Articles tagged with Stem Cell Therapy
A new stem cell therapy strategy has shown promising results in treating intestinal bowel disease in premature infants. The treatment uses human placental-derived stem cells to repair damage caused by the disease and promote healing of the intestinal barrier.
A new UCLA study finds that a one-time injection of an experimental stem cell therapy can repair brain damage and improve memory function in mice with conditions that replicate human strokes and dementia. The therapy, developed from glial cells, stimulates the brain's own repair processes and enhances neural connections.
Researchers develop a 3D biomaterial scaffold that slowly releases stem cells, reducing dosages and improving therapeutic effects in mice with osteoarthritis. The cryogel 'sponge' ensures implanted stem cells stay in the knee joint area longer, allowing for more effective treatment.
A clinical trial combining CRISPR technology with UCLA and UCSF expertise aims to directly correct the sickle mutation in blood stem cells, addressing the underlying cause of debilitating sickle cell disease. The goal is to out-compete native sickle cells by correcting 20% of genes.
A study found that gene therapy can create a long-term store of correct T cells in the human thymus, leading to sustained health in patients with SCID-X1. The treatment works by delivering corrected genes into stem cells, which then produce healthy immune cells.
Researchers at UPMC demonstrated that allogeneic adipose-derived stem cells (ASCs) can mitigate acute radiation syndrome, a condition known as total body irradiation. ASCs were found to improve survival rates and repair damage to the hematopoietic system in mice exposed to high levels of radiation.
Researchers found that impaired microRNAs, particularly miR-30c, are responsible for the ineffective function of stem cells in diabetic hearts. Increasing miR-30c levels in the heart improves stem cell survival and growth, offering a novel therapy for treating type-2 diabetic heart disease
Researchers at Children's Hospital of Philadelphia have identified genes responsible for hematopoietic stem cell regeneration via ribosome assembly. This finding enhances our understanding of the importance of proper ribosome assembly in stem cell regeneration and identifies possible targets for future therapies for ribosomopathies, ch...
Researchers have developed a novel stem-cell-based therapy targeting key targets in solid tumors, successfully prolonging the lifespan of mouse models with brain metastatic breast cancer. The engineered molecule EvDRL was delivered via allogeneic stem cells, which crossed the blood-brain barrier to home in on tumors.
Researchers develop a less invasive way to deliver stem cell and exosome therapeutics to the heart by injecting hydrogels containing these therapeutics into the pericardial cavity, showing promising results in preclinical studies
Sanfilippo syndrome is a rare genetic disorder that causes childhood dementia and premature death. Researchers are developing a new combination therapy using gene therapy and stem cells to restore metabolic defects in brain cells.
Researchers at North Carolina State University found that treating mesenchymal stem cells with TGF-β2 reduces the immune response in recipients. This could lead to simplified treatment options for ligament and tendon injuries in horses, as well as potential human therapies.
Researchers from Osaka Prefecture University have successfully isolated canine induced pluripotent stem cells, paving the way for regenerative therapies in dogs. The development of these cells could also have implications for human medicine, as they share similar environmental and genetic factors with humans.
Researchers improved understanding of intestinal stem cells' renewal and differentiation into specialized cell types. They identified a specific Wnt/planar cell polarity pathway regulating intestinal stem cell self-renewal and lineage decisions, crucial for treating diseases like diabetes and colorectal cancer.
Researchers have discovered that brain stem cells in the hippocampus of mice can divide repeatedly over several months, leading to new insights into the formation of nerve cells. This finding has significant implications for future therapeutic approaches to conditions such as depression and Alzheimer's disease.
Researchers developed a method to predict therapeutic efficacy of stem cell treatment for vascular diseases based on initial distribution and migration of transplanted cells. The method enabled predicting superior therapeutic efficacy when treatment cells form into condensed 'round shape' during initial treatment.
Researchers identified two cell signals that can guide stem cells to repair eye damage, increasing their survival and function after transplantation. The study's findings offer a promising approach to restoring eyesight by modifying stem cells with enhanced chemokine receptors.
A recent study used induced pluripotent stem cells to find drugs that enhance phagocytosis in the retinal pigment epithelium, a process critical for preventing vision loss. Several drugs showed promise, including Ramoplanin, which rescued defects in RPE from patients with a certain genetic form of RP.
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue, improving treatment efficacy for neurological disorders. The discovery could expand the use of stem cell therapies to new conditions such as heart disease or arthritis.
Researchers at the University of Toronto have created a new tool called DISCO that enables the analysis of individual cells in their natural environment. The method combines cell microscopy with single-cell omics platforms, allowing scientists to study stem cells and other rare cell types in greater detail.
Researchers have found a new way to make leukemic stem cells vulnerable by specifically dislodging them from their niches, allowing for potential treatment against chronic myeloid leukemia. The approach uses an RNA molecule complex to prevent the cancer stem cell's retention in its tumor-supporting niche.
Researchers developed a more efficient way to produce fucosyltransferase VI (FTVI) enzyme, which enhances the homing ability of cord blood stem cells. This breakthrough could improve the effectiveness of cord blood transplants for treating various life-threatening conditions.
Scientists have discovered that tiny point mutations in a gene can modify T cells to be less aggressive, leading to reduced inflammation and autoimmune responses. This finding has potential implications for stem cell transplantation, where T-cell transfusion is used to prevent severe side effects.
Researchers have designed a multifunctional cell therapy system to treat ulcerative colitis, with encouraging results obtained in animal models. The system incorporates stem cells, biomaterials, and microparticles that release interferon, aiming to improve cell persistence and biosafety.
The UK Research and Innovation has partnered with the Japan Agency for Medical Research and Development to support eight new regenerative medicine research projects. The funding will focus on developing novel therapies for a range of disorders, including Parkinson's disease, blood disorders, and liver diseases.
Scientists accelerated vision restoration by visualizing photoreceptors' response to light in the living eye. Researchers modified OCT technology to detect minute changes, enabling high-resolution visualization of cone photoreceptors and potential therapies like stem cells or gene therapy.
A clinical trial indicates that a combination of stem cell therapy and educational intervention can significantly improve social communication, language, and daily skills in children with autism spectrum disorder (ASD). The study found positive changes in various aspects after stem cell transplantation combined with educational interve...
Researchers at UIC develop a unique method for precisely controlling the deposition of hydrogel to coax bone marrow stem cells into specialized cells. This technique allows for more accurate interactions between cells and their surroundings, potentially leading to breakthroughs in regenerative therapeutics.
Researchers at Keck School of Medicine of USC have received a five-year, $14.6 million grant to advance gene therapy for HIV control without daily medicines. The approach is inspired by three cases of HIV cure and aims to prepare patients for stem cell transplants with little toxicity.
A nationwide survey of academic neurologists reveals that bad outcomes from stem cell tourism are much more common than realized, with complications including infections, strokes, spinal tumors, seizures, and even deaths. Many neurologists feel ill-equipped to warn patients about the dangers of unproven treatments.
Researchers have developed a technology to obtain microvesicles from human stem cells, showing significant biological activity and therapeutic potential. The induced microvesicles can reduce the intensity of immune response and may be used to treat inflammations and autoimmune syndromes.
Researchers from Osaka University found that adiponectin, a fat cell hormone, improves the efficacy of mesenchymal stem cell-based treatment for heart failure. The study showed that increasing adiponectin levels strengthens cardiac function following MSC therapy.
Researchers explore direct reprogramming as an alternative to cell therapy-based strategies for cardiac regeneration after myocardial infarction. They identify microRNAs and biomaterials like electrospun scaffolds and nanoparticles as potential non-viral vectors for safe delivery of genetic reprogramming.
Children's Cancer Institute researchers have discovered a new approach to treating acute myeloid leukaemia (AML) by targeting leukemia stem cells. The therapy disrupts the ability of these cells to self-renew, markedly reducing leukaemia amounts and preventing new cells from growing.
Researchers at Terasaki Institute developed a minimally invasive approach using 'Detachable Microneedle Depots' to deliver MSCs into damaged tissues, accelerating wound healing in mouse models. The technique targets damaged areas with high spatial precision, utilizing microneedles to deploy therapeutic cells and promote healing.
A new study shows that intranasal delivery of mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) reduces inflammation in the brain, a prime factor in Alzheimer's disease. The treatment also triggers actions to guard against further degenerative effects.
Researchers developed a DNA marker to identify tumors that use an alternate lengthening of telomeres (ALT) mechanism, which can help stratify patients into ultra-high risk categories. The study suggests a new scale for neuroblastoma risk stratification could lead to improved treatment outcomes.
Researchers conducted a two-center trial of autologous CD34+ cell therapy in 20 NOCAD patients with persistent angina, showing significant improvement in coronary flow reserve, angina frequency, and quality of life. The results demonstrate the potential of CD34+ cell therapy as a promising therapy for CMD patients with angina and NOCAD.
Scientists at Sanford Burnham Prebys and Loma Linda University Health have demonstrated the promise of applying magnetic resonance imaging (MRI) to predict the efficacy of using human neural stem cells to treat a brain injury. The researchers found that rats with larger penumbra areas surrounding brain injury, which received human neur...
Researchers developed an improved pluripotent stem cell differentiation protocol to generate beta cells in vitro, leading to more mature and functional beta cells. The use of CD177 as a quality control marker increases the efficiency and homogeneity of beta cell generation.
A review assesses the potential of mesenchymal stem cells to treat preeclampsia, a pregnancy complication that can cause high blood pressure and organ damage. The study found promising results in animal models, with MSCs or their secreted cargo showing promise as novel treatment options.
Researchers have developed an innovative in vivo priming strategy to train human stem cells for improved cardiac regeneration therapy. The technique, using a 3D-printed patch, enhances the survival rate and therapeutic potential of the stem cells after transplantation into failing hearts.
A new stem cell delivery system using mussel adhesive protein has been developed to efficiently deliver mesenchymal stem cells to damaged cardiac muscular tissues. The system enables prolonged transplantation and promotes rapid integration of transplanted stem cells into surrounding tissues.
Researchers successfully harnessed an evolutionarily conserved mechanism to promote tissue repair and suppress inflammation in aged tissues. This approach improved the success of stem cell-based therapies for retinal disease, restoring vision in old, blind mice.
Researchers aim to investigate leukaemia stem cells to gain a better understanding of acute myeloid leukaemia (AML) causes and therapies. The study will use isolated single cells from patient samples to analyze characteristic markers, mutations, functional data, and metabolic pathways.
A new study from North Carolina State University found that lung stem cell secretions delivered via nebulizer can help repair lung injuries due to multiple types of pulmonary fibrosis in mice and rats. The treatment resulted in a nearly 50% reduction of fibrosis compared to mesenchymal stem cells counterparts.
Researchers found that membrane vesicles derived from human mesenchymal stem cells can stimulate angiogenesis, a key process for treating ischemic tissue damage. The study suggests that these vesicles could be used for cell-free therapy of degenerative diseases such as heart disease, multiple sclerosis, and Alzheimer's disease.
A new therapy aims to regenerate brain damage caused by premature birth through human mesenchymal stem cells. The PREMSTEM project, funded by the European Union, will develop an imaging tool to identify premature babies at risk of brain injury and potentially treat conditions such as cerebral palsy.
A clinical trial is testing an experimental stem cell treatment against the best available biologic therapies for severe forms of relapsing multiple sclerosis. The trial aims to determine whether autologous hematopoietic stem cell transplantation (AHSCT) is an effective and durable treatment option for people with severe relapsing MS w...
Researchers at Brigham and Women's Hospital have uncovered a novel pathway explaining why skin thickens in psoriasis, suggesting new strategies for developing therapies. The study found a defect in the epigenetic covering that resulted in loss of DNA methylation hydroxymethylation mark, leading to dysregulated stem cell behavior.
A recent study in Nature sheds new light on heart treatment controversy by showing that stem cell therapy triggers an acute inflammatory response to enhance mechanical properties of injured areas. Injecting living or dead stem cells into the heart's infarct region provides a modest benefit to heart function after a heart attack.
A Rutgers-led team has developed a graphene and gold-based platform that detects genetic material in stem cells, enabling monitoring of their fate. This technology may help resolve key barriers to stem cell therapy for regenerative treatment of neurological disorders.
Scientists successfully induce pluripotency in adult cat cells, generating stem cells that can differentiate into various cell types. The breakthrough may lead to the development of cellular models for genetic diseases affecting domestic cats and similar human disorders.
Researchers develop novel therapies to reverse or prevent myelin loss in PMD patients, identifying iron toxicity as a key factor and discovering a potential treatment using an FDA-approved agent. Clinical trials are planned to test the effectiveness of this treatment in slowing or halting disease progression.
Researchers found that protein GAS1 suppresses muscle stem cells' ability to build new muscles and regenerate after injury. Reversing GAS1's effect by using GDNF restores muscle stem cell function and regeneration.
The CIRM grant will enable pre-investigational new drug studies for neural stem cells as a potential treatment for perinatal hypoxic-ischemic brain injury, which can cause cerebral palsy and other neurological disorders. The project aims to protect at-risk brain cells and potentially restore balance to the injured region.
A new dual stem cell therapy has shown promise in improving cardiac function and vascular regeneration following myocardial infarction. The treatment involves combining two types of stem cells to repair both the muscle cells and vascular systems of the heart, providing a potential alternative to complex heart transplants.
Researchers found that mature AML cells can become immature again, challenging traditional therapeutic strategies. This discovery highlights the need to eradicate all tumour cells, regardless of maturation state.
A phase I clinical trial demonstrates the potential of regenerative therapy for hypoplastic left heart syndrome through collecting, processing and injecting an infant's own stem cells directly into the heart at the time of surgery. The study showed no deaths or significant safety concerns over six months following surgery.
Researchers develop single-cell encapsulation technology to protect transplanted stem cells from clearance and immune attack, improving bone marrow transplant success rates in mice. The new microgels allow MSCs to persist in the body longer and resist immune rejection.