Articles tagged with Stem Cell Therapy
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A clinical trial at UC Davis Health showed that cellular therapy offers promise for patients with late-stage Duchenne muscular dystrophy, stopping deterioration of upper limb and heart functions. The therapy appears to be safe and effective in improving skeletal muscle and cardiac function.
Human immune cells occupy certain tissues and remain there for years, contrary to previous belief. T cells found to be optimally adapted to their local environment, potentially supporting barrier function.
Researchers at Helmholtz Munich have discovered that slowing down DNA replication speed improves reprogramming efficiency of cells into totipotent cells. This breakthrough could be a major advancement for stem cell therapy and regenerative medicine approaches.
Scientists have successfully produced fully functional pancreatic beta cells from stem cells for the first time, offering a breakthrough in treating type 1 diabetes. The study's findings demonstrate that these stem cell-derived beta cells can regulate insulin secretion and manage glucose metabolism in both cell cultures and mice studies.
The five-year grant will be used to mentor junior scientists, leveraging City of Hope's expertise in cancer treatment and patient care. The program will provide students with hands-on experience in cell-based therapies, regulatory approval, and commercialization.
A woman with HIV has achieved 14 months of undetectable HIV levels following a cord blood stem cell transplant to treat acute myeloid leukemia. The study suggests that CCR5Δ32/Δ32 cord stem cell transplantation may be an effective method for achieving HIV remission and cure in individuals requiring such transplants.
Researchers at Johns Hopkins Medicine found that certain stem cells have built-in tracers made of sugars that can track their movement in living tissues. The discovery could streamline and advance restorative research for diseases of the brain.
Researchers at RIKEN have developed a new retinal transplant technique by engineering human-derived retina sheets to lose bipolar cells, allowing better connections to host retinas and improved responses to light. The technique has shown substantial functional improvement in animal studies and is now poised for human clinical trials.
Researchers discovered a protein, syndecan-2, that helps identify and deploy blood stem cells for treatments. Transplanting only cells expressing syndecan-2 could make blood stem cell transplants more efficient and less toxic.
The reNEW Center aims to harness therapeutic potential in stem cell medicine for incurable diseases, with a focus on translation and collaboration. Scientists will work together to develop new treatments and therapies.
Researchers at UC Davis Health developed a new treatment that simultaneously blocks IL-6 and TNF cytokines, providing superior protection against acute graft-versus-host-disease severity and mortality. The dual-cytokine blockade approach did not impair beneficial graft-versus-tumor effects.
The Nixon Visions Foundation has given a significant gift to support studies of the PRPH2 gene linked to macular dystrophy and boost stem cell research aimed at developing early diagnosis and a cure for this devastating genetic eye disease. Researchers hope to make a tremendous impact on people with this inherited eye disease.
Researchers have developed new preclinical models to understand gastric cancer development and spread. Using these models, they identified Lgr5-expressing tumour cells as responsible for driving gastric cancer growth and spread, establishing them as a potential therapeutic target.
A multicenter clinical trial demonstrates insulin secretion from engrafted stem cells in patients with type 1 diabetes. The study shows 20% reduced insulin requirements and 13% more time spent in target blood glucose range over a one-year follow-up period.
Researchers at the University of Helsinki have developed a method to precisely and rapidly correct genetic alterations in cultured patient cells. The new technique combines two Nobel Prize-winning approaches to produce genetically corrected autologous pluripotent stem cells, paving the way for potential therapeutic applications.
A functional precision medicine study demonstrates that treatment selection based on results from drug sensitivity testing can be clinically useful in patients with aggressive hematological cancer. The approach combines deep molecular profiling with comprehensive drug sensitivity testing to advance the therapy decision-making system.
Researchers at the Texas Heart Institute have made significant breakthroughs in treating persistent heart failure with a novel stem cell therapy. The phase 3 clinical trial results show that this treatment has the potential to alter the natural history of heart disease, reducing hospitalizations and improving patient outcomes.
Researchers found that the therapeutic effects of MSCs are due to the recipient's immune cells responding to dying MSCs undergoing apoptosis, promoting anti-inflammatory effects. This understanding may lead to new therapeutic strategies targeting the responding immune cell population.
A study to investigate stem cell therapy as a potential treatment for glaucoma, the world's second leading cause of blindness, has received $6.7M in NEI funding. The research team will explore ways to make stem cell-derived neurons survive and integrate into the eye.
Researchers from Kazan Federal University have developed a gene-cell preparation that uses membrane vesicles to target and kill cancer cells. The technology has shown promise in treating various types of cancer, including breast, lung, and colon cancer.
Scientists from the University of Johannesburg found that shining two lasers on adult stem cells accelerates their transformation into different types of cells. The consecutive irradiation increases proliferation and differentiation under laboratory conditions, paving the way for potential therapies to repair damaged tissues.
Scientists at Lewis Katz School of Medicine discovered that reintroducing the protein LIN28 into adult heart stem cells improves their chances of survival. This breakthrough could lead to new treatments for heart disease using stem cell therapy.
Stem cell researchers have developed a new method to identify and develop personalized therapies for Cystic Fibrosis patients with rare mutations. By growing precursor lung cells from patients' own blood, they can screen for new drugs and validate responses in mature airway cells.
Researchers have made a breakthrough in spermatogonial stem cell research, successfully generating functional sperm cells using primate embryonic stem cells. The study, published in Fertility and Sterility Science, shows promise for future clinical therapies to treat male infertility.
Researchers report that 90% of patients who received gene therapy between 2009 and 2012 remain disease-free, with significant immune system differences observed among those treated. The therapy is most effective in younger children, but further work is needed to achieve high levels of gene correction in all patients.
A recent study highlights the negative effects of misinformation on stem cell therapies for COVID-19, including exaggerated claims and unregulated sales. The researchers advocate for increased enforcement of laws and regulations to protect patients and promote responsible science communication.
Researchers discovered that skin-derived T cells can migrate into the bloodstream and cause inflammation in other organs, such as the intestine. The study provides new approaches to therapy and diagnostic options for stem cell transplantation.
The University of California, Riverside has received a $5 million grant from the California Institute for Regenerative Medicine to train young scientists and physicians in stem cell research. The program, named TRANSCEND, will provide training in broad areas of stem cell biology and regenerative medicine.
A clinical trial conducted by TTUHSC researchers found that corneal epithelial stem cell-derived eye drops significantly improved symptoms of severe dry eye disease, with patients experiencing a 23% improvement in SPEED questionnaire scores and a 17.1% improvement in OSDI scores. No adverse reactions were reported during the 12-week tr...
Researchers link repeated injury to airway stem cells with chronic lung disease, suggesting that biological aging of these cells may contribute to the development of this condition. The study found that injury caused activation of a subset of stem cells, leading to their premature aging and loss of functional capacity.
A study found that treating wounds with mesenchymal stromal cell secretions significantly reduced MRSA viability and stimulated the surrounding skin cells to build a defense. The treatment has potential as an alternative to antibiotics, reducing antibiotic resistance in both veterinary and human medicine.
Aging stem cells in bone marrow lose function due to epigenetic changes that affect bone production. Researchers reverse these changes by adding acetate, rejuvenating the epigenome and improving stem cell activity. This finding holds promise for treating diseases like osteoporosis.
Researchers found no significant DNA changes in stem cells after transplant, but an anti-virus drug called ganciclovir may contribute to cancer development. Further research is needed to investigate this further.
Researchers have genetically engineered cells that can deliver a biologic drug in response to inflammation, reducing inflammation and preventing bone damage in mice with rheumatoid arthritis. This approach could provide personalized treatments for arthritis patients, limiting side effects associated with current therapies.
Researchers at McGill University identified proteins that drive cancer stem cells in brain tumours. Targeting the protein galectin1 may provide a more effective treatment for glioblastoma when combined with radiation therapy. The study found significant improvement in tumour response to radiation therapy, resulting in expanded lifespan.
Researchers have created brain organoids from people with 16p11.2 genomic variations, which exhibit differences in brain size seen in individuals with autism spectrum disorder. The study revealed new information about molecular mechanisms that malfunction when this region is disrupted, providing opportunities for therapeutic intervention.
A new clinical study reveals that treatment with mesenchymal stromal cells reduces inflammation in patients with chronic obstructive pulmonary disease (COPD). The study provides insights into the therapeutic potential of MSCs as a novel treatment for COPD, which is a leading cause of morbidity and mortality worldwide.
Researchers used autologous adipose micrografts to treat tendon injuries in sheep, achieving similar diameter and hardness to healthy tendons within two months. The study suggests a safe, reliable, and relatively fast way to promote tendon healing, with potential for human treatment.
Researchers identified a genetic mutation in nonhuman primates that closely resembles Pelizaeus-Merzbacher disease, a rare and progressive disorder affecting the central nervous system. The discovery was made possible by a massive genomic database built at OHSU's Oregon National Primate Research Center.
A study confirmed the safety of a novel stem cell therapy for knee pain caused by osteoarthritis. The treatment, which involves transplanting patient's own mesenchymal stem cells into the affected knee, showed no serious side effects over five years.
Experts call for global regulation to prevent unproven stem cell treatments from putting patients' lives at risk. The authors propose establishing an advisory committee on regenerative medicine and promoting harmonization among regulatory standards.
A Phase II trial found that BKV-specific T cells from healthy donors are safe and effective in treating debilitating complications after stem cell transplants. Patients experienced rapid responses, with 81.6% showing improvement after 28 days, and no cases of severe GVHD or toxicities.
A new stem cell therapy strategy has shown promising results in treating intestinal bowel disease in premature infants. The treatment uses human placental-derived stem cells to repair damage caused by the disease and promote healing of the intestinal barrier.
A new UCLA study finds that a one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia. The therapy, developed from glial cells, stimulates the brain's own repair processes and enhances neural connections.
Researchers develop a 3D biomaterial scaffold that slowly releases stem cells, reducing dosages and improving therapeutic effects in mice with osteoarthritis. The cryogel 'sponge' ensures implanted stem cells stay in the knee joint area longer, allowing for more effective treatment.
A clinical trial combining CRISPR technology with UCLA and UCSF expertise aims to directly correct the sickle mutation in blood stem cells, addressing the underlying cause of debilitating sickle cell disease. The goal is to out-compete native sickle cells by correcting 20% of genes.
A study found that gene therapy can create a long-term store of correct T cells in the human thymus, leading to sustained health in patients with SCID-X1. The treatment works by delivering corrected genes into stem cells, which then produce healthy immune cells.
Researchers at UPMC demonstrated that allogeneic adipose-derived stem cells (ASCs) can mitigate acute radiation syndrome, a condition known as total body irradiation. ASCs were found to improve survival rates and repair damage to the hematopoietic system in mice exposed to high levels of radiation.
Researchers found that impaired microRNAs, particularly miR-30c, are responsible for the ineffective function of stem cells in diabetic hearts. Increasing miR-30c levels in the heart improves stem cell survival and growth, offering a novel therapy for treating type-2 diabetic heart disease
Researchers at Children's Hospital of Philadelphia have identified genes responsible for hematopoietic stem cell regeneration via ribosome assembly. This finding enhances our understanding of the importance of proper ribosome assembly in stem cell regeneration and identifies possible targets for future therapies for ribosomopathies, ch...
Researchers have developed a novel stem-cell-based therapy targeting key targets in solid tumors, successfully prolonging the lifespan of mouse models with brain metastatic breast cancer. The engineered molecule EvDRL was delivered via allogeneic stem cells, which crossed the blood-brain barrier to home in on tumors.
Researchers develop a less invasive way to deliver stem cell and exosome therapeutics to the heart by injecting hydrogels containing these therapeutics into the pericardial cavity, showing promising results in preclinical studies
Sanfilippo syndrome is a rare genetic disorder that causes childhood dementia and premature death. Researchers are developing a new combination therapy using gene therapy and stem cells to restore metabolic defects in brain cells.
Researchers at North Carolina State University found that treating mesenchymal stem cells with TGF-β2 reduces the immune response in recipients. This could lead to simplified treatment options for ligament and tendon injuries in horses, as well as potential human therapies.
Researchers from Osaka Prefecture University have successfully isolated canine induced pluripotent stem cells, paving the way for regenerative therapies in dogs. The development of these cells could also have implications for human medicine, as they share similar environmental and genetic factors with humans.
Researchers improved understanding of intestinal stem cells' renewal and differentiation into specialized cell types. They identified a specific Wnt/planar cell polarity pathway regulating intestinal stem cell self-renewal and lineage decisions, crucial for treating diseases like diabetes and colorectal cancer.
Researchers have discovered that brain stem cells in the hippocampus of mice can divide repeatedly over several months, leading to new insights into the formation of nerve cells. This finding has significant implications for future therapeutic approaches to conditions such as depression and Alzheimer's disease.
Researchers developed a method to predict therapeutic efficacy of stem cell treatment for vascular diseases based on initial distribution and migration of transplanted cells. The method enabled predicting superior therapeutic efficacy when treatment cells form into condensed 'round shape' during initial treatment.
Researchers identified two cell signals that can guide stem cells to repair eye damage, increasing their survival and function after transplantation. The study's findings offer a promising approach to restoring eyesight by modifying stem cells with enhanced chemokine receptors.
A recent study used induced pluripotent stem cells to find drugs that enhance phagocytosis in the retinal pigment epithelium, a process critical for preventing vision loss. Several drugs showed promise, including Ramoplanin, which rescued defects in RPE from patients with a certain genetic form of RP.