Articles tagged with Heart Failure
Researchers at ISGlobal and Oxford University found that heart failure is a pathogenic mechanism in severe malaria, leading to higher mortality rates. The study identified four clusters of patients with respiratory distress and severe anaemia, where liver size increase was associated with higher mortality.
Researchers at MUSC and Ohio State University have discovered an unexpected mechanism that underlies cardiomyopathy in DMD. Inhibiting NF-κB normalizes calcium handling and significantly increases calcium gene expression, leading to improved heart function.
The COMMANDER HF trial found that rivaroxaban did not significantly reduce the risk of death, myocardial infarction, or stroke in patients with recent worsening of chronic heart failure and coronary artery disease. Rivaroxaban was associated with a lower rate of nonfatal stroke, but a higher risk of major bleeding compared to placebo.
Researchers found that reducing secondary mitral regurgitation in heart failure patients did not improve survival or symptoms, suggesting the procedure is futile. Despite successful procedure completion, there was no significant difference in primary endpoint outcomes between intervention and medical treatment groups.
A study published in the European Heart Journal reveals that microvascular dysfunction is a prevalent underlying disease mechanism in patients with heart failure and preserved ejection fraction. The research highlights the importance of identifying patients at risk and developing targeted therapies to improve outcomes.
A new study published in Circulation found that oxygen therapy for patients with suspected heart attacks does not reduce the risk of developing heart failure or dying. The study, conducted at 35 Swedish hospitals, involved over 6,600 patients and showed no significant difference in survival rates or complications.
The study found that state Medicaid expansions under the Affordable Care Act led to a decline in uninsured hospitalizations for major cardiovascular events. Cardiovascular disease is a leading cause of death in the US, and this study examined the association between Medicaid expansion and changes in uninsured hospitalizations.
A new study found significant correlations between blood levels of EPA plus DHA omega-3s and cognitive depression in heart failure subjects. The study also showed improvements in social functioning and a positive correlation between the Omega-3 Index and reduced cognitive depression scores.
Researchers at Temple University Health System have identified four BAG3 gene variants linked to poor outcomes in African American patients with dilated cardiomyopathy. The variants facilitate programmed cell death and reduce autophagy, leading to worsening heart failure.
A study led by Adam Wende found an underlying mechanism that reprograms the hearts of patients with ischemic cardiomyopathy, altering cellular remodeling and metabolism. The researchers identified epigenetic changes that encode a 'metabolic plasticity' in failing hearts, which may repair the ischemic and failing heart.
Researchers at Hiroshima University have found a genetic marker that indicates when a person with a fast heartbeat is at high risk of developing tachycardia-induced cardiomyopathy (TIC) and eventual heart failure. This discovery could lead to earlier diagnosis and treatment of the condition, reducing the risk of cardiac damage or death.
A clinical trial called GutHeart Trial examines the relationship between gut bacteria and heart failure, testing antibiotic, probiotic yeast, or no treatment on patients with heart failure. The study aims to develop new treatment strategies and better understand how gut leakage affects inflammatory processes and heart failure.
A recent study found that 8.3% of trastuzumab-treated patients developed heart failure, highlighting the need for cardiac monitoring in high-risk breast cancer patients. The study also showed a consistent increase in heart failure risk with age, emphasizing the importance of prioritizing cardiac monitoring for younger patients.
Researchers used heart imaging technology to study hearts of pregnant women with severe preeclampsia, finding higher contraction pressures in right ventricles and abnormal relaxation rates. This led to overwork and poor pumping ability, increasing risk of heart failure, stroke, and heart attack.
A UCLA-led study found that many people with heart failure do not receive recommended medications, and when prescribed, they are often at lower-than-recommended doses. The research highlights the need for new strategies to improve medication dosing and outcomes for people with heart failure.
A new study found that UVA's Hospital-to-Home program significantly improves survival and other outcomes for heart failure patients while saving money. The program slashed mortality rates by 41% and reduced hospital readmissions by 24% compared to non-participants.
Patients taking ritonavir-boosted protease inhibitors may experience worsening heart failure and cardiovascular death compared to those on non-protease-inhibitor regimens. The study found a doubled risk of hospital readmission within 30 days and increased cardiovascular death within two years.
A drug currently in clinical trials for treating Parkinson's disease shows promising effects on strengthening heart contractions in dogs and rabbits. The new compound works differently than current drugs, suggesting its use may be a safer way to increase heart contraction strength without the risk of dangerous complications.
A $1.54 million NIH grant will support research on modifying troponin T to improve cardiac function in heart failure. The study aims to develop a new approach for treating this condition by targeting the physiological modification of cardiac troponin T.
A study of over 90,000 patients found women's heart failure mortality is higher and hospitalization rates have increased in women compared to men. The research highlights sex differences in heart failure outcomes, care delivery, and access in Ontario.
A new population study in Sweden has found that genetic heritage is the dominant factor when it comes to heart failure in families. The study, led by Magnus Lindgren, found a 45% higher risk of heart failure in adoptees with at least one biological parent suffering from the condition.
Researchers have identified how a new treatment in mice can regenerate the heart after a heart attack by promoting growth of lymphatic vessels and clearing immune cells. This approach showed significant reduction in damaged heart muscle and improved recovery of pumping function.
Patients with heart failure experiencing symptoms of depression and anxiety are at higher risk for progressive heart disease and adverse outcomes. Psychotherapy may offer advantages over medications as a treatment option for these patients.
Researchers used human stem cells to restore heart function in monkeys with heart failure, finding that new muscle tissue had grown within damaged regions and restored heart function. The study suggests a potential treatment approach for people with heart failure.
Researchers highlight tragic case of baby Noah's death due to vitamin D deficiency and advocate for simplified guidance, mandatory monitoring, and food fortification. Current UK recommendations are deemed outdated and overly complex, putting dark-skinned individuals at risk.
Women are largely underrepresented in clinical trials of heart failure medications, with limited evidence on their efficacy. Precision medicine may lead to more effective medications by incorporating sex-aware randomized clinical trials.
A new study from MIT and Harvard University introduces the 'Therepi' device, which attaches directly to damaged heart tissue to deliver multiple therapies. The device addresses issues with current drug delivery methods, providing a non-invasive solution for treating heart disease.
Permanent His-bundle pacing bypasses iatrogenic left bundle-branch block caused by conventional RV pacing, maintaining or restoring ventricular synchrony. This technique is beneficial for patients with bradycardia or conduction system abnormalities.
A new cardiac pump device has been found to minimize cost of care over time for heart failure patients, with a 51% reduction in re-hospitalization rates and significant cost savings compared to the standard device.
Researchers found that higher protein intake from most sources was associated with a slightly higher risk of heart failure, with the greatest increase seen for animal-based proteins. The study suggests that moderating protein intake may be beneficial in preventing heart failure, but further research is needed.
A new study by the American Heart Association found that high protein diets may be associated with a small increased risk of heart failure in middle-aged men. The study followed 2,441 men over an average of 22 years and found that those who consumed more protein had a slightly higher risk of developing heart failure.
A new study in Circulation presents evidence that fluid redistribution from the abdominal compartment to the heart and lungs may cause heart failure. The study used splanchnic nerve block to demonstrate this phenomenon in patients with acute heart failure, improving symptoms such as shortness of breath.
Researchers at Duke University Medical Center have discovered a potential new way to treat fluid buildup in heart failure by shutting off the spigot causing it. The procedure improved symptoms in five acute heart failure patients and showed significant reductions in pressures inside the heart and increases in cardiac output.
Researchers have discovered a genetic link between alcohol consumption and heart failure, specifically in individuals with a faulty titin gene. The study found that even moderate amounts of alcohol intake can worsen the condition by reducing heart output in patients with dilated cardiomyopathy caused by the faulty gene.
A population-based study in Gothenburg, Sweden identifies BMI change during puberty as a potential novel risk factor for adult heart failure in men. Boys who were normal weight at 8 years of age and became overweight during puberty were three times more likely to be diagnosed with heart failure as adults.
A new study published in the Journal of the American Heart Association found that social isolation in patients with heart failure can lead to a higher risk of death and hospitalization. The research, which surveyed over 1,600 patients with heart failure, revealed that those who reported high levels of social isolation were 3.7 times mo...
The study found that Medicaid expansion was associated with a decline in ICU admission rates among patients with ambulatory-care sensitive conditions. Rates of uninsurance and Medicaid coverage increased significantly in expansion states, suggesting improved access to care.
A recent study by Kaiser Permanente found that hospitalized patients with acute kidney injury have a 44% higher relative risk of heart failure within one year of discharge compared to those without acute kidney injury. This increased risk highlights the importance of monitoring for signs of heart failure in these patients.
A new algorithm developed by UCLA researchers more accurately predicts which people will survive heart failure and for how long. The algorithm provides significantly better predictions than current methods, allowing doctors to make personalized assessments and potentially reduce healthcare costs.
A new study reveals that acute kidney injury (AKI) is associated with a higher risk of cardiovascular events, particularly heart failure, in patients even after discharge from the hospital. Researchers found that AKI was linked to an 18% increased risk of composite outcomes including heart failure and atherosclerotic events.
A study of 138 VA medical centers found wide variations in mortality rates for patients with ischemic heart disease and chronic heart failure. Mortality rates ranged from 5.5% to 9.4% for ischemic heart disease and 11.1% to 18.9% for chronic heart failure.
A study of over 11,000 American adults found that increasing physical activity to recommended levels over six years in middle age significantly decreases the risk of heart failure. Conversely, a decrease in physical activity during this period is linked to an increased risk of the disorder.
Researchers uncover clue to disease process development by identifying novel way to control innate immune response, which may translate to treatments for conditions such as atherosclerosis, autoimmunity, and heart failure. Animal studies support finding, showing mice with mutated sNASP proteins are more susceptible to septic infection.
Researchers have identified protein clumping in the hearts of mice and people with heart failure, suggesting a potential link between the two conditions. The team used non-invasive PET scans to visualize the clumps, which could lead to advances in monitoring disease progression and testing new therapies.
Researchers at Cedars-Sinai will compare evidence-based approaches for treating depressive symptoms in people with advanced heart failure, aiming to improve quality of life and outcomes. The study is part of a larger effort to address the significant challenge of treating depression in heart failure patients.
The MitraClip device has demonstrated improved echocardiogram measurements and six-minute walk test outcomes, with significant reductions in left ventricle volume and NYHA classification. The study also showed substantial improvement in quality of life outcomes for patients with mitral valve regurgitation.
Researchers found mice with induced heart failure fared better after being treated with antibiotics for five weeks, which sterilized the gut. This suggests that modulating the microbiota could modulate T cell activation and changes in the heart that lead to heart failure.
Researchers present a case study of an asymptomatic patient with severe mitral regurgitation who underwent successful repair. The study emphasizes the importance of timely intervention to avoid irreversible left ventricular dysfunction and improve patient outcomes.
Smoking has been linked to an increased risk of developing heart failure in African Americans, with hospitalizations for heart failure nearly three times more likely among current smokers. The study found that smoking a pack or more per day for 15 years was associated with twice the risk of heart failure compared to non-smokers.
Research published in the journal Heart found that eating several servings of nuts per week may lower the risk of atrial fibrillation and heart failure. The study, which tracked over 61,000 Swedish adults for 17 years, found a strong association between nut consumption and reduced risk of these cardiovascular conditions.
Researchers used an experimental therapy to block fibronectin protein, reducing scarred muscle tissue and saving mouse models from heart failure. The treatment restored function in damaged heart cells and reduced fibrosis.
A new study published in The Lancet found that regular drinking above the recommended UK guidelines for alcohol could take years off one's life. Drinking more than 5 drinks per week was linked to a higher risk of stroke, fatal aneurysm, heart failure, and death.
Having multiple chronic illnesses plus functional limitations increases the risk of death among older adults with heart failure. The study found that those who had other chronic conditions or problems performing daily activities had a similar risk for hospitalization or emergency room visits.
Researchers have identified a new therapeutic target, OMA1, which protects cardiomyocytes from death and deterioration in heart function when the heart is under stress. Inhibition of OMA1 prevents heart failure in models of chronic tachycardia, hypertension, and myocardial ischemia with cardiac hypertrophy.
Research articles explore associations between comorbidities, symptoms, and patient-rated health in heart failure patients. Patterns of multimorbidity were identified, with poorer clinical outcomes observed in certain groups, highlighting the need for comprehensive approaches in phenotyping patients with heart failure.
Researchers developed a new healthcare model to address both cardiovascular and non-cardiovascular comorbidities in heart failure patients. The study found that non-cardiovascular conditions had a greater burden on patients' quality of life, highlighting the need for an individualized treatment approach.
Researchers found that bariatric surgery significantly reduces the risk of heart disease events in severely obese teens. The study predicts a 4% risk of heart disease events after one year of surgery, compared to an 8% risk prior to surgery.
A multi-institutional study validated age-based NT-proBNP diagnostic cutoff levels for diagnosing acute heart failure in patients seen at hospital emergency departments. The study found that a level below 300 strongly excluded a heart failure diagnosis, and the results were consistent across all groups of participants.
A study published by the British Heart Foundation found that premature hearts are less able to cope with exercise, leading to increased risk of heart failure. Researchers compared the heart function of adults born prematurely to those carried to term and discovered a significant difference in blood leaving the heart during exercise.
Researchers at UAB identified a therapeutic target to prevent or delay heart failure by blocking early infiltration of macrophages into the heart. Macrophage targeting may also reduce inflammation and T-cell expansion in patients with pressure-overload hypertrophy.