Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
Researchers at Penn Dental Medicine have identified Foxo1 as a critical molecule that impairs wound healing in diabetics. The study found that deleting Foxo1 in keratinocytes improved wound healing in diabetic mice, suggesting a potential target for therapies to boost healing.
Researchers have identified a novel brain pathway that produces the hormone cholecystokinin (CCK), which acts as a crucial sensor of blood glucose levels. The discovery may lead to new treatments for hypoglycemia and its side effects, particularly in patients who suffer from unawareness due to repeated bouts of low blood sugar.
A recent study found that communities with higher levels of Indigenous language knowledge and cultural continuity have significantly lower diabetes rates, contrary to expectations. The research suggests that reconnecting Aboriginal Canadians to their cultural roots may be a crucial factor in addressing the epidemic of modern times.
Researchers at KU Leuven discovered genetically modified mice producing human growth hormone, altering insulin production and previous research findings. This unexpected turn reveals the need for reinterpretation of 250+ published diabetes studies.
Research found that umbilical cord-derived mesenchymal stromal cells from women with gestational diabetes have impaired growth, cellular senescence, and metabolic function. The study highlights the potential impact of gestational diabetes on the therapeutic potential of these stem cells.
Scientists have developed an ultra-thin, flexible device that sticks to skin like a rub-on tattoo and can detect glucose levels. The device has the potential to eliminate finger-pricking for people with diabetes, eliminating a major pain point in managing the disease.
A new research project funded by the Novo Nordisk Foundation will investigate why some diabetes patients develop painful neuritis, while others do not. The study aims to identify key factors and potentially develop preventive or inhibiting medicine.
A new study by Yale University researchers found that older diabetes patients often receive aggressive treatment despite questionable benefits. The study suggests a one-size-fits-all approach may be over-treating a substantial proportion of the population, increasing the risk of hypoglycemia.
A study found that nearly two-thirds of older adults with complex or very complex health status maintained tight blood sugar control, suggesting potential overtreatment. This vulnerable population is unlikely to benefit from intensive glucose management and may experience harms such as hypoglycemia.
A study published in Diabetologia found that black women working night shifts are more likely to develop diabetes than those who never work at night. The study revealed a stronger association in younger women, with increased risks of up to 39% after 10 or more years of night shift work.
Researchers found that blood sugar levels above 6.1 mmol/L increase the risk of early death, further hospitalizations, and diabetes in heart failure patients, even if they have normal blood sugar levels on arrival.
Researchers at Salk Institute develop a new compound called fexaramine that effectively stops weight gain, lowers cholesterol and controls blood sugar levels in mice. The pill tricks the body into thinking it has consumed calories, causing it to burn fat without altering appetite.
A study of 411 patients found that economic insecurity is associated with poor diabetes control and increased healthcare use. Material need insecurities, such as food insecurity and cost-related medication underuse, were significant predictors of poor diabetes control.
The American Diabetes Association is recommending that all people with diabetes take either moderate or high doses of statins to prevent heart disease. The revised Standards of Medical Care also call for a less stringent diastolic blood pressure goal of 90 mmHg, up from 80 mmHg.
Researchers have developed a safe and effective skin patch to deliver a drug that enhances the healing of diabetes-related ulcers. The patch has been shown to accelerate wound healing and prevent ulcer formation in mice, offering new hope for millions of people with diabetes.
A new study published in the Journal of Clinical Endocrinology & Metabolism found that urban stressors contribute to a rising rate of diabetes in developing nations. High cortisol levels were found to be a key factor, with urban residents having significantly higher levels than rural counterparts.
A clinical trial found no clear benefit of low glycemic index diets on key measures of heart disease and diabetes risk. Healthy eating habits focusing on fruits, vegetables, and whole grains are recommended by the study's lead researchers.
A new procedure combining surgery to remove part of the pancreas and islet cell transplantation appears safe and effective for alleviating pain from severe chronic pancreatitis. Eight out of nine patients who underwent this procedure were able to discontinue insulin use, with two requiring no insulin at all.
Researchers from McMaster University have identified a key hormone responsible for reduced brown fat activity in obese individuals, leading to increased risk of obesity and diabetes. Blocking the production of peripheral serotonin enhances brown fat activity, providing a potential new treatment approach.
A new peptide developed by IU researchers has effectively cured lab animals of obesity, diabetes, and associated lipid abnormalities. The peptide combines the properties of three gastrointestinal hormones, GLP-1, GIP, and glucagon, and has shown unprecedented efficacy in reducing body weight and controlling metabolism.
A new study published in The Lancet Diabetes and Endocrinology found that obesity can decrease life expectancy by up to 8 years. Researchers used data from the National Health and Nutrition Examination Survey to develop a model estimating annual risk of diabetes and cardiovascular disease in adults with different body weights.
Researchers at Salk Institute discover that confining caloric consumption to an 8- to 12-hour period can significantly reduce weight gain, improve body composition, and even reverse obesity and diabetes in mice. The study's findings add to mounting evidence highlighting the importance of time-restricted eating for overall health.
A senior GP argues that UK government plans to extend diagnosis targets in primary care to six other conditions are problematic and unscientific. The data on which they are based is flawed, leading to potential overdiagnosis and unnecessary tests and treatments.
A new study reveals that exercise following gastric bypass surgery provides additional benefits for obese patients, including improved insulin sensitivity and cardiovascular fitness. This clinical trial supports the inclusion of an exercise program after bariatric surgery to enhance overall health outcomes.
A new Drexel study finds that neighborhood and community-level factors play a significant role in diabetes risk, with areas of poverty, low education and high obesity rates having higher diabetes rates. The researchers report that improving the physical and social environment can reduce diabetes risk by up to 12%.
Researchers estimate that universal preconception care for pregnant women with diabetes can avert an estimated $5.5 billion in health expenditures and lost employment productivity over their children's lifetimes. Effective care could also help mitigate significant complications such as preterm deliveries, birth defects, and perinatal d...
A controlled diet study found that doubling saturated fat in the diet does not increase saturated fat in blood, but increases a fatty acid linked to diabetes and heart disease risk. Researchers also found improvements in blood glucose, insulin, and blood pressure with high-carb diets.
A new study by Intermountain Medical Center found that routine heart imaging screenings for diabetic patients at high risk of heart disease did not prevent heart attacks, hospitalization, or cardiac death. High-quality diabetes management remains the most effective way to avoid these events.
Researchers warn of increased bleeding risk from NSAIDs in atrial fibrillation patients and suggest alternative pain medications. Additionally, a study finds three in ten adults with diabetes remain undiagnosed, highlighting the need for improved care improvements.
A study published in the Asia Pacific Journal of Clinical Nutrition found that adding one gram of turmeric to breakfast improved working memory in older adults with pre-diabetes. The spice's active compound, curcumin, has been shown to reduce the risk of dementia and improve cognitive function.
A randomized trial of 900 patients with diabetes found no benefit from routine CT angiography screening for coronary artery disease (CAD) in reducing mortality, heart attacks, or hospitalizations. The study suggests that guideline-directed medical therapy for hypertension and hyperlipidemia is effective in asymptomatic patients with di...
A new analysis of current evidence suggests that expensive and cheaper drugs both work well in easing diabetes nerve pain. Considering the significant cost difference between medications, doctors should prioritize cost when prescribing treatments for diabetic neuropathy until more studies are done.
A UAlberta team discovered a protein linked to metabolic regulation is critical in pulmonary hypertension development. Lower levels of Sirtuin3 have been found in patients with the disease, and gene therapy approaches show promise for improving symptoms.
Diabetic patients using insulin pumps are at risk of dosing errors if they forget to change the clock on their devices. This can lead to severe consequences, including hypoglycemia and hyperglycemia. Researchers call for increased awareness and education to ensure proper pump settings.
A five-year national initiative has shown promising results in reducing diabetes health disparities among African Americans, Latinos, and Native Americans. The Alliance model improves chronic disease management by strengthening care coordination, patient self-management, and community engagement.
A new drug delivered through a skin patch has shown promise in healing diabetic foot ulcers and preventing their recurrence. The drug increases the protein HIF-1α, which helps form new blood vessels needed for wound healing.
A recent study suggests that moderate amounts of sunshine may help prevent obesity and diabetes by reducing glucose levels and insulin resistance. The researchers found that a compound called nitric oxide released by the skin after exposure to sunlight had beneficial effects on weight gain.
A new study found that mothers with gestational diabetes and those who were overweight before pregnancy have daughters who are more likely to be obese. The research, published in Diabetes Care, suggests that behavior modifications during pregnancy may help reduce the risk of obesity in offspring.
Researchers have found that high-fat diets can lead to brain inflammation and heart disease in male laboratory mice but not in female counterparts. The study suggests sex-specific nutritional guidance is needed for effective obesity treatment.
A study at Mount Sinai Hospital reveals that a set of molecules linked to insulin signaling in the brain may indicate an increased risk of developing diabetes. The researchers identified a key mechanism by which these molecules affect BCAA breakdown in the liver.
Dr. Mark Andermann's five-year $1.5 million grant will investigate neural pathways driving hunger and cravings, with the goal of understanding root causes of obesity and food addiction. His novel imaging techniques may lead to breakthroughs in treating these conditions.
A new review article published in Diabetes Technology & Therapeutics found that internet-based diabetes self-management education can lead to better glycemic control and enhanced diabetes knowledge. The study compared the effectiveness of various methods of delivering diabetes education via the internet and concluded that this method i...
BioMed Central partners with the University of Michigan to launch an open-access journal focused on clinical research surrounding diabetes and endocrine diseases. The new journal aims to promote better care for patients by sharing new knowledge, both research and clinical, on various aspects of endocrine disorders.
A recent study found that adhering to healthy lifestyle habits such as a healthy weight, regular physical activity, and not smoking can significantly reduce the risk of gestational diabetes. The study estimated that nearly half of all diabetic pregnancies could be prevented through these low-risk lifestyle factors.
Research found patients with DPN display greater extremes in balance sway and variability during stair climbing, indicating difficulty regulating control of balance. This increases the risk of falls, especially on steep or long flights of stairs.
Researchers at the University of Warwick found that a protein called Nrf2 continually moves in and out of human cells' nuclei to sense cell health. The team successfully increased Nrf2's movement by introducing health-beneficial substances, such as broccoli-derived sulforaphane and quercetin from onions, into food supplements.
Researchers found that excess glucose enters cells via inflammatory pathways, sparking escalating inflammation and damaging blood vessels. Lifestyle changes like exercise and weight reduction can reduce both blood sugar and inflammation.
Researchers have discovered a six-fold higher risk of developing heart failure among people with diabetes who appear healthy. A highly sensitive test found elevated troponin levels indicating microscopic heart muscle damage, unrelated to high cholesterol.
Researchers identified Maresin-Ls, molecules that promote wound healing and reduce inflammation in patients with diabetes. The study restores reparative functions to diabetic macrophages, enabling better treatment of diabetic wounds.
A nationwide Danish register study found that psychiatrically ill youth exposed to antipsychotic medications had a significantly higher risk of developing type II diabetes compared to those not exposed. Regular cardiometabolic monitoring should be integral part of antipsychotic prescribing in children and adolescents.
Researchers have developed a novel strategy to diagnose diabetic retinopathy by detecting the early molecular changes caused by diabetes on the endothelium of retinal vessels. This allows for early detection and potential intervention to prevent irreversible structural damage.
A low-carbohydrate diet is more effective than a low-fat diet in reducing body weight and cardiovascular risk factors. The study found that participants on a low-carb diet experienced greater decreases in weight, fat mass, and other cardiovascular risk factors compared to those on a low-fat diet.
Researchers analyzed 500 patients with diabetes mellitus and found altered nerve conduction in the early asymptomatic stage of diabetic peripheral neuropathy. The amplitude of sensory nerve action potential was the most sensitive measure of this condition, revealing varying degrees of nerve conduction changes.
A new online tool will help doctors predict which patients are most likely to develop diabetes based on age, sex, and blood sugar levels. The calculator will enable doctors to identify high-risk patients for testing and offer lifestyle advice.
Researchers discover that 12-lipoxygenase (12-LO) enzyme promotes pre-diabetes and diabetes by causing oxidative stress in pancreatic cells. The study shows that a high-fat diet leads to the production of harmful molecules, ultimately damaging the cell's ability to produce insulin.
A study of 1,038 adults with diabetes found that diabetic macular edema (DME) prevalence is 3.8% overall, with higher odds among non-Hispanic black patients and those with longer diabetes duration and higher hemoglobin A1c levels.
A CU Denver study found that compact city designs with many intersections are healthier, promoting more walking and biking. The research discovered a correlation between wider streets and increased obesity and diabetes rates.
Researchers have developed a new technique to measure insulin levels in fruit flies with high sensitivity and reproducibility. This breakthrough is expected to transform the field of diabetes research by bringing the power of fruit fly genetics to bear on the devastating condition, enabling rapid testing of diabetes risk factors.
A new UCLA study reveals that California diabetics living in low-income neighborhoods are 10 times more likely to lose a toe, foot or leg than those in affluent areas. The research highlights the need for earlier medical care and expanded access to treatment to prevent amputations.
Researchers found that over-expression of Xbp1s in mice protected them against obesity and diabetes, with improved body weight, decreased blood glucose levels, and enhanced insulin sensitivity. The study suggests the brain controls glucose production by the liver, paving the way for new therapies to treat these conditions.