Articles tagged with Osteoarthritis
Researchers have developed an injectable drug that inhibits the Wnt pathway, causing endogenous stem cells to regenerate knee cartilage in animals. Clinical data suggest slowing joint space narrowing and increased joint space, indicating potential preservation or regrowth of cartilage.
Samumed's Phase II clinical trial aims to evaluate the safety, tolerability, and efficacy of SM04690 in treating moderately to severely symptomatic OA patients. The trial will assess changes in WOMAC pain and function subscores at Week 13.
Researchers at Queen Mary University of London have found that lithium chloride can increase the size of primary cilia, disrupting Hedgehog Signalling and potentially treating osteoarthritis. This discovery may lead to new treatments for arthritis and other conditions.
A new international study is recruiting over 8,000 UK parkrun participants to assess the link between recreational running and osteoarthritis. The HALO study will follow participants for 15 years to identify potential benefits and risks of regular running.
Research reveals women with knee osteoarthritis have greater sensitivity to pain stimuli, such as heat and cold, and widespread pain. This study's findings may inform treatment strategies for both men and women.
A pooled analysis of studies found that Tai Chi improved physical capacity and quality of life in people with breast cancer, heart failure, osteoarthritis, and COPD without worsening pain or breathlessness. The exercise also showed benefits for muscle strength and sit-to-stand times in patients with osteoarthritis.
A new $6 million NIH grant will fund a WE-CAN study examining the success of community-based programs for treating knee osteoarthritis. The study aims to test the effectiveness of weight loss and exercise interventions in real-world settings, building on previous clinical trial results.
A study published in Arthritis & Rheumatology found that osteoarthritis patients who underwent total knee or hip joint replacement surgery were at increased risk of heart attack immediately following arthroplasty. However, long-term risk was insignificant, while the risk for venous thromboembolism remained years after the procedure.
Researchers found that total knee replacement reduces knee pain and improves subjective quality of life indices in rheumatoid arthritis patients. However, improvements were not as great as those experienced by osteoarthritis patients.
Researchers at the University of York have identified individual stem cells that can regenerate tissue, cartilage and bone, opening the way for improved treatment options for osteoarthritis. The discovery has the potential to develop targeted therapies for arthritis patients, making cell-based treatments less of a lottery.
New research from the University of Missouri reveals that even small changes in menisci can hinder knee function, providing clues to understanding osteoarthritis. The study suggests repairing meniscal tears might be worthwhile to prevent osteoarthritis.
A systematic review and meta-analysis found paracetamol to be ineffective in reducing pain intensity and improving disability or quality of life for patients with lower back pain. However, it provided small benefits in reducing pain and disability for osteoarthritis, while increasing the risk of liver function test abnormalities.
Paracetamol is ineffective in reducing pain, disability, or improving quality of life for patients with low back pain or osteoarthritis. Its use may also affect the liver, increasing the risk of liver toxicity in patients. The study calls for an urgent review of guidelines that endorse paracetamol for these conditions.
A University of Florida study found that higher levels of vitamin D may decrease pain and improve function in obese individuals with osteoarthritis. The researchers analyzed blood samples from a racially diverse group of adults and found an association between obesity and vitamin D status.
A recent study published in Osteoporosis International found that painful knee osteoarthritis in women is associated with a higher risk of early death compared to unaffected women. The study, which followed middle-aged women for 24 years, also found no link between hand osteoarthritis and excess mortality risk.
Researchers at the University of Warwick have identified a biomarker linked to both rheumatoid and osteoarthritis, potentially leading to an early diagnosis of OA and RA. The development of a blood test using this biomarker could help patients receive treatment several years before physical symptoms appear.
Postmenopausal women with mild knee osteoarthritis saw improved patellar cartilage quality through high-impact jumping exercises. High-impact loading also enhanced physical function, including knee extensors strength and cardiorespiratory fitness.
A new study uses a fluorescent probe to track osteoarthritis development in male mice, providing insights into early detection and monitoring of the disease. The findings show that the probe emits a brighter signal in injured knees as the disease progresses.
Researchers at Queen Mary University of London have developed microcapsules that can deliver C-type natriuretic peptide (CNP), an anti-inflammatory protein, to damaged cartilage in osteoarthritis patients. The microcapsules could potentially slow the progression of osteoarthritis and repair damaged tissue.
Researchers from the University of Leeds identified using stairs as the first weight-bearing task that triggers pain in people with early osteoarthritis. The study, which tracked over 4,600 participants, aims to improve early detection and treatment of the condition.
A popular knee surgery to repair meniscal tears may accelerate disease onset in some patients. Meniscal surgery was associated with a higher risk of developing osteoarthritis and cartilage loss compared to conservative management.
Dr. Peter Barrance will study the effects of in-shoe orthoses on individuals with osteoarthritis of the knee using weight-bearing MRI technology. The goal is to refine footwear modifications and reduce pain and mobility limitations associated with knee osteoarthritis.
A UTA researcher has made a breakthrough in regenerating cartilage tissue using microscaffolding injections, aiming to reduce posttraumatic osteoarthritis symptoms. The treatment utilizes patients' own stem cells to form new cartilage tissue, potentially curing the disease.
Scientists at the University of Liverpool have discovered that changes in messenger molecule mRNA creation and destruction rates contribute to osteoarthritis. The study highlights key genes involved in the disease and offers hope for developing targeted therapies.
A meta-analysis review of seven randomized control trials found no short-term pain relief and limited long-term function improvement in patients with some osteoarthritis after arthroscopic knee surgery. The study suggests that non-operative treatments should be used first for middle-aged or older patients.
A new study published in CMAJ found that arthroscopic knee surgery does not provide relief for middle-aged patients with mild osteoarthritis. The research analyzed seven randomized controlled trials and concluded that the procedure may have little to no effect on short-term and long-term outcomes.
A study by University of Liverpool scientists has identified a new mechanism of joint destruction caused by high-density mineralised protrusions (HDMPs) in human hip joints. These protrusions, seen only in horses, can snap off and grind against healthy tissue, worsening osteoarthritis.
A literature review published in JAAOS found that patients' activity levels are a strong predictor for orthopedic outcomes. The study highlights the importance of considering activity level when deciding treatment options, as more active patients may be at higher risk of re-injury after surgery.
Researchers at Duke University Medical Center found that mice consuming omega-3 fatty acids had healthier joints than those fed diets high in saturated fats and omega-6 fatty acids. The study suggests that dietary factors, rather than obesity alone, contribute to worsening osteoarthritis.
A new study published in The Lancet found that partial knee replacement surgery is safer than total knee replacement, with fewer life-threatening complications and deaths. Patients who undergo partial knee replacement are less likely to experience major complications such as heart attacks, strokes, or deep infections.
A study identifies three microRNAs as biomarkers for predicting severe osteoarthritis, allowing for early detection and preventative measures. The findings could significantly reduce the socio-economic burden of the disease.
A recent study published in JAMA found that physiotherapy for adults with painful hip osteoarthritis does not produce greater improvements in pain or function compared to a placebo treatment. The study suggests questioning the benefits of specific physiotherapy components for this patient population.
A study published in JAMA Network found that physical therapy did not significantly improve pain or function in adults with hip osteoarthritis. However, the treatment group reported more adverse events, which were relatively mild.
A 16-week study found that grape consumption significantly decreased self-reported pain related to activity and total knee symptoms in individuals with symptomatic knee osteoarthritis. The beneficial effect was more pronounced in females, particularly those under 64 years old.
A new Northwestern Medicine study found that engaging in daily light physical activity can help prevent disability in people with or at risk of knee arthritis. Spending more time in light activities reduced the risk of disability by over 30% compared to those who spent less time in such activities.
Prolotherapy injections have shown substantial improvement in knee osteoarthritis symptoms, including pain, function, and stiffness. Patients experienced symptom improvement ranging from 19.5-42.9% compared to baseline status.
New research suggests that women who frequently consume fat-free or low-fat milk may reduce the progression of knee osteoarthritis. The study found that joint space width decreased by 0.38mm, 0.29mm, and 0.26mm in women with increasing milk intake.
A study of 546 senior athletes found that genetics may play a role in preserving hip joints, with 72% of hips with FAI showing little to no evidence of OA. Most hips with signs of FAI will not develop osteoarthritis, suggesting other factors like cartilage type may contribute to joint health.
A study found that a lower ratio between the length of the index and ring fingers is associated with a higher risk of developing severe osteoarthritis in the knees. This association was stronger for total knee replacements than hip replacements, suggesting hormonal influences may play a role.
A study reveals that zinc levels inside cartilage cells regulate and respond to the destruction of cartilage tissue in joints. The researchers identified a molecular pathway involving the protein ZIP8, which transports zinc and leads to cartilage destruction.
Researchers at UD developed a smart hydrogel that delivers medicine in response to mechanical force, reducing inflammation and pain in osteoarthritis. Preliminary results indicate biocompatibility and potential applications beyond osteoarthritis.
Researchers at University of Nottingham discovered a potential drug to reduce osteoarthritis pain by targeting cannabinoid receptor2 (CB2), which also reduces joint inflammation. The synthetic compound JWH133 showed promise in animal models and human spinal cord tissue studies.
Researchers have developed a squishy gel that releases an anti-inflammatory drug when compressed, like a painful knee joint. The new material could deliver medications on-demand to alleviate osteoarthritis symptoms.
A new study by Rush University Medical Center found that mobility shoes significantly reduced knee loading in osteoarthritis patients, even after the shoes were no longer worn. The study suggests that footwear choice may be an important consideration in managing knee osteoarthritis.
Peter Barrance, a senior research scientist at Kessler Foundation, received the 2013 Clinical Biomechanics Award for his study on tibiofemoral contact location changes associated with lateral heel wedging. The study used weight-bearing MRI and was funded by NIDRR.
A new meta-analysis of 29 randomized studies involving over 4,500 patients with knee osteoarthritis found significant improvement in pain and function with intra-articular hyaluronic acid (HA) injections compared to saline injections. The study confirmed the safety profile of FDA-approved HA products.
A novel technique using ultrasound waves could reveal how abnormal forces lead to osteoarthritis development, enabling targeted intervention programs.
A new study found that adults who engage in moderate physical activity up to two and a half hours a week do not increase their risk of developing knee osteoarthritis. The study also found no association between race, sex, or body weight and the risk of knee osteoarthritis.
A study led by University of East Anglia found that sulforaphane in broccoli slows down cartilage destruction and osteoarthritis. Researchers hope to replicate the effect in humans through a small-scale trial.
A meta-analysis of 12 studies found that lateral wedge insoles had no significant or clinically important effect on reducing knee pain in patients with medial knee osteoarthritis. The overall effect estimate was moderately significant, but heterogeneity across studies suggested a null association.
Research suggests that patients' chronic pain affects their spouses' emotional well-being and marital satisfaction, leading to compromised sleep quality. In close relationships, the greater a patient's pain, the less refreshing the sleep for the spouse.
Researchers have found a naturally occurring molecule, Urocortin, which protects cells in the joints from being destroyed in osteoarthritis. The discovery could lead to the development of new medicines to prevent joint degradation.
Scientists have discovered that cartilage cells have a functioning body clock that can be reset by imposing an artificial rhythm, which could lead to new treatments for osteoarthritis. The research found that older mice had weaker body clocks, and that resetting the clock may alleviate symptoms.
Researchers at the University of Manchester found that wearing a knee brace improves symptoms, function, and muscle strength in patients with patellofemoral osteoarthritis. The study's findings have enormous potential for treating this common joint condition effectively and reducing reliance on painkillers.
Researchers used atomic force microscopy to measure the mechanical properties of single cells in articular cartilage. They found that vimentin protein plays a key role in maintaining cell integrity, and that adult tissue has higher mechanical properties than young or old tissue.
Professor Maria Luisa Brandi was awarded the prestigious ESCEO-IOF Servier Pierre D. Delmas Prize for her major scientific contributions to bone and mineral diseases. She is a renowned researcher with numerous patents and publications, recognized nationally and internationally.
Researchers discovered how nanoscale biomechanical properties of cartilage change at the earliest stages of osteoarthritis, making it more prone to damage from physical activity. GAG depletion affects cartilage stiffness and fluid flow, increasing vulnerability to high-rate activities like running and jumping.
Researchers at Rhode Island Hospital have discovered a new strategy to effectively treat and prevent osteoarthritis by adding lubricin protein to joint fluid. This breakthrough finding may reduce the risk of or even prevent OA, which affects 27 million adults in the US.
A new study found that total hip replacement (THR) is associated with reduced mortality, heart failure, depression, and diabetes rates in Medicare patients with osteoarthritis. THR also shows potential long-term benefits in terms of prolonged lifespan and reduced disease burden.
A study published in New England Journal of Medicine shows that physical therapy is just as effective as surgery for patients with meniscal tears and arthritis of the knee. The study found no significant differences in functional improvement between patients who underwent surgery with postoperative physical therapy and those who receiv...