Articles tagged with Osteoarthritis
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A study published in Arthritis & Rheumatology found that prescription opioids are commonly used long-term to treat pain in older patients with severe osteoarthritis. The study also revealed substantial statewide variation in rates of treatment with long-term opioid therapy for osteoarthritis, which was not fully explained by difference...
Scientists use 3D printing to create articular cartilage and subchondral bone from mesenchymal stem cells. This technique shows promise in repairing osteochondral defects in mini-pigs' knees.
A large-scale genetic study has uncovered 52 new genetic changes linked to osteoarthritis, which may help identify new treatment targets and repurpose existing medications. The study analyzed the genomes of over 77,000 people with osteoarthritis and found potential avenues for drug exploration.
A genetic study of over 77,000 people with osteoarthritis has identified 52 new genetic changes associated with the disease. The research could lead to new medicines and improved treatment options for those affected by the condition.
Research found a significant association between Heberden's nodes and imaging measures of knee osteoarthritis. The study suggests a link between finger joint enlargements and structural damage in the knee joint.
Researcher Jenny Robinson studies estrogen's potential to protect menisci and regenerate damaged tissue, aiming to develop targeted therapies. The goal is to create an off-the-shelf material that could be implanted into the knee to promote repair and inhibit further degeneration.
Researchers at OSU Wexner Medical Center are testing a new device designed to extend the functional life of joints affected by osteoarthritis. The Calypso Knee System aims to reduce pain and delay knee replacements, allowing patients to remain active without discomfort.
A new study analyzed combined results of 47 randomized clinical trials, lasting at least 12 months, involving 22,000 patients with knee osteoarthritis. The research found uncertainty around long-term effectiveness of medications in controlling pain, highlighting the need for large randomized clinical trials.
A study at Duke University Medical Center found that weekly whole-body massage improved symptoms of knee osteoarthritis, including pain and mobility, in patients. The treatment maintained its benefits over 52 weeks, suggesting a potential complement to existing treatments.
A charged molecule, called a dendrimer, is designed to deliver osteoarthritis drugs to knee joint cartilage. The nanocarrier effectively binds to cartilage tissue, allowing for deeper penetration and longer half-life in joint spaces.
Researchers developed a combinatorial gene therapy approach that inhibits inflammation and promotes pro-anabolic cartilage genes, preserving articular cartilage better than each approach alone. This strategy was shown to be effective in both moderate and severe post-traumatic osteoarthritis models.
A randomized clinical trial found that patellar mobilization therapy significantly reduces pain in patients with knee osteoarthritis. The technique can be easily performed in primary care practice, requiring only one hour to learn and practice.
Researchers found four subgroups with varying degrees of pain sensitization, with the highest degree associated with persistent knee pain. Identifying these subgroups may lead to novel approaches for preventing persistent knee pain.
A new study from Université de Montréal finds that increased pain sensitivity is a key risk factor for persistent knee pain in osteoarthritis. The research identified four subgroups characterized by varying degrees of pain sensitization, with the highest degree linked to the greatest risk of developing persistent knee pain.
Researchers discovered that articular cartilage degenerates specifically around injury areas due to excessive fluid flow velocity, potentially leading to osteoarthritis. The novel mechanobiological model can predict osteoarthritis in personal medicine and suggest optimal rehabilitation protocols.
Researchers at Krembil Institute have developed a novel therapeutic treatment that can potentially stop knee and spine osteoarthritis in its tracks. The treatment targets microRNA-181a-5p, a biomarker believed to cause inflammation, cartilage destruction, and collagen depletion.
A new study has found a strong association between diabetes and an increased risk of developing osteoarthritis, rheumatoid arthritis, and osteoporosis. People with diabetes were 33% more likely to suffer from osteoarthritis than their counterparts without diabetes.
Researchers found that people who report lingering symptoms after ACL surgery tend to overload or underload their injured leg, leading to cartilage damage. The study suggests that restoring proper movement mechanics through physical therapy and strength training may improve chances of avoiding osteoarthritis.
Resveratrol supplementation significantly reduced pain severity and levels of inflammatory biomarkers, including TNF-α, interleukin IL-1ß, and IL-6, in patients with mild to moderate knee osteoarthritis. The study suggests resveratrol may be an effective add-on to NSAIDs for treating knee osteoarthritis.
ANP32A protein protects cartilage from oxidative stress, which contributes to osteoarthritis development. Antioxidant treatments like NAC may prevent further cartilage damage and reduce osteoarthritis symptoms.
Researchers found that a high-carb diet, particularly with high sugar and low fiber content, increased signs of joint inflammation and altered cartilage genes in laboratory mice. The study suggests that dietary carbohydrates may be a contributing factor to osteoarthritis risk, even in the absence of obesity.
Researchers at UniSA's Body in Mind Research Group have found visual illusions can reduce knee pain in people with osteoarthritis by up to 40%. The study used visual illusions that altered the size of participants' knees and lower legs, resulting in a cumulative analgesic effect.
A new algorithm detects subtle changes in arthritic joints using 3D CT images, outperforming current x-ray methods in sensitivity. This could lead to earlier osteoarthritis diagnosis and more accurate treatment assessments.
Research suggests that non-steroidal anti-inflammatory drugs (NSAIDs) play a causal role in the cardiovascular risk of patients with osteoarthritis. A study found that over two-thirds of the increased cardiovascular risk associated with osteoarthritis is linked to NSAID use, particularly for congestive heart failure and ischemic heart ...
A two-year study found that zoledronic acid did not reduce knee pain or bone marrow lesion size in patients with osteoarthritis. However, it showed symptomatic benefit in those with milder disease. The study's results may suggest a potential role for zoledronic acid in relieving symptoms in patients with mild osteoarthritis.
A study found that decreased physical performance and greater structural disease severity are associated with a higher risk of experiencing depressive symptoms in patients with knee osteoarthritis. The study suggests using a combined treatment strategy to target both conditions.
Arthritis patients with poor sleep quality reported lower weekly minutes of moderate-vigorous activity. Participants with restless sleep had 11.9% and 23.7% less physical activity compared to those with rare restless sleep.
A study published in The Spine Journal found that one-third of people aged 40-59 have image-based evidence of moderate to severe degenerative disc disease. Additionally, the prevalence of spinal osteoarthritis increased significantly with age, particularly among women.
The study analyzed an insurance database of over 1 million patients with knee osteoarthritis treated between 2007 and 2015. Updated guidelines from the American Academy of Orthopaedic Surgeons led to a decline in hyaluronic acid injections, while steroid injection rates leveled off after a recommendation against its use was made.
Researchers found that conflicts with a spouse can exacerbate chronic pain and symptoms in individuals with osteoarthritis and type 2 diabetes. Daily diaries revealed that those experiencing tension with their partner had worse moods, greater pain, and more severe symptoms.
A new study found that low-dose fish oil supplements can reduce pain in patients with osteoarthritis. Additionally, weight loss, exercise tailored to mobility, and a diet rich in vitamin K can also ease symptoms. A calorie-restricted diet was effective in reducing pain for overweight patients.
The Keck School of Medicine of USC has received $4 million in grants from the National Institutes of Health and US Department of Defense to support basic and pre-clinical research on osteoarthritis. Researchers hope to translate foundational knowledge into clinical therapies that can improve millions of lives.
A recent study funded by Morris Animal Foundation found that tramadol is not an effective treatment for osteoarthritis pain in dogs. The research team compared tramadol to placebo and non-steroidal anti-inflammatory drugs, concluding that it was no more effective than a placebo.
Ali Guermazi, the first radiologist to receive the award, has made significant contributions to identifying structural risk factors for osteoarthritis. His research and clinical trials have been published in top-tier journals and presented at international conferences.
Researchers found that walking the course provides significantly higher health benefits and is not associated with increased pain or inflammation. Golfing while riding a cart still offers cardiovascular benefits, but walking is the superior option.
A recent study published in JCI Insight found that gut bacteria can contribute to the development of osteoarthritis in obese individuals. The researchers discovered that a high-fat diet altered the gut microbiome, leading to inflammation and joint deterioration. However, supplementing the diet with a common prebiotic oligofructose reve...
A study published in Nature Genetics has identified nine novel genes associated with osteoarthritis. Researchers used the UK Biobank resource and found that five of these genes differ significantly in their expression between healthy and diseased cartilage, offering new targets for future research into therapies.
A minimally invasive treatment called geniculate artery embolization (GAE) has been shown to significantly reduce knee pain and disability in patients with osteoarthritis. The treatment involves blocking key arteries in the knee to reduce inflammation and pain, resulting in improved range of motion and function.
Researchers have discovered nine new genes associated with osteoarthritis, a degenerative disease causing joint damage and pain. The findings could lead to the development of targeted therapies for this debilitating condition, affecting 10 million people in the UK.
Researchers at Wake Forest Baptist Medical Center have developed a nanotechnology-based approach to measure hyaluronic acid, a molecule indicative of osteoarthritis. This technology enables the detection of small amounts of HA in synovial fluid, allowing for better assessment of disease progression.
A growing number of centers are advertising stem cell therapies for knee osteoarthritis, claiming an 80% success rate. However, research has found poor levels of evidence to support the efficacy of these treatments, and no correlation between treatment costs and effectiveness.
A randomized clinical trial found that opioid medications did not improve pain-related function over 12 months compared to nonopioid medications. Nonopioid medications resulted in less intense pain and fewer medication-related symptoms.
A new study found moderate-to-vigorous physical activity levels are similarly low in older adults with symptomatic knee osteoarthritis and those from the general population without osteoarthritis or knee pain. The findings highlight the need for efforts to increase physical activity for all.
A new study finds that taking hydroxychloroquine to control debilitating pain in hand osteoarthritis patients yields no benefits compared to a placebo. The research challenges the common practice of using this drug off-label for treating hand osteoarthritis.
Researchers found hydroxychloroquine no more effective than placebo in relieving moderate to severe hand pain and radiographic osteoarthritis. The study's findings do not support the use of hydroxychloroquine as an alternative for patients with hand osteoarthritis, suggesting that tendon problems may be a major contributor to hand pain.
Researchers found FOXO proteins maintain healthy cartilage and prevent joint degeneration. Targeting FoxO could develop new therapies to treat osteoarthritis.
Black Americans experience lower total knee replacement rates, resulting in significant losses in quality-adjusted life years. Compared to white counterparts, they gain fewer QALYs due to underuse of this highly efficacious procedure.
A new study presented at the Radiological Society of North America meeting found that hip steroid injections are associated with a higher incidence of bone death and collapse compared to control groups. The research showed that 22-24% of patients who received hip injections developed osteonecrosis, while 15-17% experienced bone collapse.
Monocytes play a pivotal role in osteoarthritis pain and progression. A study found that activated monocytes increase inflammation and body mass index, leading to worsened knee osteoarthritis. Researchers aim to explore the impact of exercise on older adults with OA.
A team of researchers has found that Dolly's skeleton shows no signs of abnormal osteoarthritis, contrary to initial concerns. The study also revealed that the skeletons of other clones and naturally conceived sheep have similar radiographic OA patterns.
A large study reveals retired professional footballers are two to three times more likely to suffer from knee pain and osteoarthritis than the general population. The research found that repetitive microtrauma from playing football is a major cause of increased risk, particularly in younger age groups.
Researchers aim to discover whether acupuncture can treat vulvodynia, a women's chronic pain condition affecting up to 14 million Americans. Acupuncture has shown promise in reducing pain in various studies.
Researchers developed a novel cartilage degeneration algorithm to predict the progression of osteoarthritis. The algorithm shows great potential in patient-specific progression prediction, and may facilitate clinical decision-making in treatment.
Researchers found knee OA in 16% of postindustrial individuals 50+, but only 6% and 8% in early industrial and prehistoric samples. The findings suggest an approximate doubling of knee OA prevalence since the mid-20th century.
A recent Harvard University study reveals that knee osteoarthritis has dramatically increased in prevalence over the past 70 years, affecting an estimated one-third of Americans over 60. The research challenges the long-held assumption that osteoarthritis is simply a wear-and-tear disease related to aging and obesity.
Researchers found that self-efficacy positively affects physical activity in osteoarthritis patients, even controlling for pain and mood. Boosting confidence can increase daily steps and moderate-intensity activity.
A single genetic change linked to reduced human height is also associated with an increased risk of osteoarthritis. The variant has been positively selected in many human populations, suggesting it may have provided a survival advantage in colder climates.
A new study found that spouses' empathic responses to their partners' pain improve the partner's physical functioning over time. Patients with spouses who provided emotional support and attention showed better balance, gait speed, and ability to rise from a chair compared to those with less responsive spouses.
A systematic review of 25 studies found that recreational running is not associated with osteoarthritis, but competitive running increases the risk. Recreational runners are less likely to develop knee and hip osteoarthritis compared to sedentary individuals.
Researchers find pharmaceutical-grade chondroitin sulfate comparable to celecoxib in reducing pain and improving joint function; long-term treatment recommended for older adults with knee osteoarthritis. Effective and safe alternatives are needed due to risks associated with NSAIDs and paracetamol.