A new study published in the American Journal of Psychiatry found that most children diagnosed with ADHD don't outgrow the disorder. In fact, researchers followed a group of 558 children with ADHD for 16 years and found that only 10% completely outgrew it.
Researchers discover a new way for an antiviral enzyme to detect and destroy viruses that hide inside cell membranes. The OAS1 p46 isoform enhances the immune response against SARS-CoV-2, flaviviruses, and other RNA viruses.
Scientists identified five human monoclonal antibodies that can neutralize multiple beta-coronaviruses by targeting a conserved structure in the spike protein. These antibodies showed promise in reducing viral load and enhancing immune responses in hamsters, providing potential inspiration for broadly protective vaccines.
A meta-analysis published in Trauma & Violence & Abuse found that 81% of sexual assault survivors had significant PTSD symptoms one week after the assault and 54% after three months. The study suggests that most recovery from post-traumatic stress happens within the first three months.
A study found that transvaginal ultrasound (TVUS) screening missed over four times more cases of endometrial cancer among Black women compared to White women. The screening tool was not sufficiently accurate or racially equitable for Black women, putting them at a higher risk of false-negative results.
Researchers at the University of Washington have developed RoseTTAFold, a freely available AI tool that can predict protein structures in just 10 minutes. This breakthrough accelerates research into cancer, COVID-19, and other diseases, and has already been used by over 140 independent research teams.
The Epsilon variant's unique mutations in the spike protein reduce antibody neutralization, making it harder for vaccines and past infections to fight. The study reveals an unprecedented mechanism behind this loss of immunity, shedding light on a new strategy for immune evasion.
Scientists developed a new technique, sci-Space, to map gene expression over time and location at single-cell resolution in mouse embryos. They observed thousands of genes whose expression was anatomically patterned, including spatially restricted profiles in brain and heart cells.
A study of 1,095 patients with COVID-19 found abnormal blood-oxygen levels and breathing rates are strong predictors of poor patient outcomes. Researchers recommend monitoring for these signs at home or seeking medical attention earlier to potentially save lives.
Two studies published in Contraception found that telehealth abortion improves access to reproductive health services, particularly for low-income persons and those living in rural areas. The studies also showed that most patients prefer receiving abortion pills through the mail and interacting with healthcare providers via telehealth.
Scientists have discovered a way to control brain circuits using a protein called parapinopsin, found in lamprey. This breakthrough could lead to new treatments for mood disorders and unwanted behaviors.
A new bonobo genome assembly has been created with high accuracy, allowing for precise comparisons to other great apes and humans. The study reveals over 5,500 structural variants that distinguish the bonobo and chimpanzee lineages, providing insights into gene evolution and species divergence.
A study published in Nature Communications found that rucaparib is effective in treating ovarian cancers with inherited or somatic mutations in DNA repair genes. The drug targets the Achilles heel of cancers with defects in DNA repair, outperforming chemotherapy in early treatment stages.
A new study used autopsy data to evaluate the AT(N) framework, a standard tool for assessing Alzheimer's risk. The researchers found that even in the highest-risk group, a third of individuals did not develop dementia, highlighting the complexity of Alzheimer's disease and the need for additional biomarkers.
A worldwide study of 2,100 pregnant women found that those who contracted COVID-19 during pregnancy were 20 times more likely to die than those who did not contract the virus. The study also showed that infected mothers and their newborns experienced preterm birth, preeclampsia, and ICU admissions.
Researchers developed a new test to measure inactive HIV viruses in patients' genes, providing more accurate information on drug effectiveness. This test could help track the size of the HIV reservoir and predict how long it takes to eliminate the virus from the body.
The full assembly of human chromosome 8 has been completed, revealing novel genes and potential disease risks. The sequence fills in gaps missing from the current reference genome and provides new insights into immune disorders, brain development, and heart defects.
Researchers found altered brain activity in individuals with chronic sinusitis, affecting neural networks that modulate cognition and response to external stimuli. Despite no significant clinical impairment, participants showed subtle brain region communication changes associated with attention decline and sleep disturbances.
Researchers have developed next-generation influenza vaccines that protect against a wide variety of seasonal and pandemic strains, including avian viruses H5N1 and H7N9. These nanoparticle-based vaccines spur strong immune responses in animal trials, potentially lowering the risk of bad flu seasons.
A recent review of 150 articles suggests that a small leak in the blood-brain barrier is associated with benign forgetfulness of aging, which could be an early stage of Alzheimer's disease. Researchers also found that preserving pericyte function may lead to a healthier blood-brain barrier and potentially treat Alzheimer's.
Scientists have discovered a lesser-known site on the pandemic coronavirus that is recognized by COVID-19 infection-fighting antibodies, which potently prevent the virus from infecting cells. These antibodies were found in blood samples from previously infected patients and were as strong as those targeting the receptor-binding domain.
A year-long clinical trial by University of Washington School of Medicine found hydroxychloroquine ineffective against COVID-19 progression to pneumonia or hospitalization. Researchers were able to efficiently enroll participants remotely and obtain vital signs through self-submitted data.
A study conducted in KwaZulu Natal, South Africa among 162 people living with HIV found that home delivery of antiretroviral therapy (ART) significantly increased viral suppression compared to clinic care. The paid home delivery model improved health outcomes, particularly for men who struggle with clinic-based services.
Research reveals women of minority races and ethnicities with less education and income have lower access to 3D mammography, a technology that improves breast cancer detection. Despite FDA approval for over a decade, the technology's benefits are not equally shared across sub-populations.
A team of scientists has designed and successfully folded new protein structures into membrane-bound nanoparticles, expanding the toolkit for biomolecular engineering. These novel proteins show promise for advanced filtration and DNA sequencing techniques.
A new study found COVID-19 infection rates among pregnant women to be 70% higher than in similar-aged adults in Washington state. Pregnant patients from communities of color experienced a twofold to fourfold higher prevalence of infections compared to the general population.
Researchers created protein-based biosensors that emit light when mixed with virus proteins or antibodies, offering a rapid diagnostic solution. The new technology shows promise for detecting COVID-19 infections without the need for genetic amplification, addressing supply chain shortages.
A new study published in the American Journal of Obstetrics and Gynecology found that COVID-19 mortality rates were significantly higher among pregnant mothers than similarly aged individuals, with a 3.5 times higher hospitalization rate for pregnant women with COVID-19.
A group of researchers is calling on the National Institutes of Health and other funding agencies to address disparities in allocating support to Black researchers. The disparity has resulted in Black applicant award rates being around 55% lower than those of white principal investigators.
Two multi-year studies will investigate patient experiences with mental-health teletherapy services, including effects on engagement and treatment outcomes. Researchers aim to identify traits of individuals who benefit most from digital therapy, and develop personalized entry points to teletherapy.
Researchers designed proteins to form honeycomb structures that block uptake of receptors from cell surfaces. This discovery could enable new materials for modulating cell behavior and treating diseases such as sepsis, COVID-19, heart disease, and diabetes.
Researchers tested seven AI screening algorithms against expert ophthalmologists and found that most perform poorly in real-world settings, highlighting the need for proper image quality and training data. Only one algorithm matched human screener performance.
Chronic pain and emotional pain are intertwined, with opioids making things worse in the long term. Researchers recommend tapering down or switching to buprenorphine for high-dose long-term opioid users without improvement in pain and function.
A study published in Nature Neuroscience found that SARS-CoV-2's spike protein can cross the blood-brain barrier, suggesting the virus can enter the brain. This could explain many COVID-19 complications, including cognitive effects like brain fog and fatigue.
Researchers have identified the molecular mechanism by which tarantula venom traps voltage sensors on sodium channels, effectively immobilizing nerve signals. This finding may lead to the development of new pain therapeutics that target the Nav1.7 channel, a key player in pain transmission.
A new paper argues that robots designed for older adults can provide essential human values like social interaction, emotional fulfillment, and bodily integrity. The author suggests that Western cultures' narrow view of sex as lust needs to be challenged, and that robots can enable people to experience physical affection and self-respect.
Researchers at UW Medicine created two cell atlases that map gene expression and chromatin accessibility in human development, providing unprecedented data for understanding cell differentiation. The atlases identify 77 main cell types and approximately 650 cell subtypes, shedding light on the regulatory 'grammar' of the cell.
Researchers discovered that clonal hematopoiesis, a phenomenon where non-cancer DNA mutations are present in blood plasma, is confounding prostate cancer liquid biopsy results. This can lead to false positives and incorrect treatment for patients undergoing liquid biopsies.
Researchers found significant variation in the effectiveness of collaborative care programs for depression in primary-care clinics. Clinics with more intensive implementation support and those that had several years of practice achieved better outcomes. Patients who are more severely depressed or have fewer resources may also have wors...
A new ultrapotent COVID-19 vaccine candidate, designed via computer, has been shown to produce virus-neutralizing antibodies in mice at levels ten times greater than those seen in people who have recovered from COVID-19 infections. The vaccine candidate also elicited a strong B-cell response after immunization.
The CODA trial found that antibiotics can avoid surgery for more than 70% of patients with appendicitis. However, patients with an appendicolith may face higher complications and a greater risk of needing surgery.
Researchers at the University of Washington and Rice University are working on a novel technology that uses thermofluidic systems to manipulate gene expression in cells within 3D artificial organs. This could lead to the creation of functional artificial liver tissues that can be used for studying disease and developing new treatments.
A cocktail of powerful antibodies from recovered COVID-19 patients locks down the infection machinery, preventing the virus from entering cells. The antibodies protect hamsters from infection when exposed to the coronavirus, also setting off the infection-fighting actions of other immune cells.
Primary-care physicians and rural clinic staff improve their ability to diagnose and treat common mental health disorders using a collaborative care model with telepsychiatry. The study, published in the Annals of Family Medicine, found that this approach enhances primary-care doctors' skills in treating behavioral health disorders.
A study of Seattle-area homeless shelters found a need to provide routine viral testing outside clinical settings to identify new cases and prevent spread. The results suggest that crowded conditions, communal sleeping, and shared hygiene facilities can foster transmission of SARS-CoV-2.
Scientists accelerated vision restoration by visualizing photoreceptors' response to light in the living eye. Researchers modified OCT technology to detect minute changes, enabling high-resolution visualization of cone photoreceptors and potential therapies like stem cells or gene therapy.
Researchers have designed computer-generated antiviral proteins that protect lab-grown human cells from SARS-CoV-2 infection, rivalling the protective actions of best-known neutralizing antibodies. The most potent candidate, LCB1, is six times more effective on a per mass basis than reported monoclonal antibodies.
Researchers found that fibroblast growth factor 1 repairs damaged perineuronal nets in the brain, a critical response required for sustained diabetes remission. The discovery sheds light on the intricate biology of the brain's response to the protein and may lead to more effective diabetes treatments.
A CDC study of over 80,000 adult patients hospitalized with flu found that sudden, serious heart complications occurred in 12% of patients, or 1 in 8. The study underscores the importance of getting a flu shot early to prevent these complications. Researchers recommend that everyone 6 months and older get a flu vaccine every flu season.
A study found that nearly 85% of dialysis patients prefer CPR in the event of a cardiac arrest, despite having poor survival rates. The respondents' appreciation for life is acknowledged, but the findings highlight the need for better discussions between doctors and patients about resuscitation and end-of-life care.