Articles tagged with Stem Cell Therapy
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A Phase I clinical trial demonstrated long-term safety and feasibility of neural stem cell transplantation for treating chronic spinal cord injuries. Two patients showed durable evidence of neurological improvement with increased motor and sensory scores.
A preclinical study suggests the experimental compound K884 can restore lost muscle function in Duchenne muscular dystrophy (DMD) patients by strengthening muscle repair. The drug targets specific enzymes, allowing muscle stem cells to develop into functional tissue.
Researchers have successfully transplanted stem cells from resilient individuals into sea anemones, which are closely related to corals, demonstrating the feasibility of this approach. This innovative method could potentially lead to a new way to revive and restore coral populations damaged by climate change.
Dr. Christopher Seet has received a $2.9 million R37 MERIT Award from the National Cancer Institute to develop innovative T cell therapies for cancer. The grant will support research into iPSC-derived T cells, which can be engineered for enhanced tumor-fighting capabilities.
A Phase I clinical trial found that patients receiving itacitinib before and after a 'half-match' stem cell transplant experienced lower-than-expected rates of graft-versus-host disease, with no severe cases reported. The study also showed improved overall survival at one year, with 80% of patients remaining free from chronic graft-ver...
Mesenchymal stem cells (MSCs) show promise in delivering treatments directly to cancer cells and boosting the immune system's fight against cancer. However, ongoing research highlights challenges related to MSC behavior, including variability in their effects and potential to create conditions that support tumor growth.
Researchers at Medical University of South Carolina and University of Florida developed a novel approach to treat type 1 diabetes using tagged beta cell transplant with localized immune protection. The study, published in Cell Reports, shows promise for creating an off-the-shelf solution for T1D treatment.
Researchers from Kyushu University have developed an antibody that targets and prevents the dysfunction of hepatocyte growth factor (HGF), a critical protein for skeletal muscle development, regeneration, and repair. The new antibody, 1H42F4N, blocked nitration of HGF and did not disrupt its activity.
The new hospital will provide patient-centered care with personalized, compassionate treatment and groundbreaking research. Patients will have access to top specialists and pioneering therapies in cancer treatment.
The ISSCR has developed a comprehensive Continuing Education (CE) course on stem cell-based therapies, covering fundamental biology, clinical trials, and patient communication. The open-access course aims to equip healthcare providers with accurate information, empowering them to navigate the complexities of this evolving field.
A team of researchers at the University of Toronto has discovered two distinct subtypes of glioblastoma cancer stem cells, each with unique genetic vulnerabilities. By targeting these vulnerabilities, a more effective treatment approach may be developed, improving prognosis for patients with this lethal brain cancer.
Researchers at MD Anderson Cancer Center have made significant advancements in understanding tissue regeneration, with a focus on epigenetic regulation and retrotransposon suppression. MicroRNAs have also been identified as potential biomarkers for COVID-19 severity in cancer patients, while a novel protein complex drives lung regenera...
Researchers used ex vivo lentiviral gene therapy to treat MPS IVA in mice, achieving partial correction of bone pathology and complete correction of heart pathology. The study suggests potential for novel therapies to treat patients with MPS IVA.
A team of bioethicists and legal scholars call for clear and concise regulations on exosome-based treatments due to the lack of scientific evidence and existing regulatory frameworks. These unproven interventions can cause serious harm to patients, highlighting the need for stronger protections.
Researchers at Kumamoto University have achieved a groundbreaking advancement in stem cell biology by reproducing the developmental process of hematopoietic stem cells in vitro. This culture system enhances our understanding of HSC development and has the potential to be instrumental in stem cell therapy and blood disease treatments.
Researchers found Edaravone inhibits growth of brain tumor stem cells and prolongs survival in mice with glioblastoma. The study suggests repurposing Edaravone as a potential treatment for this aggressive brain cancer.
Glioblastoma, the most malignant primary brain tumour, has an 18-month median survival rate despite treatment. New research from the University of Ottawa suggests a drug used to slow ALS progression may also suppress glioblastoma's self-renewing cancerous stem cells.
TP53 mutations are commonly associated with therapy-related AML and complex cytogenetics. Researchers found improved long-term outcomes when allo-HCT was performed during Complete Remission 1 (CR1), despite limited effective therapies for TP53-mutated AML.
Researchers have successfully transplanted human embryonic stem cell-derived retinal organoid sheets into monkeys with macular holes, resulting in graft survival and maturation of light-detecting cells. The study suggests that this method could become a practical treatment option for difficult macular hole cases.
Researchers at Osaka Metropolitan University have successfully generated high-quality feline induced pluripotent stem cells (iPSCs) without a genetic footprint. These cells exhibit properties similar to human iPSCs and can differentiate into various cell types, making them a promising tool for veterinary regenerative medicine research.
Melbourne researchers have developed a breakthrough in creating lab-grown human blood stem cells, which can be used to treat childhood blood disorders. The cells closely mimic those found in the human embryo and can create specific matched blood cells for transplantation, reducing complications and addressing donor shortages.
Researchers led by Prof. Michael Brand successfully regenerated photoreceptors in zebrafish, demonstrating they regain their normal function and allowing the fish to recover complete vision. This breakthrough could potentially revolutionize treatment of diseases like retinitis pigmentosa or macular degeneration.
Researchers discovered that blocking Cxcr4 in mice reduced white fat tissue, while estrogen therapy could be effective with lower doses. The study offers promising avenues for understanding healthy and unhealthy fat tissue development.
Texas A&M researchers are investigating the use of extracellular vesicles to deliver immune-suppressing proteins, potentially reducing the immune system's attack on insulin-producing beta-cells. The goal is to develop a novel treatment for type 1 diabetes, which currently has only lifelong insulin therapy as an approved option.
A new technique developed by McGill researchers allows for precise targeting of stem cells to become specific cell types, such as bone or fat cells. This breakthrough has the potential to lead to new stem cell treatments for various diseases, including multiple sclerosis, Alzheimer’s and Type 1 diabetes.
Researchers at the Centre for Genomic Regulation have discovered a treatment that speeds up the production of high-quality pluripotent stem cells in mice. The finding uses interferon gamma to accelerate cellular reprogramming, paving the way for improved disease modeling and personalized treatments.
A UofL cardiologist is leading a Phase II clinical trial of a new stem cell therapy for heart failure, the first in the US to use intravenous delivery. The trial aims to determine whether one or multiple doses of mesenchymal stem cells improve health and quality of life for patients.
Researchers at the University of Helsinki have created cells that can't grow uncontrolledly, which could lead to new and safer cell therapies for hereditary diseases, myocardial infarction, and other conditions. The innovation uses thymidine supplementation to regulate cell division, eliminating the risk of cancer.
Researchers identified genetic and metabolic characteristics of leukaemic stem cells, including a specific iron utilisation process that can be blocked to kill these cells without harming healthy ones. This breakthrough paves the way for new therapeutic strategies to combat leukemia.
Researchers found that autologous bone marrow aspirate concentrate (BMAC) and adipose-derived stromal vascular fraction (ADSVF) have distinct cellular compositions and protein profiles. The study's findings challenge the marketing of these therapies as interchangeable and highlight the need for standardized cell therapies.
Researchers at University of California San Diego have found that genetically modified NK-cell therapy can effectively target and treat hepatocellular carcinoma, a highly treatment-resistant form of solid tumor. The therapy works by disabling the inhibitory protein TGF-β, allowing immune cells to kill cancer more efficiently.
Researchers at UCSF have discovered a way to turn ordinary white fat cells into beige fat cells that burn calories, opening the door to developing new weight-loss drugs. The approach uses a protein called KLF-15 and may avoid side effects associated with current treatments.
A new study demonstrates the potential of stem cell therapy to treat Hirschsprung disease by generating nerve cell precursors that produce missing nerves in the intestine. Transplanted gut samples showed improved functionality, suggesting a breakthrough for this rare condition.
Researchers at Texas A&M University have discovered a new technique for tissue regeneration using mineral-based nanomaterials inspired by ancient medical practices. The approach aims to induce natural bone formation, reducing the need for invasive procedures and long-term medication, and promoting improved quality of life.
Research led by Weill Cornell Medicine found that most colorectal cancers begin with the loss of intestinal stem cells, even before cancer-causing genetic alterations appear. This new understanding suggests a unified model for colorectal cancer initiation where damage to intestinal crypts causes a decrease in aPKC protein expression.
Researchers explore nanoparticle-based therapies to specifically target lymphatic metastasis in breast cancer, providing a promising solution for patient treatment. Nanoparticles deliver drugs directly to tumors, targeting cancer cells to destroy them or slow their growth, while also enhancing the immune response.
Researchers have developed an approach to 'delete' a diseased blood system while building up a new, healthy one with donor blood stem cells. This process involves targeting specific antibodies coupled to a cytotoxic drug that recognize and destroy diseased blood cells while sparing healthy ones.
Researchers review cell-based therapies for comprehensive sepsis management, highlighting the potential of mesenchymal stem cells and innate immune cells like macrophages. The review also emphasizes the need for further studies on optimal dosage, administration routes, and storage methods to maximize efficacy and safety.
Researchers at UMSOM identified a modified sugar molecule that enhances human neural stem cells' proliferation and transition into neurons, improving brain function and reducing anxiety and depression. The study provides a promising proof of concept for regenerative medicine in patients with cardiac-arrest induced brain injuries.
Researchers at KTH Royal Institute of Technology have developed a microfluidic device that converts skin cells into neural stem cells, speeding up the process and reducing costs. This advance brings personalized cell-based therapies for Alzheimer's and Parkinson's closer to reality.
A recent study published in Nature Cell Biology found that increased hydrostatic pressure can hinder the healthy development of neural crest cells, leading to an increased risk of facial malformations. The researchers suggest that physical cues in the womb, such as pressure, may play a role in shaping facial features.
Researchers highlight the role of post-transcriptional RNA modifications in AML pathogenesis, identifying m6A and m7G regulators as potential therapeutic targets. Targeted therapies, including selective inhibitors and Traditional Chinese Medicine compounds, show promise in promoting cell differentiation and reversing AML phenotypes.
Researchers discovered MIA-602's effectiveness against Doxorubicin-resistant acute myeloid leukemia (AML), demonstrating reduced cell viability and tumor volume. The study suggests MIA-602 as a potential alternative treatment approach for AML, potentially circumventing chemotherapy side effects.
Researchers identify a promising strategy for combating hepatitis B virus (HBV) by boosting the effects of immune cells called stem cell memory T cells (TSCMs). In a mouse model, introducing TSCMs from patients into mice resulted in the elimination of HBV-infected liver cells.
Researchers at NTU Singapore successfully grew 'mini kidneys' in the lab, grafted them into live mice, and found a potential treatment for polycystic kidney disease by boosting autophagy. The study suggests that minoxidil could be used to reduce cysts in the novel mouse model.
A clinical trial with PeriCord, a new tissue engineering product derived from umbilical cord and pericardium stem cells, confirms its feasibility in repairing damaged heart tissues after a heart attack. The therapy has demonstrated excellent biocompatibility and anti-inflammatory properties.
Researchers discovered that neonatal spinal cord ECM significantly enhanced NPC proliferation, migration, and differentiation compared to adult ECM. This study highlights the critical role of early developmental spinal cord ECM in orchestrating spinal cord regeneration processes.
JAX researchers develop platform to mimic genetic diversity in humans, allowing for precise modeling of disease mechanisms and therapeutic targets. The platform enables direct comparison between mouse and human cells, providing molecular insights into autism, intellectual disability, and other neurodevelopmental disorders.
Dr. Yoshihara's research focuses on creating functional islet cells using human pluripotent stem cells to treat insulin-dependent diabetes. The goal is to overcome the limitations of current stem cell-derived organoids and accelerate their maturation through cutting-edge transcriptional gene regulation processes.
A Mayo Clinic study found that stem cells derived from patients' own fat are safe and may improve sensation and movement after traumatic spinal cord injuries. Seven participants demonstrated improvements in motor function, including increased strength and voluntary anal contraction.
Researchers have discovered that introducing tardigrade proteins into human cells can slow down molecular processes, making them potential candidates for slowing the aging process. This new study provides evidence that these proteins can be used to induce biostasis in cells, enhancing storage and stability.
The USC CIRM ASCEND Center will offer organoids, single-cell analysis, and spatial transcriptomics services to the California research community. The center aims to facilitate collaboration, technology transfer, and a competent workforce in personalized medicine.
Scientists create a hydrogel system that can remember its shape, allowing them to control cell adhesion behavior. The elastic modulus of the hydrogel is adjusted by compressing it into different thicknesses at high temperatures.
A novel risk score predicts cardiovascular complications after bone marrow transplant with high accuracy, helping guide patient selection and post-transplant management. Patients with preexisting cardiovascular conditions are more likely to experience long-term complications.
Researchers discovered a new type of stem cell that can regenerate cartilage in arthritic mice, offering potential for treating osteoarthritis. The stem cells, derived from human pluripotent stem cells, were found to efficiently generate new cartilage when transplanted into the knees of OA mice.
A new study reveals distinct transcriptional programs and molecular features in right-sided colon stem cells, which may help explain the differences in colon cancer development. The research also highlights the importance of CDX2 in regulating stem cell differentiation and tumor initiation.
Researchers at Hokkaido University developed a technique to promote cardiac regeneration by activating mitochondrial function in transplanted cells. The study found that activated mitochondria improved cardiac function and suppressed myocardial fibrosis, suggesting a new approach for treating severe heart failure.
A new study from the University of Ottawa proposes using vanoxerine, a drug initially developed for cocaine addiction, to potentially treat advanced colon cancer. Vanoxerine has been found to suppress cancer stem cell activity in colon cancer patients' tissues and tumours implanted in laboratory animals. The drug works by interfering w...
A phase II clinical trial found Muse cell-based product CL2020 to be highly tolerated and improved ALS symptoms, but may not halt disease progression. The treatment's efficacy depends on combining it with other drugs for future treatments.
A Scripps Research team identified the energetic reactions in brain cells that malfunction and lead to neurodegeneration. They successfully restored many neuron-to-neuron connections in nerve cell models derived from human Alzheimer's patient stem cells by addressing a bottleneck in mitochondrial energy production.