A new study published in the New England Journal of Medicine found that semaglutide, an approved obesity drug for adults, also helps adolescents with obesity lose weight and have healthier hearts. After 68 weeks, 72.5% of participants who received semaglutide had achieved at least 5% weight loss compared to just 17% on placebo.
Researchers argue that obesity should be recognized as a disease and treated early on to prevent complications. Culinary medicine is proposed as an effective intervention, combining nutrition and cooking skills to promote healthy eating habits.
A UMass Amherst epidemiologist is investigating how physical and mental health during pregnancy can predict cardiovascular and mental health disorders in middle age. Pregnancy complications may be associated with poorer cardiometabolic health and mental health status in middle adulthood among Puerto Rican women.
A study of over 1.3 million young Asian American adults hospitalized for atrial fibrillation found a significant increase in obesity and other modifiable cardiovascular disease risk factors. Young adults with at least one cardiovascular risk factor were almost three times more likely to be hospitalized for atrial fibrillation.
Neighborhood walkability is associated with lower cardiovascular disease burden and risk, according to two preliminary studies. The analysis found that even after considering other factors, walkability alone was linked to a 0.1% decrease in cardiovascular disease for each one-point increase in walkability score.
Researchers at Johns Hopkins Medicine have identified TRPM7, a cation channel in carotid bodies and bloodstream, as a promising therapeutic target for sleep apnea. Blocking or eliminating this channel may offer a new treatment option for obesity-related breathing disorders.
A one-year lifestyle intervention with a digital app and group counselling improved diet quality, reduced abdominal obesity and insulin resistance among 2907 Finnish adults at risk of type 2 diabetes. The study suggests that commitment to lifestyle counselling supports positive changes.
A new study from the University of Missouri School of Medicine found that short-term exposure to reduced physical activity and increased sugar consumption disrupts insulin response in blood vessels, with men more prone to vascular insulin resistance. In contrast, young women are protected against this condition.
Researchers at Tulane University have discovered that following a low-carbohydrate diet can lead to reduced hemoglobin A1c levels and improved fasting glucose levels among individuals with unmedicated diabetes and prediabetes. The study suggests that a low-carb diet may be a useful approach for preventing and treating Type 2 diabetes.
Researchers explore the role of nutrition in cancer development, finding that precise nutritional strategies can be used to supplement treatment and treat cancer. Intermittent fasting is being studied as a promising approach to fight cancer, with studies showing it may increase toxicity on tumour cells and reduce side effects.
Researchers from University of South Australia found that porous silica can prevent fats and carbohydrates from being adsorbed in the body. Engineered particles of purified sand are designed to soak up digestive enzymes, fats, and sugars within the gastrointestinal tract.
The new guidelines, issued by the American Society for Metabolic and Bariatric Surgery (ASMBS) and the International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO), recommend metabolic and bariatric surgery for individuals with a BMI of 35 or more, regardless of obesity-related conditions. The guidelines also endo...
A recent study published in Journal of Science and Medicine in Sport reveals that high aerobic fitness does not protect children from metabolic syndrome. In contrast, a lower risk was observed when considering body size and composition.
Research at Northwestern University finds that eating during the daytime is ideal for dissipating energy as heat, while nighttime eating disrupts this process. This study's findings have broad implications for dieting, sleep loss, and patient nutrition, particularly in cases of Type II Diabetes.
The American Gastroenterological Association releases new guidelines recommending medications paired with lifestyle changes for adults struggling to lose weight. The guidelines highlight the importance of treating obesity as a biological disease, reducing health complications like diabetes and fatty liver.
A team of researchers has identified specific neurons in the amygdala that drive mice to eat fatty or sugary foods, even when not hungry. Switching off these neurons reduced overeating and protected against obesity, while also boosting physical activity and improving metabolic health.
A recent analysis found that higher BMI in adolescent men is strongly associated with developing early atrial fibrillation, as well as subsequent worse clinical outcomes after diagnosis. Men with higher BMIs had significantly increased risks of mortality, heart failure, and ischemic stroke.
A new study by Johns Hopkins Medicine reveals that stress influences appetite in both obese and lean adults, with differences in brain responses to food. The research found that obese individuals show increased activation of the orbitofrontal cortex after stress, while lean adults exhibit lower activation of cognitive control regions.
A global study found that cardiovascular disease risk factors are largely the same for men and women, except for high LDL levels which affect men more. Women have a lower risk of heart attack and stroke due to their estrogen's effect on vessel walls and liver function.
Few studies utilize high-throughput screening (HTS) and high-content screening (HCS) techniques in anti-obesity drug discovery due to a lack of original data or experimental design information. This limits the development of effective pharmaceutical treatments for obesity-related diseases.
A team of scientists at Scripps Research and Calibr discovered a naturally occurring metabolite called myristoylglycine that can convert white fat cells into brown fat cells, potentially treating obesity and related diseases. The breakthrough uses a novel drug discovery method to identify endogenous metabolites with therapeutic potential.
A national study found that patients with cardiovascular disease had a higher mortality rate than those without, but this association was largely due to shared risk factors. Myocardial injury was common among critically ill COVID-19 patients and associated with poor outcomes.
Researchers have identified microRNA-7 as a non-classic genetic risk factor for hereditary obesity. The molecule affects energy balance and appetite regulation in humans and mice, highlighting the need to examine non-genetic factors in gene-based studies. This discovery may lead to new therapeutic approaches for treating obesity.
Research suggests e-bikes won't help users reach weekly moderate to vigorous physical activity targets due to fewer and less physically demanding trips. However, they may encourage older people to take up cycling who wouldn't otherwise do so.
Taking more than 8,200 steps per day may protect against obesity, sleep apnea, and other conditions. The study analyzed data from over 6,000 participants and found that increasing daily steps can reduce the risk of chronic diseases.
Researchers call for a shift in Australia's approach to obesity, advocating for weight-inclusive policies and challenging the conventional emphasis on personal responsibility. The study highlights the need to address weight stigma in schools, workplaces, healthcare, and social media.
A new study from UCLA found that students who attended high-performing charter schools had a 50% lower rate of alcohol use disorder compared to waitlisted students. Males in the intervention group also reported better physical health and lower obesity rates, while females did not show similar benefits.
A study of 1,270 youths found that attending a high-performing public charter high school was associated with lower rates of substance use disorder and delinquent behaviors. The study also showed that attendance at such schools was linked to better physical health outcomes for males but worse outcomes for females.
A clinical trial conducted by Salk Institute and UC San Diego Health found that time-restricted eating improved measures of health and wellbeing in firefighters. The study showed that a 10-hour eating window reduced VLDL cholesterol, improved mental health, and decreased alcohol intake.
A new study in mice has mapped the cells, genes, and pathways that respond to exercise and diet, offering potential targets for drugs that mimic exercise's benefits. Exercise was found to push these systems in the opposite direction of high-fat diets.
A randomized controlled trial found that combining time-restricted eating (TRE) and high-intensity interval training (HIIT) improved long-term glycemic control and reduced fat mass in women with overweight/obesity. The study also showed increased cardiorespiratory fitness.
Research finds significant variation in obesity prevalence among Asian American subgroups, with health risks starting at lower BMIs. The study suggests using specific criteria for Asian populations to accurately assess obesity-related health risks.
A cross-sectional study of over 70,000 Asian Americans found significant variation in obesity prevalence among subgroups, with Filipino Americans having the highest rate at 28.7% and Chinese Americans the lowest at 13.2%. The study highlights the need for tailored strategies to address obesity disparities among Asian American populations.
A study from UniSA researchers found associations between metabolic profiles and adverse brain findings, including lower hippocampal and grey matter volumes. People with metabolic profiles linked to obesity were more likely to have higher accumulation of iron in the brain.
Researchers found that people who had bariatric surgery had a 45% increased risk of developing epilepsy compared to those who did not have the surgery. Those who had a stroke after their surgery were 14 times more likely to develop epilepsy.
Researchers found molecular mechanisms of brain development during early life influence obesity risk, with epigenetic maturation playing a key role. The study suggests prevention efforts targeting developmental processes could help stop the worldwide obesity epidemic.
Researchers are studying the interaction between obesity and nitric oxide synthase in triple-negative breast cancer, aiming to develop a new treatment strategy. Another team is investigating the role of NHE6 protein in multiple myeloma resistance to daratumumab treatment, with the goal of improving therapy outcomes for patients.
A cohort study of nearly 200,000 people found that intentional weight loss reduces the risk of type 2 diabetes for those who are overweight or obese. However, for lean individuals, weight loss attempts are associated with longer-term weight gain and higher risks of type 2 diabetes.
A recent poll found that rising food prices have a disproportionate impact on the diets of older adults, especially those in lower-income households and with fair or poor physical or mental health. The study also shows that these groups are more likely to experience food insecurity and eat less healthy diets due to increased food costs.
A scientific review found that cold water swimming can reduce 'bad' body fat and improve insulin sensitivity. However, the health benefits are uncertain due to limited study quality and variability in participant profiles.
Research from UVA Cancer Center finds that an unhealthy gut microbiome can trigger changes in normal breast tissue, facilitating cancer's spread to other parts of the body. The study suggests that targeting the gut-mast cell relationship could help prevent breast cancer recurrence and metastasis.
Researchers found that bodies with lower BMI had decreased bacterial diversity, while those with higher BMI maintained constant diversity. The study suggests intrinsic factors like disease and medication load may impact microbial life in the surrounding soil.
A Stanford Medicine study reveals SARS-CoV-2 can directly infect adipose tissue, leading to viral replication and inflammation. Obesity is a significant risk factor for severe COVID-19 outcomes due to the virus's ability to create an inflammatory storm in fat tissue.
A UK trial found that 70% of people with normal weight and type 2 diabetes entered remission by losing around 10% of their body weight, supporting the concept of a personal fat threshold. The study showed that even though participants had normal BMI, they had higher levels of fat in their liver and pancreas than healthy controls.
A study published in The BMJ found that adopting a healthy lifestyle can reduce the risk of type 2 diabetes by up to 90% in women with a history of gestational diabetes. Women who adhered to five key lifestyle factors had a significantly lower risk of developing type 2 diabetes, regardless of their weight or genetic risk.
A randomized clinical trial found that protein restriction diets can lead to weight loss, improved blood sugar and lipid levels, and controlled blood pressure. The study involved 21 patients with metabolic syndrome, who were given either a calorie or protein restriction diet for 27 days.
A new Chinese Medical Journal review article elucidates the potential contributors to non-alcoholic fatty liver disease (NAFLD) progression, highlighting the role of bile acid and sphingolipid biology. Researchers summarize current understanding of NAFLD, its progression, and potential therapeutic strategies.
A new study found that women experiencing food insecurity report more symptoms of food addiction, such as compulsive eating and withdrawal symptoms. Participants in food-insecure households had significantly more food-addiction symptoms than those in food-secure households.
SourceElsevier·JournalJournal of the Academy of Nutrition and Dietetics·TypeData/statistical analysis·DateSep 20, 2022
A UTHSC-led research team has been awarded $5.2 million by the National Cancer Institute to investigate the relationship between obesity and cancer risk. The team, led by Dr. Liza Makowski, aims to understand how obesity affects the immune system's ability to fight cancer.
A study found that high-fat diets fuel the creation of inflammatory immune cells in mouse bone marrow. These cells can later invade fat tissue, leading to insulin resistance and other complications associated with obesity. The bone marrow's sensitivity to environmental changes plays a crucial role in this process.
A study by researchers from UTHealth Houston and the University of Miami found that adolescents with severe obesity who underwent bariatric surgery before age 22 lost significant weight and experienced complete remission of comorbidities such as diabetes, asthma, and elevated lipids. The study's results show that these young patients c...
A 12-month video-based weight loss programme has shown significant improvements in metabolic health and dietary behaviour among children with obesity. The study, presented at the European Society for Paediatric Endocrinology Meeting, found that participants lost weight and made better food choices.
Children with obesity who lose weight show increased hunger-related brain activity, despite changes in gut hormone levels. This disconnect may underlie why many people regain weight after a strict diet, highlighting the need for targeted treatments.
For seven years after bariatric surgery, participants showed clinically important improvements in pain levels, physical function, and work productivity, with some backsliding over time. The study found durable effects on walking speed, fitness, and most metrics of pain, even among older adults.
Researchers found that eating walnuts early in life is associated with a lower risk of heart disease, obesity, and diabetes. The study suggests that walnuts may act as a 'bridge food' to promote healthy nutrition and lifestyle habits throughout life.
A review paper published in ESC Heart Failure highlights the link between obesity and combined oral contraceptives with an increased risk of venous thromboembolism (VTE) in women. Obesity and combined oral contraceptives have a synergistic effect on VTE risk, making progestin-only products a safer alternative.
Researchers at IRB Barcelona have discovered a key mechanism behind the formation of brown adipose tissue, which is essential for preventing obesity. The study found that the NCOR1 protein is degraded through autophagy to ensure correct development of brown adipose tissue cells.
A recent study by Hee-Soon Juon PhD found that the obesity paradox in lung cancer diagnosis does not hold true for African Americans. While obesity is associated with lower rates of lung cancer diagnosis in the general population, this relationship was not statistically significant among African Americans.
Researchers identify two distinct types of obesity with physiological and molecular differences that may impact health, disease, and treatment response. The study reveals new insights into the link between insulin and obesity, as well as the role of epigenetics in shaping individual body types.
A recent study found that nearly half of men and one in five women engaged in 'bulk and cut' cycles, connected with a greater desire for muscularity. The study also linked this dietary method to symptoms of eating disorders and muscle dysmorphia among participants.