Articles tagged with Statins
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Researchers at Aarhus University have discovered a new way to treat high cholesterol by targeting the sortilin receptor system, which regulates PCSK9 protein levels. This breakthrough may lead to an alternative to statins for patients who cannot tolerate or benefit from them.
The new cholesterol guidelines suggest that caregivers prescribe statins to healthy patients if their 10-year cardiovascular risk is 7.5 percent or higher. A decision-making tool can help patients and clinicians weigh the benefits and harms of treatment, making a personalized choice based on individual values and context.
A new nanotherapy breakthrough designed to deliver statin medication directly to inflamed blood vessels could potentially prevent repeat heart attacks and strokes. The technology targets inflammation in blood vessels, reducing the risk of clots and cardiovascular events.
A new UK study found that continued statin use may help prevent delirium in critically ill patients who received statins before hospital admission. The study used a validated delirium screening tool and showed a significant lower risk of delirium associated with statin administration.
Researchers found prescribing an apple a day to adults over 50 would prevent or delay 8,500 vascular deaths. This approach matches the efficacy of statins while having fewer side effects.
A study found that people taking statin drugs often take an average of three other medications that can cause muscle pain and lead to discontinued use, a major contributor to the side effect. Researchers recommend adjusting dosages or choosing alternative medications to minimize interactions.
A new study published in Annals of Internal Medicine suggests that calculating comorbidity-adjusted life expectancy may help physicians determine whether to continue or stop cancer screening in elderly patients. The researchers found that patients with higher levels of comorbidity had shorter life expectancies than healthy patients of ...
A comprehensive review of statin studies found no association between statin use and memory loss or dementia. Statin users had a lower risk of dementia, Alzheimer's disease, and mild cognitive impairment compared to non-users.
Researchers evaluated the effectiveness of early statin therapy in children with familial hypercholesterolemia and found that it significantly reduced coronary heart disease survival rates. After 10 years, young adult patients who received statins from childhood had not suffered from cardiovascular complaints.
The new guideline identifies four major groups of patients who will benefit from statin therapy to prevent stroke and heart attacks. Adopting a heart-healthy lifestyle is also crucial in preventing high blood cholesterol.
A new study published in The Lancet Diabetes & Endocrinology found that metformin had no significant impact on cardiovascular risk factors in non-diabetic individuals with heart disease taking statins. However, the medication did reduce body weight and other related risk factors for type 2 diabetes.
The Dartmouth Atlas report shows wide variation in prescription drug use among Medicare patients across US regions, with higher spending not related to proven treatment use. Effective therapies are underused in some areas, while potentially harmful medications are overprescribed.
A study of 300 ICU patients in France found that statin therapy did not decrease day-28 mortality rates among those with ventilator-associated pneumonia. The results suggest that new treatments are needed to improve outcomes for this common and costly infection.
A new class of RNAi drugs has shown promising results in lowering cholesterol levels by up to 57% in healthy volunteers. The treatment, ALN-PCS, works by blocking the production of PCSK9, a protein that destroys low-density lipoprotein (LDL) receptors.
A recent study found that high-dose statins significantly reduced gum inflammation in heart disease patients within four weeks. The research also showed a close link between gum inflammation and atherosclerotic disease, suggesting that improving oral hygiene may lead to improved cardiovascular health.
A systematic review of statin medications found that long-term use can reduce the risk of dementia by 29%. Statins do not affect short-term memory or cognition, contradicting FDA warnings. The study's findings provide reassurance for patients and doctors prescribing statins.
Researchers found that pravastatin impaired learning and recognition memory in rats, while atorvostatin showed no adverse effects. The study suggests chronic treatment with pravastatin may cause cognitive impairment, but further studies are needed to confirm this.
Research reveals that high 'bad' cholesterol levels stimulate production of hematopoietic stem/progenitor cells, which promote inflammation and atherosclerosis. The study opens up a potential new approach to preventing heart attack and stroke by focusing on interactions between cholesterol and these cells.
A new analysis finds that patients with chronic kidney disease are being prescribed statins inappropriately, despite no proven benefit. The study recommends lower dosages for early-stage kidney disease to minimize risks such as muscle pain and diabetes.
A 15-year study at Cleveland Clinic found that 72.5% of previously statin-intolerant patients could take statins on subsequent trials. Even those who couldn't tolerate daily dosing benefited from taking the drug less often.
A large-scale study of 1 million patients found that high-dose statin use was associated with a significant reduction in the risk of developing dementia. The protective effect of statins remained consistent across different age, gender, and cardiovascular risk subgroups.
A study of 2,238 CAD patients found that statin treatment reduced the risk of major cardiovascular events across all three groups: very low, low, and high LDL-C levels. Statins also showed significant benefits regardless of LDL-C level, suggesting their potential to reduce cardiovascular risk for all CAD patients.
A recent meta-analysis of 14 studies found that statin use is associated with a statistically significant decrease in cataract cases. The analysis suggests that younger individuals and those using statins for longer periods may benefit most from this effect.
A study found significant differences in LDL-cholesterol target achievement between Germany and the UK, with UK patients receiving more potent statins and higher doses. The UK system's incentive-based reimbursement may drive aggressive treatment, while Germany's restrictive system leads to conservative treatment.
Researchers found that statins can activate telomerase, slowing down senescent cells and potentially leading to healthy lifespan extension. The study suggests that statins could be used as an anti-aging therapy, mitigating age-related diseases like heart disease and cancer.
Researchers screened genes for interactions with MECP2 and found five modifiers, including squalene epoxidase, which is drug-targetable. Statin drugs improved symptoms in Rett mice, performing better on mobility tests and living longer. However, further clinical trials are necessary to confirm efficacy and determine optimal treatment.
Research in Taiwan found a link between stopping cholesterol medication and an increased risk of developing Parkinson's disease. Fat-soluble statins were associated with a reduced risk, while hydrophilic statins showed no such correlation.
A Loyola University Medical Center study found that statin-intolerant patients who received specialized lipid clinic care had significantly reduced total and LDL cholesterol levels. In contrast, those not referred to a lipid clinic showed minimal improvement in their cholesterol levels.
Researchers analyzed data from two large clinical trials to investigate the impact of high-dose statins on kidney function. The findings suggest that higher-strength statins do not increase the risk of hospitalizations with kidney injury when compared to low-dose statins.
Two independent reviews of rhBMP-2 trial data found no significant benefits and potential increased risks of cancer associated with its use. The studies suggest that patients should be counseled on the relative benefits and harms of each option, as the role of rhBMP-2 in spinal surgery is still being defined.
A study found statin use may be associated with an increased likelihood of diagnoses of musculoskeletal conditions, arthropathies, and injuries. Statin users had a higher odds ratio for these conditions compared to non-users, but the association was not significant for osteoarthritis/arthropathy.
A randomized double-blind trial showed that Coenzyme Q10 decreases all-cause mortality by half, improving survival in severe heart failure patients. The study found that CoQ10 also significantly lowers cardiovascular mortality and hospitalizations for heart failure.
A population-based study suggests that high-potency statins like atorvastatin and rosuvastatin increase the risk of developing new-onset diabetes. In contrast, fluvastatin and lovastatin appear to have a lower risk. Researchers recommend considering individual patient risk when prescribing statins.
A University of Missouri study found that simvastatin, a cholesterol-lowering drug, impairs the positive effects of exercise on fitness levels in obese adults. The study measured cardiorespiratory fitness and skeletal muscle mitochondrial content in participants taking statins while exercising.
A University of Arizona research team has identified unusual swellings within neurons caused by statin drugs, which may lead to cognitive declines. Removing statins results in the disappearance of these 'beads-on-a-string' effects, offering promise for personalized medication and therapy.
Researchers at the University of Michigan identified a new potential therapeutic target for lowering cholesterol, inhibiting a gene responsible for transporting a protein that interferes with liver cell function. This approach preserved the liver's capacity to clear plasma cholesterol from the blood without affecting overall health.
A study found that coenzyme Q10 prevents the reduction in GLUT4 induced by statin drugs, which can increase the risk of type-2 diabetes. Statins, widely prescribed for cholesterol reduction, may also raise diabetes risk due to their impact on cellular energy production.
Researchers found that obese employees who received group-based financial incentives lost more weight than those with individual incentives. In contrast, higher blood levels of long-chain omega-3 polyunsaturated fatty acids protected against death, primarily due to reduced cardiovascular events.
A study by Brigham and Women's Hospital found that over 90% of patients who stopped taking statins due to adverse reactions were able to tolerate them again. The researchers examined clinical data from over 107,835 patients and identified a pattern where most people who experienced symptoms or events related to the drug stopped taking ...
A multicenter analysis found patients taking high potency statins for high blood pressure are at a 34% higher risk of hospitalisation for acute kidney injury (AKI) compared to those taking low potency statins. This risk remains elevated for two years after initiation, highlighting the need for clinicians to consider alternative options.
Researchers have identified a new alternative to statins for patients who can't tolerate the side effects of cholesterol-lowering drugs. Pitavastatin was shown to lower bad cholesterol by an average of 34% and reduce the risk of heart attack, stroke, and death in up to 68% of patients with high cholesterol.
A recent study presented at the American College of Cardiology's Annual Scientific Session found that high doses of rosuvastatin significantly reduced the rate of acute kidney injury caused by contrast agents used in imaging tests. The statin group had lower rates of kidney damage and adverse events compared to the control group.
Exposure to statin TV ads was linked to higher rates of high cholesterol diagnosis and statin use, especially among those at low risk for heart disease
The HPS2-THRIVE study found that vitamin niacin combined with statin treatment increases adverse side-effects, including skin flushing and gastrointestinal problems. Patients taking the experimental treatment were four times more likely to stop due to skin-related reasons.
Researchers at the University of Copenhagen have identified a mechanism underlying statin-induced muscle pain, which may be related to low energy production in muscles due to Q10 depletion. Statins, commonly used to treat high cholesterol levels, can affect skeletal muscle function and lead to muscle weakness and pain.
Researchers discovered that adding lovastatin to traditional antimalarial treatment decreases neuroinflammation and protects against cognitive impairment in a mouse model of cerebral malaria. Statins may be worthy of consideration in clinical trials for treating cerebral malaria.
An analysis of nationally representative survey data found significant improvement in the delivery of underused care, including better use of antithrombotic therapy and aspirin for atrial fibrillation. However, the study also found limited changes in reducing inappropriate care, such as overuse of antibiotics for asthma exacerbations.
Patients who quit smoking and took aspirin and statin before undergoing treatment for blocked leg arteries were less likely to suffer complications six months later. The study found that more than half of patients studied failed to receive minimal medical therapy, despite doctors' efforts.
Patients with diabetes may receive high-dose cholesterol-lowering medications unnecessarily, increasing the risk of adverse side effects. The new study suggests adopting a more personalized treatment approach based on each patient's risk profile, combining blood pressure and prescription data in electronic records.
Researchers found that statin use improved progression-free survival and disease-specific survival in patients with stage III inflammatory breast cancer. Patients who took hydrophilic statins saw the greatest improvement in survival, with an average of 4.88 years.
A recent study published in The Lancet found that combining better physical fitness and statins significantly improves survival in people with unhealthy blood fat or cholesterol levels. Moderate intensity physical activity can be achieved through walking, gardening, and gym classes, making it a feasible option for many middle-aged adul...
New research suggests that statins can decrease inflammatory and thrombotic proteins in individuals with antiphospholipid antibodies, reducing the risk of blood clots and other complications. A prospective study found that fluvastatin significantly decreased protein levels in patients with APS, offering a potential new treatment option.
A study by researchers at the University of Pennsylvania School of Medicine found that apolipoprotein E (apoE) plays a key role in maintaining arterial softness. The protein is associated with the production of collagen and other extracellular matrix proteins, which contribute to cardiovascular disease risk.
A meta-analysis of 11 studies involving almost 1 million patients found that statin use was associated with a significant 30% reduction in esophageal cancer incidence. The study also found a 41% decrease in the risk of adenocarcinoma of the esophagus among patients with Barrett's esophagus.
Patients undergoing non-small cell lung cancer (NSCLC) resection who take statins may experience improved overall survival and reduced risk of recurrence. Statin use was associated with a significantly lower local recurrence rate compared to non-statin users.
A new review suggests that intensive treatment with high doses of certain statin drugs is usually the best approach for treating high cholesterol and other blood lipid problems. Increasing statin doses can reduce cardiovascular problems by up to 30% in patients who need them.
A nationwide study of over 300,000 patients found that statin use reduces the risk of open-angle glaucoma by eight percent. The study suggests that statins may protect against glaucoma by improving blood flow and reducing intraocular pressure.
A large analysis of over 100,000 participants found that statins have a very small effect on preventing venous thromboembolic events. The study suggests that high-dose and low-dose statins have no effect on blood clots.
A study published in PLoS ONE found that statin potency is a critical determinant of muscle-related side effects. Stronger statins like rosuvastatin were associated with higher rates of reported problems, highlighting the need for greater caution when prescribing these medications.
A meta-analysis of 16 statin trials and 7 fibrate trials found that statin therapy was associated with a 21% lower risk of pancreatitis. In contrast, fibrates showed no significant risk reduction. Lifestyle modifications remain important for improving lipid profiles in patients with hypertriglyceridemia.