'Dry eye' linked to chronic pain syndromes
Research links dry eye to multiple chronic pain conditions, including neuropathic ocular pain. A multidisciplinary approach may benefit dry eye patients with underlying pain issues.
Chronic Pain
Articles tagged with Chronic Pain
Most patients still prescribed opioids after nonfatal overdose, study finds
A study by Boston Medical Center found that nearly 3,000 individuals with chronic pain who experienced a nonfatal opioid overdose continued to be prescribed opioids, with 70% receiving prescriptions from the same provider. Patients who took high dosages were twice as likely to have another overdose at two years of follow-up.
Almost all patients continue to get opioid prescriptions after overdose
After a nonfatal overdose, nearly 3,000 patients continued to be prescribed opioids, with 70% receiving prescriptions from the same provider who wrote them before. Patients taking high dosages were twice as likely to experience another overdose after discontinuing opioid use.
Ending chronic pain with new drug therapy
Scientists have developed a new treatment strategy that restores a brain region controlling emotions and reduces chronic pain behavior in animal models. The combined drugs target brain circuits and eliminate chronic pain when administered together shortly after an injury.
Not ordinary growing pains
A recent study at Rush University Medical Center found acupuncture to be a safe and effective adjunctive integrative medicine treatment for chronic pain in pediatric patients. The study included 55 children aged 7-20 who experienced chronic pain conditions, with significant reductions in pain levels and related health issues.
SourceRush University Medical Center·JournalAlternative and Complementary Therapies·DateDec 15, 2015
How bad does it hurt? New research helps children suffering from chronic pain conditions
A new study has developed pediatric pain measures to help doctors better evaluate and treat children with chronic pain conditions. The study, conducted by researchers at the University of Cincinnati, found that traditional pain measures used for adults were uncomfortable for younger children and had limited vocabulary.
Fighting prescription painkiller abuse among baby boomers
Researchers at University at Buffalo find that motivational interviewing significantly reduces the risk of opioid misuse and abuse among older adults with chronic pain. The intervention increases motivation, self-efficacy, and confidence in changing behavior, while also decreasing depression and anxiety.
CWRU researchers laying groundwork for new type of pain relief
Researchers at Case Western Reserve University are developing a new type of pain relief using high-frequency electrical stimulation. The study aims to understand why this method is more effective than traditional stimulation, with potential applications in the fight against opioid addiction.
People can raise their pain threshold by altering brain chemistry, arthritis study shows
Scientists at the University of Manchester have shown that the number of opiate receptors in the brain increases to combat severe pain in arthritis sufferers. By applying heat, they found a correlation between higher receptor numbers and increased ability to withstand pain.
Pain is in the brain
Researchers have identified a key mechanism linking chronic pain to abnormal activity in the anterior cingular cortex, a region of the brain involved in cognitive functions. The study provides insights into the role of HCN channels in controlling pain signals, suggesting new therapeutic strategies for relieving chronic pain.
Living in fear: Mental disorders as risk factors for chronic pain in teenagers
A study of over 6,500 teenagers found that those with mental disorders are more likely to experience chronic pain. The researchers identified connections between various types of mental disorders and chronic pain, suggesting that mental health issues may be an underlying risk factor for chronic pain in young people.
Canadian multicenter study examines safety of medical cannabis in the treatment of chronic pain
A Canadian research team found that daily cannabis users did not experience serious adverse events, while showing improvement in pain and quality of life. However, non-serious adverse events like headaches and respiratory problems were reported.
Ringing in the ears and chronic pain enter by the same gate
Researchers at TUM and Georgetown University have discovered a common gatekeeping system for tinnitus and chronic pain, which may play a central role in the development of both conditions. The study found significant loss of gray matter and compromised circuit function in regions important for emotional experiences.
Neuroscientists uncover brain abnormalities responsible for tinnitus and chronic pain
Researchers have discovered that brain malfunctions in key areas, such as the nucleus accumbens and ventromedial prefrontal cortex, contribute to the development of tinnitus and chronic pain. These findings hold promise for developing targeted therapies for these debilitating disorders.
Education positively impacts safe opioid prescribing among clinicians
A Boston University School of Medicine program educates clinicians on safe opioid prescribing, resulting in improved knowledge, attitudes, and clinical practice. The program has empowered clinicians to make informed decisions about opioids for chronic pain sufferers.
New therapy delivers long-term relief for chronic back, leg pain, study finds
A new therapy called HF10 has been shown to provide significantly greater long-term relief for chronic back and leg pain compared to traditional SCS therapy. The study found that patients receiving HF10 therapy experienced a higher percentage of pain reduction and reported higher levels of satisfaction.
Most chronic pain patients use alternative therapies, but many don't tell their doctors
A study of over 6,000 Kaiser Permanente members found that 58% used chiropractic care or acupuncture for chronic pain, yet many didn't discuss it with their primary care providers. The majority of patients would share this information if asked, highlighting the need for better care coordination.
Stem cells provide lasting pain relief in mice
Researchers at Duke University have discovered that stem cells from bone marrow can alleviate neuropathic pain in mice by increasing levels of the anti-inflammatory protein TGF-β1. The treatment remained effective for several weeks, outlasting traditional painkillers and offering new hope for chronic pain conditions.
WSU researchers find online program helps people with chronic pain
A study by WSU researchers found that an online program can help people with chronic non-cancer pain manage their symptoms and reduce opioid use. Participants who used the program reported increased confidence and positive thinking, and made progress towards reducing or eliminating pain.
Potent approach shows promise for chronic pain
A new treatment approach uses a non-narcotic inhibitor to reduce excessive BH4 production, leading to pain relief without addiction or tolerance. The research, led by Boston Children's Hospital, shows promise for treating conditions like diabetic peripheral neuropathy and rheumatoid arthritis.
UC study links brain inflammation triggered by chronic pain to anxiety and depression
Researchers discovered that chronic pain causes brain inflammation, altering mood and motivation regions. A new treatment approach may help restore dopamine release and reward-motivated behavior in patients with chronic pain.
A better understanding of links between pain and anxiety reveals treatment opportunities
Dr. Min Zhuo's team identified a molecule that can reduce chronic pain-related anxiety by blocking pre-LTP in neurons of the ACC, which mediates anxiety. The study reveals the biological basis for the link between pain and anxiety, with implications for treating both conditions.
New findings about mechanisms underlying chronic pain reveal novel therapeutic strategies
Researchers have identified a key role for microglia in the development of chronic pain, including hyperalgesia and allodynia. Microglia-to-neuron signaling is crucial for these effects, which could lead to new treatments for chronic pain.
Brain chemical may offer new clues in treating chronic pain
A new study suggests that dopamine contributes to chronic pain states by targeting A11 neurons. Removing these neurons can selectively diminish chronic pain in mice. The findings offer potential clues for developing new treatments for chronic pain.
Impaired sleep linked to lower pain tolerance
A large Norwegian health study of over 10,400 adults found that people with insomnia have increased pain sensitivity. The effect was strongest in those with both insomnia and chronic pain, highlighting the need for treatments targeting both conditions.
Montréal discovery could impact the study of chronic pain conditions
A breakthrough study published in The Journal of Neuroscience reveals the critical role of a gene associated with a rare disease in pain processing. Lmx1b mutations cause reduced pain responses in patients, but removing this gene only in the spinal cord allows mice to survive, yet results in reduced sensitivity to stimuli.
SLU researchers show that A3 adenosine receptor can activate 'off signals' for pain
Researchers at Saint Louis University discovered that targeting the A3 adenosine receptor can 'turn off' pain signals in the spinal cord, providing potential relief for patients with chronic pain. The study found that activating this receptor promotes GABA signaling, which is often lost or diminished in chronic pain conditions.
Predicting chronic pain in whiplash injuries
Researchers at Northwestern University have identified a key indicator of chronic pain in whiplash injuries: large amounts of fat in the neck muscles. This discovery enables early treatment and may help prevent post-traumatic stress disorder (PTSD).
Brain processes ongoing pain more emotionally
Scientists at TUM discovered that brain activity changes when transitioning from sensory to emotional processing during prolonged pain. The experiment showed that nerve cells in the brain trigger a different pattern of activity after applying a placebo cream, reducing perceived pain.
Two-step treatment improved function and decreased pain severity in veterans
A new study by researchers from the Richard L. Roudebush VA Medical Center, the Regenstrief Institute, and Indiana University School of Medicine reports that a stepped-care strategy improved function and decreased pain severity in veterans with chronic musculoskeletal pain, producing at least a 30 percent improvement in pain-related di...
Analysis of spider venom reveals 7 promising compounds with potential to relieve chronic pain
Research identified seven compounds that block key pain signals to the brain, offering hope for new painkillers. The compounds show high levels of stability and potency, making them promising candidates for treating chronic pain.
Most patients with chronic kidney disease may experience long-term pain
Chronic pain in patients with chronic kidney disease is common and associated with improper use of pain medications. An estimated 26 million people in the US have CKD, making it a significant concern for patient safety.
SourceAmerican Society of Nephrology·JournalClinical Journal of the American Society of Nephrology·DateFeb 19, 2015
Painkillers for non-cancer chronic pain: New insights on risk
Two studies found that morphine equivalent doses of opioids over 100mg/day increase drug overdose risk, while antidepressant use can mitigate this risk. A third study revealed a 'catch-22' where patients without depression are more likely to overdose when taking opioids with sedatives.
SourceUniversity of Texas Health Science Center at San Antonio·JournalJournal of General Internal Medicine·DateFeb 18, 2015
100 million Americans live with chronic pain, but treatment research is insufficient
A new report by an independent panel found that evidence-based approaches to treating chronic pain are lacking, with no existing algorithm for determining the best treatment approach. The panel recommends multidisciplinary care incorporating patients' perspectives and emphasizes the need for more research on opioids and other treatments.
Panel cites need for individualized, patient-centered approach for chronic pain
The NIH panel recommends a more tailored approach to treating the estimated 100 million Americans with chronic pain. A combination of evidence-based and multidisciplinary approaches is needed to balance patient perspectives, desired outcomes, and safety.
Imaging study finds first evidence of neuroinflammation in brains of chronic pain patients
A new study from Massachusetts General Hospital has found evidence of neuroinflammation in key brain regions of chronic pain patients. The study, published in the journal Brain, identifies a possible way to measure pain and may lead to new treatment strategies.
Annals of Internal Medicine tip sheet for Jan. 13, 2015
A recent NIH report warns of dose-dependent risks of long-term opioid therapy, while an ACP policy paper tackles clinical documentation in electronic health records. These guidelines aim to improve care and documentation practices among healthcare professionals.
Utah study: Mindfulness intervention boosts brain activation for healthy pleasures
A new study published in the Journal of Behavioral Medicine found that Mindfulness-Oriented Recovery Enhancement (MORE) increases brain activation to natural healthy pleasures, reducing opioid cravings. Participants who received eight weeks of MORE instruction exhibited increased brain activity in response to enjoyable experiences.
Legally prescribed opioid use may increase mortality in chronic pain patients
A new study published in PAIN found that chronic pain patients without opioid treatment have an increased risk of death compared to those with pain but without opioid use. Long-term opioid users had a higher risk of death due to causes other than cardiovascular and cancer mortality, as well as a four times higher risk of toxicity poiso...
Smoking is a pain in the back
A Northwestern University study found that smokers are three times more likely to develop chronic back pain and that quitting the habit may reduce vulnerability to this condition. The research also identified a key brain region involved in addictive behavior and motivated learning.
A demography of unceasing discomfort
According to a WSU study, nearly one in five US adults suffer from persistent pain, with significant economic and social costs. Persistent pain affects daily life, work, family, and social interactions, increasing the risk of mental illness and addiction.
Pain words stand out more for those experiencing it: York U study
A study published in the Journal of Pain Research found that individuals with chronic pain pay more frequent and longer attention to pain-related words than those without. This discovery uses state-of-the-art eye-tracking technology to better understand how people attend to pain stimuli.
NIH and VA address pain and related conditions in US military personnel and veterans
The NIH/NCCAM initiative aims to enhance options for managing pain and associated problems in US military personnel, veterans, and their families. The research will focus on nondrug approaches to address chronic pain, PTSD, drug abuse, and sleep issues.
Pain tolerance levels between men and women are similar
Researchers found that men and women have similar pain tolerance levels, with resilience being the main determining factor. Patients who accept their chronic pain experience less anxiety, depression, and improved quality of life.
Researchers unlock new mechanism in pain management
A team of researchers at the University of Calgary has discovered a new mechanism that can reverse chronic pain conditions. They found that interfering with the communication between a specific enzyme and calcium channels in nerve cells can shut off pain signals.
State medical marijuana laws linked to lower prescription overdose deaths
New research suggests states with medical marijuana laws have 25% lower prescription opioid overdose death rates compared to those without. This could be due to people choosing alternative treatments for chronic pain, or the law changing how prescription medications are abused.
SourceJohns Hopkins Bloomberg School of Public Health·JournalJAMA Internal Medicine·DateAug 25, 2014
Controlling childbirth pain tied to lower depression risk
A new study found that controlling pain during childbirth and post delivery may reduce the risk of postpartum depression. Women who had epidural anesthesia during labor had a significantly lower rate of depression compared to those without pain control.
JAMA study: Telecare program optimizing non-opioid chronic pain medication very effective
A new study published in JAMA found that patients enrolled in a 12-month telecare program experienced significant improvement in chronic pain management, with twice the likelihood of pain reduction compared to usual care. The program also showed increased patient satisfaction.
Causes of serious pain syndrome closer to discovery
Researchers have made a breakthrough in understanding CRPS by replicating its symptoms in mice using antibodies from patients with the condition. The study suggests that autoantibodies may be the underlying cause of CRPS, offering hope for potential treatments.
Research letter examines reports of chronic pain, opioid use by US soldiers
A study found that nearly half of deployed soldiers reported combat injuries, with 44% experiencing chronic pain and 15.1% using opioids in the past month. The researchers emphasized the urgent need to address chronic pain and opioid misuse among military personnel.
Pain pilot explores hand shiatsu treatment as sleep aid
A pilot study found that self-administered hand shiatsu pressure techniques can help participants with chronic lower-back pain fall asleep faster and stay asleep longer. The study's findings suggest that this low-cost alternative may be a valuable tool in addressing the sleep deprivation that often exacerbates chronic pain.
Our ability to identify the source of pain varies across the body
Researchers create systematic map of pain acuity distribution across body, revealing surprising similarities with touch sensitivity. The study uses lasers to cause pain in healthy volunteers and a rare patient lacking touch sensation, demonstrating that pain acuity does not rely on touch.
NIH Pain Consortium's first pain care curriculum improves clinical skills
A new online training module improved medical student clinical skills in evaluating chronic pain, with 93% of exposed students passing an exam compared to 60% of non-exposed students. The module is the first curriculum resource created through the NIH Pain Consortium's Centers of Excellence in Pain Education program.
SourceNIH/National Institute on Drug Abuse·JournalJournal of the American Geriatrics Society·DateMay 21, 2014
Key genetic link between chronic pain conditions like IBS discovered
A study published in Pain journal found a genetic link between four common chronic pain syndromes, including IBS, musculoskeletal pain, pelvic pain, and dry eye disease. The research team analyzed over 8,000 twin pairs and concluded that each of the conditions is heritable, with a common genetic pathway estimated to be 66% heritable.
Low tolerance for pain? The reason may be in your genes
A study found that certain genes, such as DRD1 and COMT, are associated with low, moderate, or high pain perception. The discovery may lead to new therapies and better understanding of chronic pain.
Quality of life for couples can be improved despite PVD (vulvar vestibulitis)
Women with PVD (vulvar vestibulitis) who regulate their emotions in a satisfactory manner are more fulfilled sexually and relationally. Effective emotional communication can improve pain management and overall quality of life for couples.
Sleep may stop chronic pain sufferers from becoming 'zombies'
A study by the University of Warwick found that sleep quality is a key driver of daytime physical activity in chronic pain patients. Engaging in physical activity can be a crucial treatment process for managing chronic pain. By improving sleep quality, sufferers may overcome their motivation to stay inactive due to pain.
Chronic pain research explores the brain
Chronic pain researchers found that individuals with chronic tension-type headache exhibited impaired neuroplasticity, affecting their brain's ability to change and adapt. This discovery could lead to more targeted treatments for patients.
Managing chronic bone and joint pain
Chronic musculoskeletal pain affects an estimated 100 million Americans, with low back pain and degenerative joint processes being common causes. Non-steroidal anti-inflammatory drugs (NSAIDs) are not effective in many chronic pain scenarios, but antidepressants and anticonvulsants can provide remarkable relief.
SourceAmerican Academy of Orthopaedic Surgeons·JournalJournal of the American Academy of Orthopaedic Surgeons·DateFeb 19, 2014
Chronic pain relief more likely when psychological science involved
A comprehensive review by the American Psychological Association highlights psychologists' expertise in addressing chronic pain. Successful treatment approaches include cognitive behavioral therapy, acceptance and commitment therapy, mindfulness, and hypnosis, which offer more relief than prescription drugs or surgery.