A study suggests that online insomnia treatment, SHUTi, can provide meaningful relief for caregivers struggling with sleep difficulties. The program showed promising results in improving sleep quality and reducing stress among high-intensity caregivers, those shouldering the greatest responsibilities in caring for their loved ones.
A retrospective analysis of over 2,600 patients found that Black children were more likely to suffer severe graft-versus-host disease but overall survival rates improved across all racial groups. The study suggests that cord blood transplants are a vital lifeline for many patients and improve care for those without a matched donor.
Researchers at the University of Virginia Health System have identified a crucial biological switch that regulates renin production in certain cells, allowing them to control blood pressure. This discovery provides important direction for future research into high blood pressure and cardiovascular disease treatment.
Researchers from the University of Virginia Health System found that out-of-body experiences can foster deepened emotional connections with others, leading to increased empathy. This phenomenon, known as ego dissolution, can have a transformative effect on people's ability to experience empathy and connect with others.
Researchers discovered faulty immune processes responsible for lingering lung issues after COVID-19, which can be disrupted by existing drugs. The study also identified molecules responsible for the issue and potential therapeutic options for patients with ongoing lung damage.
A new non-hormonal hot flash treatment has been shown to significantly reduce symptom frequency and severity within weeks, while also improving sleep quality and overall well-being. The investigational drug elinzanetant was found to have a favorable safety profile with mild side effects.
Research from the University of Virginia School of Medicine reveals that nearly a quarter of children with recurrent wheezing have undetected lung infections that do not respond to commonly prescribed steroids. The study suggests that antiviral medications such as azithromycin may be a more effective treatment for these cases.
Researchers at UVA discovered an unknown cause of long COVID inside lung tissues, promoting chronic inflammation that drives lasting respiratory symptoms. They found that immune cells can go haywire and promote tissue scarring, leading to conditions like interstitial lung disease.
A randomized controlled trial found that four weeks of outdoor gait training, combined with home exercises, improved running biomechanics and reduced the time feet were in contact with the ground. This technique may help patients improve their stride and reduce pain associated with shin splints.
Research by a University of Virginia undergraduate may help explain recurrent Crohn’s disease in children and open the door to new ways to treat or even cure the devastating condition. Children with relapsing Crohn’s had persistent disruptions of their microbiomes even after inflammation was successfully controlled.
A new study analyzed over 14,600 scientific publications funded by more than $4 billion in NIH grants, revealing key research topics such as clinical trials, vaccine distribution, and virology. The findings suggest that half of the funding went to five states: North Carolina, Washington, New York, California, and Massachusetts.
The number of calls to US poison centers has increased sharply, with a 233.9% rise in intentional exposures among adults. The severity of unintentional exposures also increased, with 37.4% more cases resulting in severe harm and 65.3% more deaths.
The Planetary Child Health & Enterics Observatory (Plan-EO) is developing an online tool to identify diarrheal disease transmission hotspots and accelerate treatment deployment. The dashboard will provide up-to-date epidemiological estimates and predictions, enabling public health communities to make informed decisions and save lives.
Researchers created a new model to study the effects of undernutrition on the microbiome, which can help identify specific microbes that impact development. The model mimics early childhood experiences and shows promise in understanding the underlying causes of stunted growth and other harmful effects of undernutrition.
A late University of Virginia School of Medicine scientist's research on the SAS1B protein could lead to new cancer treatments for multiple cancers. The discovery has the potential to selectively target cancer cells while sparing healthy tissue.
University of Virginia researchers have identified a single gene on the Y chromosome that can account for the disease-promoting effects of Y chromosome loss. This discovery provides new avenues for understanding the causes of heart disease and could lead to a treatment for men with Y chromosome loss.
A second-generation melanoma vaccine has shown improved survival rates for male patients compared to female patients, particularly those who are younger and have earlier-stage cancer. The vaccine targets helper T cells to recognize melanoma proteins, leading to boosted patient survival and reduced cancer reoccurrences.
Researchers at UVA Health discovered a potential explanation for long COVID symptoms by identifying 'abzymes' that act like enzymes regulating important bodily functions. This discovery could lead to new treatments targeting these rogue antibodies to alleviate acute effects of COVID-19 and its complications.
Researchers are developing a flexible online tool to navigate information used in the fight against deadly diarrheal diseases. The Plan-EO dashboard will provide real-time data on pathogen dynamics, allowing infectious disease experts and local leaders to make smart decisions and save lives.
A new study found that multiple unsafe sleep practices, such as sharing a bed, were present in over 75% of sudden infant deaths. Infants who died were often younger, non-Hispanic Black, and publicly insured. The research emphasizes the need for better safe-sleep education and support to reduce Sudden Infant Deaths.
Researchers at UVA Health discovered a potential blood test to predict patients with severe COVID-19 who are likely to recover well and those at risk of long-term lung problems. The study found that patients with late-resolving symptoms had fewer immune cells in their blood, correlating with symptom severity.
Researchers at UVA Health System have discovered genetic clues that may help identify people at risk of cardiovascular disease, including atherosclerosis. The study identified 20 locations on chromosomes that influence protein production, shedding light on why smooth muscle cells sometimes are beneficial and sometimes harmful.
Researchers at the University of Virginia Health System are developing a technique to 'paint' tiny nanoparticles on transplanted veins to prevent blockages, potentially sparing patients from repeated surgeries. This approach could significantly reduce the number of vascular reconstructions performed annually in the US.
Researchers found that faulty mtDNA replication causes mitochondria to leak genetic material, triggering an immune response and leading to disease. By targeting this process, doctors may develop therapies to prevent harmful inflammation.
Calls to US poison centers involving psilocybin among teens and young adults tripled and doubled, respectively, after decriminalization, leading to alarming concern over potential long-term consequences. Most calls involved intentional consumption, with adverse reactions including hallucinations, agitation, and heart rate issues.
Researchers at University of Virginia Health System developed a new approach to machine learning that identifies drugs minimizing harmful scarring after heart attacks. The tool predicts and explains drug effects for other diseases as well.
Researchers found that higher levels of omega-3 fatty acids in the blood plasma were associated with better lung function and longer survival without needing a lung transplant. This was consistent regardless of smoking history or cardiovascular disease.
Researchers at the University of Virginia Health System discovered that tau proteins damage brain cells by warping their nuclei, altering gene function and increasing tau production. This finding could lead to new treatments for Alzheimer's disease and other tauopathies.
Researchers at UVA Health System created an 'atlas of atherosclerosis' revealing critical processes that form harmful plaque buildup. The study provides unprecedented insights into atherosclerosis and its impact on coronary artery disease, heart attacks, and strokes.
A study found increased brain inflammation and structural changes in special operations personnel exposed to blasts, potentially increasing the risk of long-term brain-related disease. The research suggests that repetitive exposure to low-level blasts may cause brain injuries and highlights the need for better protective measures.
Researchers at the University of Virginia Health System have discovered how Lactobacillus, a bacterium found in fermented foods and yogurt, influences mood disorders. The findings suggest that maintaining a healthy level of Lactobacillus may help prevent depression and anxiety by regulating immune response to stress.
Researchers aim to optimize digital weight-loss programs for rural populations by adding human components, such as weekly group video sessions and individual coaching calls. The goal is to help residents manage their weight and fight the obesity epidemic in areas with limited access to in-person programs.
A new study finds that people with antibodies to common foods like dairy and peanuts are at a higher risk of cardiovascular-related death. The research suggests that these subtle immune responses may lead to inflammation and contribute to heart disease over time.
Researchers from the University of Virginia Health System have made significant discoveries about the genetic influences on fatty acid metabolism in diverse populations. The study found broad similarities among groups but also notable differences, highlighting the need for genetic studies in diverse groups.
Researchers at the University of Virginia Health System are developing computer models to better understand the cellular processes and gene activity of multi-drug resistant bacteria Staphylococcus aureus and Pseudomonas aeruginosa. The goal is to identify vulnerabilities in these bacteria and advance the development of new treatments.
Researchers at UVA Health System have developed a powerful new tool to understand how medications affect men and women differently. The model has provided unprecedented insights into biological processes in the liver, helping ensure that new medications will not cause harmful side effects.
A new drug called vorasidenib has been shown to significantly slow tumor growth and extend the average time until tumor growth in patients with grade 2 IDH-mutant gliomas. This breakthrough could offer a first early treatment option for these cancer patients, potentially improving their quality of life.
Scientists have discovered that SARS-CoV-2 can infect cells using multiple entry points beyond ACE2, explaining its ability to jump between species. This finding highlights the need for continued monitoring of coronaviruses and their potential to cause future pandemics.
Researchers found that Alzheimer's patients exhibit heightened sensitivity to light changes, which can contribute to 'sundowning' and disease progression. Light therapy could help manage these symptoms and potentially slow disease progression.
Researchers found a genetic link that explains how certain individuals store fat at the abdomen but remain protected from type 2 diabetes. This discovery could pave the way for personalized medicine, tailoring treatments to individual genetic variations.
Researchers at the University of Virginia Health System discovered that improper calcium signaling in mitochondria accelerates chronic inflammation, leading to age-related conditions. Increasing calcium uptake in macrophages may help prevent harmful inflammation and its effects on the brain.
Researchers have discovered a way to identify pregnant women at risk of preeclampsia by examining lipids in their blood during pregnancy. The approach worked regardless of whether the women were on aspirin therapy, and could predict the risk of preeclampsia with significant accuracy.
A team of UVA Health experts warns that surgeon-scientists are struggling to obtain research funding, which could lead to a decline in innovations for patients. The researchers found that internal medicine trainees are six times more likely to secure R01 grants and career development awards.
Researchers at the University of Virginia Health System have identified a novel mechanism by which hair cells can repair themselves after damage. This breakthrough understanding has the potential to develop new treatments for age-related hearing loss and other conditions.
Researchers aim to identify best practices for increasing viral suppression in low-income populations with HIV. They will examine state AIDS Drug Assistance Programs to understand disparities in care and outcomes.
Scientists at University of Virginia Health System discovered a gene that acts as a master controller for immune tolerance, shedding light on how our immune systems are calibrated to prevent MS. The new understanding could lead to better, more targeted treatments.
Researchers discovered that targeting specific blood vessel enzymes can enhance immunotherapy effectiveness and prevent breast cancer metastasis. By disabling the enzyme DNMT1 in blood vessels, doctors may bolster anti-tumor immune cells entry and increase patients' response to treatment.
The study found that the immune response to spinal-cord injuries is impaired in older individuals, leading to weaker cell responses and reduced recovery. The researchers identified an essential role for the meninges surrounding the spinal cord in mounting the immune response, paving the way for new therapeutic approaches.
The University of Virginia Health System has developed a plan to improve the use of electronic health records, reduce clinician workload, and enhance patient care. The plan outlines three 'essential' steps for improving electronic health reforms, including implementing unique personal safety identifiers to streamline operations.
Dr. John H. Bushweller's team at UVA Cancer Center is developing novel drugs to block abnormal proteins that cause pediatric leukemia. The new approach aims to improve efficacy and reduce toxicity, potentially leading to better patient outcomes.