Researchers at UT Southwestern Medical Center have identified a protein called Perilipin 5 that promotes the efficient breakdown of fat. This discovery could lead to new ways to treat obesity and type 2 diabetes, as excess fat can accumulate in tissues not specialized for storage and cause dysfunction.
Researchers at UT Southwestern Medical Center developed a novel MRI method that can detect low levels of zinc ions to differentiate between healthy and malignant prostate tissue. This technique has the potential to serve as a biomarker for tracking prostate cancer progression.
Research at UT Southwestern Medical Center found that beta 1 adrenergic receptors mediate ghrelin release, which prevents hypoglycemia. The study suggests that suppression of ghrelin release by beta blockers may be responsible for low blood sugar levels in children taking these drugs.
A new study published in the American Journal of Psychiatry found that medications improved work productivity in most patients with depression, but those who showed rapid improvement had more significant reductions in depressive symptoms and were more likely to recover. The study suggests that patients requiring additional treatments l...
Researchers at UT Southwestern Medical Center have discovered a previously unknown function of poly(ADP-ribose) polymerase (PARP) proteins, which regulate gene activity and RNA synthesis. This finding has therapeutic implications for cancer treatment and may also lead to new avenues for treating inflammatory and cardiovascular diseases.
A new study by UT Southwestern Medical Center researchers found that nearly 20% of hospitalized adults are discharged with one or more vital sign instabilities. Patients who had vital sign abnormalities on the day of discharge had higher rates of hospital readmission and death within 30 days.
Researchers identified a key role for Vps33B in regulating innate immunity and found exaggerated inflammatory responses in cells lacking the protein. The study suggests potential new therapies for arthrogryposis-renal dysfunction-cholestasis (ARC) syndrome, which is associated with recurrent infections and sepsis.
Researchers identified ACSL3 as essential for mutant KRAS gene activity in lung cancer cells, leading to cell death when suppressed. The study provides a critical role for fatty acids in lung cancer and meets an urgent need for targeted therapies.
A recent study published in the journal Obesity found that severely obese women's brain activity differs from lean counterparts when it comes to responding to food cues. Despite reporting fullness, their brains continued to react similarly to hungry states, with sustained activation in reward centers.
Researchers identified ASCL1 as an essential protein in the development of small cell lung cancer, and deleting it in mice prevented cancer formation. The study highlights a new potential target for treatment, offering hope for improving survival rates for patients with this devastating disease.
Researchers at UT Southwestern Medical Center have identified a new route of entry for the tuberculosis bacteria, suggesting an alternative to traditional inhalation-based transmission. This finding opens up potential avenues for developing new therapies to prevent or treat tuberculosis infection.
Researchers at UT Southwestern Medical Center have identified a key regulatory mechanism of insulin signaling, linking it to the timing of cell division. Three spindle checkpoint proteins, crucial for accurate cell division, also regulate metabolism through their impact on insulin receptors.
Researchers at UT Southwestern Medical Center have developed a new method to detect telomere length, which can influence cancer progression and aging. The new approach uses non-radioactive probes, increasing sensitivity and stability, and may help slow or stop cancer cell growth.
A study involving UT Southwestern researchers found that primary care visits lead to higher rates of colon cancer screening and better follow-up care, even in health systems promoting mail-in stool blood tests. This result underscores the importance of primary care physician visits in a virtual care era.
Researchers at UT Southwestern Medical Center identified a previously unrecognized enzyme, MLCK4, that could optimize contraction and prevent heart failure. The study provides the first three-dimensional structure for any member of the MLCK family and sheds light on the optimal phosphorylation level for normal heart function.
Researchers at UT Southwestern Medical Center discovered that between 14 to 25 percent of lung cancer patients also have immune disease, making them unsuitable for immunotherapy treatments. This finding raises critical questions about the effectiveness and toxicity of these treatments among patients with autoimmune diseases.
Researchers found that Zika virus infects about 20% of brain progenitor cells, which can become neurons, and continues to replicate for weeks without stimulating an immune response. The study provides insights into the severe neurological effects caused by Zika, such as microcephaly and impaired growth in infants.
Researchers at UT Southwestern Medical Center have determined the 3D atomic structure of a human sterol transporter that helps maintain cholesterol balance. This knowledge could lead to finding highly targeted therapies to treat or prevent diseases related to sterol imbalance.
UT Southwestern researchers challenge long-held beliefs on acid reflux damage, finding that inflammatory response and cytokine secretion are the main causes of esophageal damage. The study could lead to novel GERD treatments targeting these proteins.
Researchers at UT Southwestern Medical Center discovered that Fanconi anemia genes play a crucial role in selective autophagy, particularly in removing damaged mitochondria. This finding has implications for treating Fanconi anemia and certain cancers, including familial breast and ovarian cancer.
Researchers at UT Southwestern Medical Center found that sedentary behavior is associated with increased amounts of calcium deposits in heart arteries, leading to a higher risk of heart attack. Reducing daily sitting time by 1-2 hours can have a significant positive impact on future cardiovascular health.
Researchers discovered measurable changes in brain cells of high school football players due to repeated impacts, even without concussion. The study used diffusional kurtosis imaging to measure changes in neural tissues and white matter abnormalities.
Dr. Hao Zhu has been awarded a $750,000 Stand Up To Cancer grant to investigate the relationship between injury, regeneration, and cancer. His research aims to understand the mechanisms shared by cancer and organ regeneration, with potential therapeutic targets in tissue repair and cancer prevention.
A five-year study shows that Stereotactic Body Radiation Therapy (SBRT) offers a higher cure rate than traditional approaches, with a 98.6% cure rate for prostate cancer patients. The treatment involves high-dose radiation beams delivered in just five treatments, resulting in fewer side effects and quicker recovery times.
Researchers at UT Southwestern Medical Center identified molecular ties between cancer cell growth and heart cell enlargement, potentially leading to repurposed cancer treatments for heart disease. The study found that inhibiting enzymes called HDACs can blunt excess heart muscle cell growth and slow the spread of cancer.
Researchers found that common treatments for prostate cancer can suppress the immune system, preventing immunotherapies from working effectively. The study suggests careful regulation of treatment timing and dosage to maximize anti-tumor effects and prevent relapse.
Researchers at CRI identified a new metabolic pathway that allows cancer cells to survive in conditions toxic to normal cells. The study reveals that cancer cells use an alternate version of the pentose phosphate pathway and the Krebs cycle to defend against reactive oxygen species.
Administering resuscitation drugs through an IV line can significantly improve survival rates for patients experiencing witnessed cardiac arrests. The study found that these drugs are only effective when given directly into a vein, rather than the commonly used intraosseous method.
Researchers found improved survival rates for acute liver failure patients, with overall survival increasing from 67% to 75%, and survival without a transplant rising from 45% to 56%. Transplant success also improved, with survival rates reaching 96%.
Researchers have determined the atomic structure of separase, an enzyme that breaks down proteins and plays a central role in cell division. This discovery could lead to better treatments for cancer, which occurs when cells divide out of control.
A recent study discovered a genetic mutation linked to X-linked reticulate pigmentary disorder (XLPDR), a rare systemic disorder affecting 14 known families worldwide. The mutation affects the POLA1 gene, involved in DNA replication, and alters cellular mechanisms leading to aberrant splicing and immune responses.
CRI researchers found that inactivating a certain protein-coding gene promotes liver tissue regeneration in mammals. The study showed that mice without the gene had healthier livers, improved liver function, and faster healing of damaged tissues.
A study published at UT Southwestern Medical Center identified over 1,000 gene variants linked to systemic lupus erythematosus (SLE), a serious autoimmune disease. The findings support the potential of precision medicine to improve diagnosis and treatment for SLE, which affects nine times more women than men.
A team of researchers at UT Southwestern Medical Center has identified a second role for RNA-binding proteins, which may contribute to neurological diseases such as autism and epilepsy. The study suggests that these proteins play a key regulatory role in translating messenger RNA into proteins.
Researchers at UT Southwestern Medical Center found a link between traumatic brain injury and mild cognitive impairment, with those who experienced loss of consciousness for over five minutes being at greater risk. The study analyzed data from 3,187 people diagnosed with mild cognitive impairment versus a normal-cognition group of 3,244.
Researchers at UT Southwestern Medical Center have developed a novel approach to improve cancer immunotherapy by recruiting T cells into tumors using a fusion protein called antibody-LIGHT. The study found that this strategy can overcome tumor resistance and increase the response rate to immune checkpoint blockade therapy.
Researchers at UT Southwestern Medical Center have identified a new innate immunity pathway that protects mammals from viral oncogenesis, a process causing cancer. The study found that the autophagy-related protein beclin 2 can help break down key oncogenic viral proteins associated with Kaposi's sarcoma.
A multinational trial found that injecting a new long-acting insulin with another drug, IDegLira, improved glucose control in Type 2 diabetes patients. Participants on the combination product lost weight and experienced fewer episodes of hypoglycemia compared to those receiving basal insulin alone.
Researchers at UT Southwestern Medical Center found that light reflectance spectroscopy can differentiate between malignant and benign prostate tissue with 85% accuracy. This technology aims to improve surgical decision-making and reduce the amount of healthy tissue removed during prostate cancer surgery.
UT Southwestern Medical Center researchers have designed a powerful 3-D microscope capable of creating high-resolution images of living cancer cells in controlled microenvironments. The new approach enables detailed study of cell interactions with their environment, accelerating discovery in biology.
Researchers have identified a way to allow normal frataxin production to resume in individuals with Friedreich's ataxia, a neurological disease for which there is currently no cure. The synthetic DNA or RNA prevents the mutant sequence from bending back and blocking the frataxin gene.
Researchers at UT Southwestern Medical Center developed a nanoparticle therapy that combines LDL and fish oil to preferentially kill primary liver cancer cells. The approach shows significant anti-cancer activity, with over 80% of tumor cells dying, and holds promise for potentially treating other cancers.
Scientists at CRI have discovered new complexities underlying cancer biology, overturning a nearly century-old perception about cancer metabolism. The study found that tumors use multiple nutrients for energy, and the surrounding environment influences metabolic activity.
Researchers at UT Southwestern Medical Center have identified a new drug, Neoseptin-3, that activates the innate immune system in a novel way. The study found that Neoseptin-3 induces an immune response similar to that caused by LPS, but with a milder effect.
A UT Southwestern study found no conclusive evidence supporting the use of more expensive biologic mesh materials over synthetic mesh in abdominal wall hernia repair. Despite their potential benefits, biologic meshes have not been proven to significantly reduce infections or erosions.
Researchers deciphered how HIV's Tat protein interacts with host genes to activate or repress several hundred human genes. Blocking Tat activity may be therapeutic value for HIV patients, suggesting a promising approach to combat the deadly virus.
Researchers create synthetic nanoparticles that can deliver miRNA-based therapies to late-stage liver cancer, inhibiting tumor growth and extending survival. The breakthrough addresses a major challenge in treating aggressive liver cancer, offering hope for patients with limited treatment options.
Researchers discovered normal p53 gene action restrains transposons, mobile genetic elements that can lead to genomic instability. Disabling p53 allows transposons to erupt, causing disease.
Researchers at UT Southwestern Medical Center have discovered that CDK4/6 inhibitors alter the metabolism of pancreatic cancer cells, revealing a biologic vulnerability. By targeting altered tumor metabolism with other drugs, it may be possible to positively impact cancer treatment.
Researchers identified the NLRP3 inflammasome's role in activating Interleukin 1 beta, triggering inflammation and BPD development. Testing FDA-approved drugs showed promise in reducing lung damage.