Research on therapies used across medicine and how they perform. Covers weight-loss injections, hormone therapy, stem-cell approaches, pain relief, and drug targets.
Researchers discovered that protein intelectin-2 has broad-spectrum antimicrobial activity against bacteria in the GI tract. It strengthens the mucus barrier and can directly neutralize or restrain bacteria, making it a potential therapeutic agent.
The new program combines limb preservation, amputation care, and reconstructive solutions like osseointegration to improve identity, functional outcome, and quality of life for patients. Patients will receive coordinated, personalized, and expert care that supports their recovery and promotes sustained overall health.
The American College of Chest Physicians released a new clinical guideline on biologic management in severe asthma. The guideline provides evidence-based recommendations for selecting biologics for different patient populations, considering factors such as baseline oral corticosteroid use and comorbid conditions.
A new clinical trial, PAGODA, seeks to minimize treatment interruptions and help patients complete their chemotherapy as planned. The trial will test a structured plan to guide doctors in making small, proactive changes to chemotherapy doses to prevent treatment delays.
A Mass General Brigham study identifies new mutations that emerge in tumor cells following treatment, driving resistance in patients with different types of cancer. The researchers found two main categories of mutations: those impairing p53 function and others disrupting drug binding, highlighting a path forward for overcoming resistance.
Researchers have made a groundbreaking discovery about how bacteria swim upstream to cause infections, pointing to new designs for biomedical devices that can prevent contamination. The study found that wider channels with faster counterflows are more prone to invasion, but sharp corner designs can inhibit bacterial growth.
A study by Anglia Ruskin University found that patients with underlying conditions such as type 1 diabetes are at a significantly higher risk of complications from cosmetic botulinum toxin injections. The researchers recommend restricting administration to medically qualified professionals.
Both bariatric surgery and semaglutide treatment were associated with significant fat mass loss, moderate fat-free mass loss, and an improved FFM to fat mass ratio. These findings support interventions aimed at preserving muscle mass while promoting weight loss.
A study found that TRAP laws increase maternal morbidity among fertility care patients, while states without such laws have better health outcomes. The study suggests a significant association between TRAP laws and adverse pregnancy outcomes.
A new study suggests that durvalumab may offer a promising treatment option for limited-stage small cell lung cancer patients, extending overall and progression-free survival. However, the therapy's high cost poses significant challenges to sustainability and access in the real-world setting.
Researchers developed a smartphone-based assessment approach to detect improvements in daytime insomnia symptoms, detecting treatment effects more powerfully than traditional methods. The new method leverages real-time, multimethod assessment and shows potential for personalizing sleep medicine care.
A study by Norwegian researchers found that adrenaline is highly effective in restarting hearts after hospital cardiac arrests. Administered intravenously, adrenaline works within one minute to increase the patient's chance of regaining their pulse.
The ASGCT and OTXL partnership, CGTxchange, aims to facilitate the development and commercialization of deprioritized cell and gene therapies for ultra-rare diseases. The joint venture leverages an AI-based platform to match CGTs with prospective investors or partners.
The new clinical standards for antimicrobial stewardship in tuberculosis care aim to integrate TB into existing AMS frameworks, strengthening surveillance and resistance monitoring. The standards prioritize effectiveness, safety, and resistance prevention, promoting structured expert consultation services and targeted testing.
A new clinical trial, RECIPROCAL, seeks to optimize targeted radiation therapy for men with advanced prostate cancer by adjusting treatment based on individual PSA levels. The trial aims to minimize side effects while preserving survival benefits.
Researchers create a novel mathematical framework to control biological noise, enabling precise single-cell control. The 'Noise Robust Perfect Adaptation' technology suppresses stochastic fluctuations while maintaining stable average behavior, with promising applications in cancer therapy and synthetic biology.
A study published in EMBO Molecular Medicine has identified a combination of statins and phenothiazines that shows promise in treating aggressive neuroblastoma. The drug combination was found to impede tumour growth and improve survival rates in laboratory trials with mice.
Researchers have identified key mechanisms underlying the evolution of fish calcitonin receptors, which resist desensitization and enable lifelong calcium regulation in marine environments. Designing sCT analogs and developing RAMP-independent CTR agonists may lead to long-acting calcitonin therapies.
The study found a significant increase in alcohol-related hospitalizations between 2016 and 2022, with rising mortality rates and extended lengths of stay. Preventive efforts are needed to reduce population-level alcohol consumption and improve treatment outcomes for individuals with alcohol use disorder.
In a prespecified exploratory analysis of the SELECT randomized clinical trial, semaglutide demonstrated significant reductions in hospital admissions and overall time spent in hospital. This finding suggests that semaglutide has broader health benefits for patients with obesity and established cardiovascular disease.
A meta-analysis found nirsevimab to be associated with reduced hospitalizations and emergency department visits for lower respiratory tract infections in young children. This suggests the potential of nirsevimab to decrease respiratory-related morbidity in this population.
A population-based surveillance study found both maternal RSV vaccine and nirsevimab effective in protecting infants from RSV hospitalizations. The studies results show that these products reduced RSV-associated hospitalization rates in newborns and infants under 11 months by up to half compared to previous seasons.
The Baveno VII consensus guidelines have reshaped portal hypertension management, focusing on early intervention and noninvasive diagnostics. Nonselective beta-blockers and transjugular intrahepatic portosystemic shunt (TIPS) are recommended for clinically significant portal hypertension diagnosis.
Researchers found that valacyclovir, an antiviral medication, was ineffective in treating early symptomatic Alzheimer's disease and may even worsen cognitive function. The study suggests that individuals with early symptomatic Alzheimer's disease and herpes simplex virus seropositivity should not be treated with valacyclovir.
The Patient-Centered Outcomes Research Institute (PCORI) has awarded funding for new comparative clinical effectiveness research studies addressing various adult and pediatric health concerns. These studies aim to generate evidence to empower individuals and their caregivers with information to make informed health care decisions and i...
Researchers at the University of Geneva have created a laboratory platform to rapidly evaluate the toxicity of new cancer treatments using human tissue-derived cell clusters. This approach allows for safer evaluation and could lead to personalized treatment options.
Researchers investigated a combination of stem cell therapy and BDNF enhancement to treat Parkinson's disease. The strategy aims to promote neuroregeneration and functional recovery by introducing progenitor cells genetically matched to the donors, while upregulating BDNF to mitigate neuronal loss and enhance motor function.
Studies show that patients with advanced ovarian and metastatic breast cancer dedicate approximately 7 hours per week to cancer-related tasks. Most participants report performing these tasks daily, impacting their time burden. The use of a mobile app facilitated the collection of detailed time-use data.
Acute sepsis alters fluid kinetics and creates a 'third space' resistant to adrenergic modulation, leading to maldistribution of crystalloid fluid. Vasoactive drugs have limited effect on fluid distribution in septic sheep compared to healthy animals.
A randomized clinical trial found digital cognitive behavioral therapy to be significantly beneficial for adults with generalized anxiety disorder. The treatment provided sustained benefits and has the potential for public health impact due to its accessibility.
A new study published in Frontiers in Human Neuroscience reveals that a visual training program called Perceptual Attention Therapy (PATH) produces rapid improvements in reading, attention, memory, and executive function after concussion. PATH addresses underlying visual timing deficits before strengthening specific cognitive skills.
A team of researchers has identified two proteins critical to the destruction of red blood cells by the Oroya fever pathogen. This discovery paves the way for a potential novel therapy against this deadly neglected tropical disease.
A repeated cross-sectional study found a significant increase in stimulant prescribing for ADHD, with the largest acceleration observed among female adolescents and young adults aged 18 to 64. The study's findings are consistent with prior research but provide new insights into population-level trends.
A multicenter study found that higher-intensity rehabilitation in the ICU is linked to faster recovery and lower risk of delayed recovery for critically ill patients on mechanical ventilation. Purposeful mobilization preserves muscle strength and function, supporting faster return to independence.
A study published in Biological Psychiatry identifies a distinct immuno-inflammatory biomarker in the brain linked to immune system dysfunction and poorer response to standard treatments. The findings provide potential value for clinical prediction and precision therapies.
Researchers at Florida Atlantic University have developed a deep learning model that detects and evaluates Alzheimer's disease (AD) and frontotemporal dementia (FTD) using EEG brainwave analysis. The model achieved over 90% accuracy in distinguishing individuals with dementia from cognitively normal participants.
A study published in JAMA found that expectant management resulted in higher survival rates compared to active treatment for patent ductus arteriosus in extremely preterm infants. The protocol-defined study showed no significant difference in mortality or bronchopulmonary dysplasia between the two groups.
A cohort study found that participation in New York's medical cannabis program was associated with lower rates of opioid prescription during a 18-month follow-up. The study controlled for unregulated cannabis use, suggesting that medical cannabis may be an effective alternative to opioids for managing chronic pain.
Researchers at Martin Luther University Halle-Wittenberg have developed a promising new substance that inhibits the ability of tuberculosis bacteria to produce energy and causes them to die. The compound, PRP020, targets the pathogen's ATP synthase but attacks a different site than existing drugs like bedaquiline.
A study found cryopreserved platelets to be a cost-effective option for managing surgical bleeding in cardiac surgery, dominating liquid-stored platelets in this setting. Further investigation is required to assess the economic benefits of cryopreserved platelets in broader populations.
A study published in JAMA found that cryopreserved platelets were less effective than liquid-stored platelets in achieving hemostasis, particularly at 24 hours after ICU admission. The research suggests that alternative storage methods may be needed for efficient surgical bleeding treatment.
A new study presented at ASH 2025 suggests that a virtual program focusing on diet and exercise can help reduce the severity of side effects associated with lymphoma treatment. The program, LIFE-L, showed significant improvements in symptoms such as anxiety, depression, pain, fatigue, and constipation among participants.
The program provides financial aid and unique clinical experiences to medical students, encouraging them to become community physicians. UCF College of Medicine hopes the program can be used as a national model to address the nation's primary care physician shortage.
Renuka Iyer, a leading oncologist with extensive experience in cancer care and research, has been appointed as the new Chief Medical Officer of the National Comprehensive Cancer Network. She will oversee the development of evidence-based guidelines for cancer prevention and treatment.
Researchers discovered that moderate ROS levels increase cell vitality and resistance to senescence in endometrial stromal cells, contributing to endometriosis progression. Identifying the CHK1/SGK1 axis as a crucial sensor of ROS, the study suggests that targeting this pathway could lead to more effective treatments for endometriosis.
The University of Tennessee, Knoxville researcher is investigating how microbial communities assemble and their metabolic interactions. This research aims to design novel therapeutic strategies leveraging these interactions to promote wound healing and prevent infection.
Researchers have developed a simple urine test that can effectively diagnose and stage bladder cancer using cell-free DNA fragmentation analysis. The study found that specific patterns of cfDNA fragmentation can identify muscle-invasive bladder cancer with excellent specificity and predictive value.
Researchers at the University of Plymouth will receive a £2.8 million funding boost to accelerate new treatments for low-grade brain tumors. The center aims to deepen understanding and translate knowledge into life-changing therapies.
A growing trend of antipsychotic medication prescription increases in older U.S. adults, with long-term care pharmacies being a primary source. Non-psychiatrist prescribers contribute to the trend, highlighting concerns over medication accessibility and oversight.
A new method developed by Penn State researchers improves the analysis of genetic data, identifying more genes associated with neurodegenerative diseases like Alzheimer's and ALS. The technique, BASIC, integrates both bulk tissue samples and single-cell data to uncover shared genetic effects across different cell types.
Researchers at Rice University have developed a way to make serum markers more sensitive by editing them inside the bloodstream, enabling clearer observation of gene-expression changes in the brain. This approach could lead to more precise diagnostic capabilities using simple blood tests.
Researchers found that FOLFIRINOX improved progression-free and overall survival in patients with advanced biliary tract cancer. The treatment may offer a benefit as a second-line option after first-line chemotherapy failure, but toxicity remains a concern.
Researchers have discovered that a mitochondrial mutation can remodel immune cell function and inflammatory signalling, leading to whole-body issues in animal models. This finding offers a plausible hypothesis for why individuals with these disorders often experience problems with multiple organs and repeated infections.
The American College of Lifestyle Medicine has published a position paper calling for the implementation of lifestyle medicine as a scalable and sustainable approach to address chronic disease burden and unsustainable healthcare costs. The framework includes training, board certification, clinical practice toolkits, and numerous resour...
Researchers at the University of Virginia Health System have developed a new treatment for acute myeloid leukemia, a deadly form of blood cancer. The FDA-approved medication works by disrupting cellular protein interactions that drive leukemia cell growth and survival, offering patients a potential cure.
A study published in JAMA Oncology found that shorter courses of androgen deprivation therapy can effectively control prostate cancer without increasing risks. The ideal duration of ADT depends on cancer risk, allowing for more personalized treatment plans.
Researchers developed a model using DNA methylation biomarkers and CT imaging to predict lymph node metastasis in early-stage gastric cancer patients. The tool helped reduce unnecessary invasive surgeries by up to 44%.
Withdrawal of tirzepatide after 36-week treatment led to 25% or greater weight regain in most participants within a year, reversing initial cardiometabolic parameter improvements. Continued obesity treatment is crucial for sustained benefits.
A cross-sectional study found that US population faces significant challenges with nervous system disorders, impacting 180.3 million people, mainly due to stroke, Alzheimer's disease, diabetic neuropathy, and migraine conditions.
The study found that GLP-1 receptor agonists are increasingly used for postpartum weight loss in overweight women without a documented diabetes diagnosis. The primary indication for use was weight reduction, suggesting a potential shift in treatment guidelines.