Articles tagged with Stem Cell Therapy
A new study from the University of Ottawa proposes using vanoxerine, a drug initially developed for cocaine addiction, to potentially treat advanced colon cancer. Vanoxerine has been found to suppress cancer stem cell activity in colon cancer patients' tissues and tumours implanted in laboratory animals. The drug works by interfering w...
A phase II clinical trial found Muse cell-based product CL2020 to be highly tolerated and improved ALS symptoms, but may not halt disease progression. The treatment's efficacy depends on combining it with other drugs for future treatments.
A Scripps Research team identified the energetic reactions in brain cells that malfunction and lead to neurodegeneration. They successfully restored many neuron-to-neuron connections in nerve cell models derived from human Alzheimer's patient stem cells by addressing a bottleneck in mitochondrial energy production.
A recent study reveals that a significant proportion of human pluripotent stem cell samples possess cancer-related mutations acquired during culture propagation. These mutations impact cell growth and differentiation, emphasizing the importance of regular evaluations in research and clinical applications.
Researchers have successfully genetically modified pluripotent stem cells to evade immune recognition, offering a viable path forward for pluripotent stem cell-based therapies. The study's findings suggest that these engineered stem cells could pave the way for new treatments for diseases such as Type 1 diabetes and macular degeneration.
Researchers found that ASCOT reverses some age-related protein expression changes, enriching processes related to the complement cascade and immune system in patients with poor ovarian response. In contrast, patients with premature ovarian insufficiency showed enrichment in responses to oxygen-containing compounds and growth hormones.
Cancer stem cell-derived exosomes (CSC-Exos) are essential for communication between CSCs and other cells in the tumor microenvironment, contributing to cancer progression. The editorial highlights their potential as a novel clinical tool for diagnosis, prognosis, prevention of tumor recurrence, and therapeutic strategy
A microbial sensor, Nod1, plays a crucial role in the development of blood stem cells. The discovery could lead to the creation of patient-derived blood stem cells, eliminating the need for bone marrow transplants and improving lives of leukemia, lymphoma, and anemia patients. Researchers are continuing to study the complex interaction...
Scientists have identified a population of progenitor cells that strongly promote new blood vessel growth in ischemic limbs, showing promise as a treatment for preventing amputations. The discovery was made through single-cell transcriptomics and confirmed in mice with limb ischemia, where the treatment rescued limbs from amputation.
Scientists have successfully grown neurons from stem cells that can repair damaged brain tissue after stroke, offering new hope for treatments. The technology also holds promise for studying neurodegenerative diseases like Alzheimer's, Parkinson's, and spinal cord injury.
A clinical trial found that stem cell-based therapy reduced daily hardship and improved physical and emotional health in patients with advanced heart failure. Patients who received the treatment had lower death and hospitalization rates compared to those on standard care.
Researchers have identified the genetic defect causing infantile cystinosis, a rare disease that shortens lifespan, and developed a protocol to differentiate stem cells into healthy kidney cells. The study suggests using CRISPR genome editing to repair the defective gene and potentially cure the disease.
Researchers from the Mass General Cancer Center presented studies on psychiatric and substance use disorders as independent predictors of treatment response and outcomes in United States Veterans with Newly Diagnosed Acute Myeloid Leukemia (AML) treated with Venetoclax Combinations. Additionally, a Phase 1 Study of CAR-T-ddBCMA for the...
A new stem cell treatment using mRNA technology from COVID-19 vaccines has shown promise in regenerating liver tissue, potentially reversing chronic and acute liver diseases. The treatment stimulates the natural repair mechanism of the liver by activating specific receptors on stem cells.
A new publication in Nature Communications has developed a method to produce high-purity dopamine cells from human stem cells, offering a potential therapeutic approach for treating Parkinson's disease. The research aims to reduce recovery time and minimize the risk of relapse and medication use.
A clinical trial of stem cell therapy in patients with secondary progressive multiple sclerosis has shown a long-lasting effect that appears to protect the brain from further damage. The study found no signs of disease progression and a substantial stability of the disease without worsening of symptoms.
A new clinical trial has shown that a stem cell-based device can reduce the amount of insulin required for some participants with Type 1 diabetes. The device, developed by ViaCyte, aims to replace the insulin-producing beta cells that people with the condition lack.
A systematic review and meta-analysis of 16 studies involving 875 patients with knee osteoarthritis found significant reductions in patient-reported pain from the third month onwards. Stem cell treatment was most effective when using patient's own fat-derived stem cells, leading to better pain alleviation and recovery of joint function.
A new study shows that autologous stem cell transplant can improve nearly all measures for two years following treatment in patients with refractory juvenile systemic sclerosis. The procedure significantly reduces disease severity and improves skin thickness, intestinal symptoms, and lung function, offering a life-saving intervention f...
Researchers at UC Irvine have identified a critical gene for muscle repair and regeneration, enabling the creation of muscle in the lab that can support human stem cells. The discovery has immense implications for treating various chronic muscle disorders and injuries, including rotator cuff tears and Duchenne Muscular Dystrophy.
Researchers in China have reported the groundbreaking achievement of creating a live birth of a chimeric monkey using embryonic stem cell lines. The study demonstrates the ability of these cells to differentiate into various tissues in vivo, opening up new possibilities for genetic engineering and species conservation. Analysis reveale...
Researchers at the University of Alberta have created a new process to produce insulin-producing pancreatic cells from patient stem cells, achieving a 90% success rate. The breakthrough could lead to injection-free glucose control in people with diabetes and eliminate the need for anti-rejection drugs.
A recent study published in Nature Medicine calls into question the effectiveness of stem cell therapy for treating knee pain. While some patients showed improvement, there was no significant advantage found in using stem cell therapies compared to corticosteroid injections over a one-year period.
A study from the University of Wisconsin-Madison and Academia Sinica of Taiwan has successfully combined lab-grown cardiomyocytes with stem-cell-derived endothelial cells to regenerate damaged heart muscle after a heart attack. This combination therapy holds promise for tackling arrhythmia and could lead to improved clinical applications.
Researchers have identified 38 businesses marketing unapproved stem cell treatments and exosome therapies for preventing and treating COVID-19. Many clinics claim to treat Long COVID, with some charging up to $25,000 for 'treatments'. Regulatory bodies must act to protect patients from misleading claims.
A UCLA-led team has identified RBFox1, an RNA splicing regulator, as a key player in promoting human stem cell-derived heart muscle cell maturation. This finding offers a deeper understanding of heart muscle cell development and hints at future therapeutic applications for regenerative therapies.
Researchers discovered an anti-nucleolin DNA aptamer that modulates gene expression and nucleolin localization to determine a cell's lineage during differentiation. The study shows promise as a regenerative therapy for cardiovascular diseases.
A phase 1/2 study shows that a stem cell-derived islet therapy has improved blood sugar control in all six adult patients with type 1 diabetes. Three patients achieved insulin independence and showed sustained improvements in blood glucose levels.
USC is partnering with seven leading regenerative medicine institutes to form the Los Angeles and surrounding area regenerative medicine consortium. The partnership aims to advance regenerative medicine using stem cells and gene therapies for treating unmet medical needs.
A small molecule drug improved the fitness of hematopoietic stem cells used in cell transplants, potentially enhancing the success of procedures like ex vivo gene therapy. The study found that targeting extracellular vesicles relieved stress on cells outside the body, improving their performance when transplanted back in.
A new biomimetic chip has been developed to simulate the human gastric mucosa, combining organoid and organ-on-a-chip technologies. The biochip replicates mechanical stimulation and cell-to-cell interactions, mimicking key features of the human stomach's defense mechanisms.
Five lung stem cell variants dominate CF lungs, causing inflammation, fibrosis, and mucin secretion. CFTR modulators fail to suppress these inflammatory variants, suggesting they as key targets for new drugs.
A recent study by Boston Medical Center and Boston University's Center for Regenerative Medicine discovered that hemogenic endothelial cells in the fetal lung contribute to blood cell formation. This breakthrough expands our understanding of blood development and its relationship with overall health.
Researchers have discovered that embryonic stem cells are guided by a complex interplay of signaling molecules to determine their cell type. The study found that fibroblast growth factor (FGF) acts as an antagonist of the signal molecule BMP, influencing cell differentiation and fate.
A systematic review and meta-analysis of 195 clinical trials found that cell therapy can reduce the risk of death from COVID-19 by 60%. The studies, conducted in 30 countries between January 2020 and December 2021, used various types of cells, including mesenchymal stem cells and natural killer cells.
A preclinical study suggests that nanowired cardiac organoids could repair hearts instead of just preventing further damage. The treatment, led by Dr. Mei and Ryan Barrs, showed a 69% increase in heart function, promising a new therapy for heart disease.
A phase I clinical trial shows that transplanting P63+ lung progenitor cells can repair damaged lung tissue in patients with chronic obstructive pulmonary disease (COPD), improving breathing and quality of life. The treatment increased lung function, reduced symptoms, and even repaired mild emphysema in some patients.
Researchers developed a new formulation of doxorubicin that targets cancer cells while reducing cardiotoxicity. The protein-shell encapsulation increases specificity for cancer cells and decreases harm to healthy heart cells.
Researchers at Prolacta and MD Anderson Cancer Center found a human milk-based synbiotic to safely control the gut microbiome in adults, opening the door to precision microbiome engineering. The study demonstrates significant precision in modulating adult gut microbiomes.
Researchers have developed a human milk-based synbiotic that safely modulates damaged adult gut microbiomes. The study found that this symbiotic reshapes gut microbial composition and metabolites, offering new possibilities for treating dysbiotic conditions.
Researchers from the Center for Regenerative Medicine at Boston University School of Medicine have discovered a novel approach for engrafting engineered cells into injured lung tissue. They successfully reconstituted the stem cell compartment of injured airways and alveoli using cells engineered from pluripotent stem cells, resulting i...
A new study by Weill Cornell Medicine researchers found that severe COVID-19 infection can alter the immune system's response, causing long-lasting changes to gene expression in immune system stem cells. This can lead to symptoms of prolonged inflammation and 'long COVID' in affected individuals.
A phase I trial of cultivated autologous limbal epithelial cell transplantation (CALEC) has shown positive results in four patients with severe chemical burns, restoring cornea surfaces and improving vision. The treatment uses a patient's own stem cells grown on a graft, offering hope to patients with untreatable vision loss and pain a...
Researchers at CityU and HKUMed developed genetically modified human neural stem cells that promote neural circuit reconstruction, reduce glial scar accumulation, and enhance axon outgrowth. The therapy demonstrates potential for treating severe spinal cord injuries with functional recovery.
Researchers successfully created stem-cell derived organoids from human stem cells that secrete three essential enamel proteins. These proteins form a matrix that undergoes mineralization to create a hardened enamel structure. The breakthrough offers hope for developing novel treatments to repair and regenerate teeth.
City of Hope will conduct Phase 1 clinical trials for novel cell and gene therapy treatments for patients with HIV, acute myeloid leukemia, and severe aplastic anemia. A CAR T therapy for HIV is also being developed to potentially target other diseases.
Researchers at Duke University Medical Center have identified a fatty molecule in breast milk that triggers a process in which stem cells produce new white matter, reversing neurological damage. This finding holds promise for developing therapies to treat preterm babies with cerebral palsy.
Researchers from Tokyo Medical and Dental University successfully generated functional parathyroid glands from mouse embryonic stem cells using blastocyst complementation. This breakthrough study demonstrates the potential for regenerating organs in vivo and provides a new treatment option for hypoparathyroidism.
Brigham researchers use induced pluripotent stem cells to restore hormone production and fertility in mice with premature ovarian failure. The study shows promise for treating incurable conditions and may lead to new therapies for patients with ovarian failure.
Researchers have made key discoveries in a new stem cell-based therapy for Parkinson’s disease, using patients’ own cells to replace lost neurons. The approach, called an autologous therapy, has shown promise in reversing symptoms of the disease in rat models and holds potential for clinical trials with improved success rates.
A new drug delivery method utilizes polymer-stabilized crystals to deliver antioxidants to stem cells, minimizing variation in drug release and extending the duration of effectiveness. This technology can be applied to various cell cultures and potentially other hydrophilic drugs, disease models, and methods applications.
Cancer cells can hide and escape therapies leading to recurrence. Researchers identify three possible mechanisms: cancer stem cells, polyploidy, and senescence. Combination treatments involving chemoradiation-induced transitory senescence and senolytic therapies may be effective in preventing repopulation.
Researchers used infected stem cells to study COVID-19's impact on organs, identifying effective anti-viral drugs for treatment. The study found distinct antiviral profiles in heart and lungs, paving the way for new therapeutic options.
Scientists from Brigham and Women's Hospital have developed a new immuno-therapeutic approach using twin stem cells that can target brain metastatic melanomas. The therapy, which uses an engineered 'twin stem cell model,' activates the immune system to suppress tumor growth and prolong survival in representative preclinical models.
Researchers from Oregon Health & Science University have discovered how stem cell transplantation can kill the virus that causes AIDS. The study, published in the journal Immunity, reveals that two circumstances must co-exist for a cure to occur and documents the order in which HIV is cleared from the body.
Researchers at Weill Cornell Medicine have successfully converted human stomach stem cells into insulin-secreting cells, offering a promising approach to treating type 1 and severe type 2 diabetes. The transplants reversed disease signs in mouse models, suggesting good durability.
Researchers found variant cells in lungs of IPF patients that can drive fibrosis and inflammation. These cells may be targeted for future therapy, offering new hope for treatment.
Increased expression of Musashi 1 on breast cancer cells has significant implications for understanding dormancy and survival in bone marrow. Msi 1 knockdown led to a reduction in cancer stem cells with undetectable PD-L1, suggesting a potential therapeutic target.
Scientists create a subcellular omics toolkit to study organelle diversity and communication in stem cells. The tool enables the identification of similar cell types, leading to more precise therapies for various diseases.
Scientists have developed a new method to deliver genetic information to stem cells using nanoparticles coated with a specific polymer, enabling more efficient control over cellular differentiation. This innovation has the potential to improve the efficiency and effectiveness of regenerative medicine treatments.