Research on diabetes and its complications. Covers glucose prediction, nerve pain, weight-loss drugs, insulin access, and diabetes management.
A recent study found that individuals with diabetes who experience major depressive symptoms are at a significantly higher risk of developing kidney failure. In contrast, minor depressive symptoms were not found to have a significant association with kidney disease development.
A study of nearly 300,000 adults found that adding glycated hemoglobin (HbA1c) information to conventional cardiovascular risk factors had little impact on predicting cardiovascular disease risk. Higher HbA1c levels were previously associated with increased CVD incidence, but this analysis did not find clinically meaningful improvement.
A new study published in Diabetes Care found that women who fail to lose excess weight within the first year after giving birth are at increased risk for developing diabetes and cardiovascular disease. The research followed 305 patients and discovered that those who gained weight showed a clear increase in risk factors.
Researchers have successfully implanted encapsulated human embryonic stem cell-derived pancreatic cells under the skin of animal models with diabetes, producing sufficient insulin to maintain glucose levels. The study suggests that these cells may be a promising treatment option for insulin-dependent diabetes.
The Lancet journals publish a special collection on tuberculosis, highlighting emerging challenges like drug-resistant strains and poor treatment outcomes. New anti-tuberculosis drugs and host-directed therapies are being developed to improve treatment efficacy.
A study published in Neurology found that developing diabetes and high blood pressure in middle age is associated with brain cell loss and cognitive problems later in life. Middle-aged individuals with these conditions had smaller brain volume and increased risk of thinking and memory issues compared to those without the conditions.
The Alberta Diabetes Institute has launched a new $600,000 partnership to advance early-stage technologies for Type I and II diabetes. The three-year fund will support novel discovery research with high commercialization potential.
Dr. Roger Unger has been awarded the 2014 Rolf Luft Award for his groundbreaking research on glucagon, which he identified as a key hormone balancing insulin regulation of blood sugar. His work revealed diabetes is a bihormonal disease with insufficiency of insulin and excess glucagon.
The Affordable Care Act's impact on healthcare coverage will significantly affect population health management providers, employers, and employees. New models of population health management services delivery are proposed to address these changes.
A large analysis of international studies suggests a time-dependent link between diabetes and pancreatic cancer. Screening programs may be necessary for patients with new-onset diabetes, particularly those without significant risk factors.
Research published in Diabetologia found that cancer patients with diabetes have a higher risk of early death due to the combination of diabetes and cancer. Patients treated with insulin had the highest mortality rate, while those with oral hypoglycaemic agents or no treatment showed lower risks
The study found that nearly 4 million Latinas were never told they were at risk for diabetes, highlighting the need for effective and culturally sensitive follow-up care and case management. Alternate sites like optometry venues, pharmacies, or places of worship could increase access to education and self-management programs.
A study identifies a key role for RBP4 in insulin resistance and inflammation of fat tissue, leading to an increased risk of diabetes. Researchers found that elevated RBP4 levels activate immune cells, triggering chronic inflammation and metabolic dysfunction.
The US FDA has approved metreleptin as a treatment for generalized lipodystrophy, a condition characterized by near-complete absence of fat tissue. Leptin replacement therapy has been shown to control severe insulin resistance and lower triglyceride levels in patients with severe generalized lipodystrophy.
A new tissue repair drug has been shown to improve healing rates for diabetic foot ulcers, reducing the risk of amputation. Patients treated with the drug were twice as likely to have their ulcers heal within eight weeks compared to those receiving a placebo.
A study by the American Academy of Neurology found that fatal heart attacks and strokes among firefighters frequently follow vigorous physical activity. The researchers analyzed data from 1998 to 2012 and discovered that 148 out of 199 events occurred after vigorous exercise lasting an average of 33 minutes.
A study of 39 young adults found that consuming polyunsaturated fat resulted in less body fat and more muscle mass than consuming saturated fat. This is significant for preventing obesity-related disorders like type-2 diabetes, as it suggests that a diet rich in unsaturated fats may help regulate fat distribution.
A study of 267 CKD patients found that 69.3% experienced at least one hazardous event related to their outpatient care, with hypoglycemia and falling/severe dizziness being common complications.
Researchers found a specific genetic flaw in the KCNE2 gene that is connected to sudden cardiac death due to heart arrhythmia. This discovery could lead to improved early detection and prevention strategies for people at higher risk, such as those with diabetes.
A cluster randomized trial found that an educational toolkit did not improve quality of care or outcomes for patients with diabetes. The study, published in PLOS Medicine, involved over 900,000 people aged ≥40 years with diagnosed diabetes in Ontario, Canada.
A new study by Joslin Diabetes Center identified three core factors and thirteen strategies to increase buy-in from practice teams in transitioning to Patient-Centered Medical Homes (PCMHs). The findings emphasize the importance of effective communication, resource utilization, team environment, defined work roles, and targeted resources.
A new study reveals that high levels of glucose in diabetes patients induce the production of PGC-1alpha in endothelial cells, preventing them from growing properly. This leads to vascular dysfunction and impaired wound healing, increasing the risk of microvascular complications.
A large international study found an independent association between diabetes and depression as well as impulse control disorders, including binge-eating and bulimia. Depression increased the risk of diabetes by 30%, while binge-eating disorder increased the risk by 2.6 times.
Researchers at Tel Aviv University discover a simple blood test can predict diabetes risk up to five years before symptoms appear. The test uses A1c levels to identify high-risk patients, who may benefit from earlier diagnosis and treatment.
A study involving 186 Type II diabetes patients found that health coaching significantly improved oral health by reducing biological markers for periodontitis by 50% and long-range blood sugar levels. The coaching group also showed increased self-efficacy in handling illness and health issues.
Studies suggest that maintaining a normal level of the protein SirT1 may be effective in preventing obesity- and age-related diseases. Researchers have demonstrated that changing three amino acids on SirT1 can produce a 'super-sirt' that functions normally despite metabolic stress.
A new study published in Diabetologia confirms that working-age adults with diabetes are at a higher risk of influenza compared to non-diabetic individuals. The research suggests that vaccinating this group could be cost-effective and mitigate healthcare costs associated with flu-related hospitalizations.
Researchers at Helmholtz Munich have made a breakthrough in creating insulin-producing beta cells from stem cells. By understanding the molecular regulation of stem cell differentiation, they can generate functional specialized cells for regenerative therapy approaches to chronic diseases like diabetes. This discovery has significant i...
A study by Joslin Diabetes Center found that care managers in Patient-Centered Medical Homes (PCMHs) increased improvements in diabetes patients. Care managers who were embedded in the care team and used electronic medical records showed better patient outcomes.
Researchers found self-rated health to be a strong predictor of depression risk in patients with recent depressive symptoms. Family physicians can assess self-rated health using a simple question and integrate indirect methods to explore treatment expectations, promoting collaborative relationships and improved antibiotic prescribing.
Researchers discovered that fermentable fibers help regulate glucose production in the intestine, reducing the risk of diabetes and obesity. Animals fed a fiber-rich diet became less fat and developed insulin sensitivity.
A new study reveals that living in densely populated neighborhoods can decrease the risk of developing diabetes and obesity. The design of Toronto's neighborhoods, such as Bridle Path-Sunnybrook-York Mills, Edenbridge-Humber Valley, and Morningside, encourage walking and discourage driving, leading to a lower risk of these health issues.
Studies examine how depleted food budgets can increase risk of hypoglycemia among low-income individuals with diabetes. Additionally, researchers find that workers with diabetes are more likely to retire earlier in countries worldwide.
Researchers have found that fructosamine and glycated albumin are strongly associated with retinopathy and kidney disease in patients with diabetes. These tests could potentially replace the standard Hemoglobin A1c test, which is not valid for some patients.
Panel members of the Institute of Medicine's Eighth Joint National Committee opposed relaxing systolic blood pressure targets to 150 mmHg, citing insufficient evidence. The decision may reduce antihypertensive treatment intensity, potentially reversing declines in cardiovascular disease mortality rates.
A study by researchers at the Medical College of Georgia has identified two players that must work together to destroy vision in patients with diabetes. The findings suggest that blocking the production of reactive oxygen species by either retinal cells or white blood cells may be a viable strategy for intervention.
Research by the University of Exeter Medical School reveals two new genetic causes of neonatal diabetes, providing insights into how insulin-producing beta cells are formed in the pancreas. This discovery increases the number of known genetic causes of neonatal diabetes, offering hope for improved treatment and potential therapies.
Elevated tyrosine levels in obese individuals are linked to a higher risk of developing diabetes. Researchers propose that tyrosine may directly affect insulin signaling, leading to increased blood sugar levels.
Researchers found that patients with congenital arrhythmia produce twice the amount of insulin after consuming sugar, leading to drastically low blood sugar levels. The discovery could have significant implications for treatment of diabetes and management of hypoglycaemia.
Researchers have made a breakthrough in packaging insulin into tiny sacs that can be absorbed through the gut, overcoming digestive enzyme hurdles. The new delivery system has shown promising results in rats, with blood glucose levels lowered almost as much as injected insulin.
The new guideline provides evidence-based recommendations for treating high blood pressure in adults, with a focus on reducing disease burden and improving health outcomes. The report recommends specific treatment thresholds and medication choices based on age, diabetes status, and kidney function.
A new study by Uppsala University reveals a strong association between high levels of perfluorinated compounds and the development of diabetes. High levels of perfluorononanoic acid (PFNA) and perfluorooctanoic acid (PFOA) were found to be linked to increased diabetes risk in elderly men and women.
Researchers found that HCV antiviral therapy reduces risks of kidney disease, stroke, and cardiovascular diseases in diabetic patients. The study also linked diabetes with chronic HCV infection, suggesting a potential association between the two conditions.
A new study has found a significant association between diabetes and an increased risk of developing hepatocellular carcinoma, also known as liver cancer, in various ethnic groups. The study revealed that people with diabetes have a two- to threefold higher risk for liver cancer compared to those without the condition.
A newly discovered human peptide called humanin may become a new treatment for diabetes by increasing insulin secretion and improving glucose metabolism in beta cells. Humanin levels naturally decline with age, suggesting potential benefits for patients with other conditions like stroke, heart disease, and Alzheimer's.
Research suggests that age-adjusted rates of dementia have declined for people born later, particularly those at higher risk. Lifestyle factors such as exercise and diet are being studied as potential contributors to this trend.
A Kaiser Permanente study of 17,217 adult members with diabetes found that those using mail order pharmacies had significantly fewer emergency room visits for any cause. The study suggests that mail order pharmacy may improve patient safety and utilization without compromising patient outcomes.
A recent study published in Stem Cells has identified brown fat stem cells in adult humans, which may lead to new treatments for heart and endocrine disorders. The discovery could help increase the body's own ability to make brown fat or find novel ways to directly implant the cells into patients.
Research found that obese people who are metabolically healthy still face an increased risk of developing diabetes and cardiovascular disease. The study analyzed data from over 5,700 participants and found that normal weight individuals with multiple metabolic abnormalities also faced a higher risk of cardiovascular disease.
A study found that younger Hispanic and black women have a higher risk of in-hospital death after a heart attack compared to white men. Additionally, they are more likely to suffer from diabetes and have limited access to treatment options such as percutaneous coronary interventions or coronary artery bypass surgery.
Swedish researchers have found a way to study glucose regulation by transplanting pancreas cells into the eye, allowing for monitoring of insulin-producing beta-cells and identification of new drug substances. This innovative method could lead to personalized treatment principles and diagnosis of pancreatic problems.
Researchers identified key factors facilitating or hindering the adoption of shared medical appointments (SMAs) in three physician offices. Successful SMA implementation requires careful planning and effective communication among healthcare providers.
A study published in Annals of Emergency Medicine found that diabetic patients treated in the emergency department who received automated daily text messages improved their blood glucose levels and self-reported medication adherence. The program reduced the need for emergency department visits and was well-received by participants.
African Americans with APOL1 gene variant experience faster chronic kidney disease progression and increased risk of kidney failure compared to those without the variant. The study found that APOL1 risk variants increase CKD progression in African Americans, regardless of their diabetes status.
African-American patients with chronic kidney disease have a faster decline in kidney function due to genetic variations, particularly the APOL1 gene variant. The study suggests that reducing the effect of this gene could lead to a significant decrease in progressive kidney and end-stage kidney disease in blacks.
Researchers at UTMB have discovered that PKC activation leads to alternative splicing events in the heart, causing developmental shift and preventing correct functioning. This finding could help lead to prevention and treatment of heart failure in diabetics.
Severely obese patients who underwent gastric bypass or laparoscopic adjustable gastric banding surgical procedures experienced substantial weight loss, with most of the change occurring in the first year. The study also found significant improvements in obesity-related complications, including diabetes, hypertension, and high choleste...
Researchers at UCSF advocate empowering all team members to care for a large number of patients based on their training and abilities. They recommend expanding the scope of practice for registered nurses, pharmacists, physical therapists, and medical assistants to provide care for uncomplicated medical problems.
Three years after bariatric surgery, patients experienced significant weight loss, particularly in the first year. The study found that while there was variability in weight loss outcomes, many patients achieved substantial improvements in diabetes, blood pressure, and lipid profiles.
A recent study of diabetic patients who underwent revascularization for multi-vessel coronary artery disease found that insulin-treated patients experienced higher rates of major adverse cardiovascular events, including death, stroke, and myocardial infarction. CABG was found to reduce mortality and myocardial infarction rates compared...