Researchers discovered that 53% of newborns with myelomeningocele had sleep-disordered breathing, highlighting the need for routine screening and early intervention to prevent long-term complications. The study's findings suggest that addressing sleep disorders in high-risk infants could meaningfully improve their neurodevelopment.
Researchers have successfully tested in-utero stem cell therapy for fetal spina bifida repair, showing promising results with no adverse effects. The therapy, combining standard surgery with stem cells, may lead to better health outcomes for babies compared to traditional methods.
A recent study found life expectancies for people with open spina bifida vary significantly by walking and feeding ability and bowel/bladder continence. Life expectancy decreases with age and is lower for males compared to females.
Researchers have developed a flexible, hair-like device that tracks vital signs of a fetus in real-time during surgery. This innovation provides continuous monitoring without invasive access, enabling faster interventions to prevent complications.
A study finds that nearly half of newborns with severe spina bifida experience breathing problems during sleep, which can be detected through comprehensive sleep studies. Early treatment may significantly improve cognitive development in these high-risk infants.
A comprehensive review synthesizes two decades of research identifying emerging genetic and environmental factors increasing spina bifida risk, including pesticide exposure, obesity, diabetes, and novel genetic variants. The findings call for integrated public health and genetic screening strategies to inform precision prevention.
A new study published in Nature reveals critical insights into how spina bifida develops, identifying specific steps in embryogenesis that contribute to the condition. The research also suggests a potential link between new DNA mutations and disease risk, opening the door for future treatments such as gene therapy and targeted drugs.
The University of Arizona researchers aim to gain a better understanding of factors contributing to the health and quality of life of people living with spina bifida. The project will collect data on patients of all ages, providing insights into gaps in care and unmet needs for individuals with spina bifida across the lifespan.
Researchers created tiny force sensors directly in chicken embryos to study spinal cord malformations. The study aims to prevent congenital malformations by identifying new preventative and therapeutic strategies. Quantifying mechanical forces during embryonic development promises a step change in understanding development.
A new study reveals a common chromosomal microdeletion, 22q11.2del, as the first identified genetic variation contributing to spina bifida. The deletion is associated with a risk of spina bifida more than 10 times greater than the general public. Folic acid supplementation may also help reduce this risk and severity.
A new study found that adding folic acid to table salt can increase serum folate levels in pregnant women, preventing severe birth defects. The researchers recommend implementing mandatory staple food fortification with folic acid as a cost-effective and equitable solution to address the issue.
The supplement to Journal of Pediatric Rehabilitation Medicine presents a compendium of abstracts from the 2023 World Congress on Spina Bifida Research and Care. The issue highlights the importance of international collaboration in addressing complex medical conditions like spina bifida.
SourceIOS Press·JournalJournal of Pediatric Rehabilitation Medicine·TypeExperimental study·DateSep 20, 2023
A new study finds that voluntary folic acid fortification of corn masa flour products has not significantly reduced the rate of births with neural tube defects in Hispanic women. The research suggests that mandatory fortification of cereal grains is more effective in preventing these congenital defects.
A recent study published in Cell Discovery found that high levels of folic acid supplementation may increase DNA mutation rates and impair DNA repair mechanisms. The researchers discovered a 'Goldilocks Effect' where too little or too much folic acid is detrimental to human health.
Recent findings in spina bifida (SB) care highlight comorbidities such as autism and scoliosis, as well as the impact of COVID-19 on healthcare use. Telecommunication platforms like Zoom have evolved into clinical tools for SB care.
A groundbreaking trial at UC Davis Health has successfully treated three babies with spina bifida using a stem cell treatment combined with fetal surgery. The procedure shows promise in improving mobility and reducing the severity of the birth defect, which affects 1,500 to 2,000 children in the US every year.
The UK government's current proposal to fortify flour with folic acid is inadequate, as it suggests a low dose that would fail to prevent hundreds of cases of severe birth defects each year. Increasing the dose could prevent about 80% of neural tube defects.
A Michigan Medicine study found that people with cerebral palsy and spina bifida are prescribed opioids at a rate up to five times higher than those without the conditions. Chronic pain is the most commonly reported symptom among these individuals, raising concerns over addiction and overdose issues.
Despite over 30 years of research evidence, only 60 countries have made folic acid fortification mandatory. Experts call for immediate action to pass a resolution to accelerate prevention globally and reach the 2030 Sustainable Development Goals on child mortality and health equity.
This special issue of the Journal of Pediatric Rehabilitation Medicine showcases recent advances in spina bifida care management, education, and research. The article highlights the need for inclusive and culturally competent services, as well as innovative approaches to address challenges such as limited access and fragmented care.
SourceIOS Press·JournalJournal of Pediatric Rehabilitation Medicine·TypeCommentary/editorial·DateFeb 9, 2022
Weill Cornell Medicine researchers have developed a new approach to analyze genetic mutations associated with spina bifida, shedding light on this complex birth defect. The study uses machine learning to identify genes and molecular pathways relevant to neural tube closure.
A new study has established recognized terms, definitions, design characteristics, and prescription criteria for off-the-shelf stability footwear. This standardized approach aims to improve the effectiveness of therapeutic footwear in treating children with various mobility issues.
A new study published in Nature Communications shows that genetic mutations during embryonic development can cause spina bifida, a severe birth defect. Researchers found that even when these mutations occur randomly in only 16% of spinal cord cells, it's enough to lead to spina bifida.
The updated guidelines provide holistic approach to care, emphasizing quality of life and health beyond traditional medical issues. Key areas covered include bowel function, mental health, mobility, and sexual health, aiming to improve patients' lives across the lifespan.
Children who received prenatal repair of their spina bifida had better gross and fine motor skills, stronger leg muscles, and were more likely to walk independently up to 10 years after surgery. They also showed improved self-care skills and a higher quality of life compared to those who underwent postnatal repair.
Researchers aim to fill knowledge gaps on spina bifida by setting up an international registry of patients and investigating the role of folic acid in disease risk. The grant will also fund whole genome sequencing to identify potential causes and underlying mechanisms of the disease.
Researchers found significant physical and emotional benefits a decade after prenatal surgery for myelomeningocele, including better walking ability and bladder control. School-age children who received corrective surgery in the womb demonstrated improved gross and fine motor skills and a lower need for shunts and surgeries.
A longitudinal study of 161 children with spina bifida found that fetal surgery improved mobility and reduced the need for follow-up surgeries. Fetal surgery also resulted in fewer shunt placements and better motor skills scores compared to traditional postnatal repair.
As demographics change, spina bifida patients' needs are evolving, highlighting the need for research on quality of life and social determinants. The article discusses emerging trends in spina bifida care and the importance of addressing health disparities among minority populations.
A team of researchers has identified specific factors in stem cell secretions that help protect neurons and reduce the severity of spinal cord injuries linked to spina bifida. The study's findings could pave the way for a cell-free treatment for the birth defect, which can cause lifelong disabilities.
New research on spina bifida provides insights into how to manage the disorder, including a transition model that prepares patients for adult life. The study's findings highlight the importance of continuity of care and teamwork between pediatric and adult providers.
An international team of researchers has identified IRF6 gene mutations as a cause of neural tube defects, including spina bifida. The study found that alterations in the IRF6 gene can disrupt the development of the neural tube and lead to structural birth defects.
Researchers will continue their decade-long study exploring stem-cell therapies that show promise for both animals and humans with spina bifida. The therapy involves using stem cells taken from donor placentas on bioengineered scaffolds to help cover and close wounds, preventing damage to the spinal cords.
Australian researchers have made a surprise discovery that many organs and tissues do not require apoptosis to develop normally, suggesting a link between abnormalities in cell death processes and common birth defects. The study also identified the pro-death protein BOK and its role in apoptosis.
This special issue of the Journal of Pediatric Rehabilitation Medicine presents significant contributions from the Third World Congress on Spina Bifida Research and Care, covering topics such as regenerative medicine, genetics, trauma care, and self-management. The goal is to improve healthcare for individuals with spina bifida, includ...
A new study by Michigan Medicine finds that babies with spina bifida have early symptoms of sleep-disordered breathing, which can contribute to lifelong issues with neurodevelopment. The research team identified SDB in all 20 newborns with the most serious form of spina bifida.
Researchers have developed a minimally-invasive bioengineered material called RTG to cover neural tube defects in utero, offering an earlier gestational age approach to spina bifida repair. The study demonstrates the feasibility and potential of this alternative treatment method.
In two studies, researchers compared the cryopreserved human umbilical cord patch to acellular dermal matrix and conventional suturing methods for in-utero spina bifida repair. The results showed improved spinal cord function with decreased meningeal scar formation and better preservation of spinal cord tracts.
Researchers at UTHealth have developed a patch made from cryopreserved human umbilical cord that may treat spina bifida in utero. The patch utilizes natural material with regenerative properties to promote local tissue growth, reducing the need for future surgeries.
Researchers compared two patches, human umbilical cord and biocellulose film, in a rat model of spina bifida. The study found that the umbilical cord patch promoted cellular migration with minimal inflammation, suggesting a potential regenerative material for antenatal spina bifida repair
The UK's failure to fortify flour with folic acid has caused around 2000 avoidable cases of neural tube defects since 1998. Researchers recommend adopting the US policy to curb associated deaths and disability, citing a potential fall in prevalence of 21% if implemented.
A UTHealth study found that children born with cleft lip or palate and spina bifida are at higher risk of maltreatment before age 2, with increased risks of 40% and 58% respectively. Medical complexity may contribute to this increased risk.
A recent study found that neural tube defects in Europe have not declined substantially over the past 20 years, despite long-standing recommendations for folic acid supplements. The study analyzed data from 11,000 cases and suggested that mandatory fortification of food staples with folic acid could be an effective means of prevention.
A new study published in the American Journal of Physical Medicine & Rehabilitation found that a smartphone app can help adolescents and young adults with spina bifida improve their daily self-management skills. The app, called iMHere, includes mobile reminders and messaging with healthcare providers.
Researchers at UC Davis Health System have combined fetal surgery with a placental stem cell treatment to reduce the effects of spina bifida, with six lambs regaining ability to walk without noticeable disability after birth. The study aims to confirm safety and determine optimal dosing for potential human clinical trials.
Researchers studying zebrafish neurons aim to understand how individual neurons develop and mature, which could shed light on birth defects such as spina bifida. The study focused on neuronal migration and its relation to human neural tube closure, with potential insights into the mechanisms behind this process.
A recent study published in the American Journal of Clinical Nutrition found that large amounts of choline are needed during pregnancy to support fetal development, and current recommendations may be too low. This increased demand is linked to elevated levels of homocysteine, which can cause birth defects.
Researchers discovered a mutation in a gene can impact offspring and subsequent generations with developmental abnormalities, epigenetic changes, and severe health effects like spina bifida. Folate fortification programs have reduced the risk but not eliminated health problems.
A new study has found a link between high doses of epilepsy medication valproate and increased risk of physical birth defects such as spina bifida and hypospadias in babies. Reducing the dose of valproate during pregnancy can significantly lower this risk, providing pregnant women with epilepsy new hope.
Researchers identified a gene mutation in dogs that is associated with neural tube defects in humans. The study found six cases of the mutation in human patients with spina bifida, suggesting a potential link between the dog gene and human neural tube defects.
A recent report by Queen Mary University of London reveals that congenital anomalies are underreported due to lack of national surveillance, with 2.2% of babies affected in England and Wales in 2010. The prevalence of anomalies was consistent with those in other European registers.
A study published by the Society for Maternal-Fetal Medicine finds that in utero surgery is more cost-effective for children with spina bifida, resulting in improved quality of life. The study also highlights the significant healthcare costs associated with caring for a child with significant deficits.
Researchers will study the role of folic acid in preventing neural tube defects, with the goal of developing individualized prevention strategies. The study aims to identify which genes are modified by folic acid levels and how those patterns can be used to assess risk for spina bifida.
A landmark study by the Children's Hospital of Philadelphia shows fetal surgery for spina bifida can improve outcomes for children with the condition. Fetal surgery significantly reduced the need to divert fluid from the brain, improved mobility, and increased the chances that a child will be able to walk independently.
A new NIH-funded study will investigate the effects of spina bifida on bone development in children and adolescents, potentially informing prevention strategies for leg fractures. The research aims to understand whether adolescence with spina bifida leads to differences in bone mass or reduced activity due to physical limitations.
Researchers identified a link between Sec24b and Vangl2 genes in mouse spinal cord development, which may lead to new research on all spinal defects. The discovery opens doors for investigating the root of spinal cord defects in humans.
A new study conducted by an Irish-led research team found no link between folic acid-related auto-antibodies and the risk of having a child with spina bifida. The study, which involved over 140 mothers of affected children, confirms previous findings that maternal folate status can prevent neural tube defects.
A study using genetically modified mice found a link between low levels of inositol and neural tube defects, such as spina bifida. The research suggests that increasing inositol doses may help prevent these birth defects.
A new study suggests that taking folic acid supplements for at least one year before pregnancy can significantly reduce the risk of premature birth. The research found a 50-70% decrease in early preterm deliveries, with the greatest reduction seen in very early premature births.
Researchers at UT-Houston have discovered an association between genes regulating glucose metabolism and spina bifida, a birth defect that affects the spine. The study found variants in three glucose metabolism genes were linked to an increased risk of spina bifida.