Articles tagged with Diabetes
A five-year national initiative has shown promising results in reducing diabetes health disparities among African Americans, Latinos, and Native Americans. The Alliance model improves chronic disease management by strengthening care coordination, patient self-management, and community engagement.
A UAlberta team discovered a protein linked to metabolic regulation is critical in pulmonary hypertension development. Lower levels of Sirtuin3 have been found in patients with the disease, and gene therapy approaches show promise for improving symptoms.
Diabetic patients using insulin pumps are at risk of dosing errors if they forget to change the clock on their devices. This can lead to severe consequences, including hypoglycemia and hyperglycemia. Researchers call for increased awareness and education to ensure proper pump settings.
A new drug delivered through a skin patch has shown promise in healing diabetic foot ulcers and preventing their recurrence. The drug increases the protein HIF-1α, which helps form new blood vessels needed for wound healing.
A new study found that mothers with gestational diabetes and those who were overweight before pregnancy have daughters who are more likely to be obese. The research, published in Diabetes Care, suggests that behavior modifications during pregnancy may help reduce the risk of obesity in offspring.
A recent study suggests that moderate amounts of sunshine may help prevent obesity and diabetes by reducing glucose levels and insulin resistance. The researchers found that a compound called nitric oxide released by the skin after exposure to sunlight had beneficial effects on weight gain.
Researchers have found that high-fat diets can lead to brain inflammation and heart disease in male laboratory mice but not in female counterparts. The study suggests sex-specific nutritional guidance is needed for effective obesity treatment.
A study at Mount Sinai Hospital reveals that a set of molecules linked to insulin signaling in the brain may indicate an increased risk of developing diabetes. The researchers identified a key mechanism by which these molecules affect BCAA breakdown in the liver.
Dr. Mark Andermann's five-year $1.5 million grant will investigate neural pathways driving hunger and cravings, with the goal of understanding root causes of obesity and food addiction. His novel imaging techniques may lead to breakthroughs in treating these conditions.
A new review article published in Diabetes Technology & Therapeutics found that internet-based diabetes self-management education can lead to better glycemic control and enhanced diabetes knowledge. The study compared the effectiveness of various methods of delivering diabetes education via the internet and concluded that this method i...
A recent study found that adhering to healthy lifestyle habits such as a healthy weight, regular physical activity, and not smoking can significantly reduce the risk of gestational diabetes. The study estimated that nearly half of all diabetic pregnancies could be prevented through these low-risk lifestyle factors.
BioMed Central partners with the University of Michigan to launch an open-access journal focused on clinical research surrounding diabetes and endocrine diseases. The new journal aims to promote better care for patients by sharing new knowledge, both research and clinical, on various aspects of endocrine disorders.
Research found patients with DPN display greater extremes in balance sway and variability during stair climbing, indicating difficulty regulating control of balance. This increases the risk of falls, especially on steep or long flights of stairs.
Researchers found that excess glucose enters cells via inflammatory pathways, sparking escalating inflammation and damaging blood vessels. Lifestyle changes like exercise and weight reduction can reduce both blood sugar and inflammation.
Researchers at the University of Warwick found that a protein called Nrf2 continually moves in and out of human cells' nuclei to sense cell health. The team successfully increased Nrf2's movement by introducing health-beneficial substances, such as broccoli-derived sulforaphane and quercetin from onions, into food supplements.
Researchers have discovered a six-fold higher risk of developing heart failure among people with diabetes who appear healthy. A highly sensitive test found elevated troponin levels indicating microscopic heart muscle damage, unrelated to high cholesterol.
Researchers identified Maresin-Ls, molecules that promote wound healing and reduce inflammation in patients with diabetes. The study restores reparative functions to diabetic macrophages, enabling better treatment of diabetic wounds.
Researchers have developed a novel strategy to diagnose diabetic retinopathy by detecting the early molecular changes caused by diabetes on the endothelium of retinal vessels. This allows for early detection and potential intervention to prevent irreversible structural damage.
A nationwide Danish register study found that psychiatrically ill youth exposed to antipsychotic medications had a significantly higher risk of developing type II diabetes compared to those not exposed. Regular cardiometabolic monitoring should be integral part of antipsychotic prescribing in children and adolescents.
A low-carbohydrate diet is more effective than a low-fat diet in reducing body weight and cardiovascular risk factors. The study found that participants on a low-carb diet experienced greater decreases in weight, fat mass, and other cardiovascular risk factors compared to those on a low-fat diet.
Researchers analyzed 500 patients with diabetes mellitus and found altered nerve conduction in the early asymptomatic stage of diabetic peripheral neuropathy. The amplitude of sensory nerve action potential was the most sensitive measure of this condition, revealing varying degrees of nerve conduction changes.
A new online tool will help doctors predict which patients are most likely to develop diabetes based on age, sex, and blood sugar levels. The calculator will enable doctors to identify high-risk patients for testing and offer lifestyle advice.
Researchers discover that 12-lipoxygenase (12-LO) enzyme promotes pre-diabetes and diabetes by causing oxidative stress in pancreatic cells. The study shows that a high-fat diet leads to the production of harmful molecules, ultimately damaging the cell's ability to produce insulin.
A study of 1,038 adults with diabetes found that diabetic macular edema (DME) prevalence is 3.8% overall, with higher odds among non-Hispanic black patients and those with longer diabetes duration and higher hemoglobin A1c levels.
A CU Denver study found that compact city designs with many intersections are healthier, promoting more walking and biking. The research discovered a correlation between wider streets and increased obesity and diabetes rates.
Researchers have developed a new technique to measure insulin levels in fruit flies with high sensitivity and reproducibility. This breakthrough is expected to transform the field of diabetes research by bringing the power of fruit fly genetics to bear on the devastating condition, enabling rapid testing of diabetes risk factors.
A new UCLA study reveals that California diabetics living in low-income neighborhoods are 10 times more likely to lose a toe, foot or leg than those in affluent areas. The research highlights the need for earlier medical care and expanded access to treatment to prevent amputations.
Researchers found that over-expression of Xbp1s in mice protected them against obesity and diabetes, with improved body weight, decreased blood glucose levels, and enhanced insulin sensitivity. The study suggests the brain controls glucose production by the liver, paving the way for new therapies to treat these conditions.
Patients with diabetes are at a higher risk for developing head and neck cancers, which account for about 6% of all cancer cases globally. A study found that the incidence of HNC was 1.47 times higher in diabetic patients compared to those without diabetes.
Researchers found that people with higher levels of brown fat have better blood sugar control, higher insulin sensitivity, and improved metabolism. Brown fat's ability to regulate blood sugar makes it an important anti-diabetic tissue.
Lab tests reveal that oregano and rosemary, commonly used herbs, have potent compounds against type-2 diabetes. Greenhouse-grown herbs contained more polyphenols but required less to inhibit a key enzyme.
A new study analyzing hospital data from 2001 to 2010 found that young women with a heart attack have longer hospital stays and are more likely to die in the hospital compared to men. The study suggests that raising awareness of controlling cardiovascular risk factors is crucial for improving outcomes in this population.
A portable, microchip-based test can diagnose type-1 diabetes outside hospital settings, distinguishing it from type-2 diabetes. The test uses nanotechnology to detect auto-antibodies in the blood, providing a more efficient and cost-effective solution for patients and researchers.
A new chemical compound, KIRA6, has shown significant protection against degenerative forms of blindness and diabetes in rats and mice. The research offers a promising drug-development path for the diseases caused by cell loss and provides insights into the unfolded protein response (UPR) network.
The LA BioMed project aims to develop integrated and comprehensive care models to help Centinela Valley residents manage their diabetes. The goal is to prevent long-term complications such as kidney failure, amputations, and blindness.
Researchers from Scripps Research Institute have identified two compounds, CoPP and ZnPP, which bind to REV-ERBs and inhibit their activation by heme. These findings suggest that altering the metal ion chemistry of these compounds could be a way to target REV-ERB for treating metabolic disorders.
Researchers have discovered an enzyme that stimulates the overproduction of fatty acids and triglycerides, leading to insulin resistance and diabetes. A new drug candidate is being developed to target this enzyme, potentially treating metabolic syndrome.
A*STAR scientists discovered that obese individuals lack a crucial protein essential for regulating blood glucose levels, increasing their risk of developing diabetes. The protein, NUCKS, is the first molecular link found between obesity and diabetes, opening up new areas of research for potential treatments.
A new study by Hassan A-R Ibrahim found that diabetic patients who don't know proper injection techniques may administer insulin incorrectly, leading to poor glycemic control and adverse outcomes. The study found that only 31% of patients answered more than half the questions correctly about injection techniques.
A new study suggests that individuals who are overweight, obese, or former smokers are more likely to follow recommended statin therapy for high cholesterol. Nonadherence to prescribed medication can lead to a significant risk of cardiovascular events, with studies indicating that nonadherence rates as high as 46% have been observed.
The Endocrine Society's publishing imprint Endocrine Press has released a comprehensive guide to treating metabolic emergencies. The book provides clinicians with practical resources for managing acute medical and critically ill patients experiencing endocrine and metabolic crises, such as dangerously low blood sugar or excessive thyro...
A new study finds that ambient temperatures can influence brown fat growth or loss in humans. Brown fat burns energy to generate heat and improves insulin sensitivity when stimulated by cool environments.
Researchers found that long-term mild cold exposure increased brown fat amount and activity in humans, while mild warmth suppressed it. This discovery may lead to new avenues in treating impaired glucose metabolism and obesity.
Researchers reconstituted VcINDY into liposomes to analyze its properties as a transporter, providing insights into the cellular level functionality of SLC13 transporters. This study paves the way for targeting these transporters to combat metabolic disease and obesity.
Research in southern Ontario found that adults living in more walkable neighborhoods experienced a lower risk of developing diabetes over a 10-year period. The most walkable neighborhoods had the lowest incidence of obesity, overweight and diabetes.
The UC Irvine Health Division of Nephrology & Hypertension will examine the nature and outcomes of transition to dialysis or kidney transplantation in advanced chronic kidney disease patients. The study will analyze data from veterans and Kaiser Permanente Southern California members.
Researchers found that periodic fasting can convert bad cholesterol in fat cells to energy, reducing the risk of diabetes and metabolic problems. After 10-12 hours of fasting, the body starts scavenging for other sources of energy, pulling LDL cholesterol from fat cells and using it as energy.
A new theory proposes that stimulating mitochondrial function and superoxide production can improve markers of renal, cardiovascular, and nerve dysfunction in diabetes. This approach may help promote tissue healing and is linked to improved outcomes for diabetic kidney disease.
Scientists have developed a new glucose-sensing protein to help prevent complications associated with dropping or spiking blood-sugar levels in diabetes. The protein, engineered to be stable and detect glucose levels within the range present in people with diabetes, could enable continuous monitoring.
Researchers discovered a specific immune response triggered by statins that impairs insulin function, increasing the risk of diabetes. Combining statins with another medication may suppress this side effect, offering potential new targets for minimizing adverse effects.
A recent study found that adding insulin to metformin for diabetes treatment is associated with an increased risk of nonfatal cardiovascular outcomes and all-cause death. The researchers analyzed data from over 178,000 patients with diabetes who received metformin as their primary treatment.
Rates of prediabetes have tripled over the past decade in England, affecting over a third of adults. Those from disadvantaged backgrounds and black and minority ethnicities are disproportionately affected, with up to one in 10 progressing to diabetes annually.
A University of Florida study found that nearly one-third of English adults have prediabetes, a condition characterized by higher than normal blood glucose levels. The study suggests that without intervention, England may experience a significant increase in diabetes cases in the coming years.
A large Canadian study of over 8,500 patients found a significant link between obstructive sleep apnea and the development of diabetes. The study confirmed earlier evidence and identified that initial severity of OSA predicted subsequent risk for incident diabetes.
Researchers at UC San Diego School of Medicine discovered that a lack of oxygen in fat cells leads to inflammation and insulin resistance in obesity-induced diabetes. Inhibiting key proteins like ANT2 and HIF-1alpha may provide therapeutic targets for prevention or reversal.
New research reveals that up to 10.1% of people who have a heart attack are newly diagnosed with diabetes due to unrecognized A1C levels. Recognizing diabetes in these patients is crucial as it can guide treatments for coronary artery disease and prevent additional cardiovascular complications.
Cystic fibrosis contributes to raised diabetes risk due to a mutated gene that inhibits insulin secretion. The mutation affects the early stage of insulin release, leading to insufficient insulin levels when demands increase.
Researchers found that low vitamin D levels combined with increased parathyroid hormone (PTH) levels are associated with pre-diabetes and diabetes. The study suggests that assessing the entire PTH/25-OH-D axis is necessary when studying the impact of vitamin D on glucose metabolism.
A new UCLA-led study found that depression is linked to a far greater chance for early death among adults 65 and older with diabetes, compared to those without depression. The researchers suggest that depressed individuals are less likely to adhere to their prescribed medications and lifestyle changes.
A study published in Cell Metabolism reveals that variations in the FTO gene indirectly affect the function of the primary cilium, a hair-like appendage on brain and other cells. This abnormality increases body weight by affecting leptin receptors, leading to increased food intake and obesity.