Articles tagged with Stem Cell Therapy
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A new study by University of Plymouth researchers has identified Prominin-1, a protein that plays a crucial role in stem cell activation and differentiation. The discovery highlights Prominin-1 as a potential therapeutic target for treating cancer and regenerating damaged tissues.
A new virus- and oncogene-free induced pluripotent stem cell (iPSC) technology has been developed to produce safer pluripotent stem cells from cord blood and peripheral blood. This approach aims to address safety challenges inherent with pluripotent stem cell therapies.
A recent study found that cancer stem cells rely on amino acids for energy, rather than glucose, and this difference makes them susceptible to targeting without harming healthy cells. Researchers have already shown promise with this approach in clinical trials against acute myeloid leukemia, with potential applications to other cancers.
Grickscheit aims to develop an 'off-the-shelf' stem cell-based therapy that might not require immunosuppression, a substantial step forward for metabolic liver disease. The UPLiFT investigation will test the effective dose and regimen of the therapy.
Researchers created a biodegradable scaffold to transplant stem cells and deliver drugs, promising relief from central nervous system diseases and injuries. The nano-size scaffolds mimic natural tissue and show promise for advanced stem cell transplantation and neural tissue engineering.
Extracellular vesicles, or 'cellular dust', have shown therapeutic properties similar to stem cells without their disadvantages. These gel-like vesicles can be produced by a single donor for several patients and have demonstrated potential in repairing heart, liver, and kidney lesions.
A study analyzed over 1,000 medical crowdfunding campaigns for five unproven treatments, raising nearly $6.8 million. The campaigns were found on four platforms and included homeopathic cancer treatments and hyperbaric oxygen therapy for brain injury.
A computer-guided algorithm may help scientists find the right spot to split a protein and then reassemble it, enabling new medical treatments and biosensors. The researchers developed a mathematical model of a protein's structure, giving them the ability to identify optimal split sites.
A new study examines Canadian clinics marketing unproven stem cell treatments, highlighting regulatory gaps and potential risks to patients. The majority of marketed treatments target orthopedic and musculoskeletal conditions, with some companies advertising for a wide range of disorders.
Researchers developed a novel method to enhance native stem cell bioelectric signals, achieving ultra-high current levels two-orders of magnitude higher than previous methods. The new method uses 2D-molybdenum disulphide sheets, demonstrating improved commercialization and therapeutic safety for future stem cell-based therapies.
Researchers at the University of Würzburg have made a breakthrough in treating myocardial infarction, with stem cells found to exist in vascular walls and intracardiac blood vessels. These cells may be able to regenerate damaged cardiac muscle tissue in response to heart attacks.
The guidelines outline lessons learned by experts in various fields to identify early signs and symptoms of treatment-related toxicity, detailing ways to manage it. Key recommendations include monitoring for cytokine release syndrome and addressing parent and/or caregiver concerns.
Researchers explore two approaches to stem cell therapy for Parkinson's disease, one using patient-specific induced pluripotent stem cells and the other utilizing parthenogenetic-derived neural stem cells. The latter approach offers advantages in terms of reduced immunogenicity and evasion of ethical issues surrounding embryos.
Researchers identify essential switch AMPK that activates mitophagy in leukemia stem cells, offering potential new treatments for acute myeloid leukemia. Without AMPK, LSCs are stressed to death, highlighting the need for targeted therapies.
Researchers developed a refillable, implantable device called Therepi that can deliver drugs and therapies directly to diseased tissue. The device increases heart function for more than four weeks when stem cells are repeatedly delivered.
Researchers at the University of California San Diego School of Medicine have found that treatment with cirmtuzumab measurably inhibited the 'stemness' of CLL cells, allowing most patients to forego additional therapy for over eight months. The drug targets ROR1, a molecule exploited by cancer cells to promote tumor growth and spread.
Researchers have identified kidney stem cells of human origin in amniotic fluid, a promising source for cell replacement therapies. The study shows an increase in these cells with gestational time, making amniotic fluid a valuable source of fetal stem cells with regenerative potential.
A new cell therapy has been developed to aid heart recovery without implanting cells, using extracellular vesicles secreted by cardiomyocytes derived from human pluripotent stem cells. The therapy shows promising results in recovering cardiac function and reducing arrhythmias in rat models of myocardial infarction.
Researchers at UTHealth will investigate a stem cell therapy using MultiStem in severely injured trauma patients to prevent post-injury organ failure and improve recovery rates. The Phase 2 clinical trial aims to enroll approximately 150 patients and is subject to FDA review and approval.
Scientists at the University of Cambridge have discovered a new type of 'sleeping' stem cell in the brain that has a high potential for repair following brain injury or disease. The G2 quiescent stem cell can awaken and produce key brain cells, such as neurons and glia, faster than previously identified quiescent stem cells.
A new study reveals that spaceflight triggers cellular adaptations in heart cells, paving the way for novel stem cell therapies. Researchers found altered calcium signaling pathways that could be harnessed to improve heart repair.
Researchers found that gene therapy using adeno-associated viral vectors can only temporarily alleviate congenital adrenal hyperplasia (CAH) by replacing the defective gene. A long-term solution requires targeting genetic mutations in adrenocortical stem cells, according to a study published in Human Gene Therapy.
Clinical trials have produced encouraging results for mesenchymal stem cell therapy in treating feline inflammatory diseases, such as chronic gingivostomatitis and enteropathies. However, further research is needed to answer questions about logistics and optimal use of the treatment.
A growing number of centers are advertising stem cell therapies for knee osteoarthritis, claiming an 80% success rate. However, research has found poor levels of evidence to support the efficacy of these treatments, and no correlation between treatment costs and effectiveness.
Researchers at CU Anschutz have discovered a new approach to reprogramming adult skin cells into induced pluripotent stem cells (iPSCs) with unprecedented efficiency. This breakthrough has significant implications for the development of new corrective stem cell-based therapies for currently incurable diseases like Epidermolysis Bullosa.
Researchers found that manipulating culture environment and 'priming' stem cells can enhance their function, optimizing therapeutic potential for diseases in humans and animals. The study's results demonstrate a significant enhancement of reparative capacity in stem cells treated with interferon gamma.
Scientists have successfully developed a biologically accurate mass-production platform for bioengineering human liver tissues suitable for therapeutic transplant into people. The new process allows researchers to generate single batches of up to 20,000 genetically matched, three-dimensional and highly functional liver micro-buds.
Researchers discovered Ryk's chaperone, Smek, which regulates key genes transforming stem cells into brain cells. The study sheds light on the mechanisms of brain development and may lead to new therapies for neurological diseases and brain cancer.
A new Northwestern Medicine clinical trial found that stem cell therapy did not improve walking ability in people with peripheral artery disease, despite exercise showing significant improvements. The study led by Dr. Mary McDermott demonstrated that regular exercise can increase six-minute walking distance in patients with PAD.
A boy suffering from extensive skin damage due to epidermolysis bullosa was successfully treated with genetically modified stem cell transplants. The treatment resulted in the growth of high-quality, stress-resistant skin, allowing him to attend school and participate in social life.
Researchers at German Cancer Research Center discovered a link between energy metabolism and epigenetic code in leukemias and brain cancer. The enzyme BCAT1 plays a key role in the development of malignant tumors, including acute myeloid leukemia and breast cancer.
A study by Fred Hutchinson Cancer Center has identified a specific subset of adult blood stem cells responsible for regenerating the entire blood and immune system. The 5% subset, marked as CD34+CD45RA-CD90+, was found to rebuild all different cells of the blood and immune system within 10 days after being infused in nonhuman primates.
Dr. Paul Tesar receives the 2017 NYSCF Robertson Stem Cell Prize for his pioneering work on pluripotent epiblast stem cells, which holds promise for treating neurological disorders like multiple sclerosis and pediatric leukodystrophies.
Researchers review the effectiveness of stem cells and emerging agents in preventing and treating neurodegenerative pathologies. They discuss potential advantages and obstacles of using different types of stem cells and present evidence for further study of certain compounds.
A new study published in Circulation Research found that umbilical cord-derived stem cells improved heart muscle function and quality of life for patients with stable heart failure. The treatment was safe and showed significant improvements over placebo, paving the way for a promising new therapy.
A new study in mice found that transplantation of donor stem cells from human brain tissue can help repair an injured spinal cord. However, the effectiveness of these stem cells is hindered by the body's immune response to injury. Immune cell depletion can improve the recovery outcome for animals receiving transplanted stem cells.
After stem cell therapy, tests like SPEP/SIFE and SFLCA may yield oligoclonal patterns that resemble the original monoclonal antibody spike. However, this is a normal response to treatment, not recurrence of the disease. The key clarifier lies in tracking the location of the malignant spike before and after treatment.
Researchers develop a potential stem cell treatment for idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) and cystic fibrosis by harvesting lung stem cells noninvasively and multiplying them in the lab. The therapy has shown promising results in treating IPF in rodent models.
Scientists have identified a molecular handle to purify cells destined to become insulin-producing cells, enabling a streamlined and cost-efficient process for generating glucose-responsive beta cells. The discovery aims to address safety and end product consistency challenges in cell therapy for type 1 diabetes.
A new review examines the role of various stem cells in corneal wound healing, highlighting similarities and differences in the process. Stem cell transplantation may fine-tune wound healing and provide benefits for patients.
Researchers at Northwestern University developed a synthetic material that can trigger reversible cell signaling, enabling potential treatments for Parkinson's and other diseases. The material can be used to control stem cell proliferation, differentiation, and return to a proliferative state on demand.
A team of researchers at Brigham and Women's Hospital developed a potential therapy using stem cells loaded with oncolytic viruses to target skin cancer metastases in the brain. The study found that this approach led to the elimination of metastatic skin cancer cells from the brain, resulting in prolonged survival.
New research suggests that educating patients' immune cells with cord blood stem cells may help combat type 1 and 2 diabetes. The therapy is safe and effective in improving islet beta cell function, making it a potential treatment for other autoimmune diseases.
Leading experts advocate for global standards on stem cell therapies, warning that unregulated advertising can harm patients. The University of Edinburgh group calls for stricter regulations and coordinated action to tackle the issue.
A new therapy developed through stem cell technology has shown promise in treating chronic asthma by reducing inflammation and reversing airway remodeling. The study, led by Monash University scientists, found that induced pluripotent stem cells could effectively treat fibrosis and lung dysfunction associated with asthma.
Researchers at Tel Aviv University discovered a molecular pathway involved in the toxic interaction between host cells and the immune system when using cardiac stem cells from patients with heart disease. The study suggests that these cells can develop inflammatory properties and exacerbate damage to the already diseased heart muscle.
Researchers developed a stem cell-based therapy to generate skin grafts for myelomeningocele defects before birth. The treatment successfully covered large defects and protected the spinal cord, but had some drawbacks, including decreased birth weight and body length.
Researchers in China have made a breakthrough in developing a new approach to treat premature ovarian failure using female germline stem cells. The study found that mice with transplanted egg-making stem cells produced healthy pups without genetic malfunctions, opening up avenues for investigating human oogenesis in vitro.
A meta-analysis of three trials found that CD34+ stem cells improved exercise time by 80.5 seconds and reduced mortality by 24 months in patients with refractory angina. This therapy has been shown to be safe and effective for treating patients with limited options.
A new study reveals that a signal in blood, called Hepatocyte Growth Factor Activator (HGFA), can alert stem cells to heal faster and more efficiently after an injury. By injecting HGFA into mice before an injury, researchers showed improved tissue repair, quicker recovery, and better regeneration of damaged tissues.
A new study found that stem cell therapy reduces lung inflammation in a mouse model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. The treatment also improves lung structure, suggesting it may repair damaged lungs.
Researchers found that a single dose of millions of adult stem cells can aid stroke recovery if given early, reducing destructive inflammation and the risk for serious infections. Early treatment within 36 hours after stroke symptoms surface also showed benefits in physical recovery and reduced disability one year out.
Researchers have identified a mechanism by which the body controls the fate of stem cells, allowing them to adapt and differentiate into various types of cells. This discovery can help improve the effectiveness of stem cell therapies, potentially leading to better treatments for diseases like Parkinson's.
Researchers have identified adipose stem cells as a suitable alternative to bone marrow stem cells for treating orthopedic diseases and injuries in dogs. The study reveals that adipose stem cells exhibit similar functional properties to bone marrow stem cells, including tissue generation and immunomodulation, but grow at a faster rate.
A study of 281 patients with aggressive MS who underwent autologous hematopoietic stem cell transplantation found a 46% five-year progression-free survival rate. Younger age, relapsing form of MS, and fewer prior immunotherapies were associated with better outcomes.
A new nanofiber-on-microfiber matrix enables the scalable expansion of human pluripotent stem cells, resulting in high-quality cells with robust growth. The innovative system allows for easy exchange of nutrients and reduces stress on the cells, making it suitable for large-scale production.
Researchers from Boston University School of Medicine have discovered an efficient way to generate thyroid cells using genetically modified embryonic stem cells. The findings, published in Stem Cell Reports, are the first step towards developing a protocol using human stem cells to model thyroid disease and develop therapies.
High-dose immunosuppressive therapy followed by stem cell transplantation has been shown to induce sustained remission in relapsing-remitting multiple sclerosis. Five years after treatment, 69% of participants had survived without progression or relapse, with some showing improvements in mobility and physical capabilities.
Researchers have developed synthetic stem cells that mimic natural cardiac stem cells, promoting tissue repair and reducing risks of tumor growth and immune rejection. These cells are more durable, can be used off-the-shelf, and can tolerate harsh freezing and thawing.
A deficiency of prohormone covertase (PC1) in the brain is linked to most neuro-hormonal abnormalities in Prader-Willi syndrome. The discovery provides insight into molecular mechanisms underlying the syndrome, highlighting a novel target for drug therapy.