Articles tagged with Myeloid Leukemia
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Researchers have discovered novel combinations of targeted therapies and chemotherapy regimens that improve survival outcomes for patients with historically poor-prognosis leukemia. These findings, presented at the American Society of Hematology Annual Meeting, offer new hope for elderly and aggressive genetic mutation patients.
The investigational drug AG-120 has demonstrated 'extremely promising' early phase 1 clinical trial results for patients with acute myeloid leukemia (AML) harboring IDH1 mutations. This finding builds on previous phase 1 results of a related drug, AG-221, and offers hope for the treatment of this high-risk population.
A novel study by Singapore researchers found that an increase in the Leo1 gene affects genes directly implicated in acute myelogenous leukaemia (AML), increasing cancer incidence. Inhibition of Leo1 and downstream signalling pathways offer a targeted treatment approach.
A team of researchers has identified 5-lipoxygenase as a target for therapeutic management of stem cell-like cells in acute myeloid leukemia. Inhibiting this enzyme selectively attacks and eliminates leukemic stem cells in both cell culture models and mouse models, suggesting a promising approach for treating the disease.
Moffitt Cancer Center's phase 3 study shows CPX-351 leads to higher remission rates compared to standard options in AML, offering a new game-changer for treatment. The innovative drug combination works by maintaining an optimal ratio of cytarabine and daunorubicin inside lipid vesicles.
Researchers at Ohio State University found that microRNA-3151 promotes AML-cell growth and survival by blocking tumor-suppressor gene TP53. High expression of miR-3151 is associated with a bad prognosis, while inhibition with the drug bortezomib offers a possible therapy.
Dr. John F. DiPersio is recognized for his work on experimental sequencing of cancer genomes, personalized medicine, and stem cell transplantation. He will present a lecture on graft-versus-host disease vs. graft-versus-leukemia.
Researchers at UT Health Science Center identified a key role of the WTAP protein in AML development and found that suppressing it with Hsp90 inhibition greatly suppressed proliferation and induced differentiation. This discovery opens up new avenues for effective therapies for children and adults with newly diagnosed AML.
Researchers at Dana-Farber Cancer Institute found that the normal enzyme SYK pairs with mutated FLT3 to promote AML progression and resistance to treatment. Combination therapy involving SYK and FLT3 inhibitors showed significant promise in treating AML.
A study by Einstein researchers identified a chemical 'signature' in blood-forming stem cells that predicts which AML patients will respond to chemotherapy. The findings, based on nearly 700 patient data, could help physicians identify patients who would benefit from standard treatment and spare them debilitating side effects.
Researchers found that methylation patterns in acute myeloid leukemia patient samples were prognostic for overall survival. A novel biomarker for lysosomal storage disorders was also identified by correlating relative acidic compartment volumes with clinical severity.
A genetically engineered mouse model has demonstrated the potent oncogenic role of mutant IDH2 protein in acute myeloid leukemia. The study provides a new tool for evaluating the pharmacological efficacy of potential mutant IDH2 inhibitors and confirms the relevance of this protein as a therapeutic target.
Researchers at Columbia University Medical Center found a single mutation in osteoblasts can cause AML in mice and nearly 40% of patients with the disease. The mutation leads to cancer in adjacent bone-marrow stem cells through signaling pathways.
The EORTC-GIMEMA AML-12 Trial found that high-dose cytarabine improved outcomes for adult patients with acute myeloid leukemia, especially those younger than 46 years. High-dose treatment resulted in higher remission and survival rates compared to standard-dose treatment.
Researchers used genetic information from fruit fly studies to develop a therapeutic strategy that stops an aggressive form of leukemia in laboratory models. They found that targeting microRNAs can significantly improve current therapies for acute myelogenous leukemia, a deadly disease with poor prognosis.
Researchers discovered Sox4 as a potential therapeutic target and histone deacetylase inhibitors as candidates in the treatment of AML. The studies also found that targeting Sox4 effectively perturbs major leukemogenic phenotypes and reactivates expression of genes responsible for blocking growth of healthy blood cells.
A study led by St. Jude Children's Research Hospital found that combining gemtuzumab ozogamicin with conventional chemotherapy improves the outcome of bone marrow transplantation for some children with high-risk acute myeloid leukemia. The treatment helped eliminate minimal residual disease, leading to better patient survival rates.
The EORTC/GIMEMA 06012 trial found sequential combination of gemtuzumab ozogamicin (GO) and standard chemotherapy has no benefit for older patients with acute myeloid leukemia. GO is too toxic for patients over 70 years old, whereas younger patients may potentially benefit from such treatment.
Researchers from Cincinnati Children's Hospital Medical Center found that inhibiting RUNX1 protein could be a promising therapeutic strategy for acute myeloid leukemia. The study suggests that blocking this protein may stop the development of leukemia cells, offering potential new treatment options.
Researchers found that cancer cells are putting healthy stem cells to sleep, preventing them from forming new blood cells. This discovery offers a potential new approach to treating Acute Myeloid Leukaemia (AML), which affects around 2,500 people in the UK each year.
A new liposomal formulation of anthracycline-based chemotherapy has shown promising results in treating pediatric leukemia patients, with high survival rates and minimal heart toxicity. The treatment regimen was found to be effective at higher-than-standard doses without causing added cardiotoxicity.
Researchers have identified nearly all major genetic mutations that drive acute myeloid leukemia (AML), a fast-growing blood cancer. The study paves the way for developing personalized treatment plans based on a patient's genetic profile.
Two studies from The Cancer Genome Atlas program reveal genomic landscapes of AML and endometrial cancer, providing new insights into molecular underpinnings. The studies identify four novel tumor subtypes in endometrial cancer and show genomic similarities with other types of cancers.
Researchers at Cedars-Sinai Medical Center discovered that the renin angiotensin system plays a fundamental role in hypertension. They found that mice without ACE in their kidneys were resistant to high blood pressure, indicating that targeting angiotensin production may be an effective approach to treat hypertension. In contrast, stud...
Researchers at RIKEN have identified a compound that could be used to prevent relapse in acute myeloid leukemia patients, particularly those with the FLT3-ITD mutation. The compound targets human primary AML stem cells and reduces AML cell counts in mouse models.
Kantarjian's contributions to leukemia treatment have improved survival rates from 50% to 90% with BCR-ABL inhibitors. His work also led to standardization of combination therapies and FDA approval for ruxolitinib, a treatment for myelofibrosis.
Researchers at the University of Minnesota have identified a genetic variation in CD33 that significantly affects the clinical outcome of AML patients who received gemtuzumab ozogamicin chemotherapy. This discovery may help predict which patients are most likely to benefit from the treatment and improve therapeutic efficacy.
Researchers present promising results from a Phase II study on quizartinib, a targeted therapy that may turn treatment-resistant leukemia into manageable conditions. The study shows great potential in turning fatal disease subtypes into chronic conditions with regular treatment.
A Phase II clinical trial found that over a third of high-risk leukemia patients responded to the experimental new drug quizartinib, experiencing complete remission and potentially life-saving bone marrow transplants. Many participants who did well with the drug had failed to respond to prior therapies.
A new study finds that a reduced intensity conditioning regimen before marrow transplant significantly boosts disease-free survival rates among older AML patients. With a rate of 39%, this approach outperforms traditional methods in preventing relapse and improving patient outcomes.
In pre-clinical experiments, Angiocidin reduced acute myeloid leukemia (AML) cells by almost two-thirds, demonstrating its potential as a safer treatment alternative to standard-of-care chemotherapy agents like Ara-C. The protein also stimulated maturation in affected white cells, causing them to behave like normal cells.
Researchers found that a specific genetic marker, WT1 SNP rs16754, is correlated with improved outcomes and reduced treatment-related mortality in pediatric patients with AML. The study suggests personalized cancer treatment may improve survival and reduce toxicity by considering individual genetic makeup.
Researchers have discovered that lithium restores cognitive function in Down syndrome mice, while stem cell-derived dopaminergic neurons improve motor defects in Parkinson's disease monkeys. Additionally, inhibiting a key protein in Alzheimer's disease may reduce plaque formation and improve memory tasks. Moreover, tempering inflammati...
A study published in the Journal of Clinical Investigation found that a transcriptional regulator called C/EBPG was highly expressed in AML samples with an epigenetically silenced C/EBPA gene. By blocking this epigenetic modification, researchers were able to reduce C/EBPG and restore normal myeloid blood cells.
A Wake Forest Baptist researcher discovered that high levels of the MN1 gene accelerate Acute Myeloid Leukemia (AML) and reduce chemotherapy's effectiveness. The study found that the p53 protein is not functioning properly in cells expressing high levels of MN1, leading to a poorer prognosis.
Researchers developed a novel method to determine how ready acute myeloid leukemia (AML) cells are to die, helping cancer specialists choose treatments more effectively. The tool measures the 'primed to die' status of AML cells by apoptosis, allowing for better prediction of patient outcomes and personalized treatment decisions.
A new diagnostic test has been identified as the most effective method for measuring treatment response in young patients with acute myeloid leukemia, which could lead to a higher cure rate. The test uses flow cytometry to identify minimal residual disease in patient bone marrow, allowing for more intensive therapy to be guided.
Dr. Ley's work on whole genome sequencing in AML has provided unprecedented insights into the disease, highlighting the importance of unbiased methods for discovering cancer-initiated mutations. His research also revealed that most AML mutations are benign background events, with only a handful contributing to pathogenesis.
Scientists at Albert Einstein College of Medicine have discovered a gene called HLX that is over-expressed in leukemia stem cells, leading to the development of abnormal white blood cells. Targeting elevated HLX expression may be a promising novel strategy for treating acute myeloid leukemia.
Researchers found a new pathway activated by FLT3 mutation in acute myeloid leukemia, leading to the activation of CDK1 and promoting cell differentiation. Clinical trials with CDK1 inhibitors are underway, suggesting therapies targeting this pathway may be effective for patients resistant to existing treatments.
Researchers have discovered a new target for treating acute myeloid leukemia by targeting cyclin-dependent kinase 1 (CDK1), which promotes differentiation of cancer cells. Additionally, inflammation has been found to play a significant role in age-related retinal degeneration.
A study published in Leukemia & Lymphoma reveals that IDH mutations drive the production of 2-hydroxyglutarate, leading to abnormal gene regulation and increased risk of relapse. Researchers believe targeting IDH mutations may hold promise for treating AML.
Researchers identify a causal link between the oncometabolite metabolite2-hydroxyglutarate and the onset of acute myeloid leukemia. The study demonstrates how a metabolite can cause cancer, setting the stage for developing inhibitors to block the mutation.
A novel family of experimental agents targeting the transport protein CRM1 may offer a new treatment for acute leukemia. The agents, called KPT-SINEs, have been shown to inhibit leukemia-cell proliferation, arrest cell division, and induce cell death and differentiation in animal models.
Researchers have discovered that activating mutations in the FLT3 gene play a crucial role in acute myeloid leukemia, making it an attractive target for new treatments. The study identifies drug-resistant mutations in FLT3 and suggests that therapies involving combinations of multiple drugs could suppress these mutated forms.
Researchers use groundbreaking gene sequencing technology to rapidly detect FLT3 mutations in AML patients who have relapsed on therapy. This discovery may help develop new therapies to treat AML, a type of leukemia characterized by rapid white blood cell growth.
Scientists have identified PRC2, a chromatin regulator, as a promising therapeutic target in acute myeloid leukemia. Blocking PRC2 halts uncontrolled proliferation and reactivates anti-tumor pathways, offering a potential new treatment option.
Researchers found that certain genetic mutations in acute myeloid leukemia patients predicted improved outcomes when treated with high-dose induction chemotherapy. Mutational profiling could help identify distinct subgroups of patients who may benefit from dose-intensified therapy.
Despite significant progress in treating chronic myeloid leukemia, a cure remains elusive for all patients. Research and adherence to treatments are crucial to advancing the field.
A study published in Leukemia identifies a molecular braking process that acute myeloid leukemia (AML) cells use to evade chemotherapy, allowing them to survive treatment. When this brake is removed, AML cells die, providing hope for improved survival rates for patients with the disease.
A new study has discovered that medications targeting the protein Mcl-1 can rapidly kill aggressive AML cells without harming non-cancerous blood cells. This finding provides hope for improved treatment options and potentially better patient outcomes for AML patients.
Researchers identified a high-risk subgroup among older AML patients with mutated ASXL1 gene, showing significantly shorter survival and lower complete remission rates. The study's findings could lead to more effective targeted therapies for these patients.
A study found that half of tumors from T-cell acute lymphoblastic leukemia (T-ALL) patients expressed genes normally found in stem cells and acute myeloid leukemia (AML) tumors. Additionally, many of these AML-like T-ALL tumors contained specific mutations associated with cancer progression.
A new study assesses the effectiveness of bedside geriatric assessments in identifying vulnerable older adults with acute myelogenous leukemia (AML) who can benefit from aggressive treatment. The assessment tool evaluated cognitive function, psychological state, physical function, and co-morbid disease to provide more individualized tr...
Researchers found a genetic defect in the GATA2 gene that predisposes people to acute myeloid leukemia and myelodysplasia. The mutation affects the production of healthy white blood cells, increasing the risk of severe infections.
Researchers at Cold Spring Harbor Laboratory identify Brd4 as a novel drug target for acute myeloid leukemia, an aggressive blood cancer. The new therapeutic agent, JQ1, shows remarkable anti-leukemia activity and minimal toxicity to non-cancerous cells.
Researchers reveal that MLL-AF9 hijacks Myb to enforce aberrant self-renewal in leukemia cells. Inhibiting Myb results in rapid and complete eradication of cancer, validating a new approach for targeting oncogene addiction in vivo.
Researchers at Wake Forest Baptist Medical Center found a specific mutation in the FLT3 receptor makes cells resistant to standard chemotherapy treatment for acute myeloid leukemia (AML). The study suggests a need for personalized approaches in treatment and may lead to new therapeutic research.
A pilot project aims to improve the accuracy of acute myeloid leukemia (AML) diagnoses in Mexico by standardizing cytogenetic testing. Four Mexican laboratories will participate in the project, which includes a two-year program with oversight from ASH, AMEH, and NCI experts.
Researchers found that higher activity of certain LSC genes was associated with worse overall, event-free and relapse-free survival in acute myeloid leukemia patients. The study defined a signature of enriched AML-initiating cells linked to clinical outcomes.