Articles tagged with Osteoarthritis
Research published in Annals of the Rheumatic Diseases found that people with atopic diseases like asthma or eczema are at a heightened risk of developing osteoarthritis. Drugs used to dampen down allergic reactions may help lessen this risk, suggesting a potential new approach to treating the condition.
Researchers have found a potential treatment for osteoarthritis by targeting the GP130 immune receptor, which causes hyper-inflammation in joints. The new compound R805/CX-011 showed promising results in animal studies, reducing joint pain and stiffness, and may lead to Phase 1 and 2A clinical trials.
A new numerical model has been developed to predict cartilage degeneration after injury, revealing mechanisms of cell death and inflammation. The model suggests that mitigation of inflammation can lead to partial recovery of cartilage composition, opening avenues for potential therapeutic targets.
Researchers found that young adults post-ACLR who exhibited lower patellofemoral joint (PFJ) loading during hopping were more likely to develop PFJ osteoarthritis at 1-year and worsening PFJ osteoarthritis between 1-5 years. Lower PFJ contact force was linked to increased risk of early osteoarthritis.
Researchers found that while some antidepressants are effective for certain pain conditions, most are either ineffective or the evidence is inconclusive. A more nuanced approach is needed when prescribing antidepressants for pain, say experts.
The American College of Physicians recommends using cognitive behavioral therapy (CBT) or second-generation antidepressants as initial treatment for adults with moderate to severe major depressive disorder. The guideline also suggests considering combination therapy and discussing patient preferences when selecting a treatment.
A new study found that increased extracellular matrix stiffness leads to a decrease in the longevity protein Klotho in knee cartilage, damaging chondrocytes. Conversely, softer extracellular matrices restored healthy cartilage states in aged cells.
A new study published in BMJ Open found no significant difference between older and newer knee replacement implants six months after surgery. This is a breakthrough for patients, as it suggests that older designs with proven track records can provide similar patient-reported outcomes to more modern designs.
Researchers have identified a key molecule, retinoic acid, that may be a promising new treatment for hand osteoarthritis. The study found that individuals with certain gene variants had lower levels of retinoic acid, which could lead to the development of disease-modifying drugs.
Researchers developed an AI-based neural network to detect early knee osteoarthritis from x-ray images, matching doctors' diagnoses in 87% of cases. This method could help reduce unnecessary examinations, treatments, and even knee joint replacement surgery.
Researchers discovered 10 novel genetic loci associated with osteoarthritis, which are robustly found in every population ancestry studied. The study also identified genes expected to contribute to OA included targets for existing drugs against cancer, epilepsy and acne.
Two studies found corticosteroid injections associated with osteoarthritis progression, while hyaluronic acid injections may slow down progression. Corticosteroids increase risk of disease progression, highlighting need for cautious use.
A new study found that taking NSAIDs for osteoarthritis pain and inflammation may worsen joint inflammation and cartilage quality over time. Researchers used MRI-based structural biomarkers to analyze the association between NSAID use and synovitis in patients with knee osteoarthritis.
Researchers created synthetic knee x-ray images to complement real images in osteoarthritis classification. Medical experts were unable to distinguish between authentic and synthetic images, highlighting the potential of synthetic data for collaboration and testing.
A randomized controlled trial found that both total ankle replacement and ankle fusion improve quality of life and have similar clinical scores in patients with end-stage ankle osteoarthritis. However, TAR is associated with greater wound-healing complications and nerve injuries, while AF is linked to more blood clots and nonunion of t...
A new study has shown that total ankle replacement and ankle fusion surgeries equally improve quality of life for patients with advanced ankle osteoarthritis. However, a fixed bearing joint replacement showed significant improvement over ankle fusion in clinical scores.
A recent clinical trial shows that genicular nerve blocks provide short-term pain relief for patients with knee osteoarthritis. Patients who received the blocks reported significant improvement in pain scores, particularly at weeks 2 and 4.
Researchers at the UArizona Arthritis Center will study 10,000 participants to identify determinants of rapid knee deterioration and predict patient outcomes. The goal is to improve treatment evaluation and understand the progression of debilitating knee osteoarthritis.
Researchers found that activating RORbeta could restore healthy cartilage levels, helping to control inflammation and prevent osteoarthritis. This discovery presents a potential new strategy to address the root cause of cartilage damage.
A randomized controlled trial found that virtual reality immersion reduced the need for sedatives during hand surgery, leading to lower doses of propofol and shorter post-operative lengths of stay. Patient satisfaction remained unchanged, but discharge times were significantly shorter.
A randomized trial found that a 12-week online yoga program improved knee function in participants, but did not significantly reduce knee pain during walking. The study suggests that unsupervised online yoga programs can be feasible and improve physical function, but more research is needed to sustain the effectiveness.
A new poll reveals that nearly half of people over 50 experience joint pain, and many turn to prescription-based treatments despite potential health risks. The poll's authors stress the need for healthcare providers to discuss medication interactions and non-drug options with patients.
A recent study published in Arthritis & Rheumatology found that losing weight can help combat the structural defects of knee osteoarthritis. Researchers analyzed data from over 9,683 knees and discovered a significant association between reduced body mass index (BMI) and lower incidence and progression of knee osteoarthritis.
Researchers at Duke University have created a lab-made cartilage substitute that is stronger and more durable than natural cartilage. The hydrogel material can withstand even more stress from pulling and squishing, with improved strength and durability compared to previous methods.
Kessler Foundation researchers will conduct studies on brain injury, knee osteoarthritis, and pediatric cerebral palsy using mixed-reality technology, robotic exoskeletons, and cycling feedback systems. The grants aim to improve safety and mobility for elderly individuals with cognitive impairments and those with neurological disorders.
A study published in Arthritis & Rheumatology found that walking for exercise can reduce new frequent knee pain and slow joint damage in people with knee osteoarthritis. Researchers analyzed data from the Osteoarthritis Initiative and found a 40% decrease in odds of new frequent knee pain among walkers compared to non-walkers.
A study found that walking for exercise reduced frequent knee pain in individuals with knee osteoarthritis. Preliminary evidence also suggested that it might modify structural effects of osteoarthritis on the knees.
A review of scientific evidence concludes that diet has little impact on the progression of osteoarthritis and rheumatoid arthritis. While a healthy diet brings other health benefits, the impact on these diseases is small and not clinically meaningful.
A research team has developed a genetic score to predict the likelihood of needing knee or hip replacement surgery for osteoarthritis. The score was validated in a study involving 12,093 individuals and found that those with high risk scores had a higher odds of needing replacement surgeries.
Steroid injections have been shown to lead to greater pain relief and improved movement in adults with hip osteoarthritis. The study found that patients who received steroid injections along with advice and education experienced significant improvements in pain intensity, physical function, and pain self-efficacy over six months compar...
The International Osteoporosis Foundation awarded five young researchers for their groundbreaking work on the role of nutrition in musculoskeletal health. The winners, from Australia, India, and Switzerland, were recognized for their studies on vitamin K1 intake, calcium sources, and dietary inflammatory index.
The Virtual WCO-IOF-ESCEO 2022 Congress will feature leading experts on osteoporosis, osteoarthritis, and musculoskeletal diseases, with a focus on new clinical research and advances in prevention and patient care. Prestigious awards will also be presented.
A study using data science and mathematical models identifies the most suitable rehabilitation method for each patient with osteoarthritis. The research aims to provide personalized treatment recommendations for healthcare professionals, ultimately leading to more effective care for patients.
The World Congress on Osteoporosis, Osteoarthritis & Musculoskeletal Diseases (WCO-IOF-ESCEO) 2022 will discuss secondary fracture prevention. Global experts will provide clinical guidance and information on post-fracture care through various sessions.
A six-year research project aims to develop an online programme providing support, information, and tailored exercise plans for managing musculoskeletal diseases. The Digital – My Arm Pain Programme (D-MAPP) will guide participants in managing their condition through the lived experience of those affected.
A recent analysis published in Arthritis & Rheumatology found that osteoarthritis prevalence increased by 113.25% globally from 247.51 million in 1990 to 527.81 million in 2019. The study also revealed higher prevalence rates in females and among countries with higher development status.
Researchers have discovered a genetic difference in the meniscus that makes about 50% of females more prone to developing knee osteoarthritis than males or other females. The study suggests potential for a blood test to identify high-risk individuals, allowing for early interventions and prevention strategies.
Researchers at RIT have created a biophysical model that can predict changes in cartilage mechanics and function during disease pathways. The model, informed by experimental data, enables noninvasive predictions using MRI scans, potentially reducing the need for invasive procedures.
Researchers aim to determine if knee structure changes predict clinical outcomes in people with osteoarthritis. The study will examine 76,000 X-rays and clinical data from diverse cohorts to establish healthy knee structure ranges.
Researchers have discovered a molecular signaling pathway associated with osteoarthritis (OA) pain, which plays a crucial role in producing and transmitting pain signals. By blocking this pathway, the study shows promise for developing new, effective pain treatments for human OA sufferers.
A new care pathway has been shown to reduce long-term pain and improve quality of life for people after knee replacement surgery. The STAR care pathway is cost-effective and could potentially save the NHS up to £14 million per year.
Researchers have developed a protein-based gel that can deliver anti-inflammatory growth factor progranulin to affected joints, halting post-traumatic osteoarthritis (PTOA) onset and progression. The study found that the gel provides prolonged release of progranulin and inhibits chondrocyte catabolism.
Researchers develop ice-inspired lubricant that enhances lubrication and reduces friction and inflammation in a rat model of osteoarthritis. The treatment, which uses microfluidic technology to create drug-loaded particles, shows promise as a potential solution for joint pain and degeneration.
A study identified factors at midlife associated with a decline in women's physical health 10 years later. Higher body mass index, smoking, osteoarthritis, and depressive symptoms were found to be significantly linked to clinically important declines in physical health.
A registry study found that people with inflammatory RMDs, such as rheumatoid arthritis and psoriatic arthritis, tolerate their COVID vaccine well, with short-lived reactions being the most common side effect. The majority of participants were able to continue on their normal medication with no changes.
Researchers at Washington State University discovered that combining gallic acid with stretching decreases inflammation markers and improves protein production in arthritic cartilage cells. This finding suggests a potential new procedure for treating osteoarthritis by growing healthy cartilage tissue.
Researchers at Keck School of Medicine of USC have developed a stem cell-based bio-implant to repair cartilage and delay joint degeneration. The Plurocart implant successfully integrates into damaged articular cartilage tissue and survives for up to six months.
A six-month telehealth-delivered exercise program improved pain, function, and quality of life for 400 individuals with knee osteoarthritis. The program, combined with a ketogenic diet, led to significant weight loss and reduced reliance on pain medications.
Researchers found that video-based, telehealth-delivered exercise and weight loss programs improved pain and function in people with knee osteoarthritis and overweight or obesity. The intervention with dietary component led to substantial weight loss and additional benefits.
Researchers have identified key genes involved in osteoarthritis, a leading cause of pain and disability worldwide. The study, conducted on over 800,000 individuals, sheds light on the genetic factors contributing to the disease and may pave the way for new treatments.
Boston University researchers found that even low levels of physical therapy before or after total knee replacement surgery lower the odds of chronic opioid use. Participation in six or more sessions of physical therapy post-surgery and initiation within 30 days of surgery were linked to reduced chance of chronic opioid use.
A new study found that telephone cognitive behavioral therapy can effectively improve sleeplessness and pain in older adults with osteoarthritis-related insomnia, reducing clinical and financial burdens. The study showed that telephone CBT reduced healthcare costs without increasing them.
A novel computational model predicts that articular cartilage can partially heal after injury by controlling inflammation. The study uses biomechanical and inflammatory aspects of osteoarthritis progression to develop a physics-based computational model.
A textile-based implant containing cartilage derived from stem cells reduced pain and restored hip joint function to baseline levels in a study of dogs with moderate osteoarthritis. The implant successfully integrated into the hip joints, effectively resurfacing them and allowing the dogs to regain activity levels.
Researchers from the University of Basel have found that nasal cartilage cells can withstand chronic inflammatory conditions and counteract inflammation in osteoarthritis. The approach involves using engineered cartilage tissue to repair or replace damaged joints, offering a promising alternative to joint prostheses.
A multi-center study found micro-fragmented adipose tissue injections to be highly effective in reducing knee pain, improving function, and enhancing quality of life. Positive effects were observed for up to 12 months, with notable differences in efficacy among demographics.
A pilot study found that a single injection of leukocyte-rich platelet-rich plasma (PRP) significantly improved functional mobility, pain, and quality of life in patients with knee osteoarthritis. The study supports the use of this combined approach to evaluate emerging biological therapies for musculoskeletal disorders.
A study published in Current Rheumatology Reviews found that rehabilitation exercises significantly improved functional strength and reduced weight in knee osteoarthritis patients. The researchers also noted an increase in exercise adherence among the rehabilitation group compared to the control group.
A large study of over 825,000 individuals has identified new genetic risk factors for osteoarthritis and pinpointed potential drug targets. The research also found specific genetic changes that underpin the risk for all forms of osteoarthritis.
A study published in Nature Communications found that microRNA-455 helps regulate cartilage homeostasis and slows cartilage degeneration in osteoarthritis. By targeting the gene hypoxia-inducible factor-2α, miR-455 treatment inhibits cartilage breakdown.