Articles tagged with Osteoarthritis
Researchers found that training the innate immune system can exacerbate inflammatory bone loss in models of chronic diseases like periodontitis and arthritis. The study suggests that a previously thought beneficial effect of trained immunity may actually contribute to harm in certain contexts.
A study of Viking skulls using CT scans reveals a range of diseases including sinus and ear infections, osteoarthritis, and dental diseases. The results provide greater understanding of the health and wellbeing of the Viking population.
Research published in PLOS Medicine found that adults with depression accrue physical illnesses around 30% faster than those without. The study suggests integrated approaches to manage mental and physical health are needed to improve care and outcomes for individuals with both conditions.
A new study identifies the molecular mechanisms underlying increased osteoarthritis risk in postmenopausal females, revealing that menopause-induced changes in sex hormone levels contribute to joint degeneration. Restoring these hormones may protect against cartilage degeneration, paving the way for novel treatments.
The study, published in Aging, introduces a new therapy for osteoarthritis that uses extracellular vesicles derived from fat tissue to repair damage caused by aging cells. The treatment showed strong therapeutic effects in both cellular and mouse preclinical studies, reducing inflammation and DNA damage markers in human joint cells.
Researchers have developed a new diagnostic test that uses two markers found in the synovial fluid of patients' joints to differentiate osteoarthritis from inflammatory arthritis. The algorithm, based on the ratio of cartilage oligomeric matrix protein and interleukin-8, has been validated with high accuracy.
A new study by the University of Nottingham found repeated paracetamol doses in older adults (65+) can lead to increased risks of peptic ulcers, heart failure, hypertension, and chronic kidney disease. The study suggests paracetamol use should be carefully reconsidered for long-term conditions such as osteoarthritis.
A study published at the Radiological Society of North America annual meeting found that ultra-processed food intake is associated with higher amounts of intramuscular fat in thigh muscles. This increase in fat can lead to knee osteoarthritis, a condition affecting millions worldwide.
Research published in the Journal of Orthopaedic Research reveals that individuals with ACL reconstruction exhibit persistent aberrant gait biomechanics, which can lead to joint loads contributing to long-term knee problems. Early rehabilitative measures may help maintain long-term knee joint health.
A minimally invasive procedure called Genicular artery embolization (GAE) has been shown to effectively relieve knee pain and improve quality of life in people with osteoarthritis. The study found that GAE can significantly reduce knee pain and improve quality of life, even in advanced cases.
Research has shown that people with hip osteoarthritis are unable to activate their muscles as efficiently due to the brain's inhibitory response. Dr. Myles Murphy and his team investigated muscle function in patients with hip osteoarthritis, finding a strong correlation between muscle activation and joint degeneration.
A University of Virginia engineer developed a workflow to combine advanced imaging technologies for improved understanding of porous bone, which could inform disease detection. The method allows for three-dimensional rendering of bone structure across various length scales.
Researchers create a new type of artificial spider silk by modifying protein sequences to produce a strong, yet stable material. The resulting silk is woven into bandages that boost wound healing in mice with osteoarthritis and diabetic skin lesions.
A new study published in the Journal of Vascular and Interventional Radiology found that genicular artery embolization (GAE) provides durable benefit to patients with osteoarthritis in the knees for at least 2 years. The procedure targets abnormal blood flow to reduce inflammation, quickly improving patients' pain.
A study analyzing National Joint Registry data found that trainee surgeons' outcomes are comparable to those of more experienced consultants. The rates of subsequent revision surgery were no different between the two groups, suggesting similar skill levels.
A new study from Australian National University found a link between kneecap shape and the risk of developing osteoarthritis. Researchers discovered that variations in kneecap surface shape were more pronounced in individuals with osteoarthritis, suggesting potential early warning signs for disease prevention.
A cross-sectional study in Australia and Canada found that physical exercise is associated with fewer depression symptoms in people with osteoarthritis. The study suggests that exercise may be particularly beneficial for individuals experiencing severe pain, improving mental health outcomes.
A 20-year study found that osteoarthritis may more than double the risk of speeding up progression to severe multimorbidity. Four different patterns of progression were identified, with those in class 4 progressing the fastest and having the highest cumulative total of long-term conditions.
Research from the University of South Australia found that people with knee OA unconsciously believe exercise is dangerous, despite medical advice. The study developed a tool to detect and evaluate these implicit beliefs, suggesting they can be a better predictor of actual behavior than reported attitudes.
The new criteria classify hand osteoarthritis based on age, morning stiffness duration, and joint features. Researchers can now apply the criteria in large studies without additional clinical joint examinations.
Researchers developed a blood test that accurately predicted knee osteoarthritis development and progression, detecting molecular signals eight years before x-ray diagnosis. This breakthrough offers new hope for early intervention and therapeutic strategies to slow disease progression and restore joint health.
A randomized clinical trial found self-administered acupressure to be efficacious and cost-effective in reducing knee pain and improving mobility in middle-aged and older adults with probable osteoarthritis. The treatment also showed significant benefits in terms of quality of life.
Researchers will develop 'live' joints with biocompatible bone and cartilage grown from human cells, aiming to scale up the technology for commercial use. The project, valued at $47.7M, targets 40 patients within five years with knee replacements.
The International Osteoporosis Foundation (IOF) and ESCEO presented awards to 20 young investigators from 16 countries for their outstanding research abstracts. The awards recognize the researchers' contributions to the prevention, diagnosis, and treatment of osteoporosis and related musculoskeletal diseases.
A study comparing progressive resistance training and neuromuscular exercise found no measurable difference in physical function, pain level, or quality of life between the two groups. The results suggest that patient involvement plays a crucial role in choosing an optimal training type for individual patients.
The World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases will showcase new clinical research from over 1507 submitted abstracts. The event will offer valuable knowledge to help clinicians treat patients more effectively in their daily practice.
Researchers developed a questionnaire to identify signs of osteoarthritis in horses, aiming to facilitate earlier treatment. The tool was found beneficial for 88% of participants, who appreciated its simplicity and ease of use, helping owners better manage their horse's pain.
A team of scientists from CU Boulder, Anschutz Medical Campus and CSU is developing non-invasive therapies for osteoarthritis, including a healing shot and annual infusion. They hope to begin trials in human patients within 3.5 years.
Researchers are developing a living knee replacement made from biomaterials and human stem cells, including patient's own cells. The goal is to create a permanent solution for patients with advanced OA where conventional knee replacements fail.
Researchers found no clear link between weather conditions and muscle and joint pain, debunking a long-standing medical myth. High temperatures, low humidity, and dehydration may increase the risk of gout flares.
Researchers found significantly higher levels of IL-18 expression in osteoarthritis patients and cells compared to healthy controls. IL-17 promoted IL-18 production through the MEK/ERK/miR-4492 axis, indicating potential therapeutic targets for OA treatment.
Researchers identified 7 genetic variants associated with surgical rhizarthrosis and 3 variants linked to nonsurgical rhizarthrosis. These findings suggest a potential genetic influence on the need for surgery, hinting at biological mechanisms underlying the disease.
Researchers at Yale University identified a sodium channel, Nav1.7, that plays a key role in joint degeneration associated with osteoarthritis. Deleting this gene from collagen-producing cells significantly reduced joint damage in mice models.
This study found that SIRT6 activation improves DNA damage repair efficiency and reduces baseline DNA damage in chondrocytes from older donors. MDL-800 treatment also lowered p16 promoter activity and decreased DNA damage in murine cartilage explants, supporting the concept of SIRT6 as a critical regulator of DNA repair.
Research suggests that anti-obesity medications can lower the risk of premature death in people with knee or hip osteoarthritis, particularly those who experience a slow-to-moderate rate of weight loss. Studies show a 28% lower risk of death for these individuals compared to those with no weight loss.
Researchers found that a higher ratio of quadriceps to hamstring muscle volume was significantly associated with lower odds of total knee replacement. Training programs that strengthen the quadriceps in relation to the hamstrings may be beneficial for preventing knee replacement surgery.
A systematic review and meta-analysis of 16 studies involving 875 patients with knee osteoarthritis found significant reductions in patient-reported pain from the third month onwards. Stem cell treatment was most effective when using patient's own fat-derived stem cells, leading to better pain alleviation and recovery of joint function.
The University of Basel has successfully treated over 100 patients with focal lesions and two advanced cases of knee OA, reporting beneficial outcomes. The N-TEC procedure uses autologous cartilage cells to grow new cartilage grafts for repairing damaged joints, offering an alternative to knee joint replacements.
A recent study published in Nature Medicine calls into question the effectiveness of stem cell therapy for treating knee pain. While some patients showed improvement, there was no significant advantage found in using stem cell therapies compared to corticosteroid injections over a one-year period.
Researchers at the University of Adelaide have discovered a novel population of stem cells responsible for osteoarthritis progression. Treatment with fibroblast growth factor 18 (FGF18) stimulated cartilage recovery and reduced osteoarthritis, offering a potential pharmaceutical treatment to address the disease.
A Monash University study found that methotrexate, a low-cost and effective treatment for inflammatory joint conditions, can reduce pain and stiffness in patients with symptomatic hand OA. The study's results suggest that methotrexate may be a viable treatment option for people with hand osteoarthritis and inflammation.
Researchers developed a DNA damage-induced senescence model in osteoarthritic chondrocytes, which reliably induces cellular senescence and accumulates senescent cells in OA joint tissues. The study provides a useful model to develop therapeutic approaches targeting senescence in osteoarthritis.
A new study projects nearly 1 billion people will be living with osteoarthritis, the most common form of arthritis, by 2050. Currently, 15% of individuals aged 30 and older experience osteoarthritis, with obesity being a major risk factor.
Researchers have discovered that lower molecular weight hyaluronan can cause cartilage degradation and alter joint structure. The study suggests using concentration changes as a diagnostic tool for early-stage osteoarthritis diagnosis.
Chronic knee osteoarthritis pain does not impair memory and behavioral flexibility, according to new research. Factors like age, pain medication, and socio-economic status are likely to play a role in cognitive decline.
Researchers have made significant progress in understanding osteoarthritis, linking degradation of articular cartilage to inflammatory and metabolic processes. Elevated levels of the protein c-Fos are found in human and mouse cartilage samples with OA, suggesting a new target for therapy.
Researchers have developed panels of protein biomarkers that distinguish healthy hips from those with developmental dysplasia of the hip. These biomarkers show high sensitivity and specificity in detecting hip dysplasia, offering a potential tool for early diagnosis and treatment.
A new study found that NHS policies on patient's weight affecting access to hip replacement surgery are inappropriate and worsen health inequalities. The study analyzed nearly 490,000 hip surgeries and found a link between BMI policies and decreased surgery rates in deprived areas.
An observational study of 329,000 Medicare admissions found that older persons receiving hospital care from allopathic (M.D.) or osteopathic (D.O.) physicians experience similar quality and cost of care. Researchers also highlight systemic health inequities faced by persons with sickle cell disease.
Researchers warn that patients with rheumatic and musculoskeletal conditions are vulnerable to long term opioid use. The study found that up to 1 in 3 patients with rheumatoid arthritis or fibromyalgia may be at risk of transitioning to long term opioid use, highlighting the need for vigilance in practice prescribing.
Dr Germain Honvo, a young investigator, receives the prestigious award for his international contributions to osteoarthritis research and publications on guideline development. He is recognized as a future thought leader in the musculoskeletal field.
Professor Bess Dawson-Hughes has been recognized with the 2023 IOF President’s Award for her significant contributions to advancing osteoporosis research and treatment. Her extensive body of work has led to a greater understanding of nutrition's role in age-related bone loss.
The IOF Medal of Achievement is awarded to individuals who significantly advance osteoporosis research and increase awareness of the disease. Professor Jean-Yves Reginster has made major impacts on the field through his original scientific contributions, education, and advocacy.
Professor Osvaldo Daniel Messina was awarded the 2023 IOF CNS Medal for his significant contributions to osteoporosis prevention. He has expanded IOF's messages and outreach in Argentina and internationally, promoting fracture prevention and healthy mobility.
The IOF-ESCEO World Congress on Osteoporosis, Osteoarthritis, and Musculoskeletal Diseases is the largest international scientific event devoted to musculoskeletal disorders. The congress presents new clinical advances and research on osteoporosis, osteoarthritis, sarcopenia, frailty, and rare skeletal disorders.
A study of joint replacements in England finds socio-economic inequalities remain, with those living in deprived areas having the least access to surgery. The findings highlight the need for healthcare commissioners to address disparities in joint replacement provision.
A new study from Lund University estimates that regression to the mean can account for up to 1 point improvement in pain scores among osteoarthritis patients. This natural phenomenon can lead to false positives in clinical trials, masking the true efficacy of treatments.
Researchers created a promising injectable cell therapy that reduces inflammation and regenerates articular cartilage in osteoarthritis patients. The treatment was tested in a pre-clinical model and showed ability to reverse cartilage damage and diminish inflammation.
A new study by University of South Australia researchers found that golfing reduces psychological distress and improves general health in people with osteoarthritis. Golfers experience lower levels of psychological distress compared to the general population.
Research explores how hyaluronic acid's molecular weight affects the joint lubricant in osteoarthritis. The study found that low molecular weight hyaluronic acid hinders the formation of an amorphous film, leading to increased wear on the cartilage surface.