Research on heart failure and its treatment. Covers light exposure, heart-in-a-dish models, microRNA therapy, and surgical interventions.
A nationwide cohort study in Korea found that frequent tooth brushing reduced the risk of atrial fibrillation and heart failure by 10% and 12%, respectively. The study suggests a potential mechanism: reducing bacteria in the subgingival biofilm, which can prevent translocation to the bloodstream.
A new Yale study found a clear association between neurohormonal blockade therapy and increased survival and quality of life for patients with left ventricular assist devices. The study, which analyzed over 12,000 patients, showed a 56% survival rate for those taking NHB therapy compared to 43.9% for those not on the medications.
Researchers developed an AI algorithm based on electronic health records data that accurately predicted life expectancy for heart failure patients, achieving an 88% success rate. The model identified eight readily available variables to determine low- and high-risk of death, providing valuable insight for informed medical decisions.
Researchers developed a novel bionic pacemaker that reads breathing signals to speed up and slow down the heart. This approach increases heart efficiency by 20% within two weeks, offering new hope for heart failure treatment.
Researchers found that patients who stopped using meth experienced a 43% improvement in their heart's pumping ability, while those who continued to use the drug saw a 4% worsening. These findings suggest that addressing meth abuse can lead to significant improvements in heart failure treatment.
Several high-impact clinical trials have yielded promising results, including the ATHENA trial showing azathioprine to be as effective as mycophenolate mofetil in preventing chronic kidney rejection, and the NOBILITY trial demonstrating that obinutuzumab improves kidney health in patients with lupus nephritis. Additionally, a phase 3 s...
Patients who underwent metabolic surgery had a lower risk of developing systolic heart failure and dying from recurrent myocardial infarction compared to those without surgery. The study found significant cardiovascular benefits of metabolic surgery, emphasizing its potential as part of the treatment plan for patients with severe obesi...
Researchers have identified HIPK2 as a novel regulator of heart failure progression. The kinase was found to play a critical role in maintaining cardiac function, with its deletion leading to progressive deterioration and apoptosis in heart muscle cells.
Kaiser Permanente research identifies a national trend of increasing deaths due to heart failure among US seniors, with over 647,000 people dying from heart disease in 2017. The study highlights the importance of addressing heart health in older adults as the population continues to age and grow.
Patients who self-identified as black, Latinx, female or over the age of 75 were less likely to be admitted to cardiology service despite heart failure diagnosis. The study highlights racial inequities in access to specialized care, which may contribute to disparities in readmissions and outcomes.
A study published in the Journal of Applied Physiology found that exercise can reduce artery stiffness associated with heart failure. Regardless of intensity level or duration, any type of physical activity was beneficial for heart health compared to no exercise at all.
Researchers at the University of Arizona have shown that Aliskiren, a FDA-approved drug, can delay the progression of congestive heart failure and lengthen survival rates in properly identified patients. The study used non-invasive technology to evaluate changes in muscle mass and fluid retention over time.
Researchers found that overweight individuals had the lowest mortality risk among those with established heart failure, contrary to previous expectations. The 'obesity paradox' suggests that obese patients may tolerate disease-modifying and prognostic medications better than non-obese patients.
Researchers at Queen Mary University of London used AI to analyze 17,000 healthy UK Biobank volunteers' heart MRI images, finding genetic factors account for 22-39% variation in left ventricle size and function. The study identified 14 genome regions associated with heart structure and function.
A new study published in The Journal of Thoracic and Cardiovascular Surgery found that hearts from donors with acute stress-induced cardiomyopathy can be safely transplanted without affecting recipient outcomes. This breakthrough could lead to a significant increase in the supply of donor hearts, estimated at 20-30%.
A study found that Asian patients with low body mass index (BMI) and high waist-to-height ratio (WHtR) have worse heart failure outcomes. The 'lean-fat' subgroup had the highest risk of composite events and worst quality-of-life scores.
Researchers have successfully recorded and processed data from 43 patients with heart failure using a machine learning-based ballistocardiogram (BCG) scale. The device measures circulation pulsing to detect worsening heart failure symptoms, potentially sparing patients hospital stays.
Research suggests dapagliflozin can reduce death and hospitalization rates in patients with heart failure, as well as improve health-related quality of life. The study found a 26% reduced risk of primary outcome in the dapagliflozin group compared to placebo, with benefits seen in both patients with and without type 2 diabetes.
A new study developed a machine-learning derived model that can predict future heart failure among patients with diabetes. The WATCH-DM risk score is based on 10 variables, including weight, age, and diabetes control, and identifies patients at high risk of heart failure.
Researchers at CNIC discover strategies to inhibit kinase GSK3? in mice with ARVC5, reducing fibrosis and improving heart function. The study aims to translate the results to patients and investigate gene therapy strategies for potential cure.
Researchers are conducting a national trial to identify transthyretin cardiac amyloidosis (ATTR-CM) in older minority patients with congestive heart failure. The goal is to use highly sensitive heart imaging and blood tests to diagnose the disease earlier, potentially leading to better patient outcomes.
Patients with diabetes are at greater risk of developing heart failure after a heart attack, with a 56% higher risk compared to those without diabetes. The study also found that diabetic patients who develop heart failure have a much higher risk of dying in the following years.
A new study suggests that heart failure care must address patients' broader health to improve survival rates. The research found that while the risk of death from cardiovascular causes declined, non-cardiovascular deaths increased, highlighting the need for a more holistic approach.
A new study from the European Society of Cardiology reveals that heart failure patients have a high likelihood of developing dementia-type brain lesions, similar to those found in stroke patients. The study also suggests a link between heart failure and an increased risk for dementia.
Treatment with sacubitril/valsartan significantly improves cardiac structure and function in patients with reduced ejection fraction heart failure. The drug's neprilysin inhibition also reduces blood levels of biomarker NT-proBNP, associated with lower risk of death and hospitalization.
A small study found a 30% increased likelihood of developing heart failure in patients with malaria infection. The researchers identified 3,989 malaria cases and followed up with the patients for 11 years, revealing 69 cases of heart failure.
The PARAGON-HF trial found that sacubitril-valsartan reduced hospitalizations for heart failure in lower ejection fraction patients, but not overall; women and those with ejection fractions 45-57% showed benefits.
Researchers developed a tiny wearable camera to track heart failure patients' daily activities, providing valuable data for fine-tuning self-management. The study found that the cameras could identify areas for improvement in diet, exercise, and medication adherence, with potential applications for guiding newly diagnosed patients.
A novel disease mechanism links circulating DPP3 to cardiac and renal dysfunction, with sustained high DPP3 levels associated with reduced cardiac function, impaired kidney function, and increased mortality. The DPP3 biomarker has high potential utility in diagnosing organ dysfunction and predicting outcomes in cardiogenic shock patients.
Procizumab shows high therapeutic potential in treating acute heart failure and cardiogenic shock by targeting the DPP3 enzyme. The company is setting up GMP process for Procizumab manufacturing and expects to enter regulatory non-clinical safety studies next year.
A new study published in The BMJ found that SGLT2 inhibitors, commonly used for type 2 diabetes, reduce the risk of heart failure by 34% compared to another type of diabetes drug. The study also showed a 20% lower risk of death among patients taking SGLT2 inhibitors.
A study of nearly 8,800 individuals found that quitting heavy smoking lowers the risk of cardiovascular disease within five years, but this benefit diminishes after 10 to 15 years compared to never-smokers. The analysis suggests a long-term risk premium for former smokers, limiting the generalizability of findings
Research reveals insomnia is tied to a higher risk of coronary artery disease, heart failure, and ischemic stroke. Genetic variants for insomnia were found to be associated with significantly higher odds of these conditions, emphasizing the importance of addressing sleep disorders.
Researchers at Medical College of Georgia have identified a chemical that can improve communication between the body's smallest blood vessels and larger vessels, which is crucial for delivering oxygen to the heart muscle. By blocking an enzyme that inhibits this chemical, they found that it can reduce diastolic heart failure symptoms.
A new study found that female offspring of women with polycystic ovary syndrome have an increased risk for developing cardiac dysfunction. Researchers linked maternal androgen excess and continuous exposure to male hormones during fetal life as contributing factors.
Researchers at UT Health San Antonio found that higher doses of spironolactone can prevent dialysis in selected heart failure patients who are not responding to conventional diuretics. The study showed significant improvement in urine output and breathing, suggesting potential for avoiding dialysis
Researchers at UTA and UT Southwestern are studying the mechanisms of exercise intolerance in heart failure patients with preserved ejection fraction (HFpEF) to develop personalized therapies. They aim to identify common characteristics among HFpEF patients based on cardiac, pulmonary, and skeletal muscle limitations.
A global study of 12 million people found diabetes increases the risk of heart failure, with a significant increase for women. Women with type 1 diabetes have a 47% greater excess risk of heart failure compared to men, highlighting the need for sex-specific research.
Pierre will explore a new Na/K-ATPase/Src pathway to limit cardiac dysfunction in hopes of developing new therapeutic interventions. The study aims to test two distinct interventions in both acute and chronic phases of myocardial infarction.
A new study finds that diabetes confers a greater excess risk of heart failure in women than men, with type 1 diabetes associated with a 47% higher risk. The study suggests several potential explanations for this difference, including sex differences in diabetes management and cardiovascular risk factors.
A global study of 12 million people found that diabetes significantly increases the risk of heart failure, with women at greater risk than men. Type 1 and type 2 diabetes both pose a stronger risk for women, highlighting the need for sex-specific research into diabetes and its impact on heart health.
A study using Veterans Affairs data found that patients with heart failure have a higher risk of death and complications after undergoing noncardiac surgery. The researchers compared over 355,000 patients with and without heart failure to identify these risks.
A large health insurance database analysis reveals people living with HIV have a significantly higher risk of heart failure and stroke. Researchers found a 3.2-times increased risk of heart failure and 2.7-times increased risk of stroke in those living with HIV compared to uninfected individuals.
Researchers found that methylmercury increases cardiac fragility by removing an inhibitory brake on Drp1, a protein involved in mitochondrial fission. Treatment with a polysulfide group-releasing compound reversed this effect, suggesting a possible strategy to mitigate cardiotoxicity.
Researchers at Stanford University School of Medicine have created a map of gene activity and connectivity as the heart shuts down. The study identified PPP1R3A as a central regulator in heart failure, linked to metabolism of glucose within cells.
A new study found that cardiac resynchronization therapy with defibrillator (CRT-D) may improve heart function in certain groups of heart failure patients, particularly those with nonspecific intraventricular conduction delay (NICD) and a QRS duration of more than 150 milliseconds. In these patients, CRT-D was associated with decreased...
A recent study found that over half of relapsed multiple myeloma patients treated with carfilzomib experienced cardiac issues during treatment. The study recommends routine monitoring with natriuretic peptide testing to mitigate this risk.
Research published by the American Heart Association found that pre-treated patients with off-label selective vasodilator drugs are more likely to develop right-sided heart failure after LVAD implantation, increasing their risk of worse outcomes.
The American Heart Association and the Heart Failure Society of America issue a statement on managing both conditions, highlighting lifestyle modifications and multidisciplinary care teams. The guidelines emphasize the importance of coordinated treatment to improve patient outcomes.
A survey shows a wide variation in UK heart failure care, with some areas having fewer than seven nurses per 1,600 patients. Many services lack administrative support and mental health professionals, despite updated guidelines recommending best practice for diagnosis and management.
A new blood test that measures multiple proteins could provide a more accurate diagnosis of heart failure, allowing for earlier treatment and improved outcomes. Researchers are now collecting further samples to confirm the accuracy of this protein-based test.
A recent study by Dr. Ganesh Halade and colleagues found that lipoxygenase deficiency delays heart failure progression and improves survival in mice. The researchers discovered that epoxyeicosatrienoic acids facilitate cardiac healing after a heart attack, reducing diabetes risk biomarkers and altering plasma metabolic signaling.
A study found that elderly patients with heart failure who visit a pharmacist weekly are more likely to take their medications and be active, resulting in improved quality of life. The intervention increased adherence by 86% compared to usual care.
Patients with stable chronic heart failure can safely discontinue diuretics without increased dyspnoea or reuse of the medication. The ReBIC-1 trial found no significant differences in symptom relief between patients who stopped and those who continued taking furosemide.
Patients with chronic heart failure are more likely to adopt lifestyle advice when accompanied by family members, according to a new study. The study found that nearly 48% of patients did no physical activity and 25% never adhered to fluid restrictions.
A new study reveals that women undergoing fertility treatment are at a higher risk of peripartum cardiomyopathy (PPCM), a life-threatening condition. PPCM affects about one in 1,000 pregnant women worldwide and is characterized by an enlarged and weak heart, leading to symptoms such as shortness of breath and swelling.
A study found that biomarkers like midregional proadrenomedullin and bio-adrenomedullin can predict mortality risk in acute heart failure patients. Patients with these biomarker levels above the median had significantly lower survival if not receiving diuretics at discharge.
Researchers found that being an occupant in a motor vehicle accident increases the risk of heart failure or stroke in older adults. The study used U.S. and Danish hospitalization data to confirm these findings.
Researchers identified a protein called gravin as key to regulating beta-adrenergic receptor expression on heart cells. Elevated adrenaline levels in heart failure desensitize receptors, reducing heart function. Researchers seek to develop treatment targeting this mechanism.
A novel therapeutic approach occluding the superior vena cava shows promise in reducing pressure and volume in heart failure patients. The treatment improves cardiac filling pressures and function without affecting systemic blood pressure or output.