Articles tagged with Atopic Dermatitis
Two new medications have been approved to treat mild, moderate, and severe eczema in both children and adults. Crisaborole reduces itching, redness, and swelling, while dupilumab targets the underlying cause through injection therapy. These treatments provide effective relief and improve quality of life for those affected by eczema.
A new study from the University of Pennsylvania found that black children with eczema are 30% less likely to see a doctor for treatment compared to white children. Despite having more severe disease, minority children experience lower healthcare utilization rates due to various barriers.
Researchers from Hokkaido University successfully treated mice with atopic dermatitis using HLA-G1, a protein that inhibits immune responses. The treatment showed marked improvement in skin lesions and reduced immune response compared to untreated mice.
Scientists have identified mutations in the CARD11 gene that lead to severe atopic dermatitis, an allergic skin disease. Supplementing with the amino acid glutamine may partially correct the underlying cell-signaling defects, according to a study published in Nature Genetics.
A new study published in the British Journal of Dermatology found that adults with atopic dermatitis were not at increased risk for cardiovascular problems such as high blood pressure, Type 2 diabetes, heart attacks, or strokes. The research suggests that eczema is likely not positively associated with cardiovascular disease.
Researchers at La Jolla Institute for Immunology pinpoint TWEAK as a common driver of skin inflammation in both diseases. The protein plays a major role in inducing pro-inflammatory signaling molecules that recruit immune cells to the skin.
A recent study published in PLOS Medicine found that genetic alterations associated with lower vitamin D levels do not predispose individuals to asthma, atopic dermatitis, or high IgE levels. The researchers looked at data from over 100,000 individuals and found no statistically significant difference between rates of these conditions.
Researchers at Newcastle University have identified the key role of filaggrin in triggering eczema by creating a human model system that mimics the skin condition. This discovery provides new understanding of the mechanisms involved and suggests targets for future drug development.
Researchers at Hokkaido University identified the PNPLA1 gene as essential for acylceramide synthesis, a lipid that forms the skin barrier. The study sheds light on potential treatments for skin diseases like atopic dermatitis and ichthyosis.
A recent study led by the University of Nottingham found that wearing silk clothing does not reduce the severity of eczema in children with moderate to severe eczema. The study involved recruiting hospitals across the UK and assessed the effectiveness of specialist silk garments against standard treatment.
A randomized controlled study found no significant difference in eczema severity for children wearing silk garments compared to their usual clothing. The results suggest that silk garments are unlikely to provide additional clinical or economic benefits over standard care.
A recent study published in Annals of Family Medicine found that antibiotics are not effective in treating eczema flares in children. The CREAM study analyzed data from 113 children with non-severely infected eczema and showed no significant difference between groups in the resolution of eczema symptoms.
A study published in the Annals of Family Medicine found that in-office automated blood pressure monitoring over 30 minutes significantly reduced the number of patients who met criteria for antihypertensive medication regimes. The technique, known as OBP30, yielded lower blood pressure readings than routine office blood pressure readings.
A recent study published in Annals of Family Medicine found that oral and topical antibiotics have no meaningful benefit for milder clinically infected eczema in children. Topical corticosteroids and emollient treatment led to rapid resolution of symptoms.
Researchers isolated and grew good bacteria with antimicrobial properties to treat atopic dermatitis. The treatment successfully reduced Staphylococcus aureus on the skin, offering a new approach to managing the condition.
A Northwestern University study found that applying petroleum jelly to high-risk newborns can prevent eczema, a costly skin disorder. The cost benefit of prophylactic moisturization was $353 per quality-adjusted life year, making it an affordable option.
A study by Tohoku University found that air pollutants cause hypersensitivity to itch, leading to skin inflammation and allergic diseases like asthma. The research team discovered that AhR, a transcription factor activated by air pollutants, causes itchy sensations through the expression of neurotrophic factor artemin.
A new study examining the genetic history of eczema finds that a key genetic variant strongly associated with the disorder has no apparent adaptive value. The research suggests that the variant may have simply endured due to chance rather than providing any survival or reproductive benefits.
Research reveals that early exposure to antibiotics is associated with a higher risk of developing eczema and hay fever. The study found that the use of antibiotics in early childhood can lead to a stronger immune response, disrupting the balance of gut microbiome.
A clinical trial showed that stem cells from umbilical cord blood significantly reduced Eczema Area and Severity Index scores by 50% in high-dose patients. Immune-related markers of atopic dermatitis also decreased, with persistent improvement throughout the 12-week follow-up period.
Research suggests that high levels of water hardness in homes may be linked to the development of eczema in early infancy. Living in a hard water area was associated with an up to 87% increased risk of eczema at three months of age, independent of domestic water chlorine content.
A population-based study published in JACI found that adults with asthma are at a 70% greater risk of developing shingles compared to those without asthma. Additionally, individuals with atopic dermatitis also showed a higher risk of shingles, even when other factors were accounted for.
A new Northwestern Medicine project aims to better understand the effects of asthma and eczema on children's quality of life. The study will use PROMIS tools to measure the impact of these conditions, providing researchers and clinicians with more accurate assessments.
A study published in Nature Communications has identified seven genetic risk loci for atopic dermatitis and asthma, suggesting a link between the two conditions. The research found that regions determining atopic dermatitis risk also influence the development of asthma and other allergies, known as the atopic march.
Researchers identified 10 new genetic variations associated with eczema, shedding light on the immune system's regulation. The study, involving 377,000 subjects, also found evidence of genetic overlap with inflammatory bowel disease.
A large-scale genetic study of 377,000 people worldwide has identified 10 new genetic variants associated with eczema, bringing the total number of known variants to 31. These variants are linked to regulating the immune system and may lead to potential new treatments for eczema.
Researchers at OSU create a new approach to treat eczema and inflammatory skin disorders by identifying specific lipid deficiencies in each person. This system uses advanced science and mass spectrometry to develop personalized treatments.
Researchers at Yale School of Medicine have successfully treated patients with moderate to severe eczema using a rheumatoid arthritis drug. Treatment led to dramatic improvement in itch, sleep, and skin redness, offering hope for a new standard of care for the chronic condition.
Researchers have identified a serotonin receptor, HTR7, as a key mediator of eczema and other forms of itch. The study suggests that targeting this receptor may lead to the development of powerful new therapies for chronic itch conditions.
Researchers at the University of Gothenburg found that linalyl acetate, a common fragrance chemical, can react with oxygen to form allergenic hydroperoxides. Approximately 2% of tested individuals had allergic reactions to oxidized linalyl acetate, highlighting the need for broader testing and declaration on cosmetic products.
Adults with eczema experience significantly increased healthcare utilization and costs, with estimated annual out-of-pocket costs of $37.7 billion. Eczema patients also face challenges in accessing care, including delayed appointments and unaffordable prescription medications.
A 10-year follow-up study of over 7,400 children found no significant association between topical pimecrolimus use and increased cancer risk. The study provides reassurance for the use of pimecrolimus in treating eczema in children.
Adults with eczema are more likely to experience health problems such as diabetes, high blood pressure, and insomnia due to the emotional toll of the disease. Physicians need to address these lifestyle risks alongside skin treatments.
A study published in JAMA Dermatology analyzed data from nine population-based studies and found no overall association between eczema and short stature. However, a small group of children with severe eczema who experienced sleep disturbances showed potentially reversible growth impairment.
A new study found a strong link between environmental exposure to peanut protein during infancy and an allergic response to peanuts in children who have eczema early in life. Exposure to peanut in dust doubled the risk of peanut allergy, particularly in children with a history of eczema.
Adults with eczema are more likely to experience accidental bone fractures and other injuries, according to a new Northwestern University study. The increased risk may be linked to the side effects of steroids and sedating antihistamines commonly prescribed for eczema.
A nationwide study reveals that adults with eczema are more likely to suffer from fractures and bone or joint injuries. The prevalence of such limitations was found to be twice as high in adults with eczema compared to those without the condition, suggesting a previously unrecognized risk factor for injury.
A one-year randomized controlled trial found that patients with atopic dermatitis who accessed online dermatologic follow-up care achieved equivalent clinical improvement as those receiving traditional in-person care. The study included 156 patients and showed significant improvements in disease severity, including a reduction in POEM ...
Daily vitamin D treatment improves symptoms of atopic dermatitis, a type of eczema, in Mongolian schoolchildren. The study found a significant reduction in symptoms, with an average improvement of 29% compared to the placebo group. Vitamin D deficiency is common among children during winter months.
Researchers at Helmholtz Munich have created a diagnostic procedure that uses only two genes to reliably differentiate between psoriasis and eczema. The new test is expected to pave the way for personalized medicine in chronic inflammatory skin diseases, reducing the need for expensive treatments.
A new medication called dupilumab has shown promising results in treating atopic dermatitis, a chronic and debilitating skin disease. Dupilumab blocks the action of two proteins involved in inflammation, leading to a marked improvement in disease activity and itch.
A new study shows wet wrap therapy can reduce eczema symptoms by 71% and eliminate the need for medications in children. The technique involves soaking, applying lotions, and dressing in wet clothing to seal in moisture, resulting in significant improvements in skin health.
Researchers found that eczema caused by skin defects could help prevent tumour formation by shedding potentially cancerous cells from the skin. The study, published in eLife, suggests that defects in the epidermal barrier protected genetically engineered mice against benign tumour formation.
A study of over 7,000 children found that most had eczema symptoms persisting into their 20s, suggesting the condition is likely to be a lifelong illness. The study suggests physicians should inform children with mild to moderate AD that it is a lifelong illness.
A La Jolla Institute researcher has discovered that mast cells and a cellular protein called STAT5 play a crucial role in causing eczema by triggering increases in mast cells. The study opens new therapeutic avenues to prevent or treat eczema, including blocking STAT5 in mast cells.
Researchers developed a new mouse model of atopic dermatitis, revealing mast cells and Stat5 play critical roles in the disease. The study identified potential targets for eczema treatment based on links to human disease.
Researchers at the Icahn School of Medicine at Mount Sinai will investigate a new intravenous medication that blocks IL-22, a protein triggering chronic inflammation and epidermal growth abnormalities in eczema. The study aims to develop safer treatments for patients with moderate to severe AD.
Researchers have identified two genetic variations associated with persistent atopic dermatitis in African-American children, shedding light on the skin disorder's mechanisms. The study found that loss-of-function mutations to Filaggrin-2 were linked to increased risk of AD in African American children.
Researchers have discovered a toxin produced by Staphylococcus aureus that causes immune-system cells in the skin to react and produce eczema-like rashes. The finding suggests a specific mechanism behind the link between staph bacteria and eczema, which could lead to new treatments.
Researchers have identified a potential new therapy for eczema by blocking sensory nerves' itch receptors, which may prevent severe consequences like asthma and allergies. The treatment targets the immune system's role in reacting to chemicals that cause itching and inflammation.
A recent study suggests that eczema can trigger food sensitivity in babies, potentially leading to the development of food allergies. Infants with impaired skin barriers and eczema are over six times more likely to be sensitized to common allergenic foods like egg, cow's milk, and peanut.
Researchers discovered that herpes simplex virus type-1 (HSV-1) binds to a receptor called MARCO, which enhances its ability to infect cells and cause disease. This interaction may lead to serious health complications in people with compromised immune systems, such as atopic dermatitis.
A novel gene associated with canine atopic dermatitis has been identified by researchers. The gene encodes a protein called plakophilin 2, which is crucial for the formation and proper functioning of the skin structure. This finding opens new possibilities in understanding the disease mechanism leading to atopic dermatitis.
Researchers found that only 19% of dermatologists accept Medicaid-insured children, and those who do often require additional paperwork and identification. Eczema affects 20% of US children and can have severe physical and emotional consequences if left untreated.
A study suggests that foreign-born US children have significantly lower odds of developing allergic diseases such as asthma, eczema, and food allergies. However, prolonged residence in the US increases their risk of developing these disorders, particularly after 10 years.
Researchers at Penn have identified innate lymphoid cells as a possible therapeutic target for treating atopic dermatitis, also known as eczema. The study found that these cells contribute to disease progression and may be regulated by different pathways in the skin.
Researchers found that stress accelerates prostate cancer development in mice, while a genetic mutation in the NESP4 gene disrupts a cellular complex essential for hearing. Combining green tea extract with vardenafil enhances anti-cancer effects in a mouse model of multiple myeloma.
A new study published in BMC Microbiology reveals that children with eczema have a more diverse set of bacteria in their guts than healthy children. The types of bacteria present were also more typical of adult gut microbes, suggesting an early change towards adult-type bacteria may be a risk factor for eczema.
Eczema is a persistent skin rash that can be triggered by inadequate Ctip2 protein, leading to inflammation and immune dysfunction. Researchers have identified two ways in which improper Ctip2 function contributes to eczema, paving the way for personalized treatments and new therapies.
New study finds that blocking leukotriene B4 production reduces allergic skin inflammation in mice with eczema. Neutrophil recruitment to the skin is essential for the disease's development.