Articles tagged with Epilepsy
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The SynGAP Research Fund has awarded grants to Dr. Clement Chow to advance therapeutic development for SYNGAP1-Related Disorders. His research uses drug repurposing to identify compounds like N-acetyl-L-leucine as potential treatments.
Scientists have discovered a long non-coding RNA called CHASERR that regulates the production of the CHD2 gene, which is associated with neurodevelopmental disorders. The study found that patients with a deletion of this RNA had excessive CHD2 protein production, leading to severe intellectual delays and other symptoms.
A new scoring system helps doctors predict which patients will likely become seizure-free after minimally invasive epilepsy surgery. The model is based on eight clinical factors and has been shown to outperform other predictive models in predicting seizure freedom.
Researchers have developed a novel gene therapy approach that targets and breaks down faulty ribonucleic acids in the KCNA2 gene, which is associated with recurring seizures. The therapy has shown promise in reducing excessive neuron activity linked to epilepsy.
Researchers have developed a lab-grown spine model that can test the effects of valproic acid on fetal development. The study found that co-treatment with Rapamycin can prevent the negative effects of valproic acid, enabling women to take life-saving medication while having healthy children.
Researchers have uncovered a shared genetic basis for bipolar disorder type I and epilepsy, identifying 1,300 genetic variants influencing both conditions. The study suggests that mood stabilizers may be effective in treating both illnesses, and could lead to personalized medicine approaches.
Researchers identify a homozygous SPAG9 gene mutation associated with intellectual disability, progressive cognitive decline, and heterogeneous brain abnormalities. The study provides a unique model for understanding disruptions in cellular transport mechanisms leading to neurodevelopmental and degenerative brain conditions.
Researchers found lamotrigine to reduce stiffness in non-dystrophic myotonias by around the same amount as mexiletine, offering a new treatment option. The trial results have direct implications for patient care and provide more 'real-world' options for patients with this life-changing muscle disorder.
A cohort study found a significant association between maternal influenza infection during pregnancy and an increased risk of childhood seizures. The study suggests that maternal influenza may affect childhood neurological development, particularly for febrile seizures, but not epilepsy.
Researchers developed a shape-morphing cortex-adhesive sensor to monitor brain activity during tFUS stimulation, enabling real-time adjustments and suppressing seizures. The innovative device overcomes challenges in existing cortex-interfacing devices, providing stable and accurate monitoring.
A new Northwestern Medicine study identifies critical language connector sites in the cerebral cortex that work together to produce language. These sites serve as connectors between subnetworks of people, serving a similar function for language in the brain.
Scientists at Kyoto University's Institute for Integrated Cell-Material Sciences have discovered a protein complex that regulates phospholipid scrambling, a process important for blood clotting and unwanted cell removal. The finding could lead to new treatments for diseases like epilepsy and anemia.
A study published in Brain Communications found that heatwaves can trigger more seizures in individuals with severe epilepsy. Researchers used intracranial electroencephalography to track brain activity during heatwaves and non-heatwave periods, revealing a significant increase in seizure frequency during hot weather.
Researchers will combine stem cell therapy with brain-computer interfaces to restore function to patients with brain damage. The goal is to create bidirectional connections between cultured brain cells and the living human brain.
A new algorithm has been developed to improve the accuracy of intracranial EEG data, which is critical for diagnosing and treating epilepsy. The Automated Bad Channel Detection (ABCD) algorithm demonstrated higher accuracy than human raters, particularly in identifying channels with high-frequency noise.
Seoul National University researchers developed a biodegradable electronic tent technology that enables non-invasive brain disease diagnosis using a needle. The device unfolds to cover the entire brain over a large area and naturally decomposes in the body after diagnosis, minimizing side effects.
Researchers at St. Jude Children's Research Hospital have discovered DNA methylation patterns that help identify the root cause of developmental and epileptic encephalopathies, a condition affecting 1 in 590 children. The findings provide a new tool for diagnosing children with DEE and could lead to more effective treatments.
A major new study by Karolinska Institutet has found that women with epilepsy are four times more likely to die during pregnancy and their babies have a 50 percent higher risk of illness or death. Despite the high relative risks, most pregnancies for women with epilepsy go well.
A study published in Nature found that propofol can restore the function of mutated HCN1 ion channels, which are associated with certain types of epilepsy. The researchers suggest using propofol to treat these conditions or designing new compounds with similar effects but reduced side effects.
Viji Santhakumar, a UCR professor, has been awarded a $3.5 million NIH grant to study brain circuit function and its impact on memory formation and cognitive deficits in diseases like epilepsy and Alzheimer's disease.
A study reveals that sexual and gender minority adults in the US have a higher risk of developing epilepsy due to unique biological and psychosocial factors. The findings highlight the need for protected access to medical care for this population.
A team of UCSF specialists predicts 24-hour seizure risk using brain activity patterns that foreshadow seizures. The discovery may improve quality of life for 2.9 million Americans living with epilepsy.
A team of researchers has developed light-activated compounds that can inhibit nerve signals locally and on demand, offering a potential treatment for neuropathic pain. The compounds, which are activated by amber-colored light, show photopharmacological activity in animal models.
Researchers from PSI and ETH Zurich studied connexin-36 gap junction channels and found that antimalarial drug mefloquine binds to the channels, potentially explaining its severe side effects. The study provides new insights into how drugs interact with connexins and may lead to the development of therapies for neurological diseases.
Researchers at Colorado State University used human stem cells to study synaptic connections in the brain, focusing on GABAergic synapses. They found that Gephyrin promotes autonomous assembly of these synapses, which can develop independently of neuronal communication. This understanding could lead to new treatments for neurological d...
The study found teleneurology to be highly acceptable across various neurological diagnoses, including headache and movement disorders. Patients with additional medical conditions showed increased satisfaction with the telemedicine service.
Researchers have developed procedures for using gold nanostars to perform more efficient, conformal, and safe laser ablations for treating brain tumors. This technique addresses limitations in traditional LITT by providing improved precision for lesions greater than 3 cm or with complex shapes.
A class of existing high blood pressure drugs appears to reduce adults' risk of developing epilepsy, with a 20-30% lower risk found among those taking angiotensin receptor blockers. Researchers hope these findings lead to randomized clinical trials to confirm the association.
Scientists at Johns Hopkins Medicine have discovered the mechanism of action of the widely-used epilepsy drug perampanel, which targets the AMPA receptor to dampen brain cell excitability. The study provides new insights into the potential applications of perampanel in treating other neurological conditions such as Alzheimer’s disease,...
Researchers at the University of Rochester Medical Center found that ketones can rescue impaired neuronal function in the hippocampal network. This study suggests a potential therapeutic approach for preventing or delaying neurodegenerative diseases like Alzheimer's.
A new study published in Neurology found that taking newer epilepsy medications during pregnancy does not affect a child's creativity. However, the study suggests that adjusting doses to reach an optimal balance between controlling seizures and minimizing negative effects on the developing child may be necessary.
Researchers used flicker stimulation to treat patients with treatment-resistant epilepsy, reducing IEDs in the brain and modulating brain waves. The study found that flicker can induce gamma oscillations in mice and has potential implications for Alzheimer's disease and other neurological disorders.
A study published in Nature Communications found that sharp-wave ripples in the hippocampus are associated with vivid, imaginative self-generated thoughts and less pleasurable states. This link may have implications for understanding conditions such as autism, attention deficit disorder, and happiness/well-being.
FutureNeuro, a leading SFI Research Centre, is expanding its research programme with a focus on diagnostics, therapeutics, and digital health. The centre aims to develop precision diagnostics, future treatments, and systems using real-time health data.
A UCL-led team of researchers warn that climate change will aggravate brain conditions such as stroke, migraine, and dementia. The study, which reviewed 332 papers, found that extreme temperatures and weather events can disrupt sleep, exacerbate cognitive impairment, and lead to increased hospital admissions and mortality.
The guideline provides recommendations on the effects of antiseizure medications and folic acid supplementation on malformations at birth and child development during pregnancy. It recommends minimizing tonic-clonic seizures and using medications like lamotrigine, levetiracetam, or oxcarbazepine to minimize risk of major birth defects.
New research emphasizes the importance of integrated care for children with epilepsy and co-occurring psychiatric conditions. The study reveals that fragmented care can lead to negative outcomes, including disjointed treatment plans and inadequate seizure control.
A recent study in Saudi Arabia assessed the effectiveness of an educational program improving epilepsy care among caregivers. The intervention showed a significant decrease in knowledge gaps, with 23.2% having sufficient knowledge post-intervention compared to 60% before.
A new study reveals that pediatric emergency departments miss signs of epilepsy in two-thirds of cases. Nonmotor seizures, which cause 'zones out' behavior, are often overlooked due to similarities with anxiety and panic attacks.
A study published by NIH/NINDS found that low oxygen levels while sleeping and sleep apnea are linked to late-onset epilepsy in older adults. People with nocturnal hypoxia were three times more likely to develop late-onset epilepsy, independent of other medical issues.
Researchers identified a spectrum of effects on sodium channel function due to SCN2A variants, with hyperactive channels linked to early seizure onset and underactive channels associated with autism. The study provides insights into the relationship between genetic changes, disease severity, and age of seizure onset.
A flexible microdisplay device can track and display neural activity in the brain, allowing neurosurgeons to visualize critical cortical boundaries and guide surgical interventions. The device reduces the need for a buffer zone, enabling more precise removal of harmful tissue.
Astrocyte activity starts approximately 20 seconds before epileptic neuronal hyperactivity, suggesting their role in triggering seizures. Researchers found that blocking metabolic activity of astrocytes reduces the magnitude of epileptic neuronal hyperactivity.
Researchers at the University of Basel discovered a molecular pathway that helps balance neural excitation and inhibition in the brain. This balance is crucial for preventing neurodevelopmental disorders like epilepsy, and understanding this process may lead to new treatments.
A large-scale animal study reveals that brain pH and lactate levels are a common feature across various neuropsychiatric conditions, including schizophrenia, bipolar disorder, autism, depression, epilepsy, and Alzheimer's disease. Changes in brain energy metabolism are linked to cognitive impairment, particularly working memory.
Researchers discovered that only a small percentage of neurons are activated in epileptic brains, which can lead to permanent changes and impaired cognition. Early intervention with an experimental treatment within 48 hours after the first seizure may prevent these long-term changes.
A new study from Harvard T.H. Chan School of Public Health finds that prenatal exposure to antiseizure medication topiramate does not increase the risk of autism spectrum disorder (ASD) among children. In contrast, valproate has been linked to a heightened risk of ASD.
A recent study by Boston Children's Hospital researchers found that activity in the dentate gyrus helps keep us focused on our environment when our mind wanders. This neural activity also aids in forming memories.
A study identifies a genetic mutation underlying KCNQ2 encephalopathy, a rare and devastating form of epilepsy. The research reveals key mechanisms by which the disorder manifests in patients, including suppression of normal gene function and altered protein distribution.
Researchers have developed a new method to trigger and image seizures in epilepsy patients, allowing for real-time data collection to tailor epilepsy surgery. This method is clinically feasible, convenient, and spares resources, providing valuable information for successful surgeries.
A new treatment has been shown to reduce mental health difficulties in children with epilepsy compared to standard care. The Mental Health Intervention for Children with Epilepsy (MICE) treatment uses a modular approach to treat multiple conditions simultaneously, reducing the likelihood of psychiatric disorders by 40%.
A new study led by Swansea University found that people with epilepsy had a significantly higher risk of COVID hospitalizations and deaths during the pandemic. Researchers analyzed data from 27,000 people with epilepsy in Wales and compared them to a control group of 135,000 without epilepsy.
Scientists trained AI models on brain activity data from mice to detect hippocampal ripples, a biomarker of memory, epilepsy, and Alzheimer's disease. The model toolbox can be applied to non-human primate and human data with similar recording techniques.
Dr. Ryyna Ethell's lab at UC Riverside has been awarded a $2.4 million NIH grant to investigate the role of astrocytes in inhibitory synapse development and their connection to neurodevelopmental disorders like ADHD and autism.
Researchers found that participants had an average of 31% fewer seizures when they had seizure dogs, with seven participants achieving a 50-100% reduction. Seizure dogs are trained to recognize seizure activity and provide companionship during the seizure subsides.
Researchers have found that inhibitory neurons play a more critical role in the pathogenesis of STXBP1 disorder. The study's findings suggest that reducing functional STXBP1 protein in GABAergic inhibitory neurons has a more significant impact on symptoms, including early lethality and developmental delay.
Scientists have found a new treatment target for CDKL5 deficiency disorder, one of the most common types of genetic epilepsy. By boosting another enzyme's activity, they may be able to compensate for the loss of CDKL5 and potentially treat some effects on the brain in early development.
The updated guidelines provide 52 recommendations that span services including inpatient evaluation, therapeutic options, and outpatient chronic disease management. A multidisciplinary approach is also emphasized to coordinate different specialists.
A Michigan Medicine-led study found that patients with functional seizures have a death rate almost 2.5 times higher than expected, comparable to epilepsy and serious mental health conditions. The study highlights the need for improved access to holistic, multidisciplinary treatment for functional neurological disorders.
A new teaching module aims to improve health equity for infants with infantile spasms by educating front-line providers. The module includes short lectures and videos illustrating the condition and ensures prompt treatment.