Articles tagged with Oncology
A cohort study reveals oral bacteria and fungi as significant risk factors for pancreatic cancer development. The findings suggest that oral microbiota may serve as biomarkers to identify individuals at high risk of pancreatic cancer, potentially contributing to personalized prevention strategies.
Researchers at Graz University of Technology created a highly detailed digital twin of the A549 lung cancer cell line, paving the way for individualized cancer treatment. The model simulates calcium dynamics and electrical voltages, allowing for testing of drugs and personalized treatment strategies.
A cohort study suggests nicotinamide reduces skin cancer risk, with greatest effect seen after initial skin cancer diagnosis, indicating potential chemopreventive properties of the vitamin B3 derivative
A new study shows that remote perioperative monitoring significantly improves recovery for cancer surgery patients, with a 6% greater functional recovery rate by day 14 after surgery. The study also found fewer major complications and improved symptom management.
A $1.7M Department of Defense grant funds the Convergent Science Virtual Cancer Center, strengthening expertise in cancer risks faced by military personnel and their families. The center provides personalized mentorship, immersive workshops, and non-traditional educational opportunities to improve patient outcomes across various cancers.
A growing body of research links environmental pollutants to worsened health and shorter life spans in childhood cancer survivors. The study found that only 25% of pediatric oncology providers felt comfortable discussing environmental pollutant impacts with patients.
These rare tumors often present with aggressive behavior, early metastasis, and resistance to chemotherapy and radiotherapy. Early detection and disease staging are key factors associated with improved survival.
The Alliance for Clinical Trials in Oncology will host a public webinar showcasing key findings from the 2025 ASCO Annual Meeting. Researchers will discuss latest information on colorectal, squamous cell, and renal cell cancers.
A new study highlights why kids' brain tumors need therapies designed for their unique biology, pointing to engineered immune cells and cancer vaccines as promising approaches. The review emphasizes the need for targeted treatments that recognize and fight childhood brain tumor differences.
Researchers found that lung cancer cells can form functional synapses with neurons, supporting their growth and survival. Disrupting glutamate signalling led to lower tumour burden and longer survival in experimental mice, highlighting promising therapeutic targets.
A consortium led by the University of Southampton aims to advance cutting-edge treatments for lung cancer, blood cancers, and chronic inflammation. The ON-TRACT project will train researchers in academic, industrial, and clinical settings to develop safer and more effective treatments.
A recent study published in the Lancet Primary Care tracked over 4,800 patients referred to the SCAN Pathway, a cancer diagnosis pathway designed for patients with non-specific symptoms. The study found that early diagnosis of cancers can save thousands of lives and reduce treatment costs for the NHS.
Researchers evaluated a tool based on NCCN Guidelines to identify high-risk medications and their association with frailty and outcomes in over 380,000 older adults diagnosed with cancer. The study found that each additional high-risk medication increased the odds of being mildly or moderately-to-severely frail by 66%.
A clinical trial found that patients with mesothelioma who received combination immunotherapy drugs before surgery had successful surgeries and improved early outcomes. The study showed that tracking tumor DNA in the blood could help predict treatment benefit.
Experts weighed in on the current state of artificial intelligence (AI) in cancer care, noting both its potential for improving efficiency and its challenges. Many expressed excitement over AI's possibilities for helping support an overburdened oncology workforce and accelerating the pursuit of new cures.
Researchers developed photo-inducible binary interaction tools (PhoBITs) to precisely control gene expression, cell signaling, and immune responses. PhoBITs enable targeted treatment with minimal side effects, opening new avenues for cancer therapy, immunotherapy, and regenerative medicine.
Phoenix SENOLYTIX and MD Anderson Cancer Center announced a cross-licensing agreement to further develop inducible switch technologies for use in cell and gene therapies. The partnership will enhance the development of these technologies, which can be used as safety features to regulate cell therapy activity.
The ASTRO's 2025 Annual Meeting will feature pivotal studies in radiation medicine, highlighting advances in radiopharmaceutical therapy and new indications for low-dose radiation therapy. The meeting will also explore cutting-edge techniques for prostate, breast, lung, and other common cancers.
Researchers discovered that disrupting protein quality control slows tumor growth in rhabdomyosarcoma, a rare and aggressive cancer primarily affecting children. The treatment, which targets the proteostasis network, significantly slowed or stopped tumor growth in mice implanted with human RMS tumors.
A study published in Oncoscience found that over 60% of oncology healthcare professionals in Morocco showed signs of severe burnout, with emotional exhaustion being the key factor. The study highlights the need for urgent institutional changes to support healthcare workers and improve work environments.
The Molecular Analysis for Precision Oncology Congress 2025 (MAP) brings together leading experts to explore the latest cancer research advances. Key topics include AI-integrated diagnostics and therapy, as well as immunotherapy and emerging developments in aging and cellular senescence.
Researchers evaluated clinical outcomes of endoscopic resection in sellar chondrosarcomas, revealing common symptoms like blurring of vision and headaches. The study also provides recommendations for accurate diagnosis using imaging data and clinical features.
A retrospective cohort study found that GLP-1 receptor agonists may reduce overall cancer risk, including lower risks of endometrial and ovarian cancers, among patients with obesity or overweight. However, these medications may also increase the risk of kidney cancer, highlighting the need for longer-term follow-up.
A telephone-based weight loss intervention significantly reduced weight in breast cancer patients with overweight and obesity. The study suggests that this intervention may improve disease outcomes, warranting further investigation in future trials.
Researchers at the University of Navarra have developed FLIP-HEDOS, a model that simulates how much radiation blood absorbs during cancer treatment. The study highlights the importance of protecting blood from radiation, which can impair immune function and lead to hematologic toxicity.
Researchers envision AI-powered systems that identify patients at risk of mental health struggles, provide continuous psychological monitoring and tailor interventions. AI can also overcome barriers to mental health care by delivering support exactly where and when it's needed, including rural areas.
The International Osteoporosis Foundation has issued an updated joint position statement on managing aromatase inhibitor-associated bone loss in women with hormone-sensitive breast cancer. The guidelines incorporate recent clinical trials and systematic reviews to provide evidence-based treatment algorithms for assessing fracture risk ...
The FDA-approved MI Cancer Seek test is a comprehensive molecular profiling assay that delivers accurate and reliable results from minimal tissue input. It identifies key biomarkers linked to FDA-approved treatments for several major cancers, including breast, lung, colon, melanoma, and endometrial cancers.
A recent study reveals woefully low awareness of human papillomavirus (HPV), the HPV vaccine, and their association with cancer in the Midwestern and Southern US states. These states have seen a rise in HPV-associated cancers, making suboptimal HPV vaccination rates even more alarming.
A new drug-releasing system, TAR-200, eliminated tumors in 82% of patients with high-risk non-muscle-invasive bladder cancer. The treatment was well-tolerated and showed improved outcomes compared to standard treatments.
A nationwide Swedish study found nearly three times as many young adults under 50 diagnosed with colorectal cancer today compared to the early 1990s. The disease has become two to three times more common in this age group, with underlying causes not fully understood.
A new study from the University of Missouri-Columbia highlights the importance of consistent primary care coordination in cancer survivorship care. The research found that only a third of patients consistently saw the same primary care clinician during and after cancer treatment, leading to fragmented care and gaps in patient services.
A study published in The Lancet Gastroenterology & Hepatology found that routine AI assistance during colonoscopies can lead to a decrease in the ability of endoscopists to detect precancerous growths without AI aid. This reduction in skills may impact patient-related outcomes and highlight the need for further research on the long-ter...
The study found that only 16% of newly diagnosed patients with MDS on Medicare received HMAs during the period analyzed, with women and non-white patients being less likely to start treatment. The analysis suggests that making changes with existing therapies and administration can have a huge impact on improving outcomes in high-risk MDS.
St. Jude receives its third consecutive Magnet designation and first Magnet Designation with Distinction, recognizing its commitment to exceptional nursing care and patient outcomes. The hospital's nursing programs, including the Nurse Residency Program and Center of Advanced Practice, have contributed to its success.
Researchers have discovered a novel microbial consortium called AUN that produces exceptional tumor eradication in both murine and human cancer models. The therapy exhibits high biocompatibility and minimal side effects, offering a long-awaited solution for immunocompromised patients.
Local-stage colorectal cancer incidence among US adults ages 45-49 increased by 50% between 2021 and 2022, with a steep rise in 2019-2022. Screening rates also increased during this period, driven by recommendations to start screening at age 45.
Researchers found that decompression with a nasogastric tube is linked to reduced complications in patients after oesophageal cancer surgery. This challenges declining trend of abandoning the tube post-surgery, which was previously thought to be safe.
Recent AI-based models, such as Asian Prostate Cancer Artificial Intelligence and Galen Prostate, optimize screening and reduce unnecessary biopsies. These models use multimodal clinical parameters and convolutional neural networks to detect prostate cancer and identify aggressiveness of cancer cells.
The Mount Sinai Hospital has been listed among the nation's top 20 hospitals for care excellence by U.S. News & World Report for 2025-26, with top-10 rankings in five specialties and top-20 rankings in nine. The hospital was also rated High Performing in all 22 procedures and conditions assessed by U.S. News.
MD Anderson is ranked No. 1 in the nation for cancer care, with consistent improvements across various specialties. The institution received high performing ratings for common adult procedures and conditions, including colon cancer surgery, gynecological cancer surgery, and leukemia treatment.
A new study finds that risk-reducing mastectomy is cost-effective for women aged 30-55 with a lifetime breast cancer risk of 35% or higher. The findings have significant clinical implications, suggesting that RRM could expand access to the procedure beyond BRCA1/BRCA2/PALB2 pathogenic variant carriers.
Researchers summarize decades of work repositioning cachexia from a localized metabolic disturbance to a cancer-driven, multi-organ pathology. Key findings include the overactivation of the ubiquitin-proteasome pathway and enhanced lipolysis mediated by two key lipases.
Researchers have identified CDX1 and CDX2 as key molecules that counteract β-catenin and suppress stemness in colon cancer. Deletion or overexpression of these proteins increased tumor aggressiveness and expression of cancer stemness-related genes, suggesting a potential therapeutic target.
Researchers at NTU Singapore and Oxford University have discovered a mechanism by which cells identify and repair highly toxic DNA damage, known as DPCs, that cause cancer, neurodegeneration, and premature ageing. The study reveals how SPRTN, a key repair enzyme, selectively targets DPC lesions, increasing its activity 67-fold.
A new study published in JAMA Network Open found no statistical relationship between pathologic complete response (pCR) and overall survival in rectal cancer patients. This challenges the FDA's use of pCR as a surrogate endpoint for drug approval, which may lead to treatments being fast-tracked without evidence of improved long-term su...
A retrospective cohort study found that COVID-19 booster vaccinations significantly protected against severe COVID-19, but uptake was low. Interventions are needed to increase COVID-19 vaccine uptake among high-risk populations with cancer.
The inaugural ESMO Targeted Anticancer Therapies (TAT) Asia Congress 2025 will convene a diverse group of stakeholders to foster collaboration and accelerate the development of innovative cancer therapies. The congress aims to become a catalyst for global collaboration and innovation in oncology.
Researchers successfully treated a patient with a rare IDH2-mutant brainstem astrocytoma using temozolomide and radiation, resulting in significant tumor shrinkage and improved hearing. The patient's unique genetic profile was identified through magnetic resonance spectroscopy and surgical biopsy, allowing for targeted treatment.
A new treatment approach using cyclophosphamide has been found to prevent most graft-versus-host disease in mismatched transplants. The study shows that 80% of patients are alive after a year, similar to outcomes seen in fully matched transplants.
A study of 62,839 people diagnosed with non-metastatic prostate cancer in Sweden found that those treated according to NCCN Guidelines were likely to survive their cancer for their remaining life-expectancy. Those with low- and intermediate-risk cancer were six times more likely to die of other causes than prostate cancer.
The revised guidelines incorporate the latest clinical advances in graft-versus-host disease prophylaxis, expanded donor options and search strategies. The updated guidelines aim to enhance transplant outcomes for patients with blood cancers and disorders.
Researchers have identified a hidden molecular mechanism involving two proteins that allows tumors to resist treatment. A new gelatin-based nanoparticle has been developed to shut down both proteins simultaneously, showing promising results in early studies with mice.
A study published in The International Journal of Cancer found that children born by planned C-section have a higher risk of developing acute lymphoblastic leukaemia (ALL) later in life. The risk was 21% higher in children born by planned C-section compared to those born vaginally.
Researchers at Fujita Health University discovered benzaldehyde's mechanism to halt therapy-resistant pancreatic cancer growth and spread. Benzaldehyde prevents key interactions that enable cancer cells' survival and treatment resistance.
A new study by the NIH found that hormone therapy may alter breast cancer risk in women under 55. Women treated with unopposed estrogen hormone therapy were less likely to develop breast cancer, while those using estrogen plus progestin hormone therapy were more likely to develop the disease.
Michael Karin, renowned for his work on chronic inflammation and cancer, will lead the Center for Metabolic and Liver Diseases at Sanford Burnham Prebys. He aims to develop new treatments for metabolic and liver diseases, which affect millions of patients worldwide.
A new study reveals that SETD1B plays a critical role in supporting the growth of aggressive acute myeloid leukemia (AML) cells, particularly in those with FLT3-ITD mutations. By targeting SETD1B, researchers believe it may be possible to develop more effective treatments.
The new NCCN Guidelines Navigator tool offers an interactive platform for accessing evidence-based guidelines, facilitating easier searching and navigation. The initiative aims to improve patient care and outcomes by providing healthcare professionals with up-to-date recommendations.
A new study reveals that cancer survivors experiencing food insecurity have a 28% increased risk of death compared to those who are food secure. The research, published in JAMA Health Forum, analyzed data from over 5,000 respondents and found that food insecurity was linked to higher all-cause mortality rates.