Articles tagged with Chronic Pain
Researchers at University of Utah developed Mindfulness-Oriented Recovery Enhancement, reducing opioid misuse and pain-related impairment in chronic pain patients. The new treatment combines mindfulness training, reappraisal, and savoring to address underlying processes involved in chronic pain and opioid misuse.
Chronic pain affects an estimated 20-25% of the population worldwide and is caused by various factors such as nerve injuries and osteoarthritis. Researchers found that serotonin release from the brain stem into the spinal cord activates TRPV1, making it hyperactive in injured V2 and uninjured V3 branches.
Researchers from the University of California, Irvine, have identified a new natural compound in a traditional Chinese medicine plant that relieves chronic pain. The compound, dehydrocorybulbine (DHCB), acts on dopamine receptors and shows promise for treating low-level chronic pain without losing effectiveness over time.
A voxel-based morphometry study reveals regional gray matter volume abnormalities in chronic back pain patients compared to upper back pain patients. Gray matter atrophy affects perception and modulation of chronic pain, with subcortical increases found only in low back pain patients.
Researchers used brain imaging to track pregabalin's effects on fibromyalgia patients, finding reduced glutamate levels and decreased insula connectivity. This study suggests a future of targeted brain imaging approaches for chronic widespread pain treatment.
Research by Tel Aviv University researchers shows that torture survivors experience diminished pain inhibition and heightened pain excitation, leading to dysfunctional pain regulation. Non-physical forms of torture, such as psychological oppression and humiliation, may also contribute to chronic pain and poor pain regulation.
A new study suggests that early life stress can lead to increased sensitivity to pain in adulthood, particularly if followed by later stress exposure. The study found that rats subjected to early-life maternal neglect showed enhanced muscle pain in response to mild stress as adults.
Researchers develop a new molecule combining elements of Botox and tetanus toxin to alleviate inflammatory pain, offering potential relief for chronic pain conditions and epilepsy. The engineered molecule could improve quality of life for those suffering from chronic pain with a single injection providing prolonged pain relief.
Researchers analyzed conversations between chronic pain patients and their physicians about opioid treatment, revealing three patterns of physician responses: reassurance, avoidance, and gathering information. The study emphasizes the crucial role of a strong therapeutic alliance in discussing risks and benefits of opioid treatment.
BMC has been approved to receive two research awards from PCORI, focusing on socio-legal barriers in cancer care and effective treatments for chronic pain. The hospital's commitment to innovative health care delivery is highlighted through these studies.
A new Pain and Interoception Imaging Network (PAIN) will feature hundreds of brain scans and clinical information to tease out similarities and differences between chronic-pain conditions. The database aims to improve research and treatment development for conditions like migraine, irritable bowel syndrome, and rheumatoid arthritis.
Researchers at Tel Aviv University found that triathletes experience lower pain intensity and have a higher pain tolerance due to a combination of physiological and psychological factors. They were able to withstand pain for longer periods and had better pain regulation, which may be attributed to their attitude towards pain.
A study found that bariatric surgery led to greater chronic opioid use in patients with chronic pain, regardless of pre-surgery depression or chronic pain diagnoses. Weight loss after surgery did not reduce opioid use for these patients.
Researchers uncover a surprisingly long-lasting opioid mechanism for chronic pain control, which also leads to physical and physiological dependence. The study suggests that stress may be a key factor in relapse in chronic pain patients and raises questions about the long-term consequences of this mechanism.
Researchers used brain scans to find an anatomical marker for chronic pain in the brain, which may lead to changes in treatment. The study found a consistent difference in white matter between subjects who recovered and those with persistent pain.
New research from Northwestern University predicts chronic back pain after lower back injuries based on abnormalities in brain structure connections. The study found that specific irregularities in the axons of the brain's white matter can trigger chronic pain with high accuracy, offering new hope for early treatment and prevention.
Research suggests that patients' chronic pain affects their spouses' emotional well-being and marital satisfaction, leading to compromised sleep quality. In close relationships, the greater a patient's pain, the less refreshing the sleep for the spouse.
Chronic pain affects an estimated 100 million US residents, costing $635 billion annually in healthcare costs and lost productivity. To address this issue, physicians must consider the psychological, social, and cultural contexts of their patients, as well as medication risks and benefits.
Researchers found significant reductions in pain severity (20%) and pain interference (30%) in patients after 24 weeks of integrative care. Integrative medicine interventions also showed improvements in mood, stress, quality of life, fatigue, sleep, and well-being.
A new study published in Pediatrics reveals that over 25% of children with cerebral palsy suffer from moderate to severe chronic pain, limiting their activity. Pediatricians should focus on identifying and treating the underlying causes of pain to improve health and quality of life for these children.
A study found that patients with COPD experience chronic pain comparable to those with osteoarthritis and rheumatoid arthritis, with higher use of opioids. The researchers also noted a significant impact on quality of life and healthcare costs.
A new study has identified a genetic risk factor for persistent pain after traumatic events, such as motor vehicle collisions and sexual assaults. The research found that variation in the gene encoding for the protein FKBP5 is associated with a higher risk of moderate to severe neck pain six weeks after a motor vehicle collision.
Scientists have developed a way to predict pain levels by analyzing brain scan patterns, with accuracy of 90-100%. This breakthrough may lead to the development of reliable methods for doctors to objectively quantify patient pain. The study also explores potential applications in measuring anxiety, depression, and other emotional states.
Researchers found chronic pain to be a common complication of ischemic strokes, associated with greater decline in physical and cognitive function. Significant risk factors for post-stroke pain include increased severity of stroke, female gender, and vascular disease.
A new Hong Kong-based study suggests that targeting feelings of mental defeat can prevent severe depression, anxiety, and daily activity interference among chronic pain patients. Mental defeat occurs when pain is viewed as an 'enemy' taking over life and autonomy.
A new syndrome, juvenile-onset small-fiber polyneuropathy (JOSeFINE), has been identified as a possible cause of widespread chronic pain in children. Diagnostic tests including skin biopsies and autonomic function testing have been found to be useful in diagnosing the condition.
A pilot study assesses the Primary Practice Physician Program for Chronic Pain (4PCP) and its impact on patients with chronic pain. The program improves symptoms, including reduced pain, fatigue, and depression, as well as boosts physician confidence and efficiency.
A University of Nebraska-Lincoln study finds that childhood socioeconomic disadvantages and maternal depression increase the risk of major depression and chronic pain in working-aged adults. Hunger experienced in childhood can lead to chronic pain and depression later in life.
Researchers found that individuals with a smaller hippocampus are more vulnerable to stress and pain, leading to increased risk of chronic pain. Stress management techniques, such as relaxation and meditation, may help alleviate symptoms and prevent chronicity.
Researchers used brain imaging technique to examine patterns of brain connectivity in adults with chronic back pain and without. They found specific brain regions became less connected, predicting worsening chronic pain, suggesting potential biomarker for chronic pain perception.
Researchers have developed a computer algorithm that accurately predicts lower back pain in patients 76% of the time using brain scans. The study suggests structural changes in gray matter are associated with chronic lower back pain and may reflect pathology within the brain.
Researchers at the University of Liverpool are leading a £1.5 million project to trial `immunoglobulin' in patients with complex regional pain syndrome (CRPS). The study aims to explore the potential benefits of this new treatment approach for people with severe chronic pain.
A cross-sectional study of over 5,370 adolescents found a significant association between parental chronic pain and chronic pain in offspring. The study suggests that family pain models and shared environmental factors play an important role in the origin of chronic pain.
Researchers discovered a specific mutation in the sodium channel Nav1.7 that predicts which chronic pain patients will respond to carbamazepine treatment. The study offers hope for more systematic and effective treatment of chronic pain, potentially benefiting millions of Americans suffering from the condition.
A study of 29 randomized controlled trials found that acupuncture was more effective than no treatment or sham acupuncture for managing some types of chronic pain. Patients who received acupuncture had lower pain scores compared to those in control groups.
Researchers at the University of Liverpool have developed novel compounds targeting the glycine receptor to treat chronic pain without sedative effects. The project aims to create a safe and effective oral tablet, addressing a huge unmet medical need for 20% of adults in Europe and the US.
A study by University of Melbourne researchers found that doctors often fail to warn patients of risks affecting quality of life, particularly chronic pain and sexual dysfunction. To avoid 'he said/she said' disputes, keeping a clear record of consent discussions is key.
A University of Michigan Health System study found that women with vulvodynia are at a higher risk for other chronic pain conditions. The study showed that millions of women suffer from unexplained vulvar pain that can severely impact daily life.
Researchers at Boston Medical Center are implementing a new model of care in primary care settings to decrease opioid misuse and addiction among patients with chronic pain. The study aims to evaluate the effectiveness of standardized practice guidelines and tools to improve provider monitoring and patient care.
Chronic pain patients with depression are more likely to misuse opioids, and primary care physicians should take a leading role in setting opioid prescribing standards. Safer alternatives like physical therapy and cognitive behavioral therapy can be effective treatments for chronic pain.
Researchers found that viewing media coverage of terrorist attacks increased pain levels and sensory component of pain in people already suffering from chronic pain. Stress and media exposure were also strongly related.
A Northwestern University study found that chronic pain develops when two brain sections communicate excessively, increasing the likelihood of chronic pain. Researchers predicted with 85% accuracy which participants would develop chronic pain based on brain scan data.
Researchers have identified a naturally occurring protein involved in generating chronic pain in rats, which could lead to new therapeutic treatments. The discovery highlights the impact of molecular signalling events on nerve transmission and offers promising avenues for pain relief.
Researchers at UCSF have successfully treated chronic neuropathic pain in mice by transplanting immature embryonic nerve cells into the spinal cord. The transplanted cells integrated into the nerve circuitry, forming synapses and signaling pathways with neighboring neurons, leading to a significant reduction in pain hypersensitivity.
A recent study by McGill University researchers has identified a key gene affecting chronic pain sensitivity, offering a potential new approach to individualized therapy. The findings suggest that targeting the pore-forming function of P2X7 receptors may provide relief for patients with genetically inherited low pain sensitivity.
A study published in Archives of Surgery found that total extraperitoneal inguinal hernioplasty (TEP) associated with lower chronic pain and improved sensation after inguinal hernia repair. However, TEP was linked to a higher incidence of operative complications.
The study found that primary care physicians need training on monitoring opioids and assessing risk factors, whereas specialists emphasize the importance of formulating treatment plans and teaching medication safety. The findings highlight the need for targeted education programs to improve public health.
A team of scientists has identified a key player in the amplification of pain signals in the spinal cord, which could lead to the development of novel treatments for chronic pain. By removing an enzyme called PKG-1 from pain-sensing nerves, researchers found that LTP was abolished and pain-related memory and behavior were also altered.
A University of Michigan Health System study found that living in a poor neighborhood worsens chronic pain for young adults. The research highlights the importance of considering structural barriers and access to resources in pain management.
Researchers developed a visual tool to help doctors assess patients' pain levels by analyzing their movement patterns, providing a more precise assessment than traditional questionnaires. The new 'barcode' tool offers a dynamic view of a patient's condition, enabling doctors to monitor progress and adapt treatment accordingly.
Researchers at McGill University have discovered that erasing neuronal memories of pain can reduce both persistent pain and heightened sensitivity to touch. By blocking the activity of a protein kinase, they were able to reverse hypersensitivity to pain in neurons.
A new therapeutic strategy using a single injection of fibronectin has shown potential to improve patient outcomes in treating chronic neuropathic pain following spinal cord injury. This approach inhibits the development of mechanical allodynia, a common type of chronic pain experienced by spinal cord injury patients.
A major public health campaign is needed to address the epidemic of unnecessary suffering caused by acute and chronic pain in the US. The need for improved education, particularly among physicians, is highlighted as a key challenge.
A systematic review of chronic pain in children and adolescents found that most types of pain are more prevalent in girls than in boys, with headache being the most common studied pain type. The prevalence rates of childhood pain have increased over the last several decades, highlighting the need for early interventions.
A recent UCSF study suggests that combining cannabinoids with opiates may lead to greater pain relief for chronic pain patients. The study found that patients who received both treatments experienced significant reductions in pain scores, with some showing a 33% decrease in morphine use.
Researchers identified increased sensitivity to pain stimuli, altered heart rate responses, and genetic variations in patients with chronic TMJD. The study also found that socio-economic status does not correlate with TMJD incidence, contrasting with other chronic pain conditions.
A new UCI study reveals that many children suffer from chronic postoperative pain, with 13% reporting lingering pain for months after surgery. The researchers emphasize the need for improved pediatric care and effective pain management strategies within 48 hours of surgery.
Researchers have developed a diagnostic tool that uses brain activity patterns to give an objective physiologic assessment of pain, accurately predicting thermal pain in healthy subjects 81% of the time. The study aims to improve detection and treatment of chronic pain.
A new commentary in The FASEB Journal emphasizes the importance of using only FDA-approved diagnostic tools for chronic Lyme disease. Patients should demand proof of safety and benefit before beginning treatment, as some treatments have little scientific evidence to support their effectiveness.
Chronic pain affects an estimated 500,000 Canadians aged 12-44 and 38% of seniors living at home, highlighting the need for better care strategies. Experts recommend a broad approach to increase pain management expertise through education, technology, and supported self-care.