Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
Patients with diabetes are at a higher risk for developing head and neck cancers, which account for about 6% of all cancer cases globally. A study found that the incidence of HNC was 1.47 times higher in diabetic patients compared to those without diabetes.
Researchers found that people with higher levels of brown fat have better blood sugar control, higher insulin sensitivity, and improved metabolism. Brown fat's ability to regulate blood sugar makes it an important anti-diabetic tissue.
Lab tests reveal that oregano and rosemary, commonly used herbs, have potent compounds against type-2 diabetes. Greenhouse-grown herbs contained more polyphenols but required less to inhibit a key enzyme.
A new study analyzing hospital data from 2001 to 2010 found that young women with a heart attack have longer hospital stays and are more likely to die in the hospital compared to men. The study suggests that raising awareness of controlling cardiovascular risk factors is crucial for improving outcomes in this population.
A portable, microchip-based test can diagnose type-1 diabetes outside hospital settings, distinguishing it from type-2 diabetes. The test uses nanotechnology to detect auto-antibodies in the blood, providing a more efficient and cost-effective solution for patients and researchers.
The LA BioMed project aims to develop integrated and comprehensive care models to help Centinela Valley residents manage their diabetes. The goal is to prevent long-term complications such as kidney failure, amputations, and blindness.
A new chemical compound, KIRA6, has shown significant protection against degenerative forms of blindness and diabetes in rats and mice. The research offers a promising drug-development path for the diseases caused by cell loss and provides insights into the unfolded protein response (UPR) network.
Researchers from Scripps Research Institute have identified two compounds, CoPP and ZnPP, which bind to REV-ERBs and inhibit their activation by heme. These findings suggest that altering the metal ion chemistry of these compounds could be a way to target REV-ERB for treating metabolic disorders.
Researchers have discovered an enzyme that stimulates the overproduction of fatty acids and triglycerides, leading to insulin resistance and diabetes. A new drug candidate is being developed to target this enzyme, potentially treating metabolic syndrome.
A*STAR scientists discovered that obese individuals lack a crucial protein essential for regulating blood glucose levels, increasing their risk of developing diabetes. The protein, NUCKS, is the first molecular link found between obesity and diabetes, opening up new areas of research for potential treatments.
A new study by Hassan A-R Ibrahim found that diabetic patients who don't know proper injection techniques may administer insulin incorrectly, leading to poor glycemic control and adverse outcomes. The study found that only 31% of patients answered more than half the questions correctly about injection techniques.
A new study suggests that individuals who are overweight, obese, or former smokers are more likely to follow recommended statin therapy for high cholesterol. Nonadherence to prescribed medication can lead to a significant risk of cardiovascular events, with studies indicating that nonadherence rates as high as 46% have been observed.
The Endocrine Society's publishing imprint Endocrine Press has released a comprehensive guide to treating metabolic emergencies. The book provides clinicians with practical resources for managing acute medical and critically ill patients experiencing endocrine and metabolic crises, such as dangerously low blood sugar or excessive thyro...
A new study finds that ambient temperatures can influence brown fat growth or loss in humans. Brown fat burns energy to generate heat and improves insulin sensitivity when stimulated by cool environments.
Researchers found that long-term mild cold exposure increased brown fat amount and activity in humans, while mild warmth suppressed it. This discovery may lead to new avenues in treating impaired glucose metabolism and obesity.
Researchers reconstituted VcINDY into liposomes to analyze its properties as a transporter, providing insights into the cellular level functionality of SLC13 transporters. This study paves the way for targeting these transporters to combat metabolic disease and obesity.
Research in southern Ontario found that adults living in more walkable neighborhoods experienced a lower risk of developing diabetes over a 10-year period. The most walkable neighborhoods had the lowest incidence of obesity, overweight and diabetes.
The UC Irvine Health Division of Nephrology & Hypertension will examine the nature and outcomes of transition to dialysis or kidney transplantation in advanced chronic kidney disease patients. The study will analyze data from veterans and Kaiser Permanente Southern California members.
Researchers found that periodic fasting can convert bad cholesterol in fat cells to energy, reducing the risk of diabetes and metabolic problems. After 10-12 hours of fasting, the body starts scavenging for other sources of energy, pulling LDL cholesterol from fat cells and using it as energy.
A new theory proposes that stimulating mitochondrial function and superoxide production can improve markers of renal, cardiovascular, and nerve dysfunction in diabetes. This approach may help promote tissue healing and is linked to improved outcomes for diabetic kidney disease.
Researchers discovered a specific immune response triggered by statins that impairs insulin function, increasing the risk of diabetes. Combining statins with another medication may suppress this side effect, offering potential new targets for minimizing adverse effects.
Scientists have developed a new glucose-sensing protein to help prevent complications associated with dropping or spiking blood-sugar levels in diabetes. The protein, engineered to be stable and detect glucose levels within the range present in people with diabetes, could enable continuous monitoring.
A recent study found that adding insulin to metformin for diabetes treatment is associated with an increased risk of nonfatal cardiovascular outcomes and all-cause death. The researchers analyzed data from over 178,000 patients with diabetes who received metformin as their primary treatment.
A University of Florida study found that nearly one-third of English adults have prediabetes, a condition characterized by higher than normal blood glucose levels. The study suggests that without intervention, England may experience a significant increase in diabetes cases in the coming years.
Rates of prediabetes have tripled over the past decade in England, affecting over a third of adults. Those from disadvantaged backgrounds and black and minority ethnicities are disproportionately affected, with up to one in 10 progressing to diabetes annually.
A large Canadian study of over 8,500 patients found a significant link between obstructive sleep apnea and the development of diabetes. The study confirmed earlier evidence and identified that initial severity of OSA predicted subsequent risk for incident diabetes.
Researchers at UC San Diego School of Medicine discovered that a lack of oxygen in fat cells leads to inflammation and insulin resistance in obesity-induced diabetes. Inhibiting key proteins like ANT2 and HIF-1alpha may provide therapeutic targets for prevention or reversal.
New research reveals that up to 10.1% of people who have a heart attack are newly diagnosed with diabetes due to unrecognized A1C levels. Recognizing diabetes in these patients is crucial as it can guide treatments for coronary artery disease and prevent additional cardiovascular complications.
Cystic fibrosis contributes to raised diabetes risk due to a mutated gene that inhibits insulin secretion. The mutation affects the early stage of insulin release, leading to insufficient insulin levels when demands increase.
A new UCLA-led study found that depression is linked to a far greater chance for early death among adults 65 and older with diabetes, compared to those without depression. The researchers suggest that depressed individuals are less likely to adhere to their prescribed medications and lifestyle changes.
Researchers found that low vitamin D levels combined with increased parathyroid hormone (PTH) levels are associated with pre-diabetes and diabetes. The study suggests that assessing the entire PTH/25-OH-D axis is necessary when studying the impact of vitamin D on glucose metabolism.
A systematic review and meta-analysis of over 850,000 people shows that women with diabetes are nearly three times more likely to develop coronary heart disease than women without diabetes. Men with diabetes are twice as likely to develop CHD. The study suggests that sex-specific interventions could improve the prevention of CHD.
A study published in Cell Metabolism reveals that variations in the FTO gene indirectly affect the function of the primary cilium, a hair-like appendage on brain and other cells. This abnormality increases body weight by affecting leptin receptors, leading to increased food intake and obesity.
Scientists at Harvard University have identified a newly discovered compound that can slow the degradation of insulin in animals, potentially leading to a new treatment for diabetes. The compound inhibits insulin-degrading enzyme (IDE), elevating insulin levels and promoting insulin signaling in mice.
Research reveals that increasing heart failure severity is associated with a higher risk of developing diabetes. Patients with more severe heart failure were found to be three times more likely to develop diabetes than those with milder cases.
Dr. Timothy J. Bartness, a world-renowned obesity researcher, has been awarded a five-year, $2.5 million MERIT grant to investigate lipolysis and thermogenesis in specialized fat cells. His research aims to understand the bidirectional communication between fat and the brain, which is thought to control body fat breakdown and metabolism.
Researchers are exploring a new therapy to eliminate the major risk of minor bleeding after stroke, focusing on diabetic patients who are at higher risk. The treatment involves an iron chelating agent that can remove excess iron from the brain, reducing damage and promoting recovery.
Researchers developed a system that predicts and prevents dangerously low overnight blood sugars in patients with type-1 diabetes. The device, which couples a glucose sensor with an insulin pump, reduces cumulative time spent with low blood sugars during sleep by 81%.
A study published in Journal of Agricultural and Food Chemistry found that chlorogenic acid in coffee may prevent retinal degeneration due to oxidative stress. Regular coffee consumption could potentially protect against eye diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.
A study published in ACS' Journal of Proteome Research found that whey protein slows down stomach emptying and lowers fatty acid levels, increasing insulin levels in obese adults. The results suggest that whey protein may be a beneficial addition to diets for those at risk of developing type-2 diabetes and cardiovascular disease.
Researchers used CT angiography to assess coronary artery plaque volume index (PVI) in asymptomatic diabetic patients. PVI was related to age, BMI, and duration of diabetes, highlighting the importance of obesity as a modifiable risk factor.
A new data-based model accurately estimates hemoglobin A1c using self-monitored blood glucose readings, providing real-time glycemic control monitoring. This allows for increased individual motivation to improve diabetes management, as patients can track their progress more easily.
Researchers found that bariatric surgery increases levels of bile acids in the blood, improving glucose metabolism and weight loss. The study suggests a new target for treating obesity and diabetes, offering a potential future therapeutic approach.
Researchers found that activating a receptor, Gpr109a, can inhibit inflammation in the retina and prevent vision damage in diabetes. The new grant will enable long-term studies to evaluate the therapeutic potential of this approach.
Researchers Jonathan Powell, G. William Wong, and Elias Zambidis will explore novel treatments for diabetes using protein design, hormone discovery, and stem cell therapy.
A study found that low birth weight and maternal conditions like diabetes and overweight/obesity are associated with an increased risk of childhood kidney disease. Researchers suggest that modifying these factors could help protect children's kidney health and reduce the incidence of CKD.
Researchers at Indiana University have developed a new technique that can detect microscopic changes in the retina caused by diabetes, which may indicate potential sight-threatening complications. The instrument uses adaptive optics to provide highly magnified retinal images and identify subtle changes in blood vessels.
Cases of diabetes and pre-diabetes in the US have nearly doubled since 1988, with obesity contributing to the surge. The burden of the disease is not evenly distributed, with higher rates among blacks, Hispanics, and the elderly.
A new delirium severity score helps predict hospital outcomes in patients with delirium. The Confusion Assessment Method (CAM) scoring system is validated for predicting adverse outcomes, including prolonged hospital stay and functional decline. Additionally, a US survey shows that obesity contributes to the dramatic increase in diabet...
A study by Women's College Hospital found women with diabetes are 14% less likely to get mammograms, despite higher breast cancer risk. Low socioeconomic status exacerbates this disparity.
Two studies confirmed NAFLD as an independent cardiovascular risk factor, increasing the risk of atherosclerosis and carotid plaques. Improvement in liver health through treatment is associated with a reduced risk of developing diabetes.
Researchers identified a protein, nicotinamide N-methyltransferase (NNMT), that can be altered to increase energy expenditures. Reducing NNMT levels in fat and liver cells dramatically reduces obesity and diabetes development in mice.
A new study finds that adult patients with diabetes who trust their medical provider and feel included in treatment decisions are more likely to take and maintain a newly prescribed antidepressant medication. Shared decision-making is also associated with better adherence later in the course of antidepressant treatment.
Research links sleep apnea with higher blood sugar levels, highlighting the need for clinicians to monitor diabetes in patients with sleep apnea. The study found a significant correlation between glucose concentration and sleep apnea severity.
A 25-year study of 76 rhesus monkeys found that those with calorie-restricted diets experienced a significant reduction in mortality and age-associated diseases. The study contradicts an earlier report on monkeys, which suggested no differences in survival rates between caloric restriction and control groups.
A recent study published in JAMA found that metformin treatment did not improve ventricular function in patients with ST-segment elevation myocardial infarction (STEMI) without diabetes. The study showed no significant difference in left ventricular ejection fraction between the metformin and placebo groups.
The meta-analysis found that ACEIs reduce the risk of death from all causes by 13%, cut the risk of CV deaths by 17%, and lower the risk of major CV events by 14%. In contrast, ARBs did not affect all-cause mortality, CV death rate, or major CV events in patients with diabetes.
A recent study published in Pediatrics found that stronger adolescents and teens have significantly lower risks of heart disease and diabetes. The research suggests that muscle strength may play an equally important role in cardiometabolic health in children, particularly in those with higher strength-to-body-mass ratios.
Researchers found Gen X has significantly poorer health status, higher obesity rates, and no difference in physical activity compared to Baby Boomers. The study suggests drastic lifestyle changes, such as increased sedentary behavior and access to unhealthy food, contribute to earlier development of age-related conditions.
A pooled analysis of studies found that adherence to the Mediterranean diet reduced diabetes risk by 21%, with an even greater reduction in those at high cardiovascular risk. The diet, rich in fruits, vegetables, whole grains, and healthy fats, may also help prevent obesity-related complications.