinephrine, and epinephrine. This discovery offers a new insight into the chemical basis of schizophrenia, potentially leading to new drug targets and therapies.
A new grant-funded program seeks to expand a 5-year-old autism early detection model, which assesses toddlers for ASD around their first birthday. The program's goal is to reduce the mean age of ASD diagnosis in multiple cities across the U.S., with potential benefits for children's brain development.
Researchers at UC San Diego developed a new version of CodeSpells, a video game that teaches children to code in Java. After playing the game, kids aged 8-12 can write code by hand in Java.
Ferrara's discovery of vascular endothelial growth factor (VEGF) led to the development of ranibizumab, a monoclonal antibody drug treating wet macular degeneration and diabetic eye disease. This achievement has significantly improved vision for patients affected by these conditions.
Researchers at UC San Diego discover that moving rocks requires a rare combination of events: water-filled playa, freezing temperatures, and thin sheets of 'windowpane' ice. Light winds drive the ice panels across the playa, pushing rocks in front of them.
Researchers at UC San Diego built the first 500 GHz photon switch, enabling ultrafast optical control and opening a new class of sensitive receivers. The team developed a measurement technique to resolve sub-nanometer fluctuations in the fiber core, critical for fast switching and processing.
Scientists at UC San Diego have identified the UBC13 enzyme as a key regulator of breast cancer metastasis, allowing them to potentially block the spread of the disease. The study found that inhibiting this enzyme may prevent metastasis in breast cancer cells.