Articles tagged with Stem Cell Therapy
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Researchers at UC Davis Health System have combined fetal surgery with a placental stem cell treatment to reduce the effects of spina bifida, with six lambs regaining ability to walk without noticeable disability after birth. The study aims to confirm safety and determine optimal dosing for potential human clinical trials.
Researchers at Harvard Medical School have developed an imageable mouse model of brain-metastatic breast cancer and shown the potential of a stem-cell-based therapy to eliminate metastatic cells from the brain and prolong survival. The study also describes a strategy to prevent negative consequences of stem cell therapy.
Researchers developed an imageable mouse model of brain-metastatic breast cancer and tested a stem-cell-based therapy that eliminates metastatic cells from the brain, prolonging survival. The treatment also prevents negative consequences by targeting tumor-specific molecules.
A new model, XactMice, allows researchers to test anti-cancer therapies in an environment similar to real patients. Human blood stem cells are used to grow a human-like immune system before tumor transplantation.
A new study by University of Alberta researchers found that media coverage of stem cell therapies often presents unrealistic timelines and overhypes the field. The study examined 307 news reports between 2010 and 2013, revealing that 69% predicted therapies would be available within 5-10 years or sooner.
Researchers developed a novel laboratory model to test factors improving MSC binding to defective cartilage. Integrins were found essential for effective MSC attachment and therapy efficacy in osteoarthritis repair.
A recent review article suggests that stem cell therapy may be less effective in older patients with chronic diseases, such as diabetes and cardiovascular disease. The study proposes strategies to enhance the regenerative properties of autologous stem cells and improve their therapeutic potential.
Research suggests that P53 gene mutations accumulate in blood stem cells as people age, increasing the risk of therapy-related AML. The study found nearly 50% of healthy individuals over 68 had P53 mutations, and these mutations can contribute to chemotherapy resistance.
A new study from Rice University's Baker Institute finds that NFL players are seeking out unproven stem cell therapies to accelerate recoveries, despite potential risks. The authors suggest the NFL should establish guidelines and regulate these treatments to protect player health.
Scientists at Stanford University School of Medicine and colleagues have discovered a previously unknown immune response to the mitochondria of pluripotent stem cells created through nuclear transfer, which can prompt rejection in mice. This finding may pose a hurdle for using such therapies in humans, but it is considered surmountable.
Researchers at Rutgers University have developed a platform called NanoScript, which can interact with endogenous DNA and regulate gene expression. This technology has great potential for advancing stem cell therapeutics and treating debilitating injuries and diseases such as Parkinson's disease and spinal cord trauma.
UC San Diego has been designated as one of three 'alpha clinics' by the California Institute for Regenerative Medicine to accelerate clinical development of emerging stem cell therapies. The designation will support the establishment of a comprehensive regenerative medicine clinical hub and attract patients, funding agencies, and study...
Researchers discovered a turmeric compound, ar-turmerone, promotes stem cell proliferation and differentiation in the brain, suggesting its potential as a future drug candidate for treating stroke and Alzheimer's disease. The study found that ar-turmerone increased neural stem cell proliferation by up to 80% without affecting cell death.
A new study supports the use of newborn screening tests for severe combined immunodeficiency (SCID), a life-threatening condition affecting approximately 1 in 58,000 infants. The test identified 52 cases of SCID, with all patients receiving lifesaving treatments and 92% surviving.
A pilot study using stem cells extracted from patients' bone marrow shows promising results in treating acute stroke. The therapy was found to be safe and improved clinical measures of disability in all five patients.
A team of researchers has identified 5-lipoxygenase as a target for therapeutic management of stem cell-like cells in acute myeloid leukemia. Inhibiting this enzyme selectively attacks and eliminates leukemic stem cells in both cell culture models and mouse models, suggesting a promising approach for treating the disease.
Spinal cord injury pain is a debilitating consequence of neurological disorders, interfering with rehabilitation and quality of life. Microenvironment modulation enhances stem cell therapy for SCI pain by preventing aberrant central sprouting of nociceptive fibers.
Researchers investigated the impact of cellular senescence on adipose-derived stem cell morphology and function. The study found that senescence compromises the clinical application of these cells for peripheral nerve regenerative cell therapy. Senescence modulating factors influence adipose-derived stem cell behavior.
Mayo Clinic researchers discover a strategy to significantly reduce the risk of tumor development using pretreatment with genotoxic etoposide. This approach establishes an adjunctive therapy to harness the clinical value of iPSC-derived cardiac regeneration, providing a promising breakthrough for heart disease treatment.
A team of scientists led by Prof. Claudia Waskow has successfully generated a mouse model that supports human blood stem cell transplantation without irradiation, enabling the study of human blood development in a physiological setting. This breakthrough could lead to improved treatment options and disease research for patients with he...
Researchers have found that using gene-editing techniques on stem cells does not increase the overall occurrence of mutations, easing previous safety concerns. The study's results were published in the journal Cell Stem Cell and provide new hope for the development of therapies for genetic diseases.
Researchers at Scripps Research Institute found that the drug rapamycin can improve the delivery of genes to blood stem cells, increasing efficiency from 30-40% to up to 80%. This breakthrough could lead to more effective and affordable treatments for leukemia and sickle cell anemia.
Researchers found that peripheral blood stem cells stimulated by granulocyte colony-stimulating factor (G-CSF) can inhibit osteoarthritis progression in rats. The therapy has potential as a treatment for OA, but further studies are needed to determine its effectiveness in humans.
A new study shows that administering G-CSF, a stem cell-stimulating therapy, early in the treatment of heart attack patients can improve their chances of survival and cardiac function. The therapy was found to increase blood flow, access to energy, and overall cardiac health.
Researchers at the University of Missouri have successfully transplanted and grown human stem cells in genetically modified pigs. The breakthrough paves the way for future research on stem cell therapies and could lead to new treatments for debilitating human diseases.
Exosomes secreted by cardiac stem cells carry messages that reduce cell death, promote growth of new heart muscle cells and encourage development of healthy blood vessels. The researchers pinpointed one microRNA as responsible for some of the benefits, suggesting it may be an attractive alternative to living-cell transplantation.
Researchers have identified a novel marker, glycan O-GLcNAc, on the surface of human umbilical cord blood stem cells. This discovery may play a crucial role in cell signaling pathways regulating embryonic development and has potential implications for stem cell therapies.
A new method has been developed to derive large quantities of highly potent mesenchymal stem cells from human embryonic stem cells. These cells display potent immunomodulatory and therapeutic properties, offering promise in regenerative medicine.
Researchers at USF Health have found that a combination of human umbilical cord blood cells and granulocyte colony stimulating factor significantly reduced TBI-induced loss of neuronal cells in the hippocampus. The therapy also showed beneficial results in animals with experimental TBI, with G-CSF alone producing short-lived benefits.
Researchers found that human umbilical cord blood cells transplanted into rats with simulated myocardial infarction improved left ventricular heart function and preserved myocardial fiber structure. The study showed long-term benefits for the treated rats, suggesting a potential therapy for MIs.
Researchers at the University of Edinburgh's Roslin Institute have created working nerve cells from horse stem cells, paving the way for cell therapies targeting neurological conditions. The breakthrough could also benefit horses affected by grass sickness, a previously untreatable condition.
A team of researchers at the University of Montreal has discovered a promising new approach to treating leukemia by targeting the Brg1 gene. The study found that removing or inhibiting this gene can permanently shut down cancerous cell growth and division.
Researchers found that intratracheal transplantation of human umbilical cord blood-derived mesenchymal stem cells can prevent or treat bronchopulmonary dysplasia (BPD) in very preterm infants. The treatment also showed a lower incidence of retinopathy of prematurity requiring surgery.
A bioengineer is researching the necessary nutrients for stem cells to grow and function as heart cells, with a focus on understanding cell metabolism. The goal is to prevent diseases such as cancer, diabetes, and obesity by optimizing heart cell nutrition.
Adolescents and young adults undergoing cancer treatment benefit from a therapeutic music process that includes writing song lyrics and producing videos. This music therapy intervention improves resilience-related outcomes, including courageous coping and social integration.
Researchers have identified a protein that enables the transfer of mitochondria from stem cells to damaged epithelial cells, rejuvenating their health. This discovery could lead to more effective therapies for lung disease in humans by engineering mesenchymal stem cells to produce healthy mitochondria.
Researchers found that a small number of transplanted stem cells was sufficient to restore normal skin function without adverse side effects. The treatment resulted in long-term restoration of normal skin, even after 80 cycles of renewal.
A systematic review of animal studies found that stem cell therapy can improve sensory and motor outcomes for spinal cord injury patients, with average improvements of 25% in both areas. The study's meta-analysis also revealed important lessons on how to design future animal studies.
Researchers identify key molecular mechanisms, cell populations and developmental stages of human articular cartilage cells. This breakthrough study provides a new cell source and biological roadmap for therapies to repair cartilage defects and damage from osteoarthritis.
A novel drug regimen featuring bortezomib has been shown to improve outcomes for patients receiving stem-cell transplants from mismatched and unrelated donors. The regimen reduced severe acute GVHD rates and treatment-related mortality, leading to better overall survival and relapse-free survival.
The World Stem Cell Report 2013 presents innovative solutions for accelerating stem cell treatments and eventual cures, addressing regulatory, legal, and ethical roadblocks. The report is a benchmark guide for moving the field forward, supporting the 2013 World Stem Cell Summit.
A recent study by the Cardiovascular Cell Therapy Research Network found that bone marrow mononuclear stem cells did not improve heart function significantly at one year compared to six months. The treatment also showed a measurable decrease in scar tissue, but its effectiveness was no different from a placebo.
The center will integrate operations at four locations, including the UC San Diego Jacobs Medical Center and the Sanford Consortium for Regenerative Medicine. It aims to translate discoveries into therapies that can improve and save lives, with a focus on treating cancer, Lou Gehrig's disease, and spinal cord injury.
A preclinical study led by UTHealth researchers found that stem cell therapy promotes lasting cognitive improvement after brain injury. The treatment, known as MAPC therapy, was shown to reduce inflammation and improve brain function in mice.
The World Stem Cell Report 2013 outlines critical challenges and key action items to overcome them, including regulatory compliance and education for physicians and patients. Key opinion leaders like Paul Knoepfler bring a fresh perspective to the stem cell universe, highlighting areas of progress and need for advancement.
Researchers developed a protocol to optimise preparatory treatment with cytostatics prior to stem cell transplantation for children with chronic granulomatous disease, achieving higher survival rates and minimal adverse reactions. The study involved tailoring doses of fludarabine and busulfan based on blood levels, resulting in a 93% s...
A study published in the Journal of AAPOS found no therapeutic effect of stem cell therapy on children with optic nerve hypoplasia. The research highlights the need for scientifically testing these procedures to validate their effectiveness and ensure safety.
Cardiology researchers at Emory have developed a solution to improve the impact of stem cell therapy on heart function. By packaging mesenchymal stem cells in alginate capsules, they can increase cell retention and survival, promoting healing factors that encourage regeneration of blood vessels.
Researchers have found that combining gene therapy with an extra boost of stem cells leads to faster healing of burns and greater blood flow to the site of the wound. The study uses elderly mice as a model to understand why older people with burns fail to heal well and how to potentially harness the body's own bone marrow stem cells to...
The study, published in the journal Blood, shows that 12 adult patients underwent successful umbilical cord blood transplantation for leukemia or lymphoma. The treatment, 16,16 dimethyl prostaglandin E2, improved blood formation and reduced complications.
A clinical study found that stem-cell enriched fat grafts retained 80.9% of their initial volume, compared to 16.3% for non-enriched grafts, after 121 days. The treated grafts showed significantly higher amounts of adipose tissue and newly formed connective tissue.
Researchers found that mesenchymal stem cell transplantation can promote recovery from simulated childbirth injury and reduce symptoms of stress urinary incontinence. The treatment uses multipotent cells found in connective tissues, which home to damaged pelvic organs and release trophic factors to stimulate repair.
Researchers have discovered a process defective in patients with autosomal dominant polycystic kidney disease, a leading cause of kidney failure. Induced pluripotent stem cells from patients were reprogrammed to study human kidney disease mechanisms, revealing a potential therapeutic strategy by correcting a protein defect.
Researchers have discovered that biphasic electrical stimulation can prevent apoptosis in stem cells used to treat spinal cord injuries, offering new hope for patients. The study's findings suggest that BES may be used to improve cell survival and prevent cell death in stem cell-based transplantation therapies.
A Scripps Research Institute team will study how cellular damage drives the aging process, with a focus on stress caused by DNA damage and potential therapeutic targets for slowing aging. The grant aims to identify ways to minimize degenerative changes associated with aging, potentially leading to improved healthspan.
Using surface-enhanced Raman spectroscopy (SERS), scientists can distinguish between adult stem cells, enabling the use of healthy ones in therapies. This technique holds promise for advancing stem cell and other cell-based therapies to treat diseases like Parkinson's.
Stem cells found in urine have been shown to differentiate into various cell types, including bladder, bone, cartilage, and endothelial cells. These cells offer a promising alternative for autologous therapy, potentially treating urology-related conditions and other fields.
Researchers have generated functional human liver cells from stem cells and transplanted them into mice with acute liver injury. The stem-cell derived human liver cells were able to function normally and increase the survival of treated animals. This breakthrough demonstrates a scalable method for producing these cells, which could lea...
A UC Davis study reveals that astrocytes can protect brain tissue and reduce disability due to stroke. The research found that a specific type of astrocyte called Olig2PC-Astros has greater antioxidant effects and improves learning and memory in rats.
A new gene therapy approach using a partially inactivated lentivirus has shown significant improvement in three children with Wiskott-Aldrich Syndrome. The therapy corrects the genetic defect in blood cells by introducing a normal WASP gene, reducing the risk of cancer-promoting genes.