Articles tagged with Cadherins
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Researchers from IBEC have improved understanding of how MSCs sense environment viscosity, a key factor in differentiation into different tissue types. Viscosity affects cell behavior and promotes differentiation into softer tissues like cartilage.
Scientists create synthetic biology approach to mechanistically study tissue patterning and engineer organoid structures by combining morphogens with cell adhesion control. The model system reveals a key feature of E-cadherin for forming sharp boundaries in synthetic tissue domains.
Researchers from Osaka University developed a fluorescent sensor to visualize Pcdh interactions in live neurons, allowing for the first time to observe dissociation of these interactions. This technique has potential applications in understanding brain disorders such as autism and epilepsy.
Researchers have elucidated the mechanism of CELSR cadherin dimerization, revealing a twisted cell-cell adhesion molecule complex structure. The extracellular domains of CELSR cadherins exhibited strand- and globule-like portions, which bound through strand-like structures in an antiparallel orientation.
Researchers at Osaka University identified T-cadherin as a factor that feeds back a lack of insulin to pancreatic β cells, inducing their proliferation. This finding suggests a potential new treatment for diabetes by targeting T-cadherin.
Researchers developed a monoclonal antibody that binds E-cadherin, strengthening cell adhesion and preventing cancer metastasis. The antibody, 19A11, has two binding modes that increase adhesive strength through salt bridge formation.
The study reveals multiple dimeric structures of cadherins in solution, including W-, cross-, and S-shaped dimers. The researchers propose a novel conformation, the S-shaped dimer, and suggest that binding mechanism progresses through sliding motion followed by flipping motion to form stable SS-dimers.
A University of Illinois study discovered that cadherin proteins can sense mechanical stress and alter cell communication, promoting tissue growth and tumorigenesis. The findings suggest a potential mechanism for preventing certain types of tissue growth by mutating cadherin molecules.
Specialized proteins called cadherins join forces to make cells stick together, forming bonds 30 times stronger than individual strengths. This discovery could lead to more life-like artificial tissues and tumor-busting drugs.
Researchers find that cell adhesion proteins and a gradient of signaling molecule Sonic Hedgehog work together to create precise sorting of cells into domains. By combining experiments from biophysics, genetics, and developmental biology, the team successfully solves the puzzle of how patterns are created in developing organisms.
Researchers from Sechenov University found that the absence of cadherin 13 protein affects mice's response to early stress differently than its activation. This discovery sheds light on the genetic basis of neuropsychiatric disorders.
A study published in Nature Physics reveals that small changes in physical parameters can significantly impact the formation and growth of cell-cell contacts. The researchers used computer simulations and experiments to investigate the biophysicics of cadherin proteins, which play a crucial role in maintaining cellular bonds.
Researchers used super-resolution imaging to map the organization of cadherin-based adhesions in cells. The study revealed a multi-layered structure with compartments separated by an interface layer containing vinculin, which plays a key role in fine-tuning mechanical properties.
Researchers at the University of British Columbia genetically engineered mice with higher levels of cadherin to resist cocaine addiction. The study found that extra cadherin prevents synapses from strengthening and forms pleasurable memories, thereby preventing addiction.
Researchers discovered that cadherin clusters prevent cortical deformation by acting as structural anchors in the cell membrane. This new function of non-junctional cadherin clusters regulates cortical movement and stability, allowing for essential processes like cytokinesis to occur without dramatic changes.
Researchers at Kobe University have discovered a mechanism for the formation of a mosaic pattern of two different cell types in the nasal cavity. The study reveals that interaction between cadherins and nectins leads to the recruitment of cadherins to cell junctions, resulting in a mosaic pattern.
Iowa State researchers discovered long-lived, force-induced hydrogen bonds are the key to forming catch bonds between cadherin proteins. This discovery is essential for maintaining tissue integrity and may help prevent cancer cells from breaking away and spreading.
A new UCSB study shows that the protein E-cadherin promotes collective cell migration by guiding cells to move and migrate. The researchers used innovative experimental tools to measure forces on E-cadherin molecules, revealing a non-perturbing approach to understanding tissue morphology.
Researchers have discovered that intestinal cells use adhesion molecules to build the nutrient-absorbing brush border, a critical structure for absorbing nutrients and defending against pathogens. The findings provide new insights into intestinal pathologies associated with inherited and infectious diseases.
A study at Stanford University reveals the mechanical mechanisms in living cells, showing that cadherin-catenin-actin structure exerts force inside and between cells in living tissues. This understanding could have implications for biological processes such as tissue development, tumor growth, and complex organism formation.
A UA-led team of researchers discovered a new edge in overcoming resistance to certain pests by modifying the structure of crop-protecting proteins called Bt toxins. The modified toxins were found to be effective against some resistant strains, but not always working as expected and requiring further testing.
Researchers found that softer surfaces lead to disorganized cytoskeletons, while stiffer surfaces promote larger traction forces and more developed cadherin adhesions. Inhibition of myosin II decreases traction forces and causes cadherin adhesions to disappear.
Researchers identified cadherin 23 and protocadherin 15 as crucial proteins in the conversion of physical cues to electrochemical signals. These proteins form a complex called 'tip links' on hair cells in the inner ear, which is believed to have a central function in converting physical cues into electrical impulses.
Researchers at Mayo Clinic found that the protein p120 catenin can both suppress and promote metastasis, depending on its interaction with cadherin proteins. The study suggests that a future designer drug could block the beginning of metastasis or stop it once it starts.
Researchers have discovered the role of cadherin 23 protein in the mechanotransduction process that converts sound waves into electrical signals. The study provides insights into Usher syndrome and age-related hearing loss, suggesting a potential therapeutic target for treating deafness.
Researchers have identified three genes, Myosin VIIa, Harmonin, and Cadherin 23, that cooperate to shape the sensory hair cell bundle. These findings provide new insights into Usher syndrome, a genetic disorder affecting vision and hearing.
Researchers found a three-stage unbinding profile of cadherins, which suggests a 'ratcheting' mechanism that prevents abrupt failure of adhesive junctions. This discovery may lead to the development of gene therapy for diseases associated with malfunctions or mutations of the cadherin protein.