Articles tagged with Osteoarthritis
Scientists have discovered that cartilage cells have a functioning body clock that can be reset by imposing an artificial rhythm, which could lead to new treatments for osteoarthritis. The research found that older mice had weaker body clocks, and that resetting the clock may alleviate symptoms.
Researchers used atomic force microscopy to measure the mechanical properties of single cells in articular cartilage. They found that vimentin protein plays a key role in maintaining cell integrity, and that adult tissue has higher mechanical properties than young or old tissue.
Researchers at the University of Manchester found that wearing a knee brace improves symptoms, function, and muscle strength in patients with patellofemoral osteoarthritis. The study's findings have enormous potential for treating this common joint condition effectively and reducing reliance on painkillers.
Professor Maria Luisa Brandi was awarded the prestigious ESCEO-IOF Servier Pierre D. Delmas Prize for her major scientific contributions to bone and mineral diseases. She is a renowned researcher with numerous patents and publications, recognized nationally and internationally.
Researchers discovered how nanoscale biomechanical properties of cartilage change at the earliest stages of osteoarthritis, making it more prone to damage from physical activity. GAG depletion affects cartilage stiffness and fluid flow, increasing vulnerability to high-rate activities like running and jumping.
Researchers at Rhode Island Hospital have discovered a new strategy to effectively treat and prevent osteoarthritis by adding lubricin protein to joint fluid. This breakthrough finding may reduce the risk of or even prevent OA, which affects 27 million adults in the US.
A new study found that total hip replacement (THR) is associated with reduced mortality, heart failure, depression, and diabetes rates in Medicare patients with osteoarthritis. THR also shows potential long-term benefits in terms of prolonged lifespan and reduced disease burden.
A study published in New England Journal of Medicine shows that physical therapy is just as effective as surgery for patients with meniscal tears and arthritis of the knee. The study found no significant differences in functional improvement between patients who underwent surgery with postoperative physical therapy and those who receiv...
A new study from Brigham and Women's Hospital found that physical therapy improves functional status, pain, and physical function in patients with meniscal tears and osteoarthritis. For a third of patients assigned to physical therapy, surgery was still necessary.
A naturally occurring protein called lubricin appears to protect against osteoarthritis, a common condition affecting over 70% of the population between 55-77 years old. Researchers found that mice with higher levels of lubricin did not develop traumatic or injury-induced osteoarthritis.
A literature review suggests that weight loss can diminish pain, restore function, and quality of life in osteoarthritis patients. Obesity may trigger biomechanical changes contributing to the condition, making weight loss a key treatment option for arthritis and joint pain prevention.
Researchers at the University of Montreal have found a way to diagnose and treat osteoarthritis in cats using meloxicam, an anti-inflammatory medication. The study showed that daily oral administration of meloxicam provided pain relief for four weeks, with higher doses continuing to provide relief for five weeks after treatment stopped.
Researchers at Yale School of the Environment linked exposure to perfluorinated chemicals (PFCs), including PFOA and PFOS, with an increased risk of osteoarthritis. The study found stronger associations for women than men, highlighting the need for further exploration of health effects in susceptible subpopulations.
Researchers at Rush University Medical Center identified a chemokine known as monocyte chemoattractant protein-1 (MCP)-1 and its receptor, chemokine receptor 2 (CCR2), as central to the development of osteoarthritis pain. This finding could lead to new treatments for this debilitating condition.
Researchers found that both high and low levels of physical activity can lead to accelerated degeneration of knee cartilage in middle-aged adults. The study suggests that finding an optimal level of physical activity may help preserve cartilage health.
A new study published in Journal of Bone and Joint Surgery found that computer-navigated total knee replacement had the same results as conventional procedures in terms of knee function, alignment, and durability. The study followed 520 patients for 10-12 years and found no significant differences between the two groups.
A recent study published in the Journal of Clinical Nursing found that nearly a quarter of patients with rheumatoid arthritis and osteoarthritis used complementary and alternative therapy (CAT) to manage their condition. The majority reported improvements in pain intensity, sleeping patterns, and activity levels after using CAT.
Obese patients are at a greater risk of post-surgical infections and require more follow-up surgeries following total knee replacement. The study advises well-informed obese patients to lose weight before surgery to lessen osteoarthritis symptoms and improve outcomes.
A Kansas State University professor's research on post-surgery pain treatment and osteoarthritis therapy in dogs aims to develop better ways to treat humans. The study found that hot and cold packing can be effective in reducing swelling, with a recommended time frame of 10 minutes.
A study by BUSM researchers reveals that approximately 90 percent of knees with no signs of osteoarthritis using X-ray showed clear signs of osteoarthritis using MRI. The findings suggest that MRI is not a useful diagnostic test for knee pain in this age group.
Researchers have discovered that blocking GM-CSF action can suppress both pain and inflammation in experimental models of rheumatoid arthritis and osteoarthritis. This breakthrough could lead to a new therapy for patients suffering from debilitating conditions.
The UIC study will compare two community-based health promotion programs for older adults with osteoarthritis, evaluating the effectiveness of adding a weight management component. Researchers aim to improve joint stiffness, pain, and function, as well as reduce anxiety and depression in participants.
Researchers have found that double bundle ACL reconstruction does not significantly reduce the risk of osteoarthritis progression in patients. Despite this, patients over 40 at the time of surgery are more likely to experience OA change over time.
Researchers found that people with osteoarthritis have a signature epigenetic change responsible for increasing the levels of the destructive MMP13 enzyme. This discovery provides hope for targeted drug development to prevent disease progression and improve quality of life for arthritis sufferers.
Researchers have identified eight new genetic variants associated with osteoarthritis, which could lead to future therapeutic intervention. The study suggests that inherited factors account for up to 60% of the risk, and the discovery provides insight into the genetics of arthritis.
Hospital noise is a significant factor affecting quality-of-care in hospitalized patients, disrupting sleep, healing, and causing negative impacts on cardiovascular health. Research found that louder sounds are more disruptive, especially those engineered to alert, while noises like ice machines are arousing at low sound levels.
Researchers found tart cherry juice significantly reduces inflammation in women with osteoarthritis, particularly those with high inflammation levels. Drinking twice daily for three weeks led to notable reductions in inflammatory markers.
A new study suggests that antidepressants, specifically duloxetine, can be an effective treatment for osteoarthritis pain. The analysis of FDA-approved studies found that duloxetine provides significant advantages over traditional treatments, including fewer side effects.
Dr. Claus Christiansen received the ESCEO-IOF Medal for his groundbreaking work on calcium metabolism in postmenopausal women. He has published extensively over 900 articles and book chapters, and has been a leading figure in osteoporosis research for over three decades.
René Rizzoli receives the award for his major scientific contributions to osteoporosis research and advocacy. He is recognized for both his clinical achievements and long-term impact as an educator and advocate in the field.
A recent study published in Radiology shows that tomosynthesis is more beneficial in diagnosing knee osteoarthritis than conventional X-ray imaging. The study detected more osteophytes and subchondral cysts in the knee joint, improving sensitivity by up to 29% and 50% respectively.
The Osteoarthritis Summit identified gaps in research and proposed a new classification system to address the disease's complexity. Experts emphasized the need for multidisciplinary approaches and biomarkers to monitor disease progression, with potential solutions including weight loss interventions and integrated treatment strategies.
More than 4.5 million Americans are living with a total knee replacement, with osteoarthritis being the leading cause. The prevalence of TKR is higher in women, with 5.3% compared to 4.1% in men.
Researchers discovered that osteoarthritic knee joints have a constant state of repair, while hip joints do not. This suggests different treatment strategies may be needed for knee and hip osteoarthritis. A biomarker was identified to measure joint degeneration and repair response.
The research will focus on lubricin, a protein that may prevent osteoarthritis following joint trauma. The study aims to advance clinical knowledge of lubricin's use in treating traumatic injuries and preventing OA development.
A study of 107 individuals with diagnosed osteoarthritis in the knee found that a DVD-based exercise program significantly improved pain and physical function, but did not affect osteoarthritis progression. Video-based home exercise programs can enhance adherence and improve life quality for patients living with knee osteoarthritis.
A new study finds that total knee replacement (TKR) in elderly osteoarthritis patients can reduce mortality rates by half and lower the risk of heart failure. Additionally, TKR may result in reduced healthcare costs due to lower Medicare payments over a seven-year period.
A Stanford University School of Medicine study reveals that osteoarthritis is driven by low-grade inflammatory processes. The researchers found that inflammation sets in motion a chain of molecular events that escalates into an attack on the damaged joint, leading to its progression.
A new study found that rheumatoid arthritis patients who undergo total knee replacement surgery have lower expectations about their postsurgical outcomes compared to osteoarthritis patients. This can lead to worse outcomes due to reduced motivation for rehabilitation, resulting in decreased function and overall quality of life.
A novel study demonstrates that nanoparticles can retain osteoarthritis drugs in the knee joint, increasing their duration of action. This technology, when used with current or new osteoarthritis drugs, may allow patients to receive injections every three months instead of once a week.
Researchers used mathematical models to assess knee replacement implants and found that older patients or those with multiple conditions may not benefit from incremental gains in implant durability. This highlights the need for personalized approach to medical device development and evaluation.
A University of Bristol study found that omega-3-rich diets reduced disease by 50% compared to a standard diet in guinea pigs with naturally occurring osteoarthritis. Omega-3 influences biochemistry and helps prevent disease progression, potentially controlling established osteoarthritis.
A new translational research center aims to predict and prevent osteoarthritis in young people and improve care for adults suffering from the disease. The center will integrate imaging, biomechanics, and clinical medicine to develop clinical tools that can assess degeneration and risk factors.
A clinical trial shows that chondroitin sulfate significantly decreases pain, improves hand function, and relieves morning stiffness in patients with osteoarthritis of the hand. The study found that 800 mg of chondroitin sulfate improved grip strength and reduced pain compared to a placebo group.
A new gene, MCF2L, associated with osteoarthritis has been identified through a genome-wide association scan using the 1000 Genomes Project data. The variant is found on chromosome 13 and regulates nerve growth factor (NGF), suggesting that MCF2L plays a role in the development of osteoarthritis.
A Northwestern University study reveals that people with arthritis are not engaging in physical activity critical to their health. The research found that more than half of women and 40 percent of men with arthritis were inactive.
Researchers have discovered a dual-action treatment combining steroids within a viscosupplement that provides superior pain relief and improved function. Hydros-TA Joint Therapy shows promise as a next-generation osteoarthritis treatment, offering faster onset and longer-lasting results.
Mayo Clinic researchers are investigating why knee osteoarthritis disproportionately affects women. The study will analyze human tissues discarded during knee replacement surgery for possible biological differences in pain fibers and hormone receptors between female and male patients.
Dr. Joanne Jordan has received the 2011 Distinguished Service to Rural Life Award from the Rural Sociological Society for her outstanding contribution to enhancing rural life and rural people through her work on the Johnston County Osteoarthritis Project, which improved health outcomes in rural North Carolinians.
Patients who showed motion limitations after surgery were more likely to develop arthritic changes in the knee. Rehabilitation emphasizing full motion was found to have more favorable results on x-rays compared to those who lost motion.
Researchers propose reclassifying osteoarthritis into distinct divisions based on clinical and structural phenotypes. This could enable targeted treatments for specific patient groups, such as those affected by obesity or trauma. Improved imaging and biomarker technologies are needed to support this new classification system.
The ESCEO Young Investigators Awards were presented to Dr. Nick Harvey and Dr. Michaël Hiligsmann for their outstanding contributions to bone and mineral research. Their awards, valued at €2,500, recognize excellence in bone mineral research and are supported by a grant from MSD.
Dr. Helena Johansson and Dr. Maria-Belen Zanchetta receive $50,000 USD Fellowship to support their osteoporosis research at Sahlgrenska Academy and Instituto de Investigaciones Metabólicas, respectively. The award aims to promote research excellence in the bone field.
John A. Kanis, a leading expert in bone and mineral diseases, has made significant scientific contributions to the study of osteoporosis. He is currently President of the International Osteoporosis Foundation and WHO Advisor on Osteoporosis.
Researchers from North America and Europe will present new osteoarthritis research at the Segal North American Osteoarthritis Workshop (SNOW) on March 25-27. The workshop aims to identify priority interventions that could improve treatment options for OA.
Professor Gerard Karsenty is awarded the first Herbert A. Fleisch ESCEO-IOF Medal for his pioneering work in understanding skeletal development and physiology. The medal recognizes his outstanding achievements in basic bone science, including identifying Runx2 as a master gene of osteoblast differentiation.
Researchers view the knee as a complex organ to develop more effective treatments for osteoarthritis. The exhibit explores degenerative knee arthritis as a failure of multiple tissue systems.
Researchers found that obesity reduces duration and quality of life by 12 percent, while knee osteoarthritis has a similar impact. A new guideline also recommends targeted prevention and treatment strategies for patients with specific characteristics, such as age, race, and functional status.
People with knee osteoarthritis are more likely to walk fast enough if they lead physically active lives, according to new research. The study found that even a small increase in activity is related to better walking function.
Researchers at Duke University Medical Center found a strong correlation between uric acid levels and severity of knee osteoarthritis in a study of 159 participants. The study suggests that lowering uric acid levels may slow the progression of osteoarthritis.