Articles tagged with Endocrine Diseases
A new study links polycystic ovary syndrome (PCOS) to an increased risk of adverse cardiovascular events and pregnancy outcomes during delivery, including preeclampsia and peripartum cardiomyopathy. Women with PCOS are at a higher risk for heart complications compared to those without the hormone disorder.
The Endocrine Society's scientific statement highlights the potential of extracellular vesicles in diagnosing and monitoring endocrine-related conditions, including cancer. These tiny vesicles may also serve as biomarkers for high blood pressure and have therapeutic roles.
A new study published in PLOS ONE finds that high and very high cardiovascular risk are associated with depressive symptoms, especially in women. The researchers used data from a Mediterranean Diet trial and found that participants with higher cardiovascular risk had lower depressive status scores after following the diet.
Professor Elaine Dennison has been awarded the IOF Olof Johnell Science Award for her significant work in musculoskeletal aging, osteoporosis, and metabolic bone diseases. She is recognized as an internationally renowned clinician, researcher, and educator.
Researchers at Penn Medicine have discovered a new approach to treat solid cancers using CDH17CAR T cells, which selectively target and eliminate gastrointestinal (GI) solid tumors like gastric, pancreatic, and colorectal cancers in preclinical models. Unlike other immunotherapies, CDH17CAR T cells do not show toxicity to healthy tissues.
A UC San Diego study found that excessive neuropeptide secretion by neuroendocrine cells in the lungs can lead to fluid buildup and poor oxygenation in both infant lung disease and COVID-19. Blocking these neuropeptides may be an effective treatment for conditions marked by excess lung fluid.
Researchers found that high levels of anti-Mullerian hormone (AMH) may cause follicles to mature too quickly, leading to problems with ovulation and fertility in women with PCOS. AMH was previously thought to be a passive byproduct of the disorder.
A study led by Kyoto University researchers found that modulating hormone levels can improve meibomian gland disorder, a common cause of dry eyes. Topical administration of nicotinamide mononucleotide (NMN) boosted NAD levels and rebooted 3-HSD activity in mutant mice, alleviating dryness.
A systematic review and meta-analysis of six studies found that polycystic ovary syndrome affects 12.7% of girls with type 2 diabetes. The study suggests a higher prevalence of PCOS in pediatric patients with T2D, highlighting the need for early detection and management.
Researchers developed an optogenetic approach to control parathyroid hormone secretion and prevent secondary hyperparathyroidism-associated bone loss. The method partially attenuated SHPT-associated bone loss in animal models, suggesting its potential as a treatment for hyperparathyroidism-induced bone disease.
Researchers discovered that toxic goiter causes shrinkage in central brain regions, such as the hippocampus and amygdala, which can lead to mental symptoms. The study provides key insights for patients with Graves' disease, a common form of hyperthyroidism.
Researchers at Boston Children's Hospital have developed an organoid platform that identifies drugs that enhance enteroendocrine cell action, potentially reversing diabetes, obesity and gastrointestinal conditions. The system identified three chemicals that drive the formation of EE cells and hormone production.
A study published in Diabetes Care found that walking regularly at greater intensity and taking more steps can lower the risk of developing Type 2 diabetes among adults aged 65 and older. For every 1,000 additional steps per day, the risk is reduced by 6%, with a 12% reduction possible if an average adult takes 2,000 more steps daily.
Recent clinical and experimental data suggest that vascular calcification and bone loss share common pathophysiological mechanisms. The International Osteoporosis Foundation's new review elucidates the key associations between the two disorders.
A new mobile phone app called GrowthMonitor can accurately measure children's height and detect potential growth disorders, enabling early diagnosis and treatment. The app uses a traffic light system to inform parents of normal, amber, or red growth status, empowering them to take action.
A team of researchers has identified the KDM1A gene as responsible for a rare form of Cushing's Syndrome caused by abnormal expression of the GIP hormone. The discovery provides an early diagnosis tool and personalized medicine options, improving patient outcomes.
The Society for Endocrinology's annual conference will feature world-leading scientific and clinical research on endocrine clinical practice. The event will showcase the latest innovations in endocrine medicine, including Medal and Award lectures by renowned experts.
The American Academy of Otolaryngology - Head and Neck Surgery will present research on ear health, head and neck cancer, sleep-disordered breathing, and more at its annual meeting. Twelve 'Best of Orals' and 14 late-breaking scientific oral presentations will be showcased.
A recent study published in the New England Journal of Medicine found that within 15 years of a Type 2 diabetes diagnosis, 60% of participants had at least one diabetes-related complication. Lifestyle modification and approved medications are not enough to manage the disease, emphasizing the need for expanded treatment options.
Only 3% of patients with high blood pressure who are at risk for primary aldosteronism receive screening, a condition that can lead to heart and kidney complications. Researchers emphasize the importance of initiatives to encourage screening to prevent cardiovascular and kidney disease.
A review proposes eight hallmarks of environmental exposures that contribute to disease, including oxidative stress, genomic alterations, and endocrine disruption. Research is needed to understand the complex mechanisms by which pollutants affect human biology.
Extended follow-up data from the monarchE trial shows that abemaciclib continues to improve IDFS among high-risk, node-positive, early-stage, HR-positive, HER2-negative breast cancer patients. The addition of abemaciclib to standard adjuvant endocrine therapy reduces the risk of invasive disease by 25 percent.
The Endocrine Society's Clinical Practice Guideline emphasizes the importance of evaluating high cholesterol and triglycerides in adults with endocrine disorders. The guideline provides recommendations for managing lipid abnormalities and cardiovascular risk in patients with hypothyroidism, menopause, and Cushing's syndrome.
MIT researchers have developed a method to remotely control hormone release from the adrenal gland using magnetic nanoparticles, offering a less invasive alternative to existing treatments. The technique uses heat-sensitive ion channels to stimulate hormone production, potentially treating conditions such as PTSD and chronic pain.
A study published in the Journal of the Endocrine Society found that exercising women with menstrual disorders can start menstruating again by consuming an additional 300-400 calories a day. This strategy is easy to implement with the help of a nutritionist and avoids complications from drug therapy.
Research published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that teens with obesity and PCOS have an altered gut microbiome compared to those without the condition. This altered microbiome is associated with higher testosterone levels, metabolic complications, and other health risks.
Researchers use genomics to unravel a 20-year mystery of two rare disorders: Angelman syndrome and P450scc deficiency. By combining genetic tools, they confirm uniparental disomy and shed light on adrenal insufficiency and sex reversal. The study showcases the power of genomic analysis in solving complex genetic cases.
The Endocrine Society's Clinical Practice Guideline recommends long-term screening for growth disorders and pituitary hormone deficiencies in childhood cancer survivors who underwent radiation therapy. The guideline aims to detect endocrine disorders early and provide optimal patient care for this vulnerable population.
Scientists at Queen Mary University of London have successfully generated an artificial adrenal gland using cells derived from urine. The new approach uses reprogramming to create steroid-producing cells that can model adrenal diseases and test personalized treatments for patients with adrenal insufficiency.
Researchers have made significant strides in understanding equine laminitis, a painful condition affecting horses' hooves. The study's findings indicate that insulin regulation is the primary cause of the disease, leading to new diagnostic and treatment approaches.
The partnership brings together the Endocrine Society's expertise and Medscape's innovative digital platforms to equip physicians with timely and useful guidance on diagnosing and treating endocrine disorders. Experts will produce original features and share case studies on Medscape Consult, leveraging its crowdsourcing platform.
Individuals with binge-eating disorder have a 2.5-times increased risk of an endocrine disorder and a 1.9-times increased risk of a circulatory system disorder. The study highlights the importance of accurate screening and detection to improve treatment outcomes for those affected.
A new study from Karolinska Institutet found a significant link between maternal polycystic ovarian syndrome (PCOS) and autism spectrum disorders (ASD) in children. The study, which analyzed data from over 24,000 ASD cases and 200,000 controls, suggests that exposure to sex hormones early in life may play a role in the development of ASD.
Individuals with sex development disorders face challenges forming positive relationships due to physical differences. Researchers suggest raising public awareness of the diverse nature of bodies and providing practical support mechanisms, such as private locker rooms and support groups.
A study of 9,387 men with fertility issues found a correlation between poor semen quality and various health conditions, including hypertension and skin/endocrine disorders. The study suggests that treating male infertility may also benefit overall health.
The Endocrine Society suggests a single dose of IV zoldedronate as the first-choice treatment for Paget's disease. This option can put the condition into remission for up to six years, making it a preferred choice over oral medications with gastrointestinal side effects.
BioMed Central partners with the University of Michigan to launch an open-access journal focused on clinical research surrounding diabetes and endocrine diseases. The new journal aims to promote better care for patients by sharing new knowledge, both research and clinical, on various aspects of endocrine disorders.
A review of President John F. Kennedy's medical records reveals a complex medical history, including Addison's disease and hypothyroidism. Researchers now believe Kennedy may have had polyendocrine syndrome type II, a rare autoimmune disorder combining the two conditions.
A new rodent study found that Fetal Alcohol Spectrum Disorders and Autism Spectrum Disorder share common molecular vulnerabilities. Low-dose thyroxin treatment appears to alleviate some effects of alcohol exposure on offspring. The study suggests a potential biochemical marker for identifying children at risk for ASD.
A Northwestern University study found that male offspring of rat mothers who were given alcohol during pregnancy exhibit social impairment and altered levels of autism-related genes. Low doses of thyroid hormone thyroxin reversed social impairments and expression of these genes, suggesting a potential treatment target for both disorders.
Men with restless legs syndrome (RLS) have a nearly 40% increased risk of death compared to men without RLS. The study also found that the association dropped only slightly after adjusting for factors such as body mass index and lifestyle, indicating that RLS may lead to higher mortality rates independently of other known risk factors.
Researchers found that cured Cushing's disease patients who had depression when symptoms started were at elevated risk of mortality and cardiovascular disease. Men were more susceptible than women due to a lack of follow-up care, while patients with diabetes were also at higher risk of developing cardiovascular disease.
A study published in CMAJ found that women with PCOS taking combined oral contraceptives have a 2-fold increased risk of venous thromboembolism compared to matched controls. The risk is similar when expanding the definition of PCOS by including its symptoms and treatment.
A UC Irvine study found a 28% rise in physical ailments among those who watched the 9/11 attacks live on TV, while reports of doctor-diagnosed illness climbed by 18% in adults. The study highlights the impact of collective trauma on health.
A recent study found that women taking hormonal contraceptives were at highest risk for Female Sexual Dysfunction (FSD), while those using non-hormonal contraceptives had the lowest risk. The researchers also discovered a significant association between smoking status and total sexual function scores.
Research published in BMC Endocrine Disorders shows that regular high-intensity interval training can significantly improve insulin action and glucose clearance. A three-minute sprint workout every couple of days may be the best way to cut the risk of diabetes, with substantial improvements in metabolic prowess seen within two weeks.
Researchers have discovered that mice with a mutated version of the MECP2 protein exhibit high levels of corticosterone, a stress hormone linked to anxiety and other symptoms of Rett Syndrome. The study suggests that blocking receptors for corticotropin-releasing hormone may reduce anxiety in individuals with RTT.
Researchers found that bretylium tosylate, an old antiarrhythmic drug, prevents arrhythmias and reduces heart muscle damage after AMI. Blocking the sympathetic nervous system may be a key factor in its effectiveness.
The largest study on the prevalence of polycystic ovary syndrome (PCOS) in the United States found that approximately 6.6% of premenopausal women have PCOS, surpassing previous estimates. This significant increase may be due to a more representative sample size and improved diagnostic methods.
The study found that 82% of patients had polycystic ovary syndrome (PCOS), while 6.75% had specific identifiable underlying disorders. Combination hormonal therapy improved most symptoms, including hirsutism, acne, and menstrual dysfunction in 86%, 81%, and 80% of cases respectively.
A population study found that hypospadias was more than 20 times as common in boys whose mothers were exposed to DES during pregnancy. Research on exposure to DES may be relevant to current concerns about weaker oestrogens in oral contraceptives and other substances.
Researchers are recruiting women with premenstrual dysphoric disorder (PMDD) to participate in a study examining hormone levels and stress response. Participants will receive useful information about their illness and potentially contribute to more effective treatment for PMDD.
A University of Washington study links hormone replacement therapy to an increased risk of temporomandibular disorders (TMD) among women. Researchers discovered that post-menopausal women using hormone replacement therapy were over 70% more likely to suffer from TMD, while those taking oral contraceptives also showed a 20% higher risk.