Articles tagged with Osteoarthritis
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A systematic review of antidepressant effectiveness for back and osteoarthritis pain found small, insignificant benefits for some patients. The evidence suggests that antidepressants may not be a worthwhile treatment option for chronic pain, highlighting the need for large-scale, industry-free trials.
Researchers at University of Pennsylvania School of Medicine have discovered a method to halt osteoarthritis-type knee cartilage degeneration by targeting a specific protein pathway. By over-activating the EGFR signaling pathway, they were able to slow down cartilage degeneration and knee pain in mice.
The American College of Physicians (ACP) has released a comprehensive framework to address disparities and discrimination in healthcare, proposing policy recommendations to enhance quality and effectiveness for all patients. The framework also discusses specific contributors to health disparities and steps to improve them.
A new study by Shriners Hospitals for Children finds that biochemical signals released by fat cells are responsible for osteoarthritis. The investigation, led by Dr. Farshid Guilak, suggests a factor given off by fat cells makes cartilage susceptible to degeneration.
David T. Felson, a renowned Boston University rheumatologist, has been honored with the Lee C. Howley Prize from the Arthritis Foundation for his groundbreaking research on osteoarthritis (OA). His work has led to significant advances in understanding OA risk factors, treatments, and outcome measurement.
The updated guidelines recommend a combination of non-pharmacological, pharmacological, and surgical interventions to manage knee osteoarthritis. Education, structured exercise, and weight loss are emphasized as core treatments, while topical NSAIDs are advised as first-line treatments for persistent pain.
A panel of experts recommends imaging for hip and knee steroid injections to mitigate joint collapse and total replacement risks. Current evidence is insufficient to draw a definitive conclusion, highlighting the need for further research.
Researchers at UniSA have identified a new biomarker for osteoarthritis using mass spectrometry imaging, which may improve early diagnosis and treatment. The study found specific sugars associated with damaged tissue compared to healthy tissue, potentially helping slow the progression of the disease.
A machine learning classifier accurately detected the beginning stages of osteoarthritis progression in a study of 86 individuals. The classifier achieved 78% accuracy up to 3 years before symptom onset, suggesting early detection may enable treatment at a reversible stage.
Researchers developed a machine-learning algorithm that can detect subtle signs of osteoarthritis on MRI scans taken years before symptoms begin. The algorithm predicted osteoarthritis with 78% accuracy from MRIs performed three years before symptom onset, offering hope for preventative treatments.
A randomized, double-blind trial found that turmeric supplements were more effective in reducing knee pain in patients with osteoarthritis compared to a placebo. The study also showed no adverse events and reduced medication usage, but highlighted the need for larger, longer-term trials.
Researchers identified a potential underlying mechanism in the nervous system responsible for varying pain patterns with knee osteoarthritis. People with more pain sensitization were more likely to suffer from constant and unpredictable pain.
Dr. Daniel Pinto has been recognized with the prestigious award for his research on cost-effectiveness and patient preferences in arthritis management strategies. He is a specialist in orthopaedic physical therapy and a member of several IOF committees.
Researchers emphasize the importance of implementing effective post-fracture care coordination programs to reduce secondary fractures, frailty, and mortality in older patients. A novel FLS benefits calculator has been introduced to support decision-making at national and local levels.
The virtual WCO-IOF-ESCEO 2020 Congress featured over 210 live and pre-recorded sessions on new clinical research and advances in osteoporosis, osteoarthritis, and related diseases. The Congress attracted a record number of registrants and was accredited by the EACCME with 16 European CME credits.
A Norwegian study shows that a structured conservative therapy programme can improve quality of care, increase patient satisfaction, and delay the need for surgery. The programme included patient education and exercise, leading to better outcomes for patients with osteoarthritis.
A new study from Lund University in Sweden found that app-based osteoarthritis treatment can halve patients' pain levels within six months and improve physical mobility. The digital program costs approximately 25% of conventional treatment, making it a cost-effective option.
A new study from NYU Langone Health suggests that injecting adenosine into joints can stimulate cartilage growth and prevent disease progression. The treatment has shown promising results in animal models of osteoarthritis, with regrowth rates of up to 50%.
Researchers found that bisphosphonates can reduce bone marrow lesions in people with knee osteoarthritis, which could lead to improved pain management and halted disease progression.
A new analysis of the CANTOS trial found that patients receiving canakinumab had significantly lower rates of total hip or total knee replacements over an average follow-up of 3.7 years. The study's findings are important as no treatments currently exist to prevent or slow osteoarthritis progression.
A researcher at the University of Oklahoma has received a $1.6 million grant to develop a biomarker for early osteoarthritis diagnosis and predict disease progression. The study aims to identify epigenetic patterns that can help determine whether a patient's condition will worsen quickly or slowly.
A recent study by Durham University found that rugby players continue to suffer from injuries after retirement, with back pain and joint pain being common complaints. The study also revealed that concussion is the most common injury among rugby players, with a significant association with long-term impact.
A novel bone imaging approach has established that bone metabolism is abnormally elevated in patients with knee osteoarthritis. This finding provides a new functional measure to assess degeneration of the knee joint, and may help develop interventions to slow or arrest its progression.
A major global systematic review has identified several jobs that may increase the risk of knee osteoarthritis, including agriculture, construction, and service work. The study found that workers in these industries are more likely to develop knee OA due to increased physical stress and repetitive activities.
A new analysis of 71 studies with over 950,000 participants found significantly higher odds of knee osteoarthritis in physically demanding job titles such as farmers and builders.
The study reveals nearly 303 million existing cases of hip and knee osteoarthritis globally, with an estimated prevalence of 3754.2 per 100,000 people. Disability attributed to the condition has risen by nearly 10% since 1990.
A new type of specially designed footwear has been shown to significantly reduce the pain associated with knee osteoarthritis. The biomechanical footwear was found to be effective in reducing pain scores, and may also have potential benefits for people with hip or back pain.
A randomized controlled trial found that intra-articular hypertonic dextrose injections significantly reduced knee pain in patients with moderate to severe osteoarthritis. The study, conducted at the Chinese University of Hong Kong, involved 76 patients who received either the hypertonic dextrose or normal saline injection therapy.
A study in mice suggests gene therapy can build significant muscle mass quickly and reduce the severity of osteoarthritis, even without exercise. The therapy also prevented obesity and improved cardiovascular health.
A new Northwestern Medicine study found that strenuous exercise does not increase the risk of developing knee osteoarthritis and may even protect against it. Adults at high risk for knee OA were 30% less likely to develop OA through vigorous physical activity participation.
Researchers found that regulatory switches involved in knee development also play a role in osteoarthritis, a partially heritable disease affecting 250 million people worldwide. The study suggests that subtle modifications in the knee's shape may increase risk of developing osteoarthritis over time.
Researchers at the University of Helsinki discovered novel loci associated with hip dysplasia and osteoarthritis in German Shepherds, highlighting the hereditary nature and polygenic background of the disorder. The study sheds light on the genetic factors influencing complex diseases and may lead to better treatment options in the future.
A new mobile app has been shown to reduce osteoarthritis pain and improve physical function in patients by an average of 43% over six months. The study, published in PLOS ONE, used a mobile app to track daily exercises and provide information on the disease, with results exceeding expectations.
A combination of two experimental drugs has reversed osteoarthritis in rats, with improved cartilage thickness and reduced cell death. The treatment may potentially translate to human use, offering a promising therapy for millions of adults affected by the disease.
A new study found that 90% of patients with knee osteoarthritis are waiting too long for knee replacement surgery, losing function, while 25% of those without need get the procedure prematurely. This delays deterioration and reduces mobility, leading to additional health issues.
A randomized study found that MIV-711 significantly reduced bone and cartilage progression in knee osteoarthritis patients. However, the treatment had no beneficial effects on osteoarthritic knee pain.
Researchers are developing a non-invasive device that uses transcranial direct current stimulation to desensitize areas tied to knee pain in the brain. Participants wear a cap powered by three AAA batteries and undergo 15, 20-minute sessions over three weeks.
A new study by Oregon State University has provided a comprehensive, cellular-level understanding of osteoarthritis, enabling better treatment options. The research uses a sophisticated scanning technique to view loaded joints in arthritic and healthy mice, revealing key features such as tissue mechanics and cellular activity.
Researchers found that patients with rheumatic diseases have a higher proportion of culture-negative prosthetic joint infections, which can make diagnosis challenging. The study highlights the need for better diagnostic tests and management strategies for these patients.
A new study reveals that hip and knee steroid intra-articular injections can lead to accelerated arthritis and joint destruction in some patients. Researchers found serious complications such as osteonecrosis and rapid progressive osteoarthritis in eight percent of patients who received the injections.
Researchers suggest corticosteroid injections for hip and knee osteoarthritis may be more dangerous than thought, potentially leading to rapid progressive osteoarthritis, joint collapse, and subchondral insufficiency fractures. Patients should be informed of these risks before receiving injections.
A new study analyzed US physician visits for knee osteoarthritis from 2007 to 2015 and found that rates of physical therapy and lifestyle recommendations decreased, while narcotic prescriptions increased. The study highlights the need for more research on barriers to prescribing exercise-based interventions to improve patient care.
A clinical trial found that an experimental growth factor increases knee cartilage thickness, preventing further loss and pain. The therapy may be effective for higher-risk patient populations with severe pain and narrow joint space.
Researchers developed a simplified computational model to predict locations susceptible to post-traumatic osteoarthritis in patients with ligament ruptures. The model identified areas prone to degeneration, suggesting potential pathways for patient-specific clinical evaluation and rehabilitation protocols.
Researchers at the University of Cambridge found that synovial fluid from osteoarthritic patients can directly excite sensory nerves, producing pain. The study provides new insights into the mechanisms of osteoarthritis and may lead to the development of more effective treatments.
A new study from the University of Eastern Finland shows that health-related quality of life in people with knee osteoarthritis varies significantly among different patient groups. The study found that females, those with higher body mass index, smokers, and lower-income individuals experience rapid worsening of their quality of life, ...
A new study found that NSAIDs contribute to cardiovascular side effects in individuals with osteoarthritis, increasing the risk of heart failure, ischemic heart disease, and stroke by 42%, 17%, and 14% respectively. The study suggests that patients with OA should discuss the risks and benefits of NSAID use with their care providers.
Researchers found that people with osteoarthritis were at a higher risk of dying from cardiovascular disease compared to the general population. The study, published in Lund University, followed 469,000 people for 11 years and found a significant link between osteoarthritis and increased mortality from cardiovascular diseases.
Researchers found that every fourth osteoarthritis patient was prescribed opioids, with codeine and tramadol being the most commonly used. Despite not being recommended as a first-line treatment, opioids were still given to nearly a quarter of patients, highlighting a significant challenge in addressing osteoarthritis pain management.
Researchers created a synthetic lubricant that mimics the natural lubricin found in joints, providing a potential cure for osteoarthritis. The synthetic lubricant is being tested in canine clinical trials and holds promise for future human use.
The HOPE study demonstrates that low-dose prednisolone significantly improves pain symptoms and function in patients with painful hand osteoarthritis. The study found that prednisolone reduces synovitis and improves physical component scale and patient global assessment, making it a suitable target for treatment.
A new study by Cornell University provides insight into the mode of action of hyaluronic acid (HA) injections, finding a direct correlation between lubricating properties and pain relief in patients. The research suggests that HA products should be reclassified as drugs to better regulate their treatment options.
A new study published in Orthopedics found that pre-operative daily life disability is a significant predictor of poor outcomes after total hip replacement surgery. Patients who cannot perform daily activities independently before surgery are more likely to experience surgical complications, longer hospital stays, and higher rates of r...
Dr Varta Babalyan, President of the Armenian Osteoporosis Association, has been recognized by the International Osteoporosis Foundation (IOF) for her dedication to osteoporosis prevention and awareness. She was awarded the IOF CNS Medal in 2019 for her work on expanding IOF's messages and outreach in Armenia.
Dr. Sabico recognized for outstanding scientific merit in vitamin D research, guiding local guidelines for osteoporosis prevention. He is a future thought-leader in musculoskeletal health, advancing awareness in the Middle East region.
A new Northwestern Medicine study found that an hour of weekly moderate-to-vigorous physical activity can help older adults maintain their independence and reduce the risk of mobility disability by 85%. The study also showed that this amount of exercise can lower the risk of activities of daily living disability by almost 45%.
Researchers found that CBX4 gene therapy helps to regenerate hMSCs and prevent osteoarthritis in mice. The study showed that CBX4 promotes nucleolar homeostasis, which is essential for maintaining healthy stem cells.
A new study reveals that osteoarthritis (OA) and rheumatoid arthritis (RA) have comparable impacts on patients when first visiting rheumatologists. Treatment significantly improves RA outcomes, whereas OA experiences a higher burden of disease, highlighting an urgent need for improved treatments.
A study of 59 individuals with mild-to-moderate knee osteoarthritis found no association between daily walking levels and pain. Alleviating pain does not likely increase physical activity, suggesting strategies focus on overcoming barriers like lack of knowledge and sedentary lifestyle.
A drug derived from omega-3 fatty acids has been found to reduce osteoarthritis inflammation caused by a high-fat diet, according to researchers at Queensland University of Technology. The study also identified another effective treatment option, clodronate liposomes.