Articles tagged with Chemotherapy
A new multicenter study emphasizes the importance of a standardized treatment plan for patients with advanced bladder cancer. The research, involving eight Italian centers, found that response rates and outcomes for salvage therapies are dismal, with no clearly established second-line therapy.
A study led by St. Jude Children's Research Hospital found that combining gemtuzumab ozogamicin with conventional chemotherapy improves the outcome of bone marrow transplantation for some children with high-risk acute myeloid leukemia. The treatment helped eliminate minimal residual disease, leading to better patient survival rates.
A new study from MIT biologists found that tumor cells with mutated p53 can be made more vulnerable to chemotherapy by blocking the MK2 gene. In a study of mice, tumors lacking both p53 and MK2 shrank dramatically when treated with the drug cisplatin.
Researchers developed a new drug-delivery technique using two types of nanoparticles to effectively treat pancreatic cancer in mouse models. The dual-wave method opens up access to tumor cells, allowing chemotherapy drugs to target and kill cancer cells more efficiently.
A new clinical trial found that low-intensity chemotherapy regimens are highly effective in treating adult patients with Burkitt lymphoma, resulting in excellent long-term survival rates of over 90%. The treatment reduces toxicity compared to standard high-dose chemotherapy, leading to improved outcomes for adults.
Researchers have discovered a new method of delivering chemotherapy drugs directly to brain tumours using a polymer originally designed to mend broken bones. The therapy has shown promising results, reducing toxic side effects and potentially leading to more effective treatment and prolonged patient survival.
Researchers at Northwestern University have successfully tested a nontoxic therapy that suppresses Lupus in blood samples of people with the autoimmune disease. The study found that the peptides can block and reduce autoantibody production to almost baseline levels, showing potential as a vaccine-like therapy.
Researchers found that Oxantel inhibits biofilm formation by targeting an enzyme crucial for bacterial growth, offering a potential therapy for periodontitis. Periodontitis is linked to various health risks, including diabetes, heart disease, and certain cancers.
The EORTC trial found that perioperative chemotherapy with FOLFOX4 increases progression-free survival compared to surgery alone, but no significant difference in overall survival was observed. The study concludes that perioperative chemotherapy should remain the reference treatment for patients with resectable liver metastases from co...
Researchers used advanced imaging techniques to determine which patients with glioblastoma would benefit from anti-angiogenic drugs. Persistent improvement in vessel perfusion and oxygen delivery was found to be associated with longer survival rates among patients.
Glen J. Weiss, MD, presents studies on TSR-011, a potent ALK and TRK inhibitor, and Ki67, a measure of cell proliferation, in non-small cell lung cancer (NSCLC) tumors collected before chemotherapy and after surgery. These studies show preliminary clinical activity against various tumor types.
Researchers at CWRU aim to build nanoparticles that can infiltrate and quash aggressive cancers that survive traditional therapy. They will perfect molecular coatings called ligands to enable nanochains to home in on micrometastases.
A study found that early stem cell transplants significantly improved remission rates among high-risk non-Hodgkin's lymphoma patients. However, the treatment did not impact overall survival for this group, except in those with the highest risk of relapse.
Researchers have developed a novel nanostructure that can carry multiple components for simultaneous detection, diagnosis, and targeted drug delivery to cancer cells. This Janus nanostructure has the potential to provide earlier diagnosis and more accurate targeting of cancer cells, reducing drug side effects.
Researchers found metformin as an effective radiosensitizer for treating stage III non-small cell lung cancer, improving local control and overall survival. The study suggests combining metformin with chemotherapy and radiation therapy may be a promising treatment approach.
The EORTC/GIMEMA 06012 trial found sequential combination of gemtuzumab ozogamicin (GO) and standard chemotherapy has no benefit for older patients with acute myeloid leukemia. GO is too toxic for patients over 70 years old, whereas younger patients may potentially benefit from such treatment.
Researchers at Oregon State University developed a nanotech system that combines heat and chemotherapeutic drugs to kill 95% of ovarian cancer cells. The system uses iron oxide nanoparticles coated with a cancer-killing drug, which are heated using an oscillating magnetic field, improving efficacy while minimizing side effects.
A new study found that targeted treatment and conventional chemotherapy can be effective in treating ovarian cancer, particularly in women with BRCA gene mutations. The treatment combination showed promising results in patients who had previously developed resistance to PARP inhibitor drugs.
Treatment with gemcitabine for 6 months significantly improved overall survival (22.8 months vs. 20.2 months) and disease-free survival (13.4 months vs. 6.7 months) in patients after pancreatic cancer surgery. The study demonstrated a 10.3% increase in 5-year overall survival rate.
Chemists at Scripps Research Institute develop new technique to create more stable antibody-drug conjugates, reducing toxicity and increasing efficacy. The new method uses a novel Thiol-Click reaction to form stronger linkages with cysteine amino acids.
Researchers found a 12.6% false-negative rate with SLN surgery, exceeding the prespecified threshold for patient selection. The study suggests that greater sensitivity is needed to support the use of SLN surgery as an alternative to ALND in patients with cN1 disease.
A Loyola University Medical Center study found that the active ingredient of ipecac syrup effectively inhibits bladder cancer cell growth, especially when combined with cisplatin. The compound has little effect on normal cells and may offer a new treatment option for patients with advanced bladder cancer.
Researchers have discovered a key signal that keeps oocytes alive: coenzyme A, which maintains enzyme CaMKII on, preventing cell death. This mechanism appears to be conserved in animals, offering potential therapies for preserving women's egg supply and fertility.
Researchers found that two benign strains of C. difficile can prevent infection by more dangerous strains. The harmless strains occupy the same niches as the infective strains, preventing colonization and ultimately infection. This study provides promising results for developing new protective measures against C. difficile infection.
A clinical trial found that cediranib, a biological therapy, extended the time before ovarian cancer recurred and increased overall survival by up to 30% compared to chemotherapy alone. The treatment showed incremental improvements in progression-free and overall survival.
Researchers at Johns Hopkins have discovered that a chemical commonly used as a dog food preservative, ethoxyquin, may prevent the painful nerve damage found in cancer patients taking chemotherapy drug Taxol. The study shows that adding ethoxyquin to mice prevented two-thirds of nerve degeneration caused by Taxol.
Researchers at University of Rochester Medical Center identified a compound, AZD6244, that counteracts tamoxifen's toxic effects on brain cells. The finding offers hope for preventing 'chemo brain' and its debilitating symptoms.
Researchers at Scripps Research Institute developed new compounds that show 10-200 times greater potency than vinblastine and overcome drug resistance. These improvements aim to boost the effectiveness of vincristine against childhood leukemias and Hodgkin's disease.
A recent retrospective study found that chemotherapy improves median survival among elderly patients with small cell lung cancer (SCLC) by more than 6 months. The study analyzed data from 10,428 patients aged 65 and older who received chemotherapy between 1992 and 2001.
Researchers develop microcapsules containing BCNU for targeted brain cancer therapy, improving drug delivery and reducing side effects. The uniform spheres provide precise control over drug release, enhancing treatment outcomes.
A study by University of North Carolina Health Care researchers found that problems with topoisomerases can affect brain development and potentially lead to autism spectrum disorder. The discovery has significant implications for ASD detection and prevention, as inhibiting these enzymes could have a profound effect on neurodevelopment.
A phase I clinical trial shows that diffuse, large B-cell lymphomas resistant to chemotherapy can be reprogrammed to respond using the drug azacitidine. Patients whose tumors do not respond to standard therapies are being treated with a combination of approaches, including high-dose chemotherapy and stem cell transplant.
Researchers found that giving chemotherapy drug carboplatin before radiotherapy could reduce relapse rates and allow radiation doses to be lowered in men with stage IIA and IIB testicular seminoma. The study showed improved treatment outcomes and reduced long-term side effects.
Researchers at Weill Cornell Medicine discovered that pretreating patients with low doses of azacitidine, a targeted drug, can enhance chemotherapy's ability to kill cancer cells. This approach has the potential to change the standard of care for patients with diffuse large B-cell lymphoma and may be applicable to other tumor types.
A study suggests blocking part of a DNA repair complex can increase chemotherapy effectiveness and enhance survival in therapy-resistant leukemia. Researchers found that combining mTOR inhibitors with chemotherapy was far more effective at treating T-cell acute lymphoblastic leukemia (T-ALL) than standalone treatments.
A targeted cancer drug has shown dramatic responses in patients with specific gene mutations, raising questions about the need for expensive Phase III trials. The author argues that a lower bar for approval could streamline the process and bring effective treatments to patients sooner.
A study found cisplatin-induced ototoxicity in mice is mediated by calpain 1 and 2, particularly calpain 2. Calpain's role suggests potential for clinical prevention and treatment strategies to mitigate deafness caused by cisplatin.
Researchers at Scripps Research Institute have successfully synthesized a highly complex, plant-derived compound called ingenol, which has long been of interest for its potential in treating various cancers. The efficient chemical synthesis will enable scientists to investigate the therapeutic properties of ingenol derivatives and pote...
Researchers discovered a biological mechanism that preserves intestinal tracts in mice treated with lethal doses of chemotherapy, increasing survival rates by up to 75%. The findings could revolutionize cancer therapy by allowing humans to tolerate stronger doses of chemotherapy and radiation, potentially curing later-stage metastasize...
Reducing overall antibiotic consumption does not necessarily decrease resistance, particularly for MRSA, where some antibiotics like clindamycin and methicillin are more effective in reducing resistance. The success of antibiotic reduction programs depends on the targeted antibiotics that are reduced.
Researchers have found that supporting cells in the inner ear can actively help repair damaged sensory hair cells, potentially offering a pathway to prevent hearing loss. The study suggests that these cells produce heat shock protein 70 (HSP70), which protects neighboring hair cells from death.
Researchers have discovered a novel approach to combat hormone-resistant breast cancer, exploiting the epigenetic 'silencing' of the BCL-2 gene. This process may be detectable in blood samples, offering a diagnostic marker for resistant tumors.
A two-year trial has shown that Avastin is equally effective to Lucentis in treating wet AMD, with better visual acuity and contrast sensitivity in the regular treatment group. The study, led by Queen's University Belfast, could lead to changes in treatment protocols and save the NHS £84.5m annually.
A new study published in the Journal of the National Cancer Institute found that epoetin alfa can help alleviate anemia in high-risk breast cancer patients while maintaining overall and relapse-free survival rates. However, the treatment may increase the risk of thrombotic events.
Recent studies have found chemotherapy-associated adverse neurological effects, including vascular complications and neuropathic pains. Chemotherapy triggers changes in ion channels on dorsal root ganglia, resulting in secondary changes that affect neurogenesis and plasticity.
A team of scientists at Cold Spring Harbor Laboratory has discovered a way to prevent pancreatic tumor cells from responding to chemotherapy. The antibody FG-3019 targets survival cues inside the tumor mass, increasing the effectiveness of treatment and reducing drug resistance.
A phase III trial found that adding chemotherapy to surgery after curative D2 gastrectomy improved 5-year survival by 34% compared to surgery alone. The study, CLASSIC, added combination chemotherapy (XELOX) to standard treatment, showing a significant reduction in cancer-related death.
A new treatment approach using MGN1703, a small DNA molecule that stimulates the immune system, has shown promise in prolonging progression-free survival in patients with metastatic colorectal cancer. The drug is designed to broadly activate all components of the innate immune system to destroy cancer cells.
Researchers found that neuroblastoma cells with low levels of HDAC10 enzyme are more resistant to chemotherapy, and blocking this enzyme using autophagy prevents cancer cell survival. The study suggests a new approach for treating aggressive neuroblastoma tumors.
Drusano's work in pharmacokinetic and pharmacodynamic modeling has been instrumental in simulating and validating dosing regimens to maximize the safety and efficacy of antibiotics. He is recognized for his groundbreaking research on anti-infective pharmacology and antimicrobial resistance.
A new phase 2 trial is underway to evaluate the efficacy of HER-2 targeted regimens in elderly patients with HER-2 positive metastatic breast cancer. The study aims to delay or avoid conventional chemotherapy while maintaining tumor control.
Researchers at Northwestern University have found a molecular pathway that prevents the death of immature ovarian eggs due to chemotherapy, potentially preserving fertility and endocrine function. Adding a specific chemotherapy drug combination may protect young women's reproductive health during cancer treatment.
Researchers used parallel PET/MR imaging to map chemotherapy distribution before surgery, improving risk stratification and patient management. This study suggests simultaneous PET/MR imaging can benefit patients by predicting cancer recurrence and avoiding unnecessary chemotherapy.
The EORTC BOS 2 trial aims to improve outcomes for patients with resectable liver metastases from colorectal cancer by testing the efficacy of bevacizumab or panitumumab added to standard peri-operative FOLFOX 4 chemotherapy. The trial plans to accrue 360 patients in 50 sites across ten countries.
A recent study by researchers at the University of Pennsylvania found that cancer drug shortages have left physicians unable to prescribe standard chemotherapies for a range of cancers. As a result, many doctors are forced to delay or substitute treatment, leading to increased costs and potential harm to patients.
Researchers found that crizotinib boosts median disease progression time to 7.7 months, compared to 3 months with standard chemotherapy, in patients with non-small cell lung cancer harboring an abnormal ALK gene.
Two MGH-led studies show crizotinib is superior to chemotherapy for advanced ALK-positive non-small cell lung cancer, with over double the progression-free survival. A second study reports the first crizotinib resistance in a ROS1-positive lung tumor, revealing the mechanism underlying that resistance.
Doctors at WashU Medicine have shown that testing cervical tumors before treatment can predict whether patients will do well with standard chemotherapy. The study supports personalized medicine for cervical cancer, a tumor normally treated with a one-size-fits-all approach.
Researchers at Lund University have developed a vaccine-based treatment that stimulates the immune system to fight brain tumors, with promising results in animal experiments. The treatment has shown significant effectiveness in curing rats of their brain tumors.
Researchers from Fox Chase Cancer Center have identified two potential biomarkers that may help identify patients with head and neck cancer whose tumors are unlikely to respond to treatment by the targeted therapy cetuximab. These biomarkers, PTEN loss and PIK3CA mutation, were found in a subset of tumor samples and showed promise in i...