Research on diseases of the nervous system. Covers mitochondrial protection, macrophage replacement, Parkinson's costs, and brain-injury recovery.
Melbourne scientist Mike Hubbard overturns long-held assumption on calcium transport, revealing a new class of protein linked to breast cancer and fertility. His research suggests an alternative calcium transport system based on the Endoplasmic Reticulum, potentially leading to new drug developments.
A study using PET scans found that schizophrenics have elevated dopamine receptor levels in both basal forebrain and SN/VTA areas of the brain. Differences were observed in cortical dopamine levels, supporting the hypothesis of dysregulated neurotransmission leading to abnormal regulation of neurons.
A new SPECT collimator pair increases sensitivity, particularly in central brain structures, while maintaining spatial resolution. The best combination of fan-beam and cone-beam collimation has been found to greatly improve dual-head SPECT images.
Researchers use eye movement tests to investigate brain abnormalities causing mental disorders, including schizophrenia, depression, and autism. The study aims to develop a noninvasive tool for diagnosing brain disorders.
Researchers found dramatic gray matter loss in the brains of men with sleep apnea, primarily in regions controlling speech production, movement, and emotion. The severity of brain damage correlated directly with disorder severity, suggesting that early brain wiring abnormalities may contribute to sleep apnea onset.
Researchers have found that ceramic-to-ceramic hip implants are more durable than metal-on-polyethylene replacements, with a 4,000-fold increase in durability. A large-scale clinical trial showed no postoperative bearing fractures or particles flaking off, indicating potential benefits for younger patients.
A recent study using MRI scans found that children with ADHD showed smaller brain volumes in all regions compared to their peers. The researchers suggest that the disorder may be caused by genetic factors rather than medication use.
A new study confirms that children with ADHD have smaller brains than those without the disorder, but found that stimulant medications do not affect brain size. The research, led by Dr. F. Xavier Castellanos, also showed that brain development in children with ADHD is normal and healthy.
A study published in Nature Genetics reveals a gene mutation underlying Amish microcephaly, a birth defect marked by a small head and brain size. The researchers found that the defect disrupts mitochondrial function, leading to abnormal brain development.
A gene mutation that affects antioxidant production is associated with a 50% increase in heart disease risk, even among those without traditional cardiovascular risk factors. Individuals carrying the mutation have an 80% higher risk of developing brain vessel disease.
A study found narcolepsy prevalence is higher in men and peaks in the 20s, with 36% of cases lacking cataplexy. The disorder affects over 100,000 Americans, with 14 new cases developing annually in a one-million population.
A double-blind clinical trial of 55 Lyme disease patients with severe fatigue revealed that while ceftriaxone showed promise in reducing fatigue, it was not without significant adverse effects. The study's results do not support the use of repeated courses of ceftriaxone due to these risks.
A team of researchers has identified a family of six proteins, called ZIGs, responsible for maintaining the wiring of the nervous system in mature organisms. These proteins play a crucial role in keeping the anatomy of the nervous system intact, and their discovery may lead to new insights into neurological diseases.
Researchers have discovered that antibodies attacking DNA in people with lupus can also target molecules controlling glutamate activity, leading to neuron death and possible cognitive symptoms. This finding suggests a potential pathway for neurological complications and may lead to new therapeutic options.
A study of over 3,000 senior citizens found that some drinking among the elderly may fight age-related brain injuries like silent strokes and white matter disease, but any level of alcohol intake may shrink brain matter. Light drinkers had fewer white matter lesions than abstainers or heavy drinkers.
A study found significant differences in spinal cord area between patients with diabetic neuropathy and healthy controls. The research suggests potential new therapies for detecting neuropathic process at an earlier stage.
Researchers found that fen-phen use can cause abnormal thickening of heart valve leaflets, possibly due to increased production of TBF-beta-1. Serotonin and tryptophan may play a role in this process.
A Phase III study found that Aslera significantly improved disease activity and symptoms in patients with systemic lupus erythematosus (SLE), a chronic autoimmune disease. The treatment also showed benefits for bone mineral density, particularly in women on steroids.
A University at Buffalo study has found that people with severe gum disease are twice as likely to suffer a stroke due to blocked arteries. Periodontal disease was associated with an increased risk for cerebrovascular events, particularly non-hemorrhagic strokes.
A recent study found that newborn boys, especially those born very prematurely, have a higher mortality rate and are more susceptible to complications than girls. The researchers analyzed data from over 6,500 babies up to two weeks old and found that death rates were one in four for boys compared to one in seven for girls.
Researchers at the University of Colorado at Boulder found that patients who received medication and a family-focused treatment program had fewer episodes of the disease, with longer delays before relapses. The study suggests that positive family interaction can help limit relapse rates.
The study will track brain development in two age groups: infants up to four years old and children aged five to 18. By correlating anatomical measurements with cognitive skills, researchers aim to establish a normal growth curve for the brain. This will provide a basis for comparison to children with developmental or neurologic problems.
A door-to-door campaign in Auckland, New Zealand raised awareness of meningococcal disease among at-risk populations. The campaign, initiated in 1998, used lay educators to visit over 11,000 homes and deliver key messages about the disease.
A study found that young women with diseases requiring strict diets may experience unhealthy eating attitudes and behaviors, which can increase the risk of vascular complications and brain damage. The research highlights the need for clinicians to monitor signs of disordered eating in patients with chronic diseases.
Researchers found that the inferior parietal lobule is smaller in people with schizophrenia and 'built backward' from normal patterns in men. This abnormality may account for symptoms of distorted reality in schizophrenic patients.
A study of 14 patients with refractory Crohn's disease found that all participants responded to thalidomide treatment, with significant improvements in disease activity and fistula closure. The median daily steroid dose fell by over 70%, indicating a potential steroid-sparing effect.
A study by American Academy of Neurology finds that 'chasing the dragon' heroin use can produce a progressive brain disorder leading to permanent damage and death. Antioxidant therapy shows promise in treating the condition, but its effectiveness is uncertain.
Scientists have developed a new 'Knockout' mouse model that closely mimics the human kidney disorder IgA nephropathy, providing a promising lead for treatment. The researchers found that supplying deficient mice with uteroglobin prevented the disorder from occurring, mirroring human cases.
A study found that over 80% of wild rats in the US have HEV antibodies, suggesting they are a natural reservoir for the virus. This raises concerns about the possibility of infected rats transmitting the virus to humans, although experts emphasize there is no evidence of human risk.
A newly developed blood test detects 97% of adrenal gland tumors, providing earlier and more accurate diagnoses. The test measures levels of hormones metanephrine and normetanephrine, which are consistently elevated in pheochromocytomas.
A computerized system, developed by Purdue University engineers, matches patient CT scans with images in a large data base of previous patients' scans. This allows less-skilled medical personnel to aid in diagnoses by reducing the need for manual comparisons.
Researchers have discovered naturally occurring enzymes that can detoxify porphyrins, building blocks of haemoglobin, in a potential breakthrough for treating variegate porphyria. This rare disorder was passed down through the royal family, including Queen Elizabeth II's first cousin Prince William of Gloucester.
Researchers found that Thalomid significantly improved symptoms for two-thirds of patients with chronic, steroid-dependent or unresponsive Crohn's disease. Common side effects included drowsiness and peripheral neuropathy. The study suggests a Phase III trial using Thalomid to treat Crohn's disease should be conducted.
African American and Mexican American adults have lower serum and red cell folates compared to white adults. This disparity underscores the importance of improving dietary habits and folate supplements among these populations. Lower folate levels are a risk factor for neural tube defects in offspring and potentially other diseases.
A mercury poisoning illness known as Minamata disease has resurfaced in the Amazon rainforest, affecting thousands of people. The disease, which causes severe neurological damage, is linked to consumption of methyl mercury-contaminated fish.
Australian scientists have discovered key facts about the Hendra disease, a mysterious virus that infects horses, cats, guinea pigs, and fruit bats. Research shows the virus can be transmitted through contaminated food and cat urine, and is often deadly, even if not highly contagious.
Researchers have designed a new genetic weapon called ribozymes to treat inherited human blindness by slowing the progression of retinitis pigmentosa. The treatment targets the autosomal-dominant form of the disease and has shown significant protection of eye cells in lab rats.
Scientists have successfully administered gene therapy orally, effectively curing lactose intolerance in rats. The study demonstrates the potential for an oral delivery system to treat other diseases, such as diabetes.
African tortoise ticks found on imported reptiles in Florida may carry heartwater, an exotic disease that kills livestock and wildlife. The US is considered a serious threat to the cattle, sheep, and goat industries, with no practical treatment for infected animals.
Researchers studied 93 gay men with HIV who showed no symptoms when they entered the trial. Stress levels were found to be significantly associated with disease progression, with higher severe life stress increasing the odds nearly fourfold over two years.
Researchers at the University of Wisconsin Medical School have identified genes for two devastating genetic disorders affecting abnormal pigmentation, including Hermansky-Pudlak syndrome and Chediak-Higashi syndrome. The discoveries may pave the way for genetic testing to identify patients and carriers, as well as new areas of biology.