Articles tagged with Osteoarthritis
A new study found evidence that common genetic variants linked to osteoarthritis may also play a minor role in human height. The variants, associated with an average difference of about 0.4 cm, lie in the region of the GDF5 gene, which influences cartilage development and bone growth.
A new study confirms a connection between decreased height and increased risk of osteoarthritis, suggesting that genetic variants may play a role in both conditions. The research analyzed the genomes of over 35,000 people and identified a variant associated with an average difference in height of about 0.4 centimeters.
Research at the University of Delaware found women with osteoarthritis in their knees have significantly reduced mobility and function compared to men. Women may need to become more educated about knee-replacement surgery risks and benefits to preserve their mobility and quality of life.
A review of six knee osteoarthritis treatment guidelines found significant differences in recommended treatments, with a focus on acetaminophen, NSAIDs, and exercise. The study highlights the need for more detailed educational interventions to improve guideline applicability.
A double-blind study published in Nutrition Research reveals Pycnogenol improves physical function by 52 percent in patients suffering from OA. The antioxidant plant extract also controls inflammation and complements existing strategies for treating osteoarthritis.
Researchers found that patients over 60 years old, experiencing morning stiffness and groin pain, are at higher risk of undergoing total hip replacement. The study also revealed that obesity may decrease the risk of THR after three years.
A clinical trial aims to identify individuals at risk of osteoarthritis through the analysis of Smurf2 enzyme expression in cartilage cells. The study seeks to develop a diagnostic test and potential injection to prevent or slow disease progression.
A meta-analysis of 9 randomized trials found that static magnets have no effect on pain scores for patients with rheumatoid arthritis and fibromyalgia. However, the study suggests that further research is necessary to explore potential benefits for people suffering from osteoarthritis.
Researchers at Duke University Medical Center found that blocking two immune system proteins, IL-1 and TNF, can promote healing in damaged meniscus tissue. The study, published in Arthritis & Rheumatism, suggests a new approach to treating knee injuries and osteoarthritis.
Experts emphasize evidence-based approach to treating osteoarthritis, citing benefits of coxibs and NSAIDs despite gastrointestinal and cardiovascular risks. The OARSI international COX-2 workshop 2007 provided guidance on safe use of these agents.
Researchers found a 15% reduction in colorectal cancer diagnosis among patients with osteoarthritis who took NSAIDs, consistent with previous findings on pre-cancerous polyps. The study supports the need for further research to identify safe NSAID agents for regular preventive therapy.
Research by Yale med student Peter Fabricant found that women and people with osteoarthritis have poorer short-term recovery from arthroscopic knee surgery. In contrast, factors such as age, obesity, and tissue removal affect long-term outcome. The study suggests that severe osteoarthritis may be a contraindication to surgery.
A new study published in the Journal of Orthopaedic Research found that femoro-acetabular impingement (FAI) was seen in all five healthy female volunteers, despite no reported hip pain. The results suggest that FAI may not be a cause of osteoarthritis in some racial groups, particularly in Asian populations.
The University of Delaware has received a $11 million grant from the NIH to conduct translational research on osteoarthritis, focusing on tissue mechanics and biomechanics. A unique mentoring program will also support women biomedical researchers at UD.
A study at EULAR 2007 found that taking x-rays of the semi-flexed knee is the most reliable and responsive way to determine structural severity in knee OA. Measuring joint space width was shown to be more able to detect change over time or after treatment than other techniques.
Researchers used dGEMRIC MRI to measure GAG distribution and correlate it with indentation stiffness. The study found a significant relationship between the dGEMRIC index and mechanical stiffness, suggesting its potential as a predictive measure of cartilage stiffness in osteoarthritis patients.
A new study found that ibuprofen significantly raises the risk of heart attacks in high-risk cardiovascular patients taking aspirin for osteoarthritis. The Mount Sinai researchers' findings underscore the importance of considering NSAID interactions with aspirin in these patients.
Research found ibuprofen may boost the likelihood of heart problems in high-risk patients with osteoarthritis. High-dose ibuprofen was linked to a higher risk of heart attacks and strokes compared to other treatments, including lumiracoxib and naproxen.
A recent study published in Arthritis Care & Research found that exercise neither protects against nor increases the risk of knee OA in middle-aged and older adults. The study, which analyzed data from over 1,200 subjects, suggests that physical activity can be done safely without concerns about developing OA.
Scientists have uncovered the molecular structure of cartilage's collagen fibrils, a key factor in osteoarthritis. The discovery could lead to treatments that prevent fibril deterioration and ultimately alleviate joint pain.
A study by Yale University researchers found that Swedish massage therapy significantly improved symptoms in adults with osteoarthritis of the knee, including reduced pain and increased flexibility. The treatment was shown to be safe and effective, with benefits persisting after completion of the massage intervention.
Men with knee osteoarthritis who smoke experience greater cartilage loss and more severe pain than non-smokers. Smoking is a potentially modifiable risk factor for worsening knee osteoarthritis.
A recent study published in Annals of the Rheumatic Diseases found that smokers are more likely to experience severe cartilage loss and knee pain due to osteoarthritis. Smokers were also significantly more likely to report greater pain severity than non-smokers.
Researchers have developed a noninvasive imaging technique that uses a contrast agent and microcomputed tomography to image cartilage in osteoarthritis research. The technique, dubbed EPIC-microCT, reveals information about cartilage thickness and composition, allowing for the monitoring of osteoarthritis progression and treatment.
A US study finds no link between rock climbing and increased osteoarthritis risk, despite increased bone density in climbers' fingers and hands. Climbing style intensity is a significant predictor of bone strength, with bouldering and sport climbing styles correlating with stronger bones.
A randomized controlled trial found that osteoarthritis patients who received acupuncture treatment in addition to routine care showed significant improvements in symptoms and quality of life. The study's results suggest that acupuncture can be an effective treatment option for OA patients, with benefits lasting beyond the therapy period.
Researchers at Duke University have devised a new way to prolong the effects of an anti-inflammatory drug, potentially making it useful for providing longer-lasting treatment for osteoarthritis. The modified drug could last for several weeks rather than just hours, offering a significant clinical gain and fewer negative side effects.
A population-based study found that people with hand osteoarthritis had significantly shorter white cell telomere lengths compared to those without the disease. Telomere length was also associated with the severity of osteoarthritis, suggesting a link between biological ageing and degenerative inflammatory bone disease.
A study found that patients who exercised prior to hip and knee replacement required significantly less inpatient rehabilitation, walking more than 50 feet at discharge. The exercise program improved lower-extremity muscle strength and function before and after surgery.
A study found that direct-to-consumer advertising of Vioxx increased the proportion of osteoarthritis patient visits for which a prescription was written for Vioxx. However, Celebrex ads were associated with higher rates of Vioxx prescribing, but not significant changes in Celebrex prescriptions.
A recent study published in Arthritis Research & Therapy reveals a strong genetic link between hereditary knee bone marrow lesions and osteoarthritis. The research, conducted on 115 siblings from 48 families, found that the prevalence of these lesions was significantly influenced by genetics.
The Osteoarthritis Initiative (OAI) has released its first set of data, featuring images and clinical outcome information for nearly 5,000 participants at risk of knee osteoarthritis. The data will facilitate the discovery of biomarkers for development and progression of OA.
A study found that lower estrogen levels, particularly estradiol and its metabolites, are associated with an increased risk of developing knee osteoarthritis. Women with lower estradiol concentrations had a higher odds of developing knee OA.
Researchers have discovered a gene, matrilin-3, that prevents the onset of osteoarthritis in adult mice. The study reveals a correlation between matrilin-3 and osteoarthritis, suggesting potential diagnostic and predictive uses. Matrilin-3 plays a role in early bone development and controls bone mineral density in adulthood.
Researchers at the University of Bristol successfully regenerated cartilage in injured knees using bioengineered tissue implants. The study showed that engineered cartilage tissue can grow and mature even in knees affected by osteoarthritis, offering a promising approach to treating joint damage.
A study of 23 clinical trials found that weight loss can predict a significant reduction in physical disability in patients with knee osteoarthritis. The research suggests that achieving a moderate weight loss of over 7.6% can lead to at least a moderate clinical effect on physical disability.
A new study found that steroid injections can improve pain and stiffness in patients with late-stage hip osteoarthritis. The treatment was more effective than placebo in primary and secondary endpoints, offering hope for patients who have not responded to conservative therapy.
The European Alliance of Associations for Rheumatology (EULAR) has developed core recommendations for rheumatology care in Europe, focusing on key disease areas such as musculoskeletal disorders and gout. These guidelines aim to enhance the standard of care across the continent and provide valuable resources for healthcare professionals.
A recent study found that only 57% of older patients with osteoarthritis received adequate care, while medication safety was a major concern. The study's results highlight the importance of targeting safe medication use in this population to improve overall quality of care.
Women with lower extremity osteoarthritis are at higher risk of developing mobility difficulties, including lower extremity mobility and daily activities. Greater knee strength can reduce this risk, while obesity is a significant contributor to these limitations.
A team of researchers found that a component of joint fluid called lubricin forms a thin barrier to prevent contact between joint surfaces, reducing wear and tear. The combination of lubricin and hyaluronic acid produces an even greater protective effect than either substance alone.
Researchers found that obese participants exhibited a greater physical response to electrical stimulation than non-obese individuals, indicating lower tolerance for painful stimuli. The study suggests that obese people may not cognitively experience pain during exercise, increasing the risk of severe pain later on.
A study found a strong association between meniscal malposition, meniscal tears, and cartilage loss in knee OA. Meniscal damage increased the risk of cartilage loss, particularly in the medial tibiofemoral joint.
A large-scale study found that glucosamine combined with chondroitin sulfate provided significant pain relief for participants with moderate-to-severe knee osteoarthritis pain, but not those with mild pain. The treatment was shown to be effective in reducing pain by 20% or more compared to placebo.
The GAIT study found that glucosamine and chondroitin sulfate were ineffective in patients with mild knee pain, while those with moderate to severe pain saw significant relief when taking the supplements in combination. The results suggest that a personalized approach to managing osteoarthritis pain may be necessary.
The University of Manchester's Wellcome Trust Centre for Cell-Matrix Research has secured a £3.1 million grant for the next five years to develop approaches for preventing and treating diseases, including cancer, osteoarthritis, and vascular disease through vascular engineering.
Researchers found that pomegranate fruit extracts inhibit the overproduction of MMP enzymes in human cartilage cells, slowing cartilage degradation in osteoarthritis. The findings suggest a potential therapeutic effect for consuming pomegranate fruit extract to protect cartilage.
A large study found that acupuncture significantly improves symptoms in patients with osteoarthritis of the knee. However, its effectiveness when compared to standard treatment remains uncertain, and further research is needed to confirm its benefits.
A head-to-head study comparing Lidoderm patches and Celebrex found that Lidoderm alleviated knee pain in 54% of patients, while Celebrex showed similar results in 62%. The study's findings are promising for further research into Lidoderm's potential as an osteoarthritis treatment.
A study published in Arthritis & Rheumatism reveals a significant association between serum hyaluronan (HA) levels and osteoarthritis severity. The research, conducted on over 3,000 volunteers, suggests that HA levels may serve as a biomarker for diagnosing osteoarthritis.
Researchers found that mice lacking type VI collagen developed osteoarthritis at a rate five times greater than those with a functioning gene. The study provides new insights into the role of type VI collagen in cartilage health and its impact on osteoarthritis development.
Researchers found a significant link between elevated hyaluronic acid levels and severity of osteoarthritis, particularly in the knees and hips. The study, involving 753 participants from diverse ethnic backgrounds, suggests that hyaluronic acid measurements may be useful for assessing overall OA load.
Research identifies DDR2 as critical signaling molecule in osteoarthritis progression, leading to increased MMP-13 expression and cartilage degradation. The study suggests that DDR2 inhibitors may slow down osteoarthritis progression, offering a potential new approach for treatment.
A multi-site study found that acupuncture significantly decreases pain and improves function in patients with knee osteoarthritis. Participants receiving acupuncture showed a 40% decrease in pain and nearly 40% improvement in function compared to baseline assessments.
A topical diclofenac sodium solution has been shown to effectively treat symptoms of primary OA of the knee, improving pain and physical function by 45.7% and 36.7%, respectively. The study found that this treatment had a superior efficacy compared to a control solution, with minimal adverse effects related to skin reactions.
Patients with knee osteoarthritis prioritize treatment characteristics, such as risk of common adverse side effects and cost, when choosing medication. Non-selective NSAIDs are the least preferred option due to their limited impact on patient preferences.
A multicenter study found that the maximum daily OTC dose of acetaminophen (4000mg) was as effective as prescription doses of naproxen (750mg) for osteoarthritis pain relief. The study involved 551 patients with mild-to-moderate OA and showed no significant differences in efficacy between the two treatments over a six-month period.
Researchers from Wake Forest University Baptist Medical Center and Wake Forest Health found a 24% improvement in physical function among participants who combined weight loss with moderate exercise. Participants reported significant improvements in knee pain, with a decrease of over 30%.
A new clinical syndrome has been discovered that leads to severe osteoarthritis, characterized by cartilage breakdown and the presence of specific FRZB gene mutations. The study sheds light on the genetic mechanisms underlying this complex disease, with potential implications for treatment and prevention.
A new study demonstrates that adding menthol to a topical cream containing cetylated fatty acids significantly reduces pain and improves functional performance in patients with knee, elbow, and wrist osteoarthritis. The treatment also shows promise for upper-extremity performance and pain relief in these individuals.