Scientists have developed a new tool to precisely target cancer cells by distinguishing them from neighboring cells. The Co-LOCKR system uses synthetic proteins to detect specific combinations of cell surface markers, allowing for more precise targeting and improved safety for cancer-killing CAR T cells.
A new study found that digital breast tomosynthesis (DBT) outperforms digital mammography in detecting cancers and reducing recalls. However, women with extremely dense breasts do not experience the same level of benefit from DBT. Most women with dense breasts saw an increase in cancer detection rates with DBT.
A replicating RNA vaccine has shown robust immune response in both young and old animal models, producing antibodies comparable to those in people recovering from COVID-19. The vaccine's design avoids immune responses that could exacerbate the virus, instead inducing protective antiviral measures and T cells.
A study of fruit flies has found that analyzing small molecules involved in cell metabolism can help understand how calorie-restricted diets affect aging and lifespan. The research identified several genes linked to changes in metabolite levels, shedding light on the complex interplay between genetics, environment, and diet.
Researchers identified an antibody, called S309, that can inhibit related coronaviruses, including the cause of COVID-19. The antibody targets a protein structure critical to the coronaviruses' ability to infect cells, neutralizing them and potentially providing a treatment for severe illness.
A new study published in Heart Rhythm found that incorporating electrocardiogram (ECG) screenings into college athletes' pre-participation physical exams can detect cardiac conditions six times more effectively than physical exams alone. The study also showed improved cost efficiency per diagnosis, reducing costs by five-fold.
Researchers found that syphilis bacteria alter a single gene, called tprK, which provides instructions for a protein on its surface. This change allows the bacterium to evade the immune system and resist eradication, contributing to its ability to hide in the body for decades.
A team of researchers from the University of Washington School Medicine has created artificial proteins that function as molecular logic gates, allowing for the programming of complex biological systems. This breakthrough has implications for future medicines and synthetic biology, particularly in the development of cell-based therapies.
Researchers found that a community-based intervention using mobile vans significantly increased viral suppression, with 74% of participants achieving suppression compared to 63% in traditional clinics. The convenience of the vans made it easier for people living with HIV to access treatment.
Researchers discovered a pigment called melanopsin sensitive to blue light affects circadian rhythms but cone photoreceptors respond strongly to long wavelength oranges and yellows at sunrise and sunset. The study identifies a cell in the retina regulating brain centers that impact sleep, mood and learning.
A coalition of health workforce researchers advocates for revising antiquated state laws limiting nurse, PA, and pharmacist practice. Relaxing restrictions could expand access to care at lower cost, with expanded medication management services.
A recent study explored how some mammals postpone embryonic development to await better conditions. The research, led by Abdiasis Hussein, advances understanding of delayed embryo implantation and suggests a link to rapidly dividing cells in tumors.
Researchers analyzed genetics of schizophrenia in South African Xhosa population, finding rare genetic mutations linked to the disorder. The study sheds light on potential mechanisms for effective treatments and informs understanding of schizophrenia across human populations.
Researchers created 3D human capillaries to study how red blood cells navigate ultra-small blood vessels. Malaria-infected cells become stalled due to shape and motion changes, increasing risk of adherence and blockage.
Scientists reveal key details about how sodium channels power heartbeats and respond to heart rhythm drugs. The study provides a blueprint for understanding cardiac sodium channels, revealing characteristics that distinguish them from other ion channels.
Researchers have found that suppressing MSUT2, a gene involved in tau regulation, may protect against Alzheimer's disease. The study also highlights the importance of preserving PABPN1 activity to prevent brain degeneration.
A large study of 799 people found that methamphetamine use was associated with more than twice the risk for dropping out of treatment for opioid-use disorder. Meth users often experience challenges in daily life, including homelessness and difficulty saying no to drug dealers.
A new technique called sci-Plex profiles gene expression in thousands of individual cells when a sample is perturbed, offering a global view of cellular responses. The results suggest that it could be scaled to thousands of samples to target diverse biochemical pathways.
A study published in Neuropsychopharmacology found that targeting cell populations in the nucleus accumbens can prevent addiction relapse. Researchers used chemogenetic receptors to control activity in this brain region, successfully reducing relapse behavior in high-risk rats.
A recent study suggests that wound healing in mucous tissues during early SIV infection may prevent disease progression and AIDS. The researchers found that African green monkeys, a natural host for HIV, quickly activate regenerative wound healing mechanisms in their mucosal tissue, interrupting the course of the disease.
Cases of melanoma declined among US adolescents and young adults from 2006 to 2015, with incidence rates dropping by 4% per year for males and 4.5% per year for females in the two age groups. Public health efforts advocating sun protection may be contributing to this trend.
A large clinical trial found that vitamin D and omega-3 fatty acid supplements did not slow the decline of kidney function in adults with Type 2 diabetes. The study involved over 1,300 participants and measured their kidney function over five years.
Researchers found that a key Alzheimer's gene (APOE) behaves differently among Caribbean Hispanics depending on ancestral origin. Individuals with African-derived APOE had a 39% lower risk of Alzheimer's compared to those with European-derived APOE.
Researchers discovered a modified protein in benign-appearing meningiomas that can reveal which are truly benign and which are more dangerous. The finding may inform the discovery of drugs to treat these tumors more effectively.
A new study found that certain gut bacteria, such as Bacteroides species, have acquired large immunity gene clusters to neutralize toxins from other bacteria. These clusters are actively acquiring new genes to protect against emerging threats.
Researchers found that skin in mice expresses its own photoreceptors using neuroposin, synchronizing circadian clocks to light-dark cycles independently of eyes or brain. This discovery has implications for understanding skin physiology and potentially enhancing medical practice.
A genetic link has been discovered between Sudden Infant Death Syndrome (SIDS) and a mutation in the HADHA gene, causing infants to die suddenly from cardiac arrest. Researchers hope that this discovery will lead to new treatments and interventions for the disease.
A potent monoclonal antibody has been developed to impede henipavirus fusion with cell membranes, blocking viral genome injection. The antibody recognizes a specific area of the viral membrane machinery, preventing membrane fusion and keeping viral material out of host cells.
Researchers discovered that patients coming off chronic opioid prescriptions were three times more likely to die of an overdose in the years that followed. This alarming outcome has raised concerns about the policy recommendations aimed at reducing opioid prescribing, highlighting the need for systems to protect patients.
A study published in JAMA finds that measuring carbon dioxide levels through an artery is more accurate than using end-tidal capnography for pediatric brain trauma patients. The protocol developed by the Harborview Injury Prevention and Research Center has been widely used at Harborview Medical Center.
Researchers have developed a soft neural implant capable of delivering multiple drugs and color lights, which can help speed up the discovery of brain diseases. The device uses replaceable drug cartridges and powerful Bluetooth low-energy technology to target specific neurons for prolonged periods.
A study published in Cell reveals that large complex neurotransmitters, such as neuropeptides, have a robust effect on animal behavior by regulating the ventral tegmental area. The findings could lead to helping people find motivation when they are depressed and decreasing motivation for drugs in substance-abuse disorders.
Researchers develop LOCKR, a dynamic designer protein that can modify gene expression, redirect cellular traffic, and control protein binding interactions. This breakthrough technology has the potential to revolutionize synthetic biology and enable new therapies for diseases such as cancer and autoimmune disorders.
A recent study found that nearly 9% of healthy women carried multi-drug resistant Escherichia coli strains in their guts, which can transfer to the female urinary tract and cause disease. The study also showed that these strains persist in the gut for a long time and can be detected in the urine without symptoms.
A machine-learning model was developed to predict surgical-case duration, with accuracy improved from 30% to 40-50% in some cases. The study used data from over 45,000 surgeries performed by 92 surgeons, finding that the greatest variability in estimates came from individual surgeon approaches.
Researchers discovered hundreds of previously unknown protein interactions through a new statistical model applied to the human genome. These findings may open new routes to develop drugs against deadly pathogens like M. tuberculosis.
Researchers identify a genetically aberrant protein that promotes rare form of liver cancer in adolescents and young adults. A targeted drug combination slows down uncontrolled cell growth, offering hope for improved treatment options.
A team of researchers collaborated with Foldit players to design synthetic proteins, with 56 of the designed proteins found to be stable. The designs were able to adopt their intended structures, suggesting that the gamers had produced realistic proteins.
Researchers created synthetic proteins that change shape in response to pH changes, moving as intended and disrupting lipid membranes. This technology could help medication enter cells more effectively, potentially rivaling viral delivery systems without drawbacks.
The website nowmattersnow.org uses dialectical behavioral therapy to reduce suicidal thoughts and negative emotions in users. Nearly one-third of visitors experienced significant reductions in suicidal thoughts and emotional intensity after using the site.
Research found that HSV-1 and HSV-2 are mixing together to result in several new, different recombinant versions of herpes. This blurring of lines has important implications for HSV vaccine development.
A new study in JAMA Pediatrics found that intimate partner homicide among teens is a serious public health issue, with 90% of victims being girls. The study analyzed data from the National Violent Death Reporting System and found that guns were the most common weapon used in these homicides.
A new nanoparticle vaccine candidate has been designed to elicit potent neutralizing antibodies against respiratory syncytial virus (RSV), a leading cause of infant mortality worldwide. The vaccine's computer-designed nanoparticle platform holds promise for applying to other diseases, including flu and HIV.
Researchers found that cognitive behavioral therapy and the drug sertraline effectively reduce depression among people undergoing maintenance hemodialysis. The study, published in Annals of Internal Medicine, suggests that physicians should select the treatment available to patients, considering each comes with its own burdens.
Researchers found that caring contacts reduced suicidal ideation and risk by lowering odds from 15% to 9%. Simple text messages can provide support during stress and transition, improving mental health outcomes.
Nearly half of adults aged 65 and older have two or more symptoms like pain, fatigue & depression, increasing the risk of negative health outcomes. Researchers urge improved training among healthcare workers to address symptom burden in older adults.
Researchers have identified a crucial role for the folliculin gene in embryo implantation. A deficiency in this gene can lead to infertility, as cells maintain their pluripotent state and fail to exit the pre-implantation stage. The study also highlights a connection between folliculin mutations and cancer, as well as its potential to ...
Scientists successfully created functional blood vessels in vitro for rat hearts after a heart attack, resulting in increased blood flow to the engineered tissue. This innovation offers hope for treatments that could help patients regrow heart muscle tissue and achieve more complete recovery.
Newer versions of gene therapy cassettes deliver better performance, increasing muscle strength and protecting against contraction-induced injuries in animal models. The treatment, micro-dystrophin, has been restructured to enhance its functionality.
Researchers discovered that a neutralizing antibody from SARS survivors can activate coronavirus membrane fusion by mimicking receptor-attachment. This breakthrough provides new insights into understanding the mechanisms of coronavirus infection and potentially lead to vaccine design.