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Teens with obesity and PCOS have more 'unhealthy' bacteria

Research published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that teens with obesity and PCOS have an altered gut microbiome compared to those without the condition. This altered microbiome is associated with higher testosterone levels, metabolic complications, and other health risks.

Using genomics to solve a 20-year case study

Researchers use genomics to unravel a 20-year mystery of two rare disorders: Angelman syndrome and P450scc deficiency. By combining genetic tools, they confirm uniparental disomy and shed light on adrenal insufficiency and sex reversal. The study showcases the power of genomic analysis in solving complex genetic cases.

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Up to half of childhood cancer survivors will develop hormone disorders

The Endocrine Society's Clinical Practice Guideline recommends long-term screening for growth disorders and pituitary hormone deficiencies in childhood cancer survivors who underwent radiation therapy. The guideline aims to detect endocrine disorders early and provide optimal patient care for this vulnerable population.

The first step in generating an artificial adrenal gland

Scientists at Queen Mary University of London have successfully generated an artificial adrenal gland using cells derived from urine. The new approach uses reprogramming to create steroid-producing cells that can model adrenal diseases and test personalized treatments for patients with adrenal insufficiency.

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Binge-eating disorder linked to other health conditions

Individuals with binge-eating disorder have a 2.5-times increased risk of an endocrine disorder and a 1.9-times increased risk of a circulatory system disorder. The study highlights the importance of accurate screening and detection to improve treatment outcomes for those affected.

Link between PCOS in the mother and autism in the child

A new study from Karolinska Institutet found a significant link between maternal polycystic ovarian syndrome (PCOS) and autism spectrum disorders (ASD) in children. The study, which analyzed data from over 24,000 ASD cases and 200,000 controls, suggests that exposure to sex hormones early in life may play a role in the development of ASD.

Sex development disorders affect the mind as well as the body

Individuals with sex development disorders face challenges forming positive relationships due to physical differences. Researchers suggest raising public awareness of the diverse nature of bodies and providing practical support mechanisms, such as private locker rooms and support groups.

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Could novel drug target autism and fetal alcohol disorder?

A Northwestern University study found that male offspring of rat mothers who were given alcohol during pregnancy exhibit social impairment and altered levels of autism-related genes. Low doses of thyroid hormone thyroxin reversed social impairments and expression of these genes, suggesting a potential treatment target for both disorders.

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Men with restless legs syndrome may be at higher risk of early death

Men with restless legs syndrome (RLS) have a nearly 40% increased risk of death compared to men without RLS. The study also found that the association dropped only slightly after adjusting for factors such as body mass index and lifestyle, indicating that RLS may lead to higher mortality rates independently of other known risk factors.

Cardiovascular risk may remain for treated Cushing's disease patients

Researchers found that cured Cushing's disease patients who had depression when symptoms started were at elevated risk of mortality and cardiovascular disease. Men were more susceptible than women due to a lack of follow-up care, while patients with diabetes were also at higher risk of developing cardiovascular disease.

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Regular sprint boosts metabolism

Research published in BMC Endocrine Disorders shows that regular high-intensity interval training can significantly improve insulin action and glucose clearance. A three-minute sprint workout every couple of days may be the best way to cut the risk of diabetes, with substantial improvements in metabolic prowess seen within two weeks.

Apple MacBook Pro 14-inch (M4 Pro)

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New findings may lead to treatment for anxiety in Rett Syndrome

Researchers have discovered that mice with a mutated version of the MECP2 protein exhibit high levels of corticosterone, a stress hormone linked to anxiety and other symptoms of Rett Syndrome. The study suggests that blocking receptors for corticotropin-releasing hormone may reduce anxiety in individuals with RTT.

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Scientists seek women who suffer from PMS

Researchers are recruiting women with premenstrual dysphoric disorder (PMDD) to participate in a study examining hormone levels and stress response. Participants will receive useful information about their illness and potentially contribute to more effective treatment for PMDD.

Hormones May Place Women At Greater Risk For Facial Pain

A University of Washington study links hormone replacement therapy to an increased risk of temporomandibular disorders (TMD) among women. Researchers discovered that post-menopausal women using hormone replacement therapy were over 70% more likely to suffer from TMD, while those taking oral contraceptives also showed a 20% higher risk.