Articles tagged with Diabetes
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A new study from the University of Copenhagen suggests that an increased activity of a particular iron-transport protein destroys insulin-producing beta cells, leading to type-2 diabetes. Mice without this iron transporter are protected against developing diabetes, providing potential insights into preventing the disease.
Research from the University of Copenhagen suggests that dividing campaigns into combating non-communicable or communicable diseases is ineffective and expensive. Integrated health programmes focusing on common risk factors like poor nutrition can effectively combat diseases such as diabetes and tuberculosis.
Researchers identified miR-34a's role in fatty liver disease and Type II diabetes. Blocking miR-34a improved metabolic outcomes, including decreased liver fat and improved blood glucose levels.
Researchers at St. Michael's Hospital found that living in less walkable neighborhoods increases the risk of developing diabetes by 50% compared to those living in more walkable areas. The study highlights the importance of neighborhood design on health outcomes, particularly for new immigrants.
A study using cardiac magnetic resonance imaging in Iceland found that unrecognized heart attacks (UMI) were associated with an increased risk of death. The prevalence of UMI was higher than previously suspected, especially among individuals with diabetes.
A steady job is associated with improved medication adherence and reduced risk of non-adherence among working-age diabetics. Lack of employment increases stress, financial strain, and access barriers, leading to lower adherence rates.
Patients with psoriasis are at higher risk of new-onset diabetes mellitus due to chronic inflammation. The study found that the risk increases with severity of psoriasis, with patients having severe psoriasis being more than twice as likely to develop diabetes.
Researchers found a significant link between radiotherapy and an increased risk of developing diabetes in childhood cancer survivors. The study, which analyzed over 2500 patient questionnaires and medical records, suggests that radiation exposure to the tail of the pancreas may be particularly damaging.
A study published in The Lancet found that statin therapy can reduce cardiovascular disease risk, even among patients at high risk of developing diabetes. Patients with diabetes risk factors were 28% more likely to develop diabetes, but still saw a 39% reduced risk of cardiovascular illness and 17% lower mortality.
A new MIT study suggests that the protein SIRT1 plays a crucial role in protecting against metabolic disorders linked to high-fat diets, including diabetes. When given a high-fat diet, mice lacking SIRT1 developed metabolic disorders much sooner than normal mice, highlighting its potential as a safeguard against obesity-linked diseases.
Researchers have identified thioredoxin-interacting protein (TXNIP) as a target for therapies in diabetes and Wolfram syndrome. The molecule is involved in the initiation of local inflammation that can lead to systemic inflammation.
Researchers analyzed data to determine if a higher diagnostic cutoff of A1C level should be used to diagnose diabetes in blacks than in whites. The study found that black people may be more vulnerable to high A1C status, and could benefit from earlier monitoring for early diabetic complications.
A study led by the Brigham and Woman's Hospital found an association between phthalate exposure and an increased risk of diabetes in American women. High levels of phthalates were linked to a higher likelihood of developing diabetes, with possible explanations including medical devices and medication used to treat diabetes.
A new glucose monitor made from inexpensive materials measures sugar levels in urine, helping people with diabetes monitor their blood sugar levels in rural areas of developing countries. The device was developed to address the challenges of providing affordable diabetes testing in regions where poverty limits healthcare access.
A new equation that combines creatinine and cystatin C levels provides a more accurate measurement of kidney function, reducing over-diagnosis of chronic kidney disease (CKD). The study suggests that this approach could be used as a confirmatory test for CKD in patients with estimated GFR near 60.
A new UC Davis study found that being overweight or obese alone is not linked to an increased risk of death in the short-term. However, severely obese individuals with diabetes or hypertension do face a higher risk of mortality, emphasizing the importance of weight loss and managing co-occurring health conditions.
A new study by UNC Chapel Hill researchers reveals Chinese teenagers have a significantly higher rate of diabetes (1.9%) compared to their US counterparts (0.5%). The study also found high levels of inflammation and cardiometabolic risk factors in Chinese children, with over one-third having at least one risk factor.
Researchers at the University of Warwick discovered that strawberry extracts positively activate the Nrf2 protein, decreasing blood lipids and cholesterol levels. This activation reduces the risk of developing heart disease and diabetes by counteracting post-meal blood glucose and low-density lipoprotein.
A Swedish study suggests that antipsychotic drugs during pregnancy are associated with a higher risk of developing gestational diabetes. Women treated with these medications had a fourfold higher risk of gestational diabetes compared to those not taking any medication, according to the study published in Archives of General Psychiatry.
A computer-software program, LOGIC-Insulin, effectively controlled blood-sugar levels in critically ill patients compared to nurse-directed care. The study showed improved blood-glucose control and reduced risk of hypoglycemia in the LOGIC-Insulin group.
A comprehensive review of 142 clinical trials found that strategies targeting patients and the healthcare system are effective in improving diabetes outcomes. Programs aimed at physicians were only successful for diabetics with poor health control, while patient-targeted interventions showed promise regardless of HbA1c levels.
A study by a CCNY-led team found correlations between the spread of obesity and food marketing and distribution patterns. The researchers suggest that collective behavior plays a significant role in the spread of the epidemic, not individual factors such as genetics or lifestyle choices.
A Wayne State University researcher is investigating the role of Nrf2-KEAP1 in diabetic retinopathy. The study aims to understand how diabetes causes oxidative stress and damage to mitochondria, ultimately accelerating cell death and developing retinopathy.
Researchers combined data from 11 integrated health systems to form the SUPREME-DM DataLink, a unique resource for population-based diabetes research and clinical trials. The database contains over 1.1 million people with diabetes, mirroring the general population, allowing for more effective prevention and treatment strategies.
Researchers at Columbia University Medical Center have identified a brain receptor called Gpr17 that appears to play a central role in regulating appetite. Blocking the action of this protein, which is also found in humans, could lead to new drugs for preventing or treating obesity.
A study of nearly 200,000 individuals found daily low-dose aspirin use associated with increased risk of major gastrointestinal or cerebral bleeding. Patients with diabetes had high rates of major bleeding, irrespective of aspirin use.
Researchers at Joslin Diabetes Center found that cold exposure stimulates brown fat energy expenditure with fewer other systemic effects, suggesting a promising approach to treating obesity. The study disproves the use of ephedrine as a weight loss drug, which has side effects.
Scientists at EMBL have created a first complete atlas of RNA-binding proteins, revealing over 300 previously unknown proteins. This discovery opens new avenues for studying diseases such as diabetes and glaucoma, suggesting that gene mutations may affect RNA control rather than protein function.
A study found that over 8% of VA patients with diabetes may be over-treated, while 6% are under-treated. An individualized approach could help identify the right treatment plan for each patient.
A new study published in Obesity found a correlation between PCB exposure and increased distribution of body fat to the abdomen. Researchers analyzed data from over 1,000 70-year-olds and found that high levels of PCB189 were related to a high proportion of visceral fat.
Women referred to the telephone-based nurse management program had a lower risk of high baby birth weight and were more likely to have postpartum glucose testing, leading to earlier identification and management of postpartum glucose intolerance or diabetes. The study suggests that this program can improve outcomes for women with gesta...
A 34-year study found that Japanese-American men who did not eat foods rich in vitamin D had a higher risk of stroke later in life. Men with the lowest dietary vitamin D intake had a 22% increased risk of stroke, while those with the highest intake had a 27% lower risk.
The study found that kidney stone prevalence nearly doubled from 8.8% in 2007-2010 to 17.6% in 1994, with obesity and diabetes being key risk factors. Maintaining a healthy lifestyle and body weight can reduce the risk of kidney stones.
A study published in CMAJ found that excess maternal weight before and during pregnancy is a significant predictor of larger-than-average babies. Researchers analyzed data from 472 women and found that maternal glucose levels and lipid levels also play a role, but to a lesser extent.
Researchers at the University of Cincinnati have identified apolipoprotein A-IV (apoA-IV) as a promising target for a new diabetes treatment. The study found that apoA-IV improves insulin secretion and reduces blood sugar levels in mice with impaired glucose tolerance.
A study found that ACE2 is protective against diabetic complications in both lab models and human patients. High levels of ACE2 in vascular reparative cells prevent heart function decline and renal failure in diabetics.
Researchers have identified methylglyoxal as the culprit behind increased pain sensitivity in diabetics. The team proposes using small peptides to target and reduce MG activity, leading to a reduction in pain.
The TEAMcare program, a collaborative approach to managing chronic diseases like depression and diabetes, appears to pay for itself. After accounting for the program's $1,224 per patient cost, it may save as much as $594 per patient in outpatient costs.
A collaborative care intervention improved depression-free days and quality-adjusted life-years among adults with depression and poorly controlled diabetes. The intervention, which included team-centered care and nurse management, resulted in significant improvements in depression scores and quality of life.
A new study challenges traditional risk factors for contrast-induced nephrotoxicity, finding that patients with history of renal disease, hypertension, and heart disease are at greater risk. In contrast, diabetes is not a significant predictor of reduced renal function.
A study found that high-fat diets cause differences in gut flora between thin and diabetic mice, with certain bacteria linked to diabetes development. The research suggests that modifying the gut microbiota through dietary fibers may prevent metabolic diseases like diabetes.
A study published in Diabetes Care found that high levels of phthalate metabolites are associated with an increased risk of developing diabetes. The research, conducted among over 1,000 elderly individuals, suggests a connection between environmental chemicals and the development of type-2 diabetes.
Researchers at Brigham and Women's Hospital found that prolonged sleep restriction with simultaneous circadian disruption increases the risk of developing diabetes and obesity. This is because disrupted internal clocks can lead to poor insulin secretion and increased glucose concentrations in the blood.
A new study reveals that overweight pregnant women with mildly elevated blood sugar levels are at a higher risk of adverse pregnancy outcomes than previously thought. These women, who do not have gestational diabetes or obesity, carry significant risks for their health and the health of their babies.
A new study from Queen Mary University of London reveals that people with diabetes face numerous challenges in self-managing their condition, including social and environmental factors. The research highlights the need for healthcare professionals to better support patients in managing their disease.
Researchers have made a breakthrough in treating autoimmune diabetes using genetically modified gut bacteria, increasing the frequency of cured mice compared to traditional methods. The new approach has no adverse side effects and allows the immune system to function normally.
A new study found that 84% of female dialysis patients experienced sexual problems, which are often overlooked by clinicians. The study also highlighted the impact of various factors such as age, education level, and presence of depression on sexual dysfunction in these patients.
A study published in the Journal of Nutrition found that genetically-determined differences in salivary amylase activity influence blood glucose levels after starch consumption. Individuals with high salivary amylase activity tend to have lower blood glucose levels and may be better adapted to eat starch-rich foods.
A phase II study found metformin reduced fasting glucose, insulin levels and body mass index in men with prostate cancer. The medication also appeared to slow the growth rate of prostate cancer in a proportion of men.
Researchers found that inhibiting only mTORC1, a protein complex regulating growth and differentiation, prolongs life in mice without adverse effects on glucose tolerance or insulin sensitivity. This discovery may lead to the development of a drug specifically targeting mTORC1 to promote longevity while preventing diabetes.
Researchers found metformin increases heart-pumping capacity, reduces fat accumulation, and limits cell death in rats. Long-term effects suggest the medicine's benefits persist for a year or more.
A study by Penn researchers found that peer mentoring significantly improved glucose control in African American veterans with diabetes. The intervention, which included financial incentives, showed a statistically significant effect on improving HbA1c levels. The authors suggest that social support and camaraderie among veteran partic...
A Stanford researcher used an integrative 'omics' profile to discover and track his own type-2 diabetes onset, demonstrating the potential of personalized medicine. By analyzing his DNA, RNA, proteins, metabolites, and immune system responses, he was able to identify the disease early and make lifestyle changes to prevent further damage.
Researchers analyzed 100,000 molecular components from a patient's genome, revealing genetic risks and biomarkers for diseases. The study provides insights into the correlation between individual genetic profiles and environmental interactions in disease development.
A new research survey found that the Bangladeshi community in NYC experiences significant barriers to diabetes care, including low English proficiency and limited awareness. The study also showed a high willingness among respondents to participate in community health programs for prevention and care.
A study by Columbia researchers suggests that intestinal progenitor cells can be coaxed into producing insulin, offering a potential new treatment for type I diabetes. The technique involves knocking out the Foxo1 gene in these cells, which then produce functional insulin-producing cells.
The study demonstrated that XMetA markedly reduced elevated fasting blood glucose levels and normalized glucose tolerance in mice experimentally rendered diabetic. After six weeks of treatment, there was a statistically significant reduction in hemoglobin A1c levels in animals treated with XMetA compared to controls.
Scientists at the Diabetes Research Institute developed an oxygen-generating biomaterial to enhance insulin-producing cell survival. The material, PDMS-CaO2, generates critical oxygen for up to six weeks, mimicking the native pancreas environment.
Researchers found elevated levels of Toll-like receptors (TLRs) in individuals at risk for heart disease and diabetes, indicating a key role in the inflammatory response. The study suggests that suppressing TLR activity may be effective in treating these conditions, providing new insights into the development of metabolic syndrome.
Researchers found that women with pregnancy-related hypertensive disorders or diabetes may be at increased risk of cardiovascular disease later in life. Complications such as preeclampsia and gestational diabetes were linked to higher CVD risk factors, including fasting glucose and insulin levels.