Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
Scientists identify chimeric RNA molecules as essential in cellular health and disease, finding they play a wide variety of critical roles in vital cellular processes. Faulty chimeric RNA are often malfunctioning in breast cancer tumors, prompting new cancer treatments targeting specific chimeras.
The new guidelines establish a common approach to stress ulcer prevention and treatment, identifying risk factors such as male sex, coagulopathy, and higher illness severity scores. The panel suggests acid-suppressive therapy, proton pump inhibitors, and close monitoring for patients at risk of bleeding.
Viacure Therapeutics, a spin-off from Helmholtz Munich, is developing an antibody therapy to protect insulin-producing beta cells and restore their function in type 2 diabetes. The therapy aims to preserve or regenerate beta cells, supporting the body's ability to regulate blood glucose.
A new study reveals that the CASS4 gene plays a crucial role in Alzheimer's disease by directing brain-cleaning immune cells, which can be disrupted leading to the buildup of toxic plaques. This discovery offers new hope for the development of treatments or prevention strategies by targeting the gene or microglia in the brain.
Scientists have developed a treatment that 'reawakens' heart muscle cells, promoting repair and improving heart function after a heart attack. The treatment, using mRNA therapy, temporarily activates proteins that help regenerate heart tissue, leading to a stronger heartbeat and increased blood pump efficiency.
A new treatment approach combining immunotherapy with targeted cancer drug enfortumab vedotin improves survival in patients with muscle-invasive bladder cancer. The treatment reduces the risk of death by 42% and cancer recurrence or progression by 49% in patients unable to receive standard chemotherapy.
The UVA Biotech Innovation Fund will support the SPARK Innovative Medicines program, helping to accelerate promising discoveries into new treatments and cures. The fund will provide long-term support for researchers to overcome the critical gap between discovery and clinical application.
Researchers review evidence on obesity drugs, finding potential benefits for brain function, especially for those with type 2 diabetes or obesity. They call for clinical trials to track cognitive abilities and emphasize the importance of monitoring older patients.
Alliance Clinical Trials is advancing early detection, improving treatments, and enhancing survivorship for lung cancer patients. The organization is conducting seven active clinical trials focused on prevention, early detection, treatment, and survivorship.
A recent study published in Genomic Psychiatry analyzed the Alzheimer's Disease Neuroimaging Initiative and found that people with frequent anxiety scored lower on a standard test of global cognition. The authors suggest that a single serotonin receptor may be responsible for both worry and cognitive decline in Alzheimer's disease.
A gene therapy treatment has shown sustained efficacy in patients with Crigler-Najjar syndrome, a rare liver disorder, with two patients able to discontinue phototherapy and one successfully completing a pregnancy. The treatment also normalized liver enzyme levels, paving the way for future therapeutic solutions for rare diseases.
Extracorporeal shockwave therapy may reduce short-term pain and improve short-term flexion for frozen shoulder, but longer-term effects are uncertain. Manipulation under anaesthesia with or without steroid injections also show promise in improving short-term flexion.
Exerkines, exercise-responsive signals, coordinate interorgan crosstalk to regulate glucose and lipid metabolism, insulin sensitivity, and inflammation. Exerkine-based diagnostics and therapeutics hold promise for precision management of chronic metabolic diseases.
The annual number of TAVR procedures among patients younger than 70 rose from 15 in 2014 to 134 in 2024, with surgical aortic valve replacement remaining the predominant approach. TAVR was particularly popular among patients aged 60 to 69, with lower rates of acute kidney injury and bleeding compared to SAVR.
Researchers develop transdermal bioreactor patch to reprogram patient's own cells to fight disease or repair tissue, with potential applications in melanoma, diabetes, and autoimmune diseases. The technology aims to make advanced cell therapies faster, less costly, and available to more patients.
China's contributions to treating chronic hepatitis B focus on identifying patients most likely to benefit from shorter courses of therapy. Emerging treatments like bepirovirsen show promise, but durability and effectiveness remain uncertain.
Researchers found that pegylated interferon-α therapy significantly increases hepatitis B surface antigen clearance in different chronic hepatitis B infection groups, including nucleos(t)ide analogs-experienced patients and children. The therapy achieves high clearance rates in these groups, particularly in those with high baseline lev...
This study demonstrates that interleukin-33 alleviates the immunosuppressive tumor microenvironment in hepatocellular carcinoma, activating the STING/IRF axis and increasing functional CD8⁺ T cells. Combining IL-33 with anti-PD-L1 therapy synergistically reduces tumor burden and boosts anti-tumor immunity in vivo.
A recent study found that about 1 in 4 patients who took lemborexant experienced frightening nights and groggy mornings, leading to high discontinuation rates. The researchers suggest that the medication's side effects, including vivid dreams and sleep paralysis, may be contributing factors.
A recent study found that a greater reduction in dorsal lung ventilation is independently associated with postoperative pulmonary complications in laparoscopic colorectal cancer surgery. Patients with a reduction of dorsal lung ventilation ≥14.5% had a higher incidence of postoperative pulmonary complications.
Early Paxlovid treatment was associated with modestly lower risks of Long COVID, post-acute hospitalization, and death among high-risk, nonhospitalized patients with COVID-19. No clear reduction in Long COVID risk was observed among low-risk patients.
MIT researchers have designed an implantable drug-delivery device that uses ultrasound to enhance the distribution of drug molecules in the brain. The device, called LUCID, can release drugs over an extended period and bypass the blood-brain barrier, offering a potential way to prevent the recurrence of aggressive brain tumors.
Cryptogenic organizing pneumonia (COP) has a good prognosis, but relapse is common, occurring in over 20% of patients, with nearly 50% of relapses happening within 12 months after diagnosis. A multicenter prospective cohort study from China identified three independent risk factors for relapse: younger age, platelet count exceeding 350...
A retrospective study of 30 patients undergoing awake craniotomy found that 30% experienced new or worsened neurological dysfunction within 48–72 hours after surgery. Early functional and cognitive score reductions were common, while new-onset aphasia occurred in 10% of patients. The findings highlight the importance of interpreting ea...
Researchers have developed a blood test that can identify brain injury severity in patients, helping clinicians escalate care. The test uses two proteins, GFAP and UCH-L1, which rise in the bloodstream after injury, and can differentiate between patients with acute brain injury and those with no evidence of pathology.
A Chinese Neurosurgical Journal study identified promising pharmacological and non-pharmacological strategies for managing agitation after traumatic brain injury. The study highlighted the need for more precise measures and larger clinical trials to guide safer, evidence-based care.
Researchers have identified new predictors of relapse in children with acute lymphoblastic leukemia treated with immunotherapy drug blinatumomab, allowing for more precise treatment tailoring. The study also found genetic subtypes associated with poorer response to treatment and higher risk of relapse.
Researchers at the University of East Anglia found that tiny changes in pupil size and blinking patterns can reveal an individual's mental workload during virtual reality tasks. This could lead to wearable systems that automatically adapt therapy in real-time, offering personalized pain relief for millions living with chronic pain.
The new regulations require eligible patients to document 80 hours of employment or similar activities each month, potentially leading to loss of insurance coverage. Physicians face increased administrative burdens, pressure to document patients' medical needs, and declining Medicaid payments, ultimately compromising patient care.
Gene therapies can already change clinical care, but their use in common conditions raises concerns about permanent harm and competition with existing treatments. Cardiologists propose strategies for determining when genomic therapy is justified, including considering the benefits, risks, and long-term safety monitoring.
A research team at POSTECH developed an AI technology that analyzes genetic information from cancer patients to predict their response to immunotherapy. The study, published in npj Digital Medicine, outperformed biomarkers in predicting treatment response across four cancer types and six patient cohorts.
A new UVA study finds that Black children are more likely to develop severe asthma due to harmful inflammation, regardless of environmental factors. The research suggests tailored treatments for Black children with severe symptoms, and testing for high levels of T2 inflammation in all children with difficult-to-treat asthma.
Scientists have identified Id3 as a key molecular regulator of low-intensity pulsed ultrasound (LIPUS)-induced bone formation. An Id3 inhibitory peptide, rID3, combined with LIPUS, enhances osteogenesis and improves bone-defect healing in mice. The study provides a potential strategy for enhancing ultrasound-based bone regeneration.
Researchers at Aston University have engineered vegan honey alternatives with antimicrobial properties similar to mānuka honey, a natural product known for its antibacterial activity. The vegan honey formulations were tested against a culture of a highly drug-resistant bacterium, with promising results.
A new treatment using drug-coated balloons performed just as well as conventional stents in preventing heart attacks and cardiovascular deaths. However, patients treated with drug-coated balloons were more likely to need a repeat procedure in larger arteries.
Artificial intelligence can match human doctors in certain tasks, but human doctors are essential for making complex decisions about patient care. AI may identify a patient's medical condition, but human doctors must consider individual circumstances and make choices that work in the patient's best interest.
Researchers at IIT have developed a new technology that introduces a switch into CAR-T cells, controlling their activation in response to cancer cells. This switch allows for precise control over the therapeutic genes, reducing side effects and increasing effectiveness against melanoma and breast cancer.
Researchers propose recognizing recompensation as a distinct treatment-related disease state, distinguishing stable and unstable recovery, to better capture recovery and continuing risks after cirrhosis treatment. This framework could support more consistent research, clinical assessment, and long-term surveillance for patients recover...
Researchers at the University of Cincinnati have developed a proof-of-concept gene therapy that targets and reduces the production of cerebrospinal fluid, potentially providing a minimally invasive treatment for hydrocephalus. The therapy uses an adeno-associated virus to deliver therapeutic genetic material into a patient's cells, wit...
A new study found that states in New England, the Midwest, and West have a higher prevalence of alcohol use disorder among women, but fewer services that address women's unique concerns and common barriers to alcohol treatment. The study highlights the need for treatment programs tailored to women's needs, as research shows that these ...
The rapid expansion of private testosterone prescribing may extend treatment to those with non-specific symptoms, raising concerns about overtreatment and strain on the NHS. National data on private prescriptions are needed to ensure evidence-based care and protect patients.
UChicago Medicine launches a groundbreaking clinical trial testing a new personalized cell therapy for advanced solid tumors, including ovarian cancer and melanoma. The treatment uses specially engineered T-cell receptors to detect hidden cancer proteins, expanding the number of cancers that can be targeted.
Juvmo, a Parkinson's disease drug, has been approved by the FDA and offers a new treatment option for patients, potentially reducing side effects. The drug's unique mechanism of action provides relief from motor symptoms, and its approval marks a significant milestone in the research of UVA Health scientists.
Researchers propose a voluntary program that targets waitlisted candidates aged 65 or older with 'marginal' kidneys, prioritizing them over younger patients. The redesign aims to improve access to harder-to-place kidneys, potentially preventing over 190 deaths annually.
CU Anschutz will evaluate emerging technologies and therapeutics for severe hemorrhage, including novel blood products and diagnostic technologies. The award aims to improve care for patients experiencing severe bleeding, including trauma patients and those with postpartum hemorrhage.
A new UCLA study suggests that adding a targeted radioactive drug to stereotactic body radiation therapy may help delay the spread of recurrent prostate cancer. The treatment showed a 62% lower risk of progression or needing additional hormone therapy, and improved control of disease on conventional imaging.
A Cochrane review found that marketing strategies, including payments and gifts, can influence physicians' prescribing habits, leading to more expensive and less appropriate drug prescriptions. The review suggests that robust conflict-of-interest policies can mitigate these influences.
Researchers discovered a protein called activated protein C (aPC) that helps blood stem cells remain in a protected state, reducing premature differentiation and improving transplantability. This approach shows promise for improving the success of stem cell transplantations and gene therapies for treating blood disorders.
A study of 9,000 injury patients in Africa and South Asia found that access to care, hospital route, and service type significantly impact survival and recovery. Patients arriving by ambulance had significantly worse outcomes, challenging the assumption that faster treatment leads to better outcomes.
A recent study has raised concerns about the safety of antifungal treatments during pregnancy, finding potential changes in fetal hormone production and its effects on children. Researchers analyzed data from 589 Danish mother-child pairs and found altered adrenal hormone levels in children after birth.
A study of mental health stigma in Japan found that high levels of social distancing toward people with mental illness serve as a barrier to care. However, a sense of 'mattering' may encourage treatment. Prior treatment experience and beliefs about treatment efficacy were also associated with greater treatment-seeking willingness.
The Peninsula Innovation District, a collaboration between the University of Tennessee and UT Medical, has received the 2026 Emerging Community of Innovation award. The award recognizes the district's potential for continued growth and its commitment to building sustainable ecosystems that move technology from early-stage ideas toward ...
Multimodal management of obesity extends beyond pharmacological treatment to screening, early management, and intensive behavioral therapy. A comprehensive approach is necessary to address obesity and comorbidities effectively in the GLP-1 therapy era.
Mount Sinai has launched an international clinical trial to determine the optimal treatment for spontaneous coronary artery dissection (SCAD), a sudden tear in the wall of a heart artery that can reduce blood flow and cause an uncommon type of heart attack. The trial, known as SCAD-ALIGN, will compare a moderate antiplatelet strategy o...
A multidisciplinary approach is crucial for treating recurrent prostate cancer, combining advanced imaging, radiation, and systemic therapies to address microscopic disease. The case report follows Larry Hardesty, who underwent several clinical trials, including PSMA-targeted radioligand therapy, leading to undetectable PSA levels and ...
Zhen Xu, U-M Engineering professor, wins Golden Goose Award for development of histotripsy, a noninvasive cancer treatment. The technology has been used to treat over 5,000 patients worldwide and has the potential to treat various diseases, including brain diseases and cardiovascular diseases.
A regulator-mandated study found no link between semaglutide use and pancreatic cancer using nationwide registry data from Denmark, Sweden, and Norway. The study, funded by Novo, included over 97,000 semaglutide users and compared them to users of other non-incretin antidiabetic drugs.
A Chinese registry report presents real-world perioperative and survival outcomes for surgically treated pancreatic cancer patients, achieving high overall survival rates and encouraging surgical safety metrics. The study emphasizes the need for national-level benchmarks and standardized clinical protocols for pancreatic surgery in China.
A digital therapeutic intervention CT-155 has shown promising results in improving motivation and pleasure negative symptoms of schizophrenia with a small-to-moderate effect size comparable to psychosocial interventions and pharmacologic treatment. CT-155 is a scalable and accessible option for improving schizophrenia negative symptoms.
A study of 955 adults with diagnosed eye conditions found that nearly 19% reported receiving or encountering treatments they believed to be 'bogus'. The survey highlights the importance of clear and evidence-based communication between clinicians and patients in navigating the complex environment of health information and commercial tr...