Articles tagged with Pediatrics
The International Pediatric MS Study Group has released updated standards for clinical trials involving children and teens with multiple sclerosis. The new recommendations prioritize pharmacokinetic/pharmacodynamic studies, phase 3 trials in adults considering teenagers, and open-label extension studies to ensure high-quality evidence ...
The Bili-ruler is a novel, low-cost device for screening neonatal hyperbilirubinemia, which affects up to 80% of newborns. It uses six color strips arranged in a stepwise gradient of increasing yellow hue and has high diagnostic accuracy, validating its use in improving early recognition and care seeking in low-resource settings.
A study by Children's Hospital of Philadelphia found that teen drivers with ADHD are at higher risk of crashes and traffic violations due to risky driving behaviors. The study analyzed records of 14,936 adolescents and identified 1,769 with childhood-diagnosed ADHD.
Researchers from Deerfield Institute found a significant increase in DMD prevalence attributed to enhanced treatments and increased longevity. The study suggests that there is a larger patient population that may benefit from novel treatment interventions such as targeted gene therapies.
Researchers found that infants with bacterial pneumonia were more likely to require supplemental oxygen, bronchodilators, or steroids due to lingering breathing issues. The study suggests a potential long-term impact of bacterial pneumonia on lung health in vulnerable populations.
A pre-clinical study investigates the use of nicotine-like medications to reduce limb damage caused by inflammation. The research could potentially modulate the immune response to protect limbs after an injury.
A new study reveals that over 25% of Quebec children diagnosed with type 1 diabetes already have diabetic ketoacidosis, a life-threatening complication. The number of cases has increased by two percent per year since 2001, highlighting the need for awareness campaigns and earlier diagnosis.
Researchers found that millennial parents, despite being younger, exhibited higher rates of reckless behavior while driving compared to their older counterparts. Despite this, most parents across all age groups reported reading and writing texts while driving in the past month.
Children who receive kidney transplants have impaired quality of life with higher mental health difficulties and disrupted sleep patterns. Parents' reports often differ from children's self-reports, indicating more difficulties in emotional functioning and social domains.
A study found that parents of children with cancer frequently search for health-related information, including ways to support their child and logistical issues. The study suggests that healthcare providers should consider these day-to-day concerns when offering family education and support.
A new standardized measurement tool has been developed to track outcomes in children with pediatric facial palsy, a condition that can impact various aspects of their life. The tool assesses factors such as facial appearance, oral continence, speech, and health-related quality of life.
A study found that children who developed de novo donor-specific antibodies (dnDSA) after kidney transplant had thicker carotid intima-media layers than those without these antibodies. Being African American was also associated with increased CIMT in transplant recipients.
Researchers at Nemours Children's Health System have found the military's Combat Application Tourniquet (CAT) to be effective in controlling blood flow in children's arms and legs, with a success rate of 100% for upper extremities and 93% for lower extremities.
The Pennsylvania Pediatric Medical Device Consortium has awarded four companies with $50,000 each to develop innovative medical devices for children. Devices include a rapid platelet monitoring system and tracheostomy tube dislodgement alarm, which aim to improve care for newborns and pediatric patients.
A University of Cincinnati expert supports raising the age limit on tobacco purchases in Ohio to combat nicotine dependence among youth. Research suggests that e-cigarette use has increased among adolescents, and banning certain flavors may have contributed to this trend.
Researchers developed a new screening approach that combines DNA sequencing and metabolomics to identify mutant genes causing rare genetic diseases in children. The technique helped pinpoint the gene responsible for a specific disease, enabling faster diagnosis and potential treatment.
Researchers at Université de Montréal found that MEK inhibitor trametinib can reverse hypertrophic cardiomyopathy and valvular obstruction in patients with RIT1-associated NS. Dramatic improvement was seen in two infants treated with the drug, suggesting a new treatment option for life-threatening heart disease.
A recent study published in JAMA Network Open shows that precision medicine can be a reality for pediatric tumours, identifying genomic anomalies to guide treatment and offer targeted therapies. The TRICEPS project has successfully enrolled 84 patients, leading to better patient management and more effective treatment options.
Researchers found that pre-treatment with caffeine prevented PGE1-induced respiratory complications and inflammation in baby rats. Caffeine, commonly used to treat apnea of prematurity, may offer similar benefits for infants with congenital heart disease.
A new study aims to validate the pediatric version of Sequential Organ Failure Assessment (pSOFA) score in the emergency department setting as a predictor of mortality. The pSOFA score showed increasing mortality with higher scores, but poor sensitivity for predicting death in non-infectious patients.
Recent studies found a strong association between teen vaping and increased engagement in nine out of ten sexual risk behaviors, as well as several substance-use behaviors. The research suggests that initiatives to reduce youth substance use and risky behavior should focus on reducing teen vaping at all frequency levels.
The 2020 US Census resulted in a significant undercount of young children, impacting healthcare resources and funding. Pediatricians urge communities to take action to ensure all children are counted, as the Census has far-reaching implications for education, nutrition, and special education.
A recent study examines the alarming rise in firearm fatalities among US children, particularly those from marginalized communities. The research found that public health approaches must consider underlying demographic trends to effectively address this issue.
A new systematic review provides a comprehensive update on vaccine safety science, assessing 47 adverse events following immunization (AEFI). The study found that 12 AEFIs have been established to have causal relationships with at least one vaccine currently recommended in the US population.
A new American Academy of Pediatrics (AAP) study found that U.S. pediatric residents have a significant amount of experience with treating gun injuries, even during early stages of training. The study also revealed strong support for pediatricians' role in counseling families and advocating for public policies to reduce gun injury.
A new study found that pediatric opioid deaths increased nearly 3-fold over 18 years, with the Midwest experiencing a four-fold increase and the West a two-fold increase. The study highlights the need for targeted interventions to mitigate the growing public health problem of fatal pediatric opioid poisonings.
A new study reveals that HPV vaccine coverage is far behind other infant vaccines, with only 13 and three US states reaching above 60% coverage by 2016. The study tracked over 7.5 million children from 2003 to 2016 and found increased uptake among girls and boys, but still fell short of the Healthy People 2020 goal of 80%.
A new study examining opioid fill patterns among Medicaid-enrolled children in the US revealed that prescriptions for these age groups were relatively rare, with an adjusted rate of 0.8% by 2016. The study also found that opioids were most frequently prescribed in combination with other pain relievers.
A new study reveals that vaccination in immunocompromised children is suboptimal due to lack of knowledge and concern for triggering a disease flare. The majority of patients received vaccines from their primary care physician or health department, but there were significant barriers to completing vaccines.
A national survey of pediatricians and family physicians reveals substantial progress in recommending HPV vaccination to adolescents over the past five years. However, significant areas for improvement exist, including physician communication style and practice-based delivery methods.
Researchers analyzed plasmablasts in children with Kawasaki Disease to identify potential causes of the condition. The study found massive expansions of specific antibodies, supporting an infectious disease etiology for KD. This discovery may lead to new therapeutic approaches targeting these clones.
A new study found that text message reminders significantly improved timely HPV vaccine series completion among eligible adolescents. The study showed that even when compared to historical controls, those receiving text message reminders had higher rates of completing the full vaccine series.
A study found that state-run PDMPs, pain clinic legislation, and opioid prescribing guidelines significantly decrease pediatric opioid exposures. The analysis of NPDS data from 2005-2017 showed a notable reduction in opioid exposures among children following the implementation of these policies.
Researchers identify antigens targeted by the antibody response of children with Kawasaki Disease, strongly suggesting a new human virus is etiologically related. The study found that monoclonal antibodies from these patients recognized peptides from a hepacivirus non-structural protein.
A new AAP PROS study assesses influenza vaccine hesitancy among caregivers of children who received the first dose. Researchers found that over 90% of caregivers believed their child would be 'protected with only one flu shot,' and 12% had moderate/high vaccine hesitancy.
A new study in Massachusetts aims to improve health and social outcomes for maternal-infant dyads impacted by Opioid Use Disorder (OUD) through sharing best practices, educational materials, and data collection. The initiative resulted in significant increases in skin-to-skin contact and decreases in pharmacologic therapy.
Despite available safety and effectiveness, HPV vaccine coverage rates remain suboptimal. Pediatricians and nurse practitioners report using various strategies, including prompts, communication tools, and performance feedback, to improve HPV vaccination rates.
A new study found that rapid whole genome sequencing can identify etiology and direct therapy in neonates with unexplained seizures. The analysis revealed six molecular diagnoses out of 19 patients, leading to changes in management for four patients, including targeted seizure medications and dietary supplements.
Despite the availability of a safe and effective HPV vaccine since 2006, coverage rates remain suboptimal. Pediatricians and nurse practitioners reported using various strategies to improve HPV vaccination rates, but still face challenges such as parent refusal and lack of training. The study suggests that more work is needed to overco...
A recent study by Children's National Hospital found that firearm injuries disproportionately impact African American youth in Washington D.C.'s Wards 7 and 8. The majority of these injuries (64%) were accidental, and nearly all patients (94%) were African American.
A new study explores the history and resurgence of milk sharing practices, tracing them back to ancient times. The research highlights the importance of understanding the cultural context and advocating for safe sharing practices.
A new quality improvement tool called Eat, Sleep and Console (ESC) has been shown to improve care of opioid-exposed newborns in NICUs. The ESC approach uses non-pharmacologic interventions and reduces hospital stays and medication exposure.
A new study found that personal gun access is associated with depression, suicidal ideation, and perceiving school as unsafe. In contrast, attending a school with common gun access is linked to lower odds of perceiving school as unsafe. The findings suggest complex associations between gun access and adolescent health.
A new genetic test accurately identified over 200 disease-causing gene variations in the Old Order Amish and Old Order Mennonite communities. The test could help reduce morbidity and mortality by detecting asymptomatic newborns with rare genetic disorders.
A new study from Kaiser Permanente suggests that adolescents with access to SBIRT services have sustained reductions in mental health conditions and lower healthcare utilization over a period of three years. The study found that those with access to SBIRT were less likely to have mental health or chronic medical conditions after one year.
A machine-learning system using clinical natural language processing and genome sequencing diagnose rare genetic diseases in record time, providing critical information to intensive care physicians. The automated pipeline achieved significant time-savings and concurred with expert manual interpretation in 97% of cases.
A study by MassGeneral Hospital for Children finds that dual-using parents are more likely to quit smoking, plan to quit in the next six months, and have attempted to quit in the past three months. However, they may not be getting the necessary help, as few pediatric offices deliver evidence-based tobacco control treatments.
Children with chronic constipation exhibit heightened sensory sensitivity, particularly in oral processing, leading to feeding problems and avoidance behaviors. This association could transform clinical practice by incorporating sensory considerations into treatment plans.
New lead screening recommendations from the USPSTF conclude that current evidence is insufficient to assess benefits and harms. NYU researcher Michael Weitzman emphasizes the need for environmental interventions to prevent lead exposure, particularly in homes with lead-based paint.
Joanne Kurtzberg, MD, has been awarded the 2019 Bernard Sanberg Memorial Award for her groundbreaking work in pediatric hematology and regenerative medicine. The award recognizes her clinical trials that have led to positive results in treating adult ischemic stroke patients with cord blood therapy.
A new study identifies four key factors influencing transgender youth's decision on fertility preservation, including family values, cost, and concerns about worsening gender dysphoria. The findings highlight the need for standardized protocols in primary care counseling and support for young adults navigating this complex issue.
A new study published in Pediatrics found that adolescents with cognitive impairments and intellectual disabilities have similar weight-loss outcomes after bariatric surgery as those with typical cognitive function. The study's authors recommend a case-by-case approach to determining eligibility for weight-loss surgery.
A new study in JAMA Pediatrics found that intimate partner homicide among teens is a serious public health issue, with 90% of victims being girls. The study analyzed data from the National Violent Death Reporting System and found that guns were the most common weapon used in these homicides.
A recent study estimates that 4 million children worldwide develop asthma each year due to exposure to nitrogen dioxide pollution. The study found that urban areas account for 64% of these new cases, and cities with high NO2 concentrations also experience high levels of greenhouse gas emissions.
Annual ED visits for child suicide attempts and suicidal thoughts increased significantly between 2007 and 2015. The proportion of these visits among pediatric encounters also rose, emphasizing the need for improved physician preparedness and community mental health initiatives.
A new study found that children who had telemedicine visits for acute respiratory infections were more likely to receive antibiotics than those who visited primary care offices or urgent care centers. The use of unnecessary antibiotics during these visits may contribute to antibiotic resistance.
According to a study published in the Canadian Medical Association Journal, vaccine allergies are extremely uncommon, affecting only one in 760,000 vaccinations. Most side effects from vaccines are not allergic reactions, but rather minor responses that can be managed with over-the-counter medications.
A new study published in the Journal of Pediatric Surgery found that post-operative success rates for pediatric thyroid patients correlate with institution patient volume. The study showed extremely low complication rates, underscoring the importance of high-volume centers with specialized pediatric surgeons.
The ACMG Foundation has recognized six next-generation fellows with the Takeda/ACMG Foundation Genetics and Genomics Residency Fellowship Program. Dr. Elizabeth Jalazo will focus on pediatric genetics, while Dr. Joshua Baker will work on lysosomal storage disorders research.
The Pediatric Cell Atlas will create a high-resolution data reference for child development, benchmarking healthy and abnormal tissues at the level of single cells. This will provide a standard tool for researchers to better understand childhood illnesses and develop precision treatments.