A recent study by UT Southwestern Medical Center found that patients with a prior cancer diagnosis have similar clinical outcomes to those without a history of cancer. The researchers studied over 102,000 patients and found that these patients had better overall survival and lung cancer-specific survival rates.
Research by UT Southwestern Medical Center Emergency Medicine physicians found that deeper chest compressions result in decreased survival due to collateral damage, while faster compression rates are crucial for survival. The ideal compression rate is between 100-120 beats per minute.
Researchers at UT Southwestern Medical Center developed a wearable sensor system to track gait, balance, and other movements in individuals with Parkinson's disease. The APDM Mobility Lab can effectively assess the severity of the disorder even when medications are used to reduce symptoms.
A UTSW study reveals a strong correlation between low levels of beclin 1 and both triple-negative breast cancer incidence and poor prognosis. Patients with low beclin 1 activity had a 67% increased risk of dying from breast cancer compared to those with higher levels.
A study by UT Southwestern Medical Center investigators found that patients with heart failure who used left ventricular assist devices (LVADs) for six months or longer showed significant regeneration of heart muscle. Oxidative damage to a cell-regulator mechanism was prevented, leading to an increase in cardiomyocyte proliferation.
A recent study published in the Journal of Clinical Investigation identified hyaluronon as a critical substance made by the body that protects against premature births from infection. The findings suggest that HA plays a crucial role in epithelial barrier function and offers cervical protection against bacterial infections.
Scientists discovered a small molecule, 6-thiodG, that can stop cancer cell growth and shrink tumors in mice. The compound works by disrupting the normal way cells maintain telomere length, triggering cell death.
A clinical trial combining stereotactic body radiation therapy with erlotinib improved overall and progression-free survival times for stage 4 lung cancer patients. The treatment combination increased survival rates by more than doubling, from 6-9 months to 20 months.
A recent study by UT Southwestern Medical Center researchers confirms that whole-genome sequencing can successfully identify cancer-related mutations in patients. The method was used to analyze the genomes of 258 cancer patients, detecting nearly 90% of clinically identified mutations and discovering additional cancer gene mutations.
A five-year national trial will investigate interventions for patients with multiple chronic conditions, including chronic kidney disease, diabetes, and hypertension. The study aims to identify effective treatments for patients with coexistent diseases and implement integrated healthcare delivery models.
Researchers found that endogenous retroviruses play a critical role in the body's immune defense against common bacterial and viral pathogens. The ERV DNA can activate B cells to produce protective antibodies, suggesting that these viruses have an 'physiological' function.
A new real-time radiation monitor significantly reduces radiation exposure for medical workers during cardiac-catheterization procedures, resulting in a one-third decrease in radiation exposure. The device provides auditory feedback, enabling operators to take actions to reduce radiation exposure and adopt safer radiation practices.
UT Southwestern Medical Center researchers have identified a cell signaling mechanism that plays a crucial role in brain cancer growth and may provide a new therapeutic target. Non-canonical epidermal growth factor receptor (EGFR) signaling is highly active in glioblastomas, making tumor cells more resistant to chemotherapy treatment.
Researchers identified a possible therapy to treat NF1 by reversing anatomical defects in the cerebellum with an ERK pathway inhibitor. This approach may reverse some aspects of the disease despite embryonic gene loss.
Researchers at UT Southwestern Medical Center found that enterohemorrhagic E. coli (EHEC) uses Bacteroides thetaiotaomicron to worsen its own infection by stealing scarce resources from other gut bacteria. This discovery opens up new avenues for understanding how microbiota composition impacts infection outcomes.
CPRIT awards UTSW faculty $22.5 million for groundbreaking research into leukemia, liver cancer, and anti-cancer immunotherapy, aiming to drive innovative therapies and better care for cancer patients. The grants will support investigations targeting promising new discoveries in cancer and commercial development.
Researchers from UT Southwestern Medical Center found a strong, protective relationship between cholesterol efflux and cardiovascular risk. The study revealed that measuring cholesterol efflux provides significantly different information than traditional HDL cholesterol levels.
Researchers at UT Southwestern Medical Center have identified over 3,000 new gene mutations involved in certain kidney cancers. The study reveals how these mutations transform a normal kidney cell into a cancer cell through the interaction of two genes, VHL and BAP1.
Researchers at UT Southwestern Medical Center found a novel looping mechanism involving DNA end caps that determines gene regulation, contributing to aging and disease. The study reveals how telomere length affects gene expression patterns, potentially influencing the onset of disease and optimizing fitness with age.
Researchers at UT Southwestern Medical Center have identified the specific type of cell that gives rise to large, disfiguring plexiform neurofibromas, a finding that could lead to new therapies for preventing tumor growth. The study suggests ways to develop treatments by understanding the steps leading to tumor development.
A recent study found that pediatricians often fail to inform parents of overweight Latino children, highlighting the challenges of addressing rising obesity rates among minority youth. The study recommends using family-preferred terms when discussing weight with Latino families.
Dr. Schoggins has received a $2.385 million NIH New Innovator Award to pursue research on why bats can harbor numerous viruses without getting sick. The award supports his lab's work in understanding the science behind this phenomenon.
UT Southwestern Medical Center is expanding its genetic screening program to 22 North Texas counties, serving underserved populations with HBOC and Lynch syndrome risk. The new grant will connect patients with genetic specialists through telemedicine, increasing accessibility and reducing transportation costs.
Researchers found that the FGF21-CRF pathway activates the sympathetic nervous system to signal to brown fat, which burns fat to generate heat. The study provides new insights into obesity and weight loss regulation, highlighting the importance of the central nervous system in weight management.
A team of researchers at UT Southwestern Medical Center has identified PPARγ as a crucial metabolic pathway that can be targeted to stop the growth of lung cancer cells. By activating PPARγ with antidiabetic drugs, they were able to inhibit tumor cell division and induce oxidative stress, leading to cancer cell death.
Researchers at UT Southwestern Medical Center discovered that acetate supplements stimulate the formation of new red blood cells in mice with anemia. This could lead to alternative treatments for anemia, potentially reducing side effects associated with current therapies.
A substantial proportion of potential subjects are reflexively excluded from lung cancer clinical trials due to prior cancer. The exclusion criterion was applied in more than two-thirds of trials in which survival was not the primary endpoint, resulting in up to 18% exclusion rate.
A new review by UT Southwestern Medical Center surgeons found gastric bypass surgery to be more effective than banding for long-term weight loss (66% vs. 45%) and controlling type 2 diabetes, high blood pressure, and high cholesterol levels. Long-term complication rates also favored gastric bypass.
Patients who lost more than 100 pounds had the highest risk of complications from later surgical procedures to reshape their bodies. Nutrition plays a crucial role in skin healing and collagen production after bariatric surgery.
ApoE3 helps repair blood vessels, while apoE4 prevents this process, leading to increased cardiovascular disease risk. Researchers discovered a potential preventive treatment using NO donors for individuals with the apoE4 variant.
A combination of chemotherapy drugs cisplatin and pemetrexed improved survival rates and response to advanced cervical cancer by 31% compared to standard alternative, while being less toxic to patients. Adding bevacizumab further increased patient survival, suggesting the cocktail may offer further benefits.
A nationwide team of experts led by UT Southwestern hematologist Dr. George Buchanan developed the first comprehensive, evidence-based guidelines for managing sickle cell disease from birth to end of life. The guidelines consist of over 500 specific directions for physicians caring for patients with sickle cell disease.
Researchers at UT Southwestern Medical Center have identified several new genetic causes of Wilms tumor, a type of kidney cancer found only in children. The most common mutations were found in genes called DROSHA and DICER1, which affect the production of microRNAs that control cell growth.
Researchers identified rare stem cells in testis that produce PAX7, helping give rise to new sperm cells and potentially restoring fertility. These stem cells were found to be highly resistant to cancer treatments, suggesting they may play a key role in recovering fertility.
CPRIT awards UT Southwestern $26 million to expand cancer screenings, investigate therapy effectiveness, and conduct cancer biology research. The grants also support recruitment efforts and innovative approaches to improve treatment and prevention of cancer.
Researchers found that high insulin levels foster processes leading to obesity, even in mice given insulin to counter diabetes. Suppressing glucagon action may prevent hyperinsulinemia without causing diabetes.
Scientists at UT Southwestern Medical Center discovered a new way internal body clocks are regulated by long non-coding RNA qrf. The discovery sheds light on how circadian clocks work and has implications for understanding human diseases such as sleep disorders and depression.
Researchers used CRISPR/Cas9 to correct genetic mutations leading to Duchenne muscular dystrophy in a mouse model, preventing progressive muscle weakness and degeneration. The technique may lead to permanent correction of the disease, offering hope for future therapeutic applications.
Researchers found triheptanoin oil to be an efficient treatment for Glut 1 deficiency, reducing seizure frequency and improving brain metabolism. The oil has been shown to have a positive impact on neuropsychological performance in patients with the rare disease.
CRI scientists have identified a gene that contributes to the development of several childhood cancers, including neuroblastoma and hepatoblastoma. The study found that overproduction of Lin28b specifically causes hepatoblastoma, while blocking it impairs cancer growth.
Researchers have found an irreversible inhibitor, SML-8-73-1, that selectively and irreversibly interferes with the activity of mutated KRAS genes. This breakthrough has significant potential to target cancer cells and improve treatment outcomes for patients with lung, pancreas, and colon cancers.
Researchers found that over-expression of Xbp1s in mice protected them against obesity and diabetes, with improved body weight, decreased blood glucose levels, and enhanced insulin sensitivity. The study suggests the brain controls glucose production by the liver, paving the way for new therapies to treat these conditions.
A study by UT Southwestern found a five-fold increase in cancer patients using MyChart from 2009 to 2015, with those over 60 making up the majority of frequent users. The technology's convenience and ease of use contribute to its widespread adoption among this demographic.
New study finds sedentary behavior can be detrimental to cardiovascular health, independent of exercise. Researchers recommend taking short walks, tracking daily steps, and replacing desk chairs with fitness balls or treadmill desks.
A UT Southwestern Medical Center study found that combining cognitive behavioral therapy with medication improves long-term success of depression treatment in children and adolescents. Relapse rates were significantly lower for those who received both forms of treatment compared to those on medication alone.
Researchers at UT Southwestern Medical Center suggest that inhibiting the action of enzyme Cdk5 could substantially reduce brain damage after a stroke. The study found that aberrant Cdk5 activity causes nerve cell death during stroke and that blocking this enzyme can help preserve brain tissue.
A new microRNA has been identified as a potential therapeutic target for treating osteoporosis by blocking bone destruction. Researchers believe this discovery could lead to innovative treatments for conditions such as osteoporosis and other bone diseases.
Researchers at the Children's Medical Center Research Institute have identified a biomarker to accurately characterize mesenchymal stem cells (MSCs) in the body. This breakthrough finding could improve the success of clinical trials using MSCs for conditions such as bone fractures and osteoarthritis.
Researchers at UT Southwestern Medical Center have discovered a new driver of atherosclerosis, a molecule called 27-hydroxycholesterol (27HC), which exacerbates the condition and may be a promising therapeutic target. Blocking 27HC or inhibiting its actions could provide a complementary approach to preventing vascular disease.
Research from UT Southwestern Medical Center found that a level of 'healthy' inflammation is necessary to prevent fatty liver and metabolic diseases. Inflammation helps remodel fat tissue, preventing the buildup of excess lipids in other tissues.