JAK-STAT signaling keeps leukemia cells alive
Researchers have found that leukemia cells resist apoptosis due to constitutive activation of STAT3 and/or STAT1. AG-490, a JAK inhibitor, promotes apoptosis in these cells by blocking STAT3 function.
Leukemia
Articles tagged with Leukemia
Dietary bioflavonoids induce DNA breaks, may contribute to infant leukemia
Researchers found that 10 out of 20 bioflavonoids tested caused breaks in the MLL gene, which is a key player in about 80% of infant leukemias. The study suggests that high dietary intake of bioflavonoids could cause DNA damage and potentially trigger leukemia.
SourceUniversity of Chicago Medical Center·JournalProceedings of the National Academy of Sciences·DateApr 10, 2000
Molecular markers may help to redefine relapse for leukemia patients
A study using polymerase chain reaction detects MRD in long-term CML survivors, finding that approximately 25% of patients had evidence of disease at some time after transplant. The team aims to identify patients who appear cured but may still harbor disease and benefit from early therapeutic intervention.
Magnetic field exposure associated with childhood leukemia
Researchers at the University of Toronto found a strong association between magnetic field exposures in residences and the risk of developing childhood leukemia. Children exposed to higher levels of magnetic fields were two to four times more likely to develop leukemia, with risks highest for those diagnosed before age six.
Hutch Director Dr. Lee Hartwell To Share His Vision Of Biotechnology In The 21st Century At BIO '99 Meeting
Dr. Lee Hartwell, president of the Fred Hutchinson Cancer Research Center, will join four biotechnology leaders in discussing the future of biotechnology. They will address topics such as new methods for diagnosing diseases like lupus and leukemia, and the potential impact on drug development.
Newly Discovered Viral Gateway Into Cells Could Play Role In Diagnosis And Treatment Of Leukemia, HIV And Other Viral Diseases
Researchers at Oregon Health Science University have uncovered a mechanism used by certain leukemia viruses to attach themselves to cell surfaces and sneak into cells. They've also developed a rapid cloning method for human genes encoding viral receptors, which could lead to new treatments for viral diseases.
SourceOregon Health & Science University·JournalProceedings of the National Academy of Sciences·DateFeb 1, 1999
Scientists Induce A Form Of Leukemia In Mice, Gaining An Unprecedented Glimpse Into The Disorder's Roots
Researchers at Brandeis University have induced a form of chronic myelogenous leukemia (CML) in mice, allowing them to study its molecular mechanisms and potential treatments. The breakthrough could lead to the development of new therapies for CML, which affects one-fifth of all leukemia patients.
University of Kentucky Markey Cancer Center Researchers Awarded Grant To Fight Leukemia Recurrence
Researchers aim to prevent leukemia relapse by educating the immune system using immunotherapy and genetically modified cells. The new technology could eliminate second rounds of chemotherapy, reducing toxicity and hospital stays.
OHSU Scientists Begin Human Trials Of A Drug Aimed At The Underlying Cause Of Chronic Myelogenous Leukemia
Oregon Health & Science University scientists begin human trials of a targeted drug therapy for chronic myelogenous leukemia, aiming to eliminate leukemia cells with a faulty gene. The investigational drug has shown success in destroying BCR-ABL cells in mice and animal trials.
Memorial Sloan-Kettering Investigators
Researchers at Memorial Sloan-Kettering Cancer Center have identified a combination of drugs that can induce leukemia cells to mature and behave like normal blood cells. By targeting genetic changes underlying acute promyelocytic leukemia, the team developed a novel 'transcription therapy' approach that may improve treatment for other ...
90% Leukemia Cure Rate Said Possible As International Meeting Of Research Leaders Convenes
Top researchers gathered at St. Jude Children's Research Hospital to discuss breakthroughs in acute lymphoblastic leukemia (ALL) treatment, aiming for improved cure rates and reduced side effects. Rearrangement of the ETV6/TEL gene is associated with favorable treatment outcomes, enabling safer alternatives to radiation therapy.
Science Article: Abnormal Gene Transcription And Acute Leukemia
Researchers at St. Jude Children's Research Hospital have discovered a novel leukemia-producing transcription factor called E2A-HLF, which transforms immature lymphocytes by preventing normal destruction programs. This finding provides a potential window into understanding leukemias that result from altered survival signals.
New Cancer Switch Discovered By Duke Medical Center Pharmacologists
Researchers identify a molecular 'safety key' that normally regulates cell growth, and discovering how it can be disrupted to trigger cancer. The team found a protein called Abi-2 that fits into the normal enzyme cABL, keeping it turned off, and proposes a new way to treat cancers by targeting this molecular pathway.