Articles tagged with Endocrine Diseases
Regular moderate coffee or caffeine intake is associated with a lower risk of new-onset cardiometabolic multimorbidity. The study found that moderate consumption could play an important protective role in almost all phases of CM development.
A deadly marine cone snail's venom contains a toxin that interacts with human cells in a specific manner, regulating blood sugar levels and hormone balance. This discovery may lead to the design of more effective drugs for treating diabetes and endocrine disorders.
Scientists have developed a new compound, ZTA-261, which selectively binds to the thyroid hormone receptor beta (THRβ) to treat lipid disorders. Mice administered the drug showed decreased lipid levels in the liver and blood with fewer side effects compared to existing compounds.
Research reveals TRPV4 complex promotes sweat secretion in mouse foot pads, suggesting its potential role in human perspiration. The study also suggests that TRPV4 may regulate friction forces, which could impact traction on hind paws.
A new global definition of sarcopenia is proposed, aiming to unify research and clinical practice. The definition may help identify low muscle mass or strength in older people, increasing the risk of poor outcomes such as fragility and disability.
The IOF position paper emphasizes the need for population-specific vitamin D approaches, considering factors like diet, skin pigmentation, and supplement use. The authors also highlight the importance of standardized measures of 25(OH)D in future studies.
Researchers found that patients wearing a brain-tracking headband while meditating experienced improved physical functioning and reduced body pain after surgery. The MUSE-2 device provides audio biofeedback to aid meditation.
Research reveals a three times greater risk for metabolic-dysfunction-associated steatotic liver disease in women with moderate-to-severe vasomotor symptoms compared to those with mild symptom severity. The study highlights the importance of addressing hot flashes and night sweats to assess cardiovascular health.
Researchers found that GLP-1 receptor agonists and SGLT-2 inhibitors lower the risk of major cardiovascular events, such as heart attacks, and severe liver complications compared to other diabetes treatments. These medications also showed no significant increase in severe adverse events.
Research presented at ENDO 2024 found that older women with low bone density are more likely to experience their first hip fracture in their 60s. A study analyzing NHANES data revealed a significant increase in osteoporosis, but surprisingly, a decrease in fragility hip fractures between 60-70 years.
A study found that patients with thyroid eye disease who received teprotumumab infusions maintained efficacy 51 weeks after treatment. Nearly two years later, 82% of patients did not require additional treatment for their condition.
A new study found that children who are sedentary for more than six hours a day have a significantly increased risk of severe fatty liver disease and liver cirrhosis by young adulthood. Engaging in light-intensity physical activity for at least 3 hours a day can reverse premature liver damage.
Researchers at UCSF have identified laryngeal and tracheal neuroendocrine cells that sense water and acid in the upper airway, triggering a cough reflex. The discovery could lead to interventions to prevent pneumonia and treat certain types of chronic cough.
The International Osteoporosis Foundation (IOF) and ESCEO presented awards to 20 young investigators from 16 countries for their outstanding research abstracts. The awards recognize the researchers' contributions to the prevention, diagnosis, and treatment of osteoporosis and related musculoskeletal diseases.
The International Osteoporosis Foundation has presented the prestigious IOF President’s Award to Professor Peter Ebeling AO in recognition of his longstanding contributions to advancing the work of the IOF. He is an internationally renowned expert in bone health, with a total of over 536 peer-reviewed publications and a h-index of 93.
The World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases will showcase new clinical research from over 1507 submitted abstracts. The event will offer valuable knowledge to help clinicians treat patients more effectively in their daily practice.
Researchers at Kyushu University identified a new type of tumor cell population, steroids-producing nodules (SPNs), which lead to cortisol-producing adenomas. The study provides clues into the formation and maintenance of the human adrenal cortex.
Researchers found a strong bidirectional relationship between premenstrual disorders and perinatal depression among over 900,000 women. Women with perinatal depression were more likely to develop premenstrual disorders after pregnancy and childbirth.
Healthcare providers must prioritize patient experience to improve diabetes care. This includes explaining treatment options and considering each patient's level of health literacy and cultural background.
A retrospective study found that PRRT was effective in controlling hypoglycemia in 81% of patients with malignant insulinomas, enabling 58% to reduce medication use. The treatment resulted in improved symptom control and reduced potential drug side effects for over 80% of patients.
Polycystic ovarian syndrome (PCOS) affects 10% of females, causing infertility, miscarriage, and pregnancy complications. Effective management includes weight loss support, hormonal contraceptives, and nonhormonal medication like metformin.
A novel imaging approach has been shown to accurately identify sub-types of primary aldosteronism, an adrenal gland disorder. The technique provides a clearer picture of the adrenal glands, helping doctors decide whether surgery is necessary.
A new study published in the Journal of the Endocrine Society estimates that chemicals in plastics contribute to various diseases and disabilities in the US, resulting in significant healthcare costs. The study found that $67 billion is attributed to phthalate exposure, while PFAS exposure leads to $22 billion in health costs.
The Cre-LoxP system's specificity is compromised due to non-specific promoters driving Cre expression, leading to inaccurate results. This limitation requires careful consideration for proper interpretation of experimental outcomes.
A new study has found that most patients with osteoporosis want to receive information on their fracture risk, but only half of them actually get it. Patients prefer visual representations, such as graphs with a colored traffic-light system, to communicate fracture risk and are more likely to take medication if presented in this way.
A new study found pediatric endocrinologists are concerned about threats to their personal safety and the impact of transgender health bans on medical practice. The researchers surveyed 223 pediatric endocrinologists, with 56% providing gender-affirming care, and identified safety concerns, pressures on hospitals, and threats against p...
Researchers found that AI/ML based programs can successfully detect PCOS with an accuracy of 80-90%, making it a promising tool for early diagnosis and reducing the burden on patients. The study suggests integrating large population-based studies with electronic health datasets to identify sensitive diagnostic biomarkers.
Researchers at the University of Chicago developed a potential new PCOS treatment using mesenchymal stem cell-derived extracellular vesicles, which can lower androgen hormone activity and stabilize ovarian function. This approach offers a better safety profile and potential for wide-scale applications compared to conventional methods.
Women with polycystic ovary syndrome (PCOS) who follow a keto diet for at least 45 days may experience significant weight loss and improvements in reproductive hormone levels. Lower testosterone levels can also help reduce excess hair growth and other symptoms associated with PCOS.
Researchers discovered that aging alters the pancreas's circadian rhythm by reorganizing its transcriptome. The study found that fibroblasts play a crucial role in regulating this reorganization, which affects the organ's resilience to aging-related pathologies.
Researchers from Tokyo Medical and Dental University successfully generated functional parathyroid glands from mouse embryonic stem cells using blastocyst complementation. This breakthrough study demonstrates the potential for regenerating organs in vivo and provides a new treatment option for hypoparathyroidism.
The Capture the Fracture Partnership has successfully driven global Fracture Liaison Services implementation, effectiveness, and sustainability. The partnership's unique approach, including policy, coalitions, mentorship, and scalable solutions, has delivered impactful resources and activities to prioritize secondary fracture prevention.
A team of UVA Health experts warns that surgeon-scientists are struggling to obtain research funding, which could lead to a decline in innovations for patients. The researchers found that internal medicine trainees are six times more likely to secure R01 grants and career development awards.
A new study reveals that preoperative hydroxyprogesterone administration can improve disease-free and overall survival in patients with node-positive breast cancer by modulating cellular stress response and negative regulation of inflammation. Non-coding RNAs, such as DSCAM-AS1, play a regulatory role in this process.
A new special issue of Calcified Tissue International & Musculoskeletal Research explores how the skeleton functions as both a secretory organ and an endocrine target tissue. Researchers discuss key avenues in this area of research, including deciphering hormone messages encoded in bone cell secretory products.
A new wearable device can track adrenal steroid levels in real-time, providing insights into hormonal rhythms and revolutionizing endocrine disease diagnosis. The U-RHYTHM technology offers a more accurate picture of hormone balance than traditional tests taken at one point, enabling earlier treatment interventions.
Research presented at ENDO 2023 found women with PCOS died 47% earlier than those without the condition. They were also at higher risk for deaths due to cardiovascular disease, tumors, diabetes, and lung infections.
Researchers at Nagoya University have discovered that targeting Fusobacterium bacteria can reduce the formation of lesions associated with endometriosis. The study suggests an effective non-hormonal antibiotic treatment for this gynecological disorder, which affects one in ten women between 15 and 49 years old.
A study of 48,320 Japanese patients with type 2 diabetes found that 10.5% achieved remission per 1,000 person-years, with factors such as HbA1c levels, BMI reduction, and sex significantly associated with remission. Those who relapsed had longer durations of diabetes, lower BMI at baseline, and lower BMI reduction over time.
Researchers have demonstrated a clinically relevant oxytocin deficiency in patients with vasopressin deficiency, which could lead to new therapeutic approaches for conditions like autism.
A study of over 43,000 adults found that parathyroidectomy has no estimated effect on long-term kidney function in older adults. However, early treatment may preserve kidney function in patients younger than 60 years old.
The BIAL Award in Biomedicine is a prestigious international award that recognises outstanding biomedical research. The €300,000 prize is given to researchers whose work has shown exceptional quality and scientific relevance, published within the last ten years.
A UC Riverside study found that fathers exposed to chemicals in plastics can affect the metabolic health of their offspring for two generations. Paternal DCHP exposure led to high insulin resistance and impaired insulin signaling in F1 offspring, while F2 offspring showed weaker effects.
A team from the University of Pennsylvania led by Kotaro Sasaki coaxed stem cells to take on the characteristics and functions of a human adrenal gland. The researchers developed an organoid culture system to direct iPSCs to transition into adrenocortical progenitor-like cells, resulting in cells producing steroid hormones.
Children born to mothers with gestational diabetes and obesity are twice as likely to develop attention-deficit/hyperactivity disorder (ADHD), according to a new study. The researchers found that excessive weight gain during pregnancy was a significant risk factor for ADHD in offspring, but not within normal weight gain ranges.
The ISM Annual Meeting highlights new topics in oral, vaginal, skin, and gut microbiota, as well as their metabolites and potential implications in diseases like cancer, depression, and stroke. The meeting aims to explore the mechanism behind microbiota efficacy and its potential application in precision medicine.
A new study links polycystic ovary syndrome (PCOS) to an increased risk of adverse cardiovascular events and pregnancy outcomes during delivery, including preeclampsia and peripartum cardiomyopathy. Women with PCOS are at a higher risk for heart complications compared to those without the hormone disorder.
Untreated primary hyperparathyroidism increases the risk of hip fracture by 51% and heart attack or stroke risk by 45%. Surgical removal of parathyroid glands significantly reduces these risks. The study highlights the importance of identifying patients with this hormonal disease and considering cardiovascular risk in surgery decisions.
The Endocrine Society's scientific statement highlights the potential of extracellular vesicles in diagnosing and monitoring endocrine-related conditions, including cancer. These tiny vesicles may also serve as biomarkers for high blood pressure and have therapeutic roles.
A new study published in PLOS ONE finds that high and very high cardiovascular risk are associated with depressive symptoms, especially in women. The researchers used data from a Mediterranean Diet trial and found that participants with higher cardiovascular risk had lower depressive status scores after following the diet.
Professor Elaine Dennison has been awarded the IOF Olof Johnell Science Award for her significant work in musculoskeletal aging, osteoporosis, and metabolic bone diseases. She is recognized as an internationally renowned clinician, researcher, and educator.
Researchers at Penn Medicine have discovered a new approach to treat solid cancers using CDH17CAR T cells, which selectively target and eliminate gastrointestinal (GI) solid tumors like gastric, pancreatic, and colorectal cancers in preclinical models. Unlike other immunotherapies, CDH17CAR T cells do not show toxicity to healthy tissues.
A UC San Diego study found that excessive neuropeptide secretion by neuroendocrine cells in the lungs can lead to fluid buildup and poor oxygenation in both infant lung disease and COVID-19. Blocking these neuropeptides may be an effective treatment for conditions marked by excess lung fluid.
Researchers found that high levels of anti-Mullerian hormone (AMH) may cause follicles to mature too quickly, leading to problems with ovulation and fertility in women with PCOS. AMH was previously thought to be a passive byproduct of the disorder.
A study led by Kyoto University researchers found that modulating hormone levels can improve meibomian gland disorder, a common cause of dry eyes. Topical administration of nicotinamide mononucleotide (NMN) boosted NAD levels and rebooted 3-HSD activity in mutant mice, alleviating dryness.
A systematic review and meta-analysis of six studies found that polycystic ovary syndrome affects 12.7% of girls with type 2 diabetes. The study suggests a higher prevalence of PCOS in pediatric patients with T2D, highlighting the need for early detection and management.
Researchers developed an optogenetic approach to control parathyroid hormone secretion and prevent secondary hyperparathyroidism-associated bone loss. The method partially attenuated SHPT-associated bone loss in animal models, suggesting its potential as a treatment for hyperparathyroidism-induced bone disease.
Researchers discovered that toxic goiter causes shrinkage in central brain regions, such as the hippocampus and amygdala, which can lead to mental symptoms. The study provides key insights for patients with Graves' disease, a common form of hyperthyroidism.
Researchers at Boston Children's Hospital have developed an organoid platform that identifies drugs that enhance enteroendocrine cell action, potentially reversing diabetes, obesity and gastrointestinal conditions. The system identified three chemicals that drive the formation of EE cells and hormone production.
A study published in Diabetes Care found that walking regularly at greater intensity and taking more steps can lower the risk of developing Type 2 diabetes among adults aged 65 and older. For every 1,000 additional steps per day, the risk is reduced by 6%, with a 12% reduction possible if an average adult takes 2,000 more steps daily.