Articles tagged with Stem Cell Therapy
Cancer cells can hide and escape therapies leading to recurrence. Researchers identify three possible mechanisms: cancer stem cells, polyploidy, and senescence. Combination treatments involving chemoradiation-induced transitory senescence and senolytic therapies may be effective in preventing repopulation.
Researchers used infected stem cells to study COVID-19's impact on organs, identifying effective anti-viral drugs for treatment. The study found distinct antiviral profiles in heart and lungs, paving the way for new therapeutic options.
Scientists from Brigham and Women's Hospital have developed a new immuno-therapeutic approach using twin stem cells that can target brain metastatic melanomas. The therapy, which uses an engineered 'twin stem cell model,' activates the immune system to suppress tumor growth and prolong survival in representative preclinical models.
Researchers from Oregon Health & Science University have discovered how stem cell transplantation can kill the virus that causes AIDS. The study, published in the journal Immunity, reveals that two circumstances must co-exist for a cure to occur and documents the order in which HIV is cleared from the body.
Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
Researchers found variant cells in lungs of IPF patients that can drive fibrosis and inflammation. These cells may be targeted for future therapy, offering new hope for treatment.
Increased expression of Musashi 1 on breast cancer cells has significant implications for understanding dormancy and survival in bone marrow. Msi 1 knockdown led to a reduction in cancer stem cells with undetectable PD-L1, suggesting a potential therapeutic target.
Scientists create a subcellular omics toolkit to study organelle diversity and communication in stem cells. The tool enables the identification of similar cell types, leading to more precise therapies for various diseases.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.
Researchers have created a novel bioadhesive material to facilitate stem cell transplantation into damaged cartilage. The adhesive, derived from mussel protein and hyaluronic acid, enables the secure encapsulation of stem cells, promoting cartilage regeneration.
Cedars-Sinai investigators have discovered a novel way to treat amyotrophic lateral sclerosis (ALS) and retinitis pigmentosa using human induced pluripotent stem cells. The new approach uses cells derived from iPSCs that are renewable, scalable, and can delay disease progression in rodents.
Researchers at the University of Washington School Medicine have engineered stem cells that do not generate dangerous arrhythmias. These 'MEDUSA' cardiomyocytes can engraft in the heart, mature into adult cells and beat in sync with natural pacemaking without generating dangerous heart rates.
A study published in Lasers in Surgery and Medicine suggests that light therapy, known as photobiomodulation (PBM), can improve heart function and reduce the thickness of the cardiac wall in middle-aged mice. The research also found improved neuromuscular coordination and a significant survival rate among mice with severe heart disease.
A new method to cure HIV using umbilical cord blood stem cells has yielded long-term successful results for a middle-aged mixed-race woman with leukemia and HIV. The approach broadens the opportunities for people of diverse ancestry to attain cures.
Researchers at University of Technology Sydney have successfully created personalized 'bio-inks' from patients' own stem cells, which are then used to 3D-print cardiac tissues to repair areas of dead tissue. This technology shows promise in treating heart failure and may reduce the need for expensive and traumatic heart transplants.
Two compounds, A5 and C1, have shown promising results in inhibiting the growth of glioblastoma cells, a type of aggressive brain cancer. Further research is needed to confirm their effectiveness on normal nerve cells and to move towards clinical trials.
Researchers at Mayo Clinic found that a dissolvable plug delivering stem cells can heal single-tract fistulas in patients with Crohn's disease. The treatment has shown durable results with minimal side effects, offering hope for patients with refractory perianal fistulas.
A patient with Parkinson's disease has received a pioneering stem cell-based transplant at Skåne University Hospital in Sweden. The procedure aims to replace lost dopamine nerve cells and is part of a clinical trial testing the safety and efficacy of this innovative treatment, which could potentially help millions of people worldwide.
A new cell therapy has demonstrated significant benefits in improving the heart's pumping ability and reducing the risk of cardiovascular death, heart attack, or stroke in patients with chronic heart failure. The therapy, using mesenchymal precursor cells (MPCs), also showed a strong signal in reducing inflammation and improving microv...
Researchers have successfully converted pluripotent stem cells into hematopoietic stem and progenitor cells using optimized transcription factors. The resulting PSC-derived cells generated all types of white blood cells in mice without giving rise to tumors or leukemias, suggesting a promising future for PSC-based transplant therapies.
The ISSCR 2023 Annual Meeting will showcase the year's most compelling stem cell research and clinical breakthroughs. Attendees can participate in dedicated poster sessions and interact with presenters.
Researchers generated cochlear avatars from stem cells, recreating hair cell function and transmitting electrical signals. This breakthrough enables the investigation of sensorineural hearing loss mechanisms and potential treatments.
Pusan National University researchers have identified a novel gene, SURF4, that regulates cell death and differentiation in acute myeloid leukemia (AML). The study found that suppressing SURF4 expression increases cell differentiation, cell death, and accumulation of ROS, leading to arrested tumor growth in mice.
A new Pitt study reframes understanding of graft-versus-host disease, suggesting that GVHD is locally maintained by donor T cells in target tissues. The research, published in Immunity, offers an alternative model that could guide development of novel therapies and improve outcomes for stem cell recipients.
A novel form of chemoimmunotherapy has been proven to be a promising treatment for canine cancer, extending the lives of terminally ill dogs. The therapy uses modified Mesenchymal Stem Cells carrying a potent 'kill-switch' that induces anti-cancer immunity and improves quality of life.
Researchers at Children's Hospital of Philadelphia have developed a custom-built application to automate the determination of engraftment after hematopoietic stem cell transplant. The tool has been shown to improve accuracy of reported engraftments, reducing errors in neutrophil and platelet engraftment reporting.
Researchers have created highly mature human neurons from induced pluripotent stem cells using 'dancing molecules.' These mature neurons demonstrate enhanced signaling capabilities and branching ability, making them suitable for studying neurodegenerative diseases like ALS and Alzheimer's. The breakthrough technique opens new opportuni...
The São Paulo School of Advanced Science on Stem Cell Biology will highlight the latest scientific advances in stem cell therapy and tissue bioengineering. Internationally renowned scientists will present state-of-the-art science and results of new research.
Researchers at the University of Montreal discovered a key mechanism in muscle regeneration, enabling targeted therapies for diseases like muscular dystrophy. By biasing the conformation of a protein called ELMO2, they improved muscle fusion and regeneration in mouse models.
The study shows that RXR ensures hematopoietic stem cells remain youthful and fit, reducing the risk of developing myeloproliferative syndromes. The regulatory action of RXR on these cells is essential for maintaining a balanced production of blood cell types throughout life.
Researchers found that activating the non-mutated form of P53 can change the fundamental makeup of cancer stem cells in mouse models of mucoepidermoid carcinoma. This new therapy approach shows promise for treating this lethal form of salivary gland cancer.
Researchers at the University of Waterloo have identified a new method for scheduling radiation therapy that could be up to 22% more effective at killing cancer cells. The algorithm takes into account the differing radiation resistances of stem cells and non-stem cells, allowing doctors to predict how a tumour will respond to treatment.
A team from the University of Pennsylvania led by Kotaro Sasaki coaxed stem cells to take on the characteristics and functions of a human adrenal gland. The researchers developed an organoid culture system to direct iPSCs to transition into adrenocortical progenitor-like cells, resulting in cells producing steroid hormones.
Scientists at Texas A&M University found that transplanting intestinal epithelial stem cells can repair the gut and reduce inflammation, potentially preserving cognitive function after a stroke. The study suggests that targeting gut health may be key to developing more effective stroke therapies.
The USC+CHLA Alpha Clinic will advance clinical trials of new cell and gene therapies, engaging underserved communities and training the workforce that conducts them. This program complements existing efforts to translate discoveries into new therapies for better health outcomes.
Researchers from the University of Zurich have discovered why a stem cell transplant is effective in treating multiple sclerosis. The study found that memory T cells reappear immediately after the transplant and do not trigger an autoimmune reaction due to pre-damage caused by chemotherapy. This knowledge enables the body to gradually ...
Researchers used monoclonal antibodies to suppress the immune system in mice, tracking human neural stem cell survival using luciferase. The study reveals that monoclonal antibody-mediated immunosuppression enabled long-term survival of transplanted human neural stem cells in mouse brains for at least six to eight months.
The Alpha Stem Cell Clinic will develop preclinical studies into early and later phase clinical trials with the goal of establishing advanced regenerative medicine treatments. The clinic will also foster greater collaboration with eight similar clinics across the state and educate the public about stem cell and related therapies.
Scientists discovered the first direct evidence that Stargardt-related ABCA4 gene mutations affect a layer of cells in the eye called the retinal pigment epithelium (RPE). The study suggests a therapeutic strategy for the disease, which currently lacks treatment.
A new study reveals that urolithin A from pomegranates can rejuvenate T cells by recycling and renewing mitochondria, enhancing their ability to fight tumors. The researchers plan to investigate the application of urolithin A in clinical trials for colorectal cancer.
A novel stem cell-gene therapy has been shown to be safe in humans, with no serious side effects reported in the first trial. The treatment targets motor neurons that die in patients with amyotrophic lateral sclerosis (ALS), a fatal neurological disorder.
A study published in Cell Stem Cell found that mitochondrial dynamics regulate the dormant state of adult muscle stem cells, which are essential for tissue stability. The researchers discovered that the protein OPA1 regulates this process and its depletion leads to severe muscle stem cell defects.
Researchers at UBC develop new process to produce T cells, the most essential human immune cells, in the lab with improved efficiency. The breakthrough could lead to cost-effective production of cancer-fighting cells for CAR T therapy, a treatment with an efficacy rate of close to 50%.
A KAUST-led research team identified two drug treatments that boost the activity of molecules involved in cell adhesion, enhancing the ability of blood-forming stem cells to enter the bloodstream and produce new blood. This breakthrough could lead to improved bone marrow transplant success for leukemia patients.
Researchers have identified a group of latent stem cells in the central nervous system of mice that respond to injury by dividing, migrating towards damaged areas, and differentiating into astrocytes. If similar cells exist in humans, they could provide a new therapeutic approach for treating spinal cord injuries.
Scientists have identified a critical source of essential molecules that enables the intestine's self-renewal and regeneration after injury. The study reveals that lymphatic endothelial cells play a key role in maintaining stem cell activity and tissues in the intestine.
Researchers from FSU College of Medicine and FAMU-FSU College of Engineering have developed a promising strategy to produce therapeutic particles in stem cells, which could help patients with neurological diseases such as stroke or multiple sclerosis. The new technique combines three-dimensional growing platforms with wave motion, lead...
A new study successfully introduces healthy photoreceptor cells derived from stem cells into the retinas of dogs, marking significant progress toward a cell-based therapy for blindness. The treatment enables cells to survive and form connections with existing retinal cells, paving the way for a regenerative medicine approach.
Researchers developed a mathematical model to predict the efficiency of nanoparticle delivery into cells, particularly in stem cells. They found that nanoparticles become trapped in bubble-like vesicles, preventing them from reaching their targets.
Researchers at UCLA have developed a roadmap detailing how stem cells become sensory interneurons, which enable sensations like touch and pain. The study identifies protocols for producing all types of sensory interneurons in the laboratory, paving the way for cell therapies to restore sensation in people with spinal cord injuries.
Researchers at Tokyo Institute of Technology have revealed that zinc (Zn) content is essential for the methionine-mediated regulation of pluripotent stem cells (PSCs). The team developed a protocol to convert PSCs into insulin-producing β cells, overcoming diabetes treatment challenges.
Researchers have discovered that human urine-derived stem cells have the ability to regenerate tissue and become various cell types, making them a promising source for stem cell therapy. The study also highlights the importance of telomerase activity in maintaining regenerative potential.
The study found that autologous stem cell transplantation (ASCT) was underutilized in community settings, but maintenance therapy after standard therapy improved outcomes for patients over 65. Maintenance rituximab after bendamustine and chemotherapy regimens also significantly extended times to disease progression and overall survival.
Researchers have developed a unique 3D printed system to harvest mesenchymal stem cells from bioreactors, which can be used for various treatments. The system combines microfluidics and 3D printing to process adult stem cells, potentially making stem cell therapies more widely available.
A new platform mimics live cellular environment to guide stem cell differentiation outside the body. Researchers from Chung-Ang University developed a novel platform based on metal-organic frameworks, which offers advantages over conventional methods for in vitro stem cell differentiation.
A team of researchers at the University of Texas at Austin has developed a new therapeutic that uses transmembrane stem cell factor to treat ischemia and stroke without causing allergic reactions. The therapeutic, delivered in engineered lipid nanocarriers, shows promise in enhancing revascularization in ischemic tissues.
A new cell therapy has been developed to target and eliminate leukemia stem cells that cause disease relapse. The treatment uses genetically engineered T cells with a chimeric antigen receptor that recognizes specific markers on these cancer cells.
Researchers have developed a novel therapeutic strategy for treating glioblastoma using allogenic stem cells that can target and kill tumor cells. The therapy demonstrated profound efficacy in preclinical models, with 100% of mice living over 90 days after treatment.
A team of researchers has successfully treated damaged pig hearts with cardiac progenitor cells, demonstrating the formation of new cardiac tissue and improved cardiac function. The treatment could potentially be used to treat patients with serious heart failure, particularly older patients with coexisting conditions.
A receptor protein called insulin receptor is pivotal for brain stem cell longevity, according to a Rutgers study. The researchers also found that the same protein plays a crucial role in sustaining brain cancer cells.