Research on how the immune system defends the body. Covers immune-cell imaging, T-cell responses, longevity genetics, and cancer immunotherapy.
A team of researchers connected the dots for one important gut bacterium, revealing its molecular structure and function in the immune system. The study found that Akkermansia muciniphila's lipid activates toll-like receptors, triggering the release of certain cytokines while leaving others alone.
Researchers at the University of Copenhagen have developed a new method to detect biliary tract cancer and other serious cancers by analyzing changes in microRNA molecules in patient blood. This approach enables early diagnosis and has potential for targeted treatments.
A third COVID-19 booster helped identify and neutralize 20 different variants, reducing the risk of breakthrough infections and severe disease. The study provides valuable insights into the immune system's response to new variants and informs strategies for managing the pandemic.
A new study from Tel Aviv University found that CRISPR therapeutics can lead to a significant loss of genetic material in treated cells, potentially destabilizing the genome and promoting cancer. The researchers detected up to 10% of cells with lost chromosomes, highlighting the need for extra care when using this technology.
Researchers found that mothers who didn't transmit HCMV to their infants had higher levels of antibody-dependent cellular phagocytosis, suggesting a non-neutralizing immunity mechanism. This finding has implications for the development of effective HCMV vaccines.
A study by Goethe University Frankfurt found that antibodies against Omicron variants BA.1 and BA.2 decline rapidly, even after a second vaccination or booster shot, offering limited protection against infection.
Researchers at Max Delbrück Center for Molecular Medicine found that silencing the EBAG9 gene in CAR T cells increases their effectiveness and reduces side effects. This breakthrough could lead to a new therapy approach for blood cancer patients.
Researchers have developed a novel COVID-19 vaccine based on altered plasmid DNA that effectively blocks cell infection across all tested variants. The vaccine targets a specific vulnerability in the SARS-CoV-2 virus's spike protein, inducing a focused antibody response.
Researchers at the Institut Pasteur and CNRS studied SARS-CoV-2 replication in bat cells, finding that viral infection triggers a powerful immune response that prevents the virus from replicating. The study uses real-time imaging techniques to visualize the speed of cell infection and the formation of syncytia.
Researchers analyze delta variant's biophysical characteristics, revealing unique traits that evade neutralizing antibodies and contribute to severe symptoms. The study sheds light on why vaccinated individuals can still contract the virus and why delta variant hospitalizations are higher than other variants.
Researchers at the University of South Australia have discovered that combining anti-rejection medication with immune checkpoint inhibitors can significantly reduce the risk of organ rejection and eliminate cancer cells in a quarter of patients. The study involved 22 patients with renal transplants and incurable locally advanced or met...
Researchers found that men who lose their Y chromosome as they age are more likely to experience deadly heart scarring and earlier death. The study suggests an existing drug may help counteract the effects of this loss, potentially leading to longer, healthier lives for affected men.
The SARS-Arena program identifies conserved peptides in the SARS-CoV-2 virus that could be used to develop vaccines. The peptides are part of the nucleocapsid protein, which is highly expressed upon infection and highly immunogenic.
Researchers found that breastfeeding provides an immune boost to infants, reducing the risk of respiratory infections such as pneumonia. However, milk also mounts responses to beneficial gut bacteria, which can be disruptive and increase the risk of gastrointestinal infections.
Scientists have uncovered how the innate immune system detects HIV-1, even at very small amounts, and activates a two-step molecular strategy to combat the virus. This discovery could lead to new methods for treating HIV and vaccines, as well as insights into other diseases like Alzheimer's.
Researchers propose a theory on how SARS-CoV-2 infects the body, leading to hyperactivation of the immune system and post-COVID syndromes. The hypothesis suggests that molecular motifs on the spike protein interact with immune cells, causing an overreaction and mistakenly attacking organs.
New research reveals that specific proteins in plant cells explain why plant defenses falter under high temperatures, leaving them susceptible to infections. Scientists have also discovered a way to reverse this effect by constantly activating the CBP60g master switch gene, which bolsters plant defenses without stunting growth.
Researchers at the University of Chicago have made a breakthrough in understanding the development of type 1 diabetes by targeting the role of pancreatic beta cells. Deleting a gene called Alox15 in mice preserved their beta cells, reduced immune T cell infiltration, and prevented diabetes from developing.
Researchers at Gladstone Institutes and Stanford University identified key genes linked to T cell exhaustion. They discovered how to block these genes, resulting in healthier T cells and smaller tumors in mice with cancer. This breakthrough may lead to improved immune-based treatments for cancer patients.
A new study from UTHealth Houston found that flu vaccination was associated with a 40% lower risk of developing Alzheimer’s disease in US adults over a four-year period. The study analyzed a large sample of patients and found that consistent flu vaccination every year had the strongest protective effect.
A Phase II study published in Frontiers in Oncology found that daily use of AHCC supplementation may help most patients eliminate their HPV infection and decrease the risk of HPV-related cancers. The study showed that 14 of 22 patients (63.6%) became HPV-negative, suggesting a potential treatment option for persistent HPV infections.
Researchers analyzed data from over 1.3 million patients and found females experience ear, nose, and throat issues, mood disorders, and fatigue, while males are more likely to suffer from renal disorders. Sex-disaggregated research is crucial for effective therapies and public health interventions.
A new study reveals that COVID-19 variants are formed in chronic patients with weakened immune systems, who experience prolonged infections. This leads to the accumulation of mutations, similar to those found in severe illness variants.
Scientists have discovered a new, high-resolution view of the rabies virus glycoprotein, which could lead to more effective vaccines. The study's findings suggest that a better-shaped vaccine could provide lifelong protection against the deadly disease.
A new study published in iScience found that the co-development of the gut microbiome, immune system, and respiratory system is correlated with a baby's respiratory health. Disruption of any of these systems resulted in greater respiratory morbidity for infants, highlighting the importance of timing in intervening with therapies.
Researchers at Kyoto University identified the mechanism behind active inflammation and immunosuppression in tumor microenvironments. EP2/EP4 inhibitors suppress tumor growth by allowing regulatory T cells to infiltrate and activate within tumors, benefiting patients with certain cancers.
Researchers discuss Hepatitis D's life cycle and interactions with its host, exploring strategies for further research to combat this overlooked virus. HDV coinfects people with hepatitis B, rapidly progressing to liver cirrhosis and cancer if left untreated, with a review published in the Chinese Medical Journal.
A groundbreaking study using cellular barcoding in mice reveals that blood cells originate from two independent sources: hematopoietic stem cells and embryonic multipotent progenitor cells. These findings have significant implications for understanding blood cancers, bone marrow transplant, and the aging immune system.
A study from Cincinnati Children's Hospital Medical Center found that early antibiotic use disrupts the developing immune system of newborns, increasing risks of severe pneumonia and life-long health issues. Fecal transplants may offer a solution to mitigate these effects.
A detailed understanding of interleukin 2's role in the immune system has been gained through a new mouse model, enabling scientists to identify potential new uses as an immune-modulating biologic drug. This breakthrough may lead to optimized autoimmune and cancer treatment while avoiding unwanted side effects.
A new preclinical study by Weill Cornell Medicine researchers shows that naturally-produced IgG antibodies in breast milk can protect infants from infection-induced diarrheal illness. These antibodies enhance infant immunity against bacterial pathogens causing gastrointestinal diseases.
A new study published in Nature reveals that a small population of neurons near the base of the brain can induce symptoms of sickness, including fever, appetite loss, and warm seeking behavior. The researchers found these neurons have receptors capable of directly detecting molecular signals from the immune system.
A study analyzing 17 million patient GP records in England found that people with certain inflammatory immune conditions were at higher risk of dying or needing hospital care from COVID-19. The analysis suggests that targeting prevention strategies and early interventions towards those most at risk can help inform evidence-based policy.
Researchers at the Messerli Research Institute developed a lozenge that compensates for micronutrient deficiencies in immune cells, reducing inflammation and allergic reactions. The study showed a 45% reduction in symptom burden during peak pollen season, presenting a new approach to allergy care.
Researchers developed nanoparticles that deliver NAD(H), a molecule with anti-inflammatory properties, to treat sepsis in mice. The treatment improved survival rates and prevented multiorgan injury.
Researchers have identified glycans in mucus that can prevent Candida albicans from causing infection. These molecules can be used to develop new antifungal medicines or make disease-causing fungus more susceptible to existing drugs.
Researchers found that combining chemotherapy with immunotherapy increased one-year survival rates for patients with advanced pancreatic cancer, with anti-PD-1/chemo regimen showing the highest response. The study identified key immune system biomarkers associated with better outcomes, offering new hope for precision oncology.
A randomized, placebo-controlled pilot study found that NB-UVB phototherapy decreased mortality in hospitalized COVID-19 patients with no adverse events reported. The treatment was effective in both vaccinated and unvaccinated patients, with reduced pathologic inflammation and improved intracellular killing of pathogens.
Researchers at the University of Chicago's Pritzker School of Molecular Engineering have developed a version of interleukin-12 that is activated only when it reaches a tumor, reducing side effects. The new 'masked' molecule has shown promising results in eliminating cancer cells and outperforming existing immune therapies.
A team of researchers has found a way to block the replication of one strain of the influenza virus in human cells by inhibiting a specific protein modification process called SUMOylation. This breakthrough could lead to highly effective treatments for the flu and other respiratory viruses.
Researchers at Karolinska Institutet discovered that electrical stimulation of the vagus nerve promotes healing in acute inflammation by shifting the balance between inflammatory and anti-inflammatory molecules. This finding opens new avenues for treating inflammatory diseases, including autoimmune and cardiovascular conditions.
Researchers at Washington State University have discovered that a specific population of CD4-positive helper T cells initiates antitumor immunity defenses, which can enhance the effectiveness of killer cell attacks on cancer cells. This finding holds promise for improving cancer immunotherapy response rates.
This study shows how specific brain regions control the immune response during acute stress, highlighting the detrimental effect on fighting off infection. Researchers found that acute stress prompts a major migration of immune cells, diminishing an immune response to viruses like COVID-19 and influenza.
Researchers develop targeted delivery system to boost regulatory T cells, which manage inflammation and reduce brain damage. The treatment increases IL2 levels, allowing regulatory T cells to survive and reducing cognitive impairment.
Australian researchers have discovered specific gene networks rewired to drive peanut allergy remission through a combination treatment of probiotic and oral immunotherapy. This network reprogramming shuts down the allergic immune response responsible for causing food allergies.
Researchers identified a blood biomarker that predicts severe Crohn's disease and is detectable up to seven years prior to diagnosis. The biomarker neutralizes protective effects of a cytokine, leading to intestinal damage and weakening the immune system.
Researchers developed a genetic test that diagnoses primary immunodeficiency disorders (PID), revealing inherited genetic defects in nearly half of patients. The test uses next-generation sequencing technology to identify specific gene variants associated with PID, enabling targeted treatment and earlier intervention for family members.
A global effort has been launched to create a digital twin of the human immune system, inspired by the COVID-19 pandemic. This 'digital twin' could enable precision medicine for various ailments, including cancer and autoimmune diseases.
Researchers discovered that Clostridium septicum kills cells by releasing a toxin that acts like a hammer, triggering an overactive immune response. This can lead to sepsis and shock, resulting in rapid patient death. New therapies are being developed to neutralize the toxin and block the immune receptor.
Researchers linked dietary cholesterol to exacerbation of viral infections in mice, showing that high levels of cholesterol made mice sicker when infected with influenza. The study found that dietary cholesterol increased the number of cytokine-producing immune cells in the lungs, contributing to excessive inflammation.
Scientists found a connection between the SARS-CoV-2 virus and the production of misfolded proteins called amyloids, which can cause complex symptoms and damage in organs such as the heart and kidneys. The researchers' discovery may help explain why COVID-19 often affects multiple parts of the body.
The Mount Sinai Microbiome Lab will use advanced methods to study the microbiome's role in autoimmune diseases such as rheumatoid arthritis and systemic lupus. The lab aims to identify microbial features that can help find more precise matches between diseases and treatments.
A randomized clinical trial found that a specific probiotic supplement accelerated the maturation of the microbiome in extremely preterm infants, leading to reduced intestinal inflammation and improved feeding tolerance. The study also showed potential benefits for reducing the risk of food allergies in these vulnerable infants.
Scientists estimate 20% of children and 26% of adults in the US consume high levels of live microorganisms daily. These findings suggest a link between dietary microbes and health outcomes, highlighting the importance of quantifying live microbes consumed through food and supplements.
A new study by Gladstone Institutes and UC San Francisco found that infection with the Omicron variant provides weak immune response in unvaccinated individuals, failing to confer broad protection against other variants. In contrast, vaccinated individuals show stronger immunity against multiple COVID-19 strains.
A McMaster University research team found that Type I interferon regulates the immune response to target infected tissues, preventing bystander damage. The study used mice and COVID-19 patient data to investigate IFN's role in regulating a potentially dangerous immune response.
Scientists discovered that commensal fungi like Candida albicans need to be alive and actively producing proteins to elicit a beneficial immune response. The fungus oscillates between high and low expression of the UME6 gene, signaling its benefits to the body.
Researchers discovered that adaptive immune response against TB matures over time, with key players in immunity becoming activated by three months after infection. The emergence of these activated T cells is inversely correlated with the number of granuloma-contained live bacteria, suggesting they play critical roles in bacterial control.
A new biomaterial-based technique has improved islet transplants for type 1 diabetes treatment by inducing permanent immune acceptance. The microgels educate the immune system to accept the graft, making it possible to regulate blood glucose levels without chronic immunosuppression.
A study from the University of Birmingham and National Institutes of Health found that antibiotics can lead to fungal infections by disrupting the gut's immune system. Using immune-boosting drugs alongside antibiotics may reduce health risks associated with these complex infections.