Articles tagged with Chemotherapy
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A new trial found that giving chemotherapy immediately to men with newly diagnosed, hormone-sensitive prostate cancer can extend their survival by more than a year. The study showed significant benefits in both overall and high-extent disease populations.
A preclinical study of Rice University's quadrapeutics technology found that it can detect and kill cancer cells instantly, without harming surrounding normal organs. The technology uses a combination of existing clinical treatments and mechanical events triggered by nano-explosions to target cancer cells.
An analysis by Fox Chase Cancer Center has revealed a dramatic increase in the use of chemotherapy before surgery to remove ovarian cancer, with 26.72% of patients receiving it in 2011 compared to 8.94% in 1998.
A retrospective analysis of adjuvant chemotherapy's impact on overall survival in patients with stage III soft tissue sarcomas (STS) found a significant benefit. Patients treated with adjuvant chemotherapy had an improved median overall survival, with a 23% increase compared to those not treated.
Researchers at Fox Chase Cancer Center found that genetic mutations in three specific genes can predict which bladder cancer patients will benefit from early chemotherapy. Patients with these mutations are more likely to respond to treatment and have a higher chance of being cancer-free after surgery.
A new clinical trial found that adding goserelin to chemotherapy regimens for premenopausal women with early-stage breast cancer significantly reduced the risk of early menopause. The study also showed improved overall survival rates and a higher pregnancy rate in the goserelin group.
Researchers at Fox Chase Cancer Center halted a trial after 23% of patients experienced severe cardiovascular events while receiving a chemotherapy regimen. The study aimed to investigate the effectiveness and safety of gemcitabine and cisplatin in patients with muscle-invasive bladder cancer.
Researchers have developed nanoscale structures called 'nanodaisies' that can deliver multiple anti-cancer drugs to cancer cells. These daisy-shaped structures show promise in treating lung, leukemia, breast, prostate, liver, ovarian and brain cancers.
Researchers used large population-based data to compare six common chemotherapy regimens, identifying those with the highest risk of hospitalization. The study found that TAC and AC+T were associated with high hospitalization rates in younger patients, while all regimens except ddAC+P had higher risks for older patients.
A phase I study found that alisertib inhibited aurora A kinase, a target for aggressive lymphoma treatment, in about one-third of patients with non-Hodgkin lymphoma and chronic lymphocytic leukemia. The oral drug showed manageable side effects, paving the way for advanced trials.
Berkeley Lab researchers unveiled the atomic-scale mechanism of microtubule assembly and disassembly. They found that GTP hydrolysis leads to conformational strain, which is reversed by Taxol binding, stabilizing the microtubule lattice.
Researchers at UC Berkeley have discovered the mechanism by which Taxol interferes with microtubule polymerization, preventing cell division in cancer cells. This finding could lead to the development of better anticancer drugs and improvements to existing treatments.
Circadian rhythm disruption during chemotherapy worsens its side effects, including fatigue and body weight loss. Researchers suggest personalising chronotherapy delivery to improve clinical tolerability and potentially boost treatment effectiveness.
Researchers at University of Maryland School of Medicine have identified over 60 drugs that could inhibit the Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV). These drugs, which are either approved for another condition or in advanced clinical trials, provide new targ...
A new chemotherapy regimen administered before surgery and chemoradiation improves tolerance to treatment in most rectal cancer patients. The study found that over 90% of patients were able to complete a full course of standard treatment, with many experiencing a significant reduction in symptoms.
Researchers develop nanoparticles that release two chemotherapy drugs, erlotinib and doxorubicin, at staggered times to weaken tumor cells' defenses before delivering DNA-damage. This approach dramatically shrinks lung and breast tumors in mice, including aggressive triple-negative breast cancer cells.
Researchers at Georgia State University identify two enzymes that suppress proteins important for cell survival and chemoresistance in ovarian cancer. Their findings suggest inhibiting these enzymes could be a novel therapeutic approach to overcoming resistance.
A gene expression profiling test analyzes patterns of 21 genes to predict cancer recurrence and benefit from chemotherapy. Many patients misunderstand the test's meaning, viewing it as a personalized and emotionally significant result rather than population-based statistics.
A new study from the University of Michigan Comprehensive Cancer Center found that nearly one-third of working women who had breast cancer were unemployed four years later. Women who received chemotherapy were most affected, with a significant increase in unemployment over time.
A study found that many women with early-stage breast cancer lose paid employment after diagnosis, particularly those who received chemotherapy. Women who received chemotherapy were 1.4 times more likely to be unemployed at follow-up.
Researchers at the University of Manchester discovered a key role for protein Bid in mitosis-related cell death, which may help overcome chemotherapy resistance in colon cancer. By targeting Bid, resistant cells can be made more susceptible to treatment.
A 20-year analysis of HIPEC treatment shows significant improvement in patient outcomes for selected individuals with advanced abdominal cancer. The median overall survival was 29.9 months, with a five-year survival rate of 32.5%.
Researchers at King's College London have identified new pain relief targets that could help chemotherapy patients who suffer from persistent pain. The discovery was made by investigating how pain occurs in nerves and found that the immune system plays a key role in causing pain.
Researchers have created nanoparticles that can deliver three or more different chemotherapy drugs to cancer cells, offering new hope for more effective treatments. The particles are designed to release the drugs in response to specific triggering mechanisms, reducing side effects and increasing efficacy.
Scientists discovered a surprising collaboration between p53 and NF-kappaB proteins in immune cells, which can lead to increased inflammation. This finding may help develop new strategies to prevent inflammatory side effects of chemotherapy.
Clinical trials show chemotherapy before surgery improves muscle-invasive bladder cancer survival. Chemotherapy after surgery also increases survival rates, with a significant improvement over time.
Research finds that long-term antibiotic treatment with doxycycline and hydroxychloroquine can cause significant changes in gut microbiota, leading to weight gain in nearly one quarter of patients. The study highlights the need for reduced calorie diets during long-term antibiotic treatment.
Researchers at the University of Southampton found that a combination of cetuximab and chemotherapy was not effective in treating advanced bowel cancer that had spread to the liver. The study, published in The Lancet Oncology, suggests that this treatment approach may even accelerate cancer progression in some cases.
A meta-analysis of randomized controlled trials found that chemotherapy improved progression-free survival compared to epidermal growth factor receptor tyrosine kinase inhibitors in patients with wild-type EGFR tumors. However, overall survival did not differ between the two groups.
A University of Colorado study shows that cancer cells can outlive chemotherapies by using autophagy, a process where cells recycle damaged parts. This finding has implications for developing drugs that inhibit autophagy to sensitize cancer cells to chemotherapy.
Researchers have developed a new drug delivery method that targets cancer cells using nanoballoons encapsulating anti-cancer drugs. The nanoballoons release the drugs when struck by a red laser, limiting interactions with healthy bodily systems and reducing side effects.
A landmark study found pathological complete response after neoadjuvant chemotherapy to be an independent predictor of favorable clinical outcomes in all molecular subtypes of breast cancer. The treatment administered, taxane or non-taxane, was also shown to impact event-free survival.
Researchers measured p16 levels before, after and a year after chemotherapy to determine its impact on molecular aging. The study found that curative chemotherapy increased molecular age by an equivalent of 15 years in breast cancer patients. This suggests the p16 test may help evaluate treatment effects on long-term health and survival.
A new study found that adjuvant chemotherapy increases markers of molecular aging in the blood of BC survivors, including p16INK4a and ARF expression. These age-promoting effects may last for several years after treatment and even be permanent.
Researchers at Plant & Food Research identified falcarinol-type compounds that inhibit transport mechanisms interfering with cancer chemotherapy. These compounds, found in carrots and parsley, may complement conventional treatments to deliver better results for patients.
A new study has developed a revolutionary new drug called ZL105 that manipulates the body's natural energy systems to attack and shut down cancerous cells. The compound is based on the precious metal iridium and may be ten times more effective in treating various types of cancers.
A study of 439,628 veterans found that taking Valproic acid for at least one year lowered the risk of developing head and neck cancer by 34%. Higher doses and longer durations of use provided additional benefits with up to 16,000 new cases potentially prevented annually in the US.
Research finds that obese patients have a higher risk of cancer recurrence and metastasis after neoadjuvant chemotherapy. Diabetes also affects cancer outcomes, particularly in hormone receptor-positive tumours, increasing the risk of death from all causes by 49%.
Interim results show omitted radiotherapy associated with higher early relapse rates in stage I/II Hodgkin's lymphoma. The study found no significant differences in progression-free survival between standard and experimental treatment arms.
A new class of BTK inhibiting drugs has shown significant improvements in patients with terminal forms of leukemia and lymphoma. The treatment has virtually no side effects and improves a patient's life expectancy and quality of life.
Scientists have developed 'chemosynthetic livers' that can mimic human metabolism, allowing researchers to test drug safety and interactions without animal testing. The technology has already demonstrated accurate results with over 50 pharmaceutical compounds.
Researchers found that CT scans can predict chemotherapy effectiveness by analyzing tumor density and contrast uptake. This breakthrough could lead to personalized treatment plans for patients with pancreatic cancer.
Researchers at North Carolina State University developed a new technique using ATP as a trigger for targeted anti-cancer drug delivery. In laboratory tests, it increased the effectiveness of drugs targeting breast cancer, with a 3.6 times higher success rate than non-ATP techniques.
Researchers found that several chemotherapy drugs cause hyper proliferation in stem cells, leading to tumor recurrence. The study used fruit flies as a model, discovering compounds that inhibit tumors without causing this side effect.
A new study led by the University of South Florida found that molecular subtyping can better identify women at high risk of recurrence. The method classifies breast cancer tumors into four genetically-distinct categories, providing valuable information for personalized treatment decisions.
Research suggests that palliative chemotherapy can lead to more invasive medical procedures and a higher risk of death in intensive care units among advanced cancer patients. The findings highlight the need for clearer discussion of the harms and benefits of palliative chemotherapy at the end of life.
Research finds that chemotherapy induces epigenetic changes in breast cancer patients' blood cells, leading to inflammation and symptoms like fatigue. The study identifies eight sites of methylation altered by chemotherapy, correlating with increased inflammatory signaling proteins.
Research suggests that terminally ill cancer patients who receive chemotherapy in the last months of life are more likely to undergo intensive medical care and die in an intensive care unit. The study highlights the importance of end-of-life discussions between patients and physicians.
Researchers are exploring innovative approaches, including medication like Bevacizumab and handheld optical coherence tomography, to improve vision in young children with optic pathway gliomas. These treatments have shown promising results, offering improved visual acuity and stability.
Researchers developed nanoparticles that absorb energy from infrared red wavelength and release chemotherapy drugs when triggered by two-photon laser. The delivery system shows promise for treating cancer with reduced treatment side effects and increased cancer-killing effect.
Researchers from the University of Surrey launch eSMART, a programme using mobile phone technology to remotely monitor patients undergoing chemotherapy for breast, bowel and blood cancers. The system assesses symptoms and triggers alerts to doctors or nurses within minutes.
Researchers at Tel Aviv University propose a new nanoscale drug-delivery system to tackle aggressive ovarian cancer using a cluster of nanoparticles called gagomers. The system accumulates in tumors, producing dramatic therapeutic benefits and reducing toxic accumulation in healthy organs.
A multi-site research project led by Dr. Bradley J. Monk found that women with advanced cervical cancer live an average of 17 months longer when combined with bevacizumab and chemotherapy compared to chemotherapy alone. The study reveals a significant improvement in treatment outcomes for patients with metastatic cervical cancer.
Researchers discovered a new drug, spironolactone, that inhibits DNA repair mechanisms, making cancer cells more susceptible to chemotherapy. This finding has the potential to enhance cancer treatment protocols and improve patient outcomes.
A study of 285 stage III-IV SCCOP patients found that HPV-positive patients developed distant metastases later, in more subsites, and atypical sites compared to HPV-negative patients. The most common sites were lung and bone for both groups.
Researchers have developed a biologic drug that prevents the production of HE4 protein, allowing ovarian cancer cells to grow aggressively and resist chemotherapy. The novel biologic has shown promising results in cell and animal models, increasing the potential for improved treatment and survival rates for women with ovarian cancer.
A new treatment approach has been proposed to prevent intestinal inflammation in cancer patients. Researchers suggest using IL-1b beta blocking reagents, such as Anakinra, to alleviate mucositis, a common side effect of chemotherapy and irradiation.
Researchers discovered that altering chemotherapy drugs to react only with palladium could minimize damage to healthy cells. By implanting devices coated with palladium into tumours, the drugs would become activated only where needed, potentially reducing side effects.
Researchers have developed 'smart' gold nanoshells that target cancer cells specifically, delivering anticancer drugs and converting near-infrared light into heat. This breakthrough could lead to more effective cancer treatments by overcoming the limitation of traditional chemotherapy techniques.
Researchers at the University of Adelaide found that grape seed extract improves chemotherapy's potency and reduces intestinal damage in laboratory studies. Grape seed extracts showed no side effects on healthy intestine, decreased inflammation by up to 55%, and increased growth-inhibitory effects on colon cancer cells.