Articles tagged with Diabetes
A systematic review and meta-analysis of over 850,000 people shows that women with diabetes are nearly three times more likely to develop coronary heart disease than women without diabetes. Men with diabetes are twice as likely to develop CHD. The study suggests that sex-specific interventions could improve the prevention of CHD.
Scientists at Harvard University have identified a newly discovered compound that can slow the degradation of insulin in animals, potentially leading to a new treatment for diabetes. The compound inhibits insulin-degrading enzyme (IDE), elevating insulin levels and promoting insulin signaling in mice.
Research reveals that increasing heart failure severity is associated with a higher risk of developing diabetes. Patients with more severe heart failure were found to be three times more likely to develop diabetes than those with milder cases.
Dr. Timothy J. Bartness, a world-renowned obesity researcher, has been awarded a five-year, $2.5 million MERIT grant to investigate lipolysis and thermogenesis in specialized fat cells. His research aims to understand the bidirectional communication between fat and the brain, which is thought to control body fat breakdown and metabolism.
Researchers are exploring a new therapy to eliminate the major risk of minor bleeding after stroke, focusing on diabetic patients who are at higher risk. The treatment involves an iron chelating agent that can remove excess iron from the brain, reducing damage and promoting recovery.
Researchers developed a system that predicts and prevents dangerously low overnight blood sugars in patients with type-1 diabetes. The device, which couples a glucose sensor with an insulin pump, reduces cumulative time spent with low blood sugars during sleep by 81%.
A study published in Journal of Agricultural and Food Chemistry found that chlorogenic acid in coffee may prevent retinal degeneration due to oxidative stress. Regular coffee consumption could potentially protect against eye diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.
A study published in ACS' Journal of Proteome Research found that whey protein slows down stomach emptying and lowers fatty acid levels, increasing insulin levels in obese adults. The results suggest that whey protein may be a beneficial addition to diets for those at risk of developing type-2 diabetes and cardiovascular disease.
Researchers found that bariatric surgery increases levels of bile acids in the blood, improving glucose metabolism and weight loss. The study suggests a new target for treating obesity and diabetes, offering a potential future therapeutic approach.
Researchers used CT angiography to assess coronary artery plaque volume index (PVI) in asymptomatic diabetic patients. PVI was related to age, BMI, and duration of diabetes, highlighting the importance of obesity as a modifiable risk factor.
A new data-based model accurately estimates hemoglobin A1c using self-monitored blood glucose readings, providing real-time glycemic control monitoring. This allows for increased individual motivation to improve diabetes management, as patients can track their progress more easily.
Researchers found that activating a receptor, Gpr109a, can inhibit inflammation in the retina and prevent vision damage in diabetes. The new grant will enable long-term studies to evaluate the therapeutic potential of this approach.
Researchers Jonathan Powell, G. William Wong, and Elias Zambidis will explore novel treatments for diabetes using protein design, hormone discovery, and stem cell therapy.
A study found that low birth weight and maternal conditions like diabetes and overweight/obesity are associated with an increased risk of childhood kidney disease. Researchers suggest that modifying these factors could help protect children's kidney health and reduce the incidence of CKD.
Researchers at Indiana University have developed a new technique that can detect microscopic changes in the retina caused by diabetes, which may indicate potential sight-threatening complications. The instrument uses adaptive optics to provide highly magnified retinal images and identify subtle changes in blood vessels.
Cases of diabetes and pre-diabetes in the US have nearly doubled since 1988, with obesity contributing to the surge. The burden of the disease is not evenly distributed, with higher rates among blacks, Hispanics, and the elderly.
A new delirium severity score helps predict hospital outcomes in patients with delirium. The Confusion Assessment Method (CAM) scoring system is validated for predicting adverse outcomes, including prolonged hospital stay and functional decline. Additionally, a US survey shows that obesity contributes to the dramatic increase in diabet...
A study by Women's College Hospital found women with diabetes are 14% less likely to get mammograms, despite higher breast cancer risk. Low socioeconomic status exacerbates this disparity.
Two studies confirmed NAFLD as an independent cardiovascular risk factor, increasing the risk of atherosclerosis and carotid plaques. Improvement in liver health through treatment is associated with a reduced risk of developing diabetes.
Researchers identified a protein, nicotinamide N-methyltransferase (NNMT), that can be altered to increase energy expenditures. Reducing NNMT levels in fat and liver cells dramatically reduces obesity and diabetes development in mice.
A new study finds that adult patients with diabetes who trust their medical provider and feel included in treatment decisions are more likely to take and maintain a newly prescribed antidepressant medication. Shared decision-making is also associated with better adherence later in the course of antidepressant treatment.
Research links sleep apnea with higher blood sugar levels, highlighting the need for clinicians to monitor diabetes in patients with sleep apnea. The study found a significant correlation between glucose concentration and sleep apnea severity.
A 25-year study of 76 rhesus monkeys found that those with calorie-restricted diets experienced a significant reduction in mortality and age-associated diseases. The study contradicts an earlier report on monkeys, which suggested no differences in survival rates between caloric restriction and control groups.
The meta-analysis found that ACEIs reduce the risk of death from all causes by 13%, cut the risk of CV deaths by 17%, and lower the risk of major CV events by 14%. In contrast, ARBs did not affect all-cause mortality, CV death rate, or major CV events in patients with diabetes.
A recent study published in Pediatrics found that stronger adolescents and teens have significantly lower risks of heart disease and diabetes. The research suggests that muscle strength may play an equally important role in cardiometabolic health in children, particularly in those with higher strength-to-body-mass ratios.
A recent study published in JAMA found that metformin treatment did not improve ventricular function in patients with ST-segment elevation myocardial infarction (STEMI) without diabetes. The study showed no significant difference in left ventricular ejection fraction between the metformin and placebo groups.
A pooled analysis of studies found that adherence to the Mediterranean diet reduced diabetes risk by 21%, with an even greater reduction in those at high cardiovascular risk. The diet, rich in fruits, vegetables, whole grains, and healthy fats, may also help prevent obesity-related complications.
A recent study found that individuals with diabetes who experience major depressive symptoms are at a significantly higher risk of developing kidney failure. In contrast, minor depressive symptoms were not found to have a significant association with kidney disease development.
Researchers found Gen X has significantly poorer health status, higher obesity rates, and no difference in physical activity compared to Baby Boomers. The study suggests drastic lifestyle changes, such as increased sedentary behavior and access to unhealthy food, contribute to earlier development of age-related conditions.
A new study published in Diabetes Care found that women who fail to lose excess weight within the first year after giving birth are at increased risk for developing diabetes and cardiovascular disease. The research followed 305 patients and discovered that those who gained weight showed a clear increase in risk factors.
A study of nearly 300,000 adults found that adding glycated hemoglobin (HbA1c) information to conventional cardiovascular risk factors had little impact on predicting cardiovascular disease risk. Higher HbA1c levels were previously associated with increased CVD incidence, but this analysis did not find clinically meaningful improvement.
Researchers have successfully implanted encapsulated human embryonic stem cell-derived pancreatic cells under the skin of animal models with diabetes, producing sufficient insulin to maintain glucose levels. The study suggests that these cells may be a promising treatment option for insulin-dependent diabetes.
The Lancet journals publish a special collection on tuberculosis, highlighting emerging challenges like drug-resistant strains and poor treatment outcomes. New anti-tuberculosis drugs and host-directed therapies are being developed to improve treatment efficacy.
A study published in Neurology found that developing diabetes and high blood pressure in middle age is associated with brain cell loss and cognitive problems later in life. Middle-aged individuals with these conditions had smaller brain volume and increased risk of thinking and memory issues compared to those without the conditions.
The Alberta Diabetes Institute has launched a new $600,000 partnership to advance early-stage technologies for Type I and II diabetes. The three-year fund will support novel discovery research with high commercialization potential.
The Affordable Care Act's impact on healthcare coverage will significantly affect population health management providers, employers, and employees. New models of population health management services delivery are proposed to address these changes.
Dr. Roger Unger has been awarded the 2014 Rolf Luft Award for his groundbreaking research on glucagon, which he identified as a key hormone balancing insulin regulation of blood sugar. His work revealed diabetes is a bihormonal disease with insufficiency of insulin and excess glucagon.
A large analysis of international studies suggests a time-dependent link between diabetes and pancreatic cancer. Screening programs may be necessary for patients with new-onset diabetes, particularly those without significant risk factors.
Research published in Diabetologia found that cancer patients with diabetes have a higher risk of early death due to the combination of diabetes and cancer. Patients treated with insulin had the highest mortality rate, while those with oral hypoglycaemic agents or no treatment showed lower risks
The study found that nearly 4 million Latinas were never told they were at risk for diabetes, highlighting the need for effective and culturally sensitive follow-up care and case management. Alternate sites like optometry venues, pharmacies, or places of worship could increase access to education and self-management programs.
A study identifies a key role for RBP4 in insulin resistance and inflammation of fat tissue, leading to an increased risk of diabetes. Researchers found that elevated RBP4 levels activate immune cells, triggering chronic inflammation and metabolic dysfunction.
The US FDA has approved metreleptin as a treatment for generalized lipodystrophy, a condition characterized by near-complete absence of fat tissue. Leptin replacement therapy has been shown to control severe insulin resistance and lower triglyceride levels in patients with severe generalized lipodystrophy.
A new tissue repair drug has been shown to improve healing rates for diabetic foot ulcers, reducing the risk of amputation. Patients treated with the drug were twice as likely to have their ulcers heal within eight weeks compared to those receiving a placebo.
A study of 39 young adults found that consuming polyunsaturated fat resulted in less body fat and more muscle mass than consuming saturated fat. This is significant for preventing obesity-related disorders like type-2 diabetes, as it suggests that a diet rich in unsaturated fats may help regulate fat distribution.
A study by the American Academy of Neurology found that fatal heart attacks and strokes among firefighters frequently follow vigorous physical activity. The researchers analyzed data from 1998 to 2012 and discovered that 148 out of 199 events occurred after vigorous exercise lasting an average of 33 minutes.
A study of 267 CKD patients found that 69.3% experienced at least one hazardous event related to their outpatient care, with hypoglycemia and falling/severe dizziness being common complications.
Researchers found a specific genetic flaw in the KCNE2 gene that is connected to sudden cardiac death due to heart arrhythmia. This discovery could lead to improved early detection and prevention strategies for people at higher risk, such as those with diabetes.
A new study reveals that high levels of glucose in diabetes patients induce the production of PGC-1alpha in endothelial cells, preventing them from growing properly. This leads to vascular dysfunction and impaired wound healing, increasing the risk of microvascular complications.
A cluster randomized trial found that an educational toolkit did not improve quality of care or outcomes for patients with diabetes. The study, published in PLOS Medicine, involved over 900,000 people aged ≥40 years with diagnosed diabetes in Ontario, Canada.
A new study by Joslin Diabetes Center identified three core factors and thirteen strategies to increase buy-in from practice teams in transitioning to Patient-Centered Medical Homes (PCMHs). The findings emphasize the importance of effective communication, resource utilization, team environment, defined work roles, and targeted resources.
A large international study found an independent association between diabetes and depression as well as impulse control disorders, including binge-eating and bulimia. Depression increased the risk of diabetes by 30%, while binge-eating disorder increased the risk by 2.6 times.
A study involving 186 Type II diabetes patients found that health coaching significantly improved oral health by reducing biological markers for periodontitis by 50% and long-range blood sugar levels. The coaching group also showed increased self-efficacy in handling illness and health issues.
Studies suggest that maintaining a normal level of the protein SirT1 may be effective in preventing obesity- and age-related diseases. Researchers have demonstrated that changing three amino acids on SirT1 can produce a 'super-sirt' that functions normally despite metabolic stress.
Researchers at Tel Aviv University discover a simple blood test can predict diabetes risk up to five years before symptoms appear. The test uses A1c levels to identify high-risk patients, who may benefit from earlier diagnosis and treatment.
A new study published in Diabetologia confirms that working-age adults with diabetes are at a higher risk of influenza compared to non-diabetic individuals. The research suggests that vaccinating this group could be cost-effective and mitigate healthcare costs associated with flu-related hospitalizations.
Researchers at Helmholtz Munich have made a breakthrough in creating insulin-producing beta cells from stem cells. By understanding the molecular regulation of stem cell differentiation, they can generate functional specialized cells for regenerative therapy approaches to chronic diseases like diabetes. This discovery has significant i...
A study by Joslin Diabetes Center found that care managers in Patient-Centered Medical Homes (PCMHs) increased improvements in diabetes patients. Care managers who were embedded in the care team and used electronic medical records showed better patient outcomes.
Researchers found self-rated health to be a strong predictor of depression risk in patients with recent depressive symptoms. Family physicians can assess self-rated health using a simple question and integrate indirect methods to explore treatment expectations, promoting collaborative relationships and improved antibiotic prescribing.
A new study reveals that living in densely populated neighborhoods can decrease the risk of developing diabetes and obesity. The design of Toronto's neighborhoods, such as Bridle Path-Sunnybrook-York Mills, Edenbridge-Humber Valley, and Morningside, encourage walking and discourage driving, leading to a lower risk of these health issues.
Studies examine how depleted food budgets can increase risk of hypoglycemia among low-income individuals with diabetes. Additionally, researchers find that workers with diabetes are more likely to retire earlier in countries worldwide.