Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
A cohort study of 1,582,834 veterans with MDD found that most received recommended treatment, but there was an increasing trend in the proportion who did not. This highlights the need to investigate potential undertreatment and examine mental health service availability that influences treatment selection decisions.
Active surveillance for favorable-risk prostate cancer increased significantly in the Veterans Affairs healthcare system, with high rates among low-risk and intermediate-risk patients. This trend suggests that many veterans are avoiding unnecessary treatment, but disparities in care persist.
Celiac disease is a chronic autoimmune disorder caused by gluten intolerance, characterized by small intestine damage and malabsorption. Symptoms include diarrhea, abdominal pain, fatigue, and weight loss, with accurate testing and early treatment available to prevent complications.
A new study emphasizes the importance of accessible maternity and psychiatric care for pregnant women suffering from major depressive disorder. The research highlights the need to balance treatment benefits with potential risks associated with SSRI exposure, suggesting a structured approach to decision-making.
Patients with severe traumatic brain injury in resource-limited settings are at higher risk of mortality. The study highlights the need for improved acute and postdischarge care to reduce mortality rates.
A hybrid lifestyle program showed potential benefits for cardiometabolic health among adherent participants with obesity, but failed to achieve significant weight loss. The study suggests further investigation into the program's effects on metabolic health.
A study found that Nirsevimab was associated with a substantial reduction in respiratory syncytial virus-lower respiratory tract infection hospitalizations during the first year. It was not linked to reduced hospitalizations due to non-RSV infections or asthma, nor during the second year of follow-up.
Dr. Amoako's evidence-driven services improve early diagnosis, expand access to treatment, and advance locally led research in Ghana. Her work aims to strengthen childhood cancer care across the country.
A cross-sectional study found that over one-third of high-risk therapeutic medical devices were recalled due to lack of consistent association between device characteristics, premarket evidence, and regulatory factors. Postmarket surveillance is crucial for ensuring patient safety.
A new study uses mathematical biomarkers to accurately predict prostate cancer patient outcomes and survival, outperforming traditional PSA monitoring. These metrics can inform personalized treatment protocols, enabling more effective adaptive therapy.
A review of cannabis and cannabinoids' therapeutic use reveals potential health benefits while emphasizing the need for risk assessment and harm reduction strategies. The study highlights the importance of evidence-based guidelines for safe and effective treatment.
A cohort study evaluates histotripsy's short-term outcomes for liver tumors, highlighting its potential as a treatment option. The study also examines national practice patterns and adult patient results.
A study of comatose survivors treated with therapeutic hypothermia found that longer cooling durations did not improve neurological outcomes. Increasing cooling duration was ineffective in improving patient recovery after out-of-hospital cardiac arrest, suggesting alternative treatments may be more effective.
Researchers tracked nearly 80,000 adults with type 2 diabetes over ten years, finding those who consistently took their prescribed medication stayed free of serious heart and circulatory complications for over seven extra months. Low adherence was linked to a higher risk of cardiovascular disease, especially in younger adults.
Researchers found that dietitians recommend fish oil and creatine to support concussion recovery. The study also highlights the importance of a food-first approach, focusing on energy intake, hydration, and healthy eating patterns. More clinical research is needed to inform safe and consistent nutrition advice for athletes.
Researchers have developed an experimental drug that tricks cancer cells into consuming more sugar than usual, then blocks their backup fuel source – fat. This approach puts cancer cells under so much stress that many die, demonstrating effectiveness in treating aggressive melanoma in mice.
Individuals in psychotherapy for trauma from killing in war experienced improvements in psychosocial functioning. IOK participants showed greater improvements in work, social, and family life compared to PCT group at posttreatment.
A rare case of uterine carcinosarcoma was reported, characterized by a dual molecular signature that may refine prognosis and guide treatment decisions. The patient's tumor displayed a high-grade endometrioid homologous uterine carcinosarcoma with TP53 and MSH6 genetic alterations.
A randomized clinical trial found video laryngoscopy with a Macintosh blade (VLM) and hyperangulated blade (VLH) to have significantly higher first-pass success rates compared to direct laryngoscopy (DL). The study supports the use of video laryngoscopy as a new standard for routine airway management in adult patients.
Researchers have identified a promising strategy to improve the effectiveness of targeted therapies in advanced prostate cancer. By combining ADCs with a drug that blocks BCL-XL, they triggered greater cancer cell death and slowed tumor growth. The approach could offer a new strategy for improving antibody-drug conjugates against metas...
A randomized clinical trial found that dexamethasone eye drops reduced the progression of retinopathy of prematurity to severe disease requiring invasive treatment in preterm infants. However, no differences in adverse events were observed.
A phase 3 clinical trial found that adding high-dose vitamin D to standard treatment did not improve progression-free survival in patients with metastatic colorectal cancer. Median progression-free survival was 11.8 months with high-dose vitamin D compared to 10.3 months with standard dose.
This randomized clinical trial evaluates safety and efficacy of intra-arterial thrombectomy vs. medical management in patients with large-core infarcts after an acute ischemic stroke. The study found that endovascular treatment showed significant benefits in improving outcomes.
Autonomous oxygen titration increased the proportion of time spent in normoxemia and decreased time spent in hypoxemia compared to usual care. The intervention safely increased targeted normoxemia range time in acutely ill adults.
Liquid biopsy targeting viral ctDNA holds promise as a diagnostic and surveillance tool for head and neck cancer. The study aims to monitor treatment response and assess minimal residual disease (MRD) to adapt treatment via precision oncology.
A pilot clinical trial of psilocybin-assisted therapy in veterans with severe PTSD found that 75% of participants were in remission one month after treatment, with no serious adverse events reported. The results suggest the protocol may be a game-changer for those struggling with treatment-resistant PTSD.
Nicotine pouches are a new form of nicotine delivery that has sparked concerns over safety and efficacy. Researchers warn of potential harms, side effects, and accidental use, as well as the risk of dependence on these products.
Combining cemiplimab, fianlimab, and paclitaxel-based neoadjuvant chemotherapy improved pathologic complete response rates in high-risk -negative breast cancer. Patients with the ImPrint immune signature showed enhanced sensitivity to the combination.
A recent study published in JAMA finds that nicotine e-cigarettes are an effective treatment for smoking cessation. The research suggests that e-cigarettes can help reduce the harms of cigarette smoking and support evidence-based pharmacologic treatment for smokers seeking to quit.
Researchers at UMass Chan Medical School have developed a microRNA-based gene therapy that suppresses mutant SOD1 production, delaying disease onset by 60 days and extending lifespan by 100 days in mice models of ALS. The therapy, delivered via adeno-associated virus (AAV) vector, preserves motor neurons and maintains neuromuscular con...
A multidisciplinary study has identified a novel biofilm regulatory protein called Biofilm Architecture Regulator (BatR) and its role in Pseudomonas aeruginosa infections. The discovery may lead to new targets for anti-infective treatments, including those for people with cystic fibrosis.
Circulating circRNAs show high cell-type and tissue specificity, making them ideal for non-invasive cancer management. They can be detected in multiple body fluids and reflect treatment response, positioning them as functional drivers of therapy resistance.
Dr. Yi Li receives CPRIT funding to develop treatments for solitary fibrous tumor, a rare cancer driven by gene fusions. Researchers are working on novel therapies, including immunotherapy and antisense oligonucleotides, to reduce cancer-causing signal activity.
A new study from Reichman University found that a short three-week digital training program improved motor function and brain activity in Parkinson's patients. The program, called DopApp, strengthened connectivity between brain regions responsible for movement and induced localized changes in neural circuits.
Researchers developed a framework to integrate AI into hospitals, emphasizing patient care, staff experience, and economic sustainability. The Total Mission Value framework aims to ensure high-quality patient care remains the top priority amidst AI's transformative potential.
A recent cohort study found similar rates of secondary treatment receipt among men with localized prostate cancer by race, but observed mortality disparities persisted. These findings raise concerns about healthcare inequities and the need for targeted interventions to address racial disparities in cancer care.
Researchers have developed a new assessment tool to standardize reporting of transcranial magnetic stimulation (TMS) studies. The Transcranial Magnetic Stimulation Reporting Assessment Tool (TMS-RAT) helps compare results, build on each other's findings, and support progress in brain stimulation research. This tool addresses the need f...
A UMass Amherst-led team is developing a new approach to prevent bladder cancer recurrence by exfoliating the bladder lining. The technology uses irreversible electroporation to target premalignant cells, offering a potential alternative to surgical removal or aggressive treatments.
Researchers at Mass General Brigham have been awarded $25.8 million in ARPA-H funding to develop a scalable gene editing platform for treating rare genetic vascular diseases. The VESSEL program aims to create durable, potentially one-time treatments for severe genetic vasculopathies.
A global monitoring platform reveals that antimicrobial resistance in children is rising, driven largely by Gram-negative bacteria. The platform forecasts that last-line carbapenem antibiotics will be highly resistant to these pathogens by 2035, posing a significant threat to children's health.
A nationally representative analysis found substantial gaps in LDL-C control, with increasing disparities across primary prevention categories and underuse of lipid-lowering therapy. The study provides a contemporary population-level benchmark for the updated guideline framework.
The 2026 American College of Cardiology/American Heart Association guideline substantially expands the U.S. population recommended for primary prevention statin therapy, targeting lower-risk individuals. The updated recommendations aim to reduce atherosclerotic cardiovascular disease risk and improve public health outcomes.
University of Minnesota researchers found that certain immune cells, regulatory T cells, prevent helpful T cells from eliminating hidden cancer cells. By combining treatment strategies, they improved the immune response and reduced cancer spread in preclinical models.
Researchers at Kyoto University discovered an RNA aptamer, 1R6, that targets the disordered regions of alpha-synuclein protein, inhibiting its aggregation and promoting disassembly of pre-existing aggregates. This finding offers a new therapeutic strategy for neurodegenerative disorders like Parkinson's disease.
A cross-sectional study reveals substantial commercial price variation for common cardiovascular services, influenced by payer contracting strategies and market dynamics. The findings underscore the need for greater transparency and regulatory oversight to promote efficient healthcare spending.
A new study suggests venture capital is playing a significant role in driving innovation in radiology, particularly in medical devices and artificial intelligence. The study found $11.4 billion was invested across 646 companies between 2000-2023, with funding peaking in 2021.
Incorporating structured, video-enhanced feedback into training programs halves prescribing errors by newly qualified doctors. This approach closes the performance gap between novice and experienced prescribers, demonstrates cost-effectiveness and scalability.
Researchers at Texas A&M University have found a way to intervene early in traumatic brain injuries using a natural, gut-derived chemical that prevents post-traumatic epilepsy from taking root. The treatment reduced brain inflammation, improved memory and mood, protected brain cells, made seizures both rarer and harder to trigger.
A cohort study reveals that colorectal cancer treatment delays are associated with increased metastasis risk. This finding highlights the need for integrated care and tailored benchmarks for treatment initiation to improve timely and equitable care.
Researchers investigated hantavirus infection's neurological effects, finding that they can be severe and uncommon. The study aims to improve understanding of the pathophysiology, identify therapeutic targets, and develop management guidelines for these manifestations.
A review of hundreds of studies suggests that polyphenol-rich foods like berries, tea, and olive oil may support healthy brain aging by reducing inflammation and promoting nerve cell function. While no single food can prevent Alzheimer's disease, a balanced diet rich in plant-based foods may help preserve cognitive function over time.
Athletes with ADHD face unique concussion challenges, requiring more scrutiny for diagnosis and recovery. The study suggests a longer recovery period, up to four to six days, and highlights the need for tailored return-to-play decisions.
A new study found that simple weekly electronic symptom check-ins with care teams significantly improves the quality of life for individuals undergoing treatment for advanced cancer. The benefits were notable among patient groups that historically faced barriers to care, including Black patients and those with less formal education.
A clinical trial of Ceperognastat, a novel O-linked N-acetylglucosaminidase inhibitor, found no significant slowing of Alzheimer's disease progression in early symptomatic patients. The study published in JAMA suggests that Ceperognastat may not be effective in treating this stage of the disease.
Amyloid clearance after amyloid-targeting therapy reduces downstream neuropathologic changes, particularly in gyral crests. Extensive amyloid clearance may be necessary for beneficial effects.
The center aims to address the structural gap in care delivery by offering advanced functional diagnostics, individualized treatment planning, surgical intervention, and long-term management. Led by Professor Sungsoo Park, it provides objective, precision-based diagnosis and tailored treatment strategies for patients with refractory GERD.
A recent study found that frequent formulary rejections of single-source branded drugs in the US lead to delayed or absent treatment, highlighting trade-offs between cost and access to medicines. The study highlights the need for more affordable medication options, particularly for patients with chronic conditions.
The University of California, San Francisco is launching a novel clinical trial to test a combination of therapies for the most common form of Alzheimer's disease. The trial will enroll up to 825 participants and test drugs that target both amyloid and tau proteins, with the goal of slowing disease progression.
Researchers found that KCL-286 enhances DNA repair and reduces neuronal inflammation in a mouse model of Alzheimer's disease. The drug activates the retinoic acid receptor-beta pathway, promoting the expression of certain repair genes.
A large clinical trial found that commonly used antihistamines and an anti-inflammatory drug, colchicine, had a small but significant benefit in reducing long Covid fatigue. However, the benefits were not sustained after stopping treatment.