Articles tagged with Atopic Dermatitis
A study from North Carolina State University found that the protein periostin can directly activate itch-associated neurons in the skin, leading to increased itching in atopic dermatitis. Blocking periostin receptors reduced itch response in a mouse model of eczema.
A drug strategy aimed at boosting natural killer cells appears to effectively treat eczema in mice, reducing inflammation and improving skin rash. Researchers hope this approach could help patients with asthma and food allergies as well.
Researchers identify precise receptor chain involved in atopic dermatitis, a condition marked by chronic inflammation and itchy patches of skin. A novel antibody targeting this receptor may serve as a potential therapeutic treatment for the disease.
A new study by the University of Nottingham found that daily moisturizer use cannot prevent childhood eczema in newborn babies. The research suggested a small increase in skin infection risk and early indications of potential food allergy connections.
A study of three million UK adults found that atopic eczema increases the risk of fractures by up to 13%, with those with severe eczema having a significantly higher risk. Targeted screening and fracture-prevention strategies are recommended for these individuals.
Oral food challenges (OFCs) are the most effective way to diagnose a food allergy, say two new studies. A child with atopic dermatitis and suspected peanut allergy passed an OFC despite prior skin testing results, while another boy who had removed peanuts from his diet after eczema flares developed anaphylaxis to peanut
A small proof-of-concept trial has shown promising results for a new therapy targeting the immune system to treat atopic dermatitis. The treatment, called etokimab, led to significant improvements in physical symptoms and a reduction in eosinophils in patients with severe eczema.
Researchers used non-invasive tape strips to assess molecular signs of immune dysfunction and skin changes in young children with eczema. These biomarkers can predict response to medicine and development of associated conditions, paving the way for routine use in clinical trials.
A systematic review of over 2.1 million allergy sufferers found that each kilogram increase in birth weight is associated with a 44% increase in the risk of food allergies and a 17% increase in the risk of eczema. However, increased birth weight has no influence on the risk of childhood hay fever.
Family members and caregivers of young children with atopic dermatitis experience mild to moderate severity anxiety and depression, affecting up to 74%. The study found no association between disease severity and anxiety/depression scores, highlighting the need for holistic management of the condition.
A phase IIa trial and a subsequent extension trial show dupilumab's long-term safety and efficacy in treating moderate-to-severe atopic dermatitis in adolescents. The medication works by blocking specific substances that cause eczema symptoms, providing substantial clinical benefit with an acceptable safety profile.
A new study uses tape strips to analyze skin lesions and non-lesional skin in infants and young children with early-onset eczema, identifying biomarkers for immune and barrier abnormalities. The technique provides a non-invasive alternative to skin biopsies, which are often difficult to perform in children.
Research found that introducing fish or cod liver oil early in life significantly reduces the occurrence of eczema, wheezing and asthma at age six. Children who consumed fish weekly until two years old showed a 28-40% lower risk.
Researchers have identified a key mechanism underlying atopic dermatitis, a chronic inflammatory skin disease affecting 20% of children and 5% of adults. The study reveals that mast cells and sensory neurons interact in 'sensory neuroimmune units' to detect allergens, triggering inflammation.
A new index developed from the skin microbiome of children can identify eczema and predict treatment response. The Microbial Index of Skin Health (MiSH) achieved high accuracy in identifying skin conditions across different cities, paving the way for precise skin care.
A new study has identified 141 genetic regions associated with the risk of developing asthma, hay fever and eczema. The research also found that many patients diagnosed with one disease develop the others at some stage in life.
Infants with eczema are at risk of developing food allergies, hay fever, and asthma as they grow older. Moisturizers can help prevent these conditions by protecting the skin barrier.
A study led by NTU Singapore found that 34% of eczema management apps provide information not in line with international guidelines. The research highlights the need for mechanisms to ensure app quality, guiding personalized app selection for patients, caregivers, and doctors.
Children with severe eczema infected with Staphylococcus aureus are at a higher risk of developing peanut, egg, and milk allergies. The bacteria may reduce the chance of young infants gaining tolerance to peanut despite early consumption.
Researchers found Hispanic children are most likely to have missed at least six days of school over a six-month period due to their condition. Black children also saw higher probabilities of missed school days compared to white children.
Research suggests that scratching the skin can lead to allergic reactions to foods, including anaphylaxis, in children with eczema. The study found that mechanical skin injury expands and activates intestinal mast cells, promoting anaphylactic reactions.
Researchers found that scratching the skin triggers a series of immune responses culminating in increased activated mast cells in the small intestine. This skin-gut communication helps illuminate the relationship between food allergy and atopic dermatitis.
A study analyzing data from over 11,600 mother-child pairs found that having a child with eczema was associated with difficulty falling asleep, insufficient sleep, and increased daytime exhaustion for mothers. The severity of a child's eczema was linked to worse sleep outcomes for mothers.
Researchers found that a small yeast species called Malassezia strengthens the body's defenses against pathogens, but its balance with the immune system is key to preventing atopic dermatitis. A new potential treatment targets this balance by neutralizing interleukin-17 cytokine production.
A study found substantially higher anxiety and depression rates among US adults with atopic dermatitis compared to those without. Virtually all patients with moderate to severe atopic dermatitis had symptoms of anxiety and depression.
Children who were exclusively breastfed for three months or longer had significantly lower odds of having eczema at age 6. This study found that exclusive breastfeeding may protect children from experiencing extended flare-ups of eczema.
Researchers found elevated salt concentrations in the skin of patients with atopic dermatitis, which can lead to Th2 cell activation and increased production of IL-4 and IL-13. The study suggests a link between salt intake and the occurrence of atopic dermatitis.
Researchers found structural and molecular differences in skin near eczema lesions of children with both conditions, suggesting an elevated risk for developing food allergies. These differences may help identify children at elevated risk and inform early intervention strategies.
Food allergies are associated with unique skin properties and abnormalities in pediatric patients with atopic dermatitis. The study found decreased filaggrin, elevated type 2 immune responses, and increased keratin expression in skin samples from patients with food allergy and dermatitis.
Researchers found that teenagers with asthma or eczema had the same levels of physical activity as their peers without these conditions. However, obese teenagers were less active and experienced increased periods of inactivity. The study used data from over 6,400 teenagers aged 12-16.
A study published in the British Journal of Dermatology found that an investigational nonsteroidal topical cream, PAC-14028, improved clinical symptoms and signs in adults with mild to moderate atopic dermatitis. The cream blocks a specific ion channel involved in pain perception and inflammation.
Scientists at EMBL Rome have discovered a way to treat itchy skin conditions like eczema by using near-infrared light to bind to specialized nerve cells. This method has shown promising results in mice with eczema and amyloidosis, offering new hope for potential human treatments.
A recent study published in JAMA Dermatology found a significant association between eczema and suicidal thoughts or attempts. The research, analyzing data from over 310,000 patients with eczema and 4.4 million without, suggests individuals with eczema are more likely to experience suicidal thoughts and attempts compared to those without.
A modelling study suggests that statins may be significantly overprescribed for people with a 10-year cardiovascular disease risk between 7.5% and 10%. The study found that the benefits of statin therapy did not outweigh the harms until the 10-year CVD risk threshold was above 21% for men aged 70-75, highlighting the need to reassess g...
A review from the Center for the Study of Itch identifies key factors contributing to the itch-scratch cycle, including immune responses and behavior. The study suggests that targeting specific molecules, such as cytokines, may be effective in treating chronic itching conditions.
A medically challenging case presented at the American College of Allergy, Asthma and Immunology Annual Scientific Meeting found that allergy shots provided significant benefits to a patient with severe eczema. The treatment successfully reduced the need for high-dose steroid therapy and improved symptoms such as itching and dry skin.
A study of 1,278 adults found that atopic dermatitis affects 7.3% of the population, with 6.6 million cases being moderate-to-severe. The condition can significantly impact quality of life and may change over time, highlighting the need for innovative therapies.
Researchers at Massachusetts General Hospital report significant hair regrowth in a 13-year-old patient with total alopecia and eczema after treatment with dupilumab. The drug's mechanism of targeting an immune system pathway overactive in eczema may also induce hair growth in other alopecia patients.
Researchers found that bee venom and melittin suppress inflammation in atopic dermatitis by regulating T helper cell differentiation. The study suggests bee venom may be an effective treatment for eczema, potentially alleviating inflammatory skin diseases.
A new study found that eczema is associated with a worse quality of life than several other chronic illnesses. Moderate and severe eczema were particularly burdensome, causing symptoms like blisters, pain, and sleep disturbance.
A review of 16 studies reveals a strong association between fast food intake and an increased risk of asthma, wheeze, and other allergic diseases. Hamburger consumption was found to be most prominently associated with these conditions in a dose-dependent manner, regardless of income level.
Researchers found that prurigo nodularis disproportionately affects African-Americans, particularly between ages 50 and 65. The study also identified associations with HIV infection, diabetes, chronic kidney disease, and clinical depression.
Patients with severe eczema have a 20% increased risk of stroke and a 70% increased risk of heart failure compared to those without eczema. The absolute risk is low, but targeted screening and primary prevention strategies could be needed for these patients.
Adults with severe eczema are at a higher risk of cardiovascular problems, including heart attacks and strokes. The study found that patients with severe eczema had a 20-70% increased risk of major cardiovascular events compared to those without eczema.
A long-term study has found that exposure to ozone at birth is associated with an increased risk of developing asthma, allergic rhinitis, and eczema in childhood. The study, which followed 1,881 children from birth to age 17, found that even small increases in ozone exposure were linked to a higher risk of developing these conditions.
Researchers found that topical treatment with live Roseomonas mucosa was safe and associated with reduced disease severity in adults and children with eczema. The study's findings support further evaluation of this potential new therapy for atopic dermatitis, a condition linked to increased risks of asthma, hay fever, and food allergy.
A trial found that emollient bath additives provide no meaningful benefit when used in addition to standard eczema care in children. The study included 482 children and found no statistically significant difference in eczema control between the two groups. This may help guide decisions around effective prescribing in this area.
A new study reveals that seasonal skin changes are caused by climatic and humidity fluctuations, which affect the skin's barrier function. The research suggests that individuals should protect their skin with emollients in winter and sunscreen in summer to manage skin disorders such as eczema.
Researchers discovered that retinoid-related orphan receptor alpha (RORα) in skin Tregs regulates immune response. Removing RORα from Tregs led to an increase in inflammatory cells and worsened eczema symptoms. The study suggests boosting RORα or targeting related pathways may be effective treatments.
Research from Imperial College London found that taking daily fish oil capsules during pregnancy reduced the risk of egg allergy in children by 30%, while daily probiotic supplements reduced the risk of eczema by 22%. No significant impact on allergy or eczema risk was found from avoiding potentially allergenic foods.
Eczema patients' skin shows shorter lipids that protect less effectively, allowing irritants to enter and setting the stage for lesions. An allergic immune response shortens lipids, making skin more susceptible to eczematous lesions.
Researchers have discovered a potential new therapy for eczema that also reduces asthma severity, offering hope for effective treatments for both conditions. The study found that alleviating skin inflammation can significantly reduce asthma symptoms.
LJI researchers reveal LIGHT, a tumor necrosis factor super family member, drives skin inflammation in atopic dermatitis. The discovery provides a novel therapeutic target for the treatment of severe eczema. Therapies blocking LIGHT signaling may halt disease symptoms and reverse symptoms.
The study identified five subgroups of eczema in children, with one-third resolving by age five and others persisting into adulthood. Genetic risk factors contribute to long-lasting eczema, highlighting the need for tailored treatments and clinical trial approaches.
A large-scale study has identified 136 genetic loci that increase the risk of developing atopic dermatitis, hay fever, and asthma. These variants are associated with genes involved in regulating the immune system, suggesting a shared genetic origin for the three diseases.
A new Northwestern Medicine study found that water baths were just as effective as bleach baths in reducing eczema symptoms, with no added benefits to using bleach. Regular bathing can help control bacterial infections and prevent dryness, making it a better alternative for patients with eczema.
A new study found that breastfed babies have a 54% lower risk of eczema at age 16. The study examined over 13,000 Belarussian teenagers and found that exclusive breastfeeding for four to six months significantly reduced the risk of eczema.
A breastfeeding program was associated with reduced atopic eczema risk in adolescents, but no protective effect on lung function or asthma. The study involved over 13,500 children born to mothers participating in a breastfeeding promotion trial.
The study identifies a protein called IL-36 as a key player in inducing skin inflammation in response to bacteria on the skin surface. This finding has significant implications for developing alternative treatments for atopic dermatitis, a condition affecting 20% of children and 5% of adults.
A study found that children with eczema and a family history of asthma had more severe hospital experiences, including increased oxygen use and longer stays. The research suggests these factors may help identify children at higher risk for severe asthma hospitalizations.