Articles tagged with Metabolism
Researchers found 323 unique genes influenced by smoking, with a strong involvement in processes related to cancer, cell death, and metabolism. The study's results indicate that exposure to cigarette smoke alters gene expression, leading to a sobering scale of influence on human disease risk.
A new data mining algorithm called GOALIE reveals how biological processes are coordinated in time. The algorithm uses gene expression data to reconstruct temporal models of cellular processes, improving our understanding of cell division and metabolism.
John A. Kanis receives IOF Medal of Achievement for his long-standing and distinguished career advancing the field of osteoporosis research. He has published widely on disorders of skeletal metabolism, including osteoporosis, Paget's disease of bone, hyperparathyroidism, renal osteodystrophy and neoplasia.
Researchers have provided evidence-based data on changes in drug metabolism in obese children compared to healthy weight children. They found that obese children metabolized caffeine and dextromethorphan at different rates, which could impact optimal drug dosing in pediatric patients.
Age-related nerve decline is associated with metabolic factors like blood sugar levels within normal ranges. Peripheral nerves are affected more in men than women later in life, suggesting a link between aging, gender, and inflammation. Modifiable risk factors may help prevent or delay peripheral nerve function decline.
Researchers followed 1162 healthy French men and women for nine years, monitoring plasma selenium concentrations and incidence of dysglycemia. High selenium levels in men were associated with a lower risk of developing dysglycemia, while no such association was found in women.
The European Journal of Drug Metabolism and Pharmacokinetics will be published by Springer starting in 2010, covering aspects of drug delivery and bioavailability. The journal focuses on pharmacokinetics, drug metabolism, and drug development, publishing original articles and conference proceedings.
A new study found that obese teenage girls with a higher ratio of visceral fat to subcutaneous fat have lower bone density than their peers. Visceral fat may also increase the risk of fractures in some obese individuals, highlighting its negative impact on bone health.
A study by Harvard researchers found that overeating in mice activates a molecule called PKR, which destroys normal metabolism and leads to insulin resistance. The discovery could lead to targeted drugs or nutrients to regulate PKR and prevent diseases such as heart disease and cancer.
A study at Cold Spring Harbor Laboratory has identified three molecular factors that contribute to high levels of PK-M2 in cancer cells, which promotes rapid cell proliferation and tumor growth. The researchers found that forcing a reduction in the levels of these factors could reverse the Warburg effect and restore normal metabolism.
The 2010 awards support groundbreaking research in cancer metabolism, tumor metabolism, and drug resistance. Three scientists will explore novel approaches to fighting cancer using innovative technologies.
Researchers from Universitat Autònoma de Barcelona found that compound genomes lose essential properties for evolution when complex. The study challenges the 'metabolism first' theory and supports the idea that genetic information stored in nucleotide polymers, like RNA and DNA, is crucial for life to emerge.
Researchers at the University of North Carolina found genetic variations that lead to less efficient glucose metabolism in African-American patients compared to whites. These findings suggest a link between diet and environment in shaping genetic predispositions to diabetes.
A nutrition professor at the University of Rhode Island found that chewing sugar-free gum can help reduce calorie intake by 67 calories at lunch and increase energy expenditure by 5%. Gum chewing also leads to feelings of fullness and reduced hunger, potentially aiding in weight management.
Concurrent imaging of metabolic and electric signals in the heart reveals a dynamic relationship between multiple cardiac variables. The new dual-camera system allows for rapid setup, dichroic image separation, and high spatial resolution, enabling correlative multimodal cardiac imaging.
Researchers at UC San Diego discover that a protein interaction generates force that shapes the Golgi apparatus, revealing a link between form and function. The discovery sheds light on the mechanism of the Golgi apparatus, a processing center for protein export.
Postmenopausal women can improve cardiovascular fitness and reduce risk factors for chronic diseases through regular, vigorous exercise. Studies show that even less strenuous aerobic exercise produces benefits, and women's metabolism changes after menopause affect glucose clearance from the blood.
Poor air quality in megacities, driven by pollution and urban metabolism, has severe consequences on residents and global climate. The urban metabolism model reveals how megacities consume energy, release wastes, and pollute, impacting climate change on regional and global levels.
Researchers analyzed over 1,800 urine samples and identified individual patients with an accuracy of over 99 percent using metabolic profiling. The study provides evidence that the metabolic fingerprint remains stable over time, paving the way for personalized medical care.
Researchers found that interrupting selenoprotein production can halt growth of bacteria such as Clostridium difficile and Treponema denticola. The study uses auranofin, an FDA-approved gold salt compound, to block bacterial growth by altering selenium metabolism.
A Finnish study found that low glycogen levels predict forthcoming violent offending among antisocial male offenders. Low glycogen stores may contribute to impulsive violent behavior during alcohol intoxications.
Researchers have found that white tea extract effectively reduces the generation of new adipocytes and stimulates fat mobilization from mature fat cells. White tea, a less processed version of green tea, contains ingredients such as methylxanthines and epigallocatechin-3-gallate that may be responsible for its anti-adipogenic effects.
Consuming a low-glycemic breakfast before exercise may boost fat oxidation during and after physical activity. A recent study found that this type of pre-exercise meal increased fat metabolism in sedentary individuals, potentially aiding in weight loss efforts.
A rat model study shows that dietary soy supplementation can prevent menopause-related syndromes, improve lipid profiles, and reduce LDL cholesterol while increasing HDL cholesterol levels. The findings support the indication that soybean consumption may prevent coronary heart disease.
A new study found that babies born with lower weight are more likely to develop chronic diseases like heart disease and diabetes later in life due to increased inflammation. Researchers followed over 5,600 children from birth to adulthood, finding a link between early growth and adult inflammation.
A Canada-US study published in Journal of Clinical Endocrinology & Metabolism found that insufficient vitamin D can cause higher body mass and shorter stature in girls during puberty. The researchers discovered a significant association between low vitamin D levels and increased abdominal fat, but no link to bone strength.
A research team at the University of Pennsylvania School of Medicine has discovered a key molecular partnership that coordinates body rhythms and metabolism, leading to leaner mice and improved insulin sensitivity. The study suggests that disrupting this partnership could be a valuable new weapon in the fight against obesity and diabetes.
A non-invasive device has been shown to treat obesity and resolve diabetes in an animal model by altering complex gastrointestinal signals. The procedure resulted in a significant reduction in food intake and weight loss, as well as restoration of normal glucose metabolism.
Hybrid plants exhibit increased growth and biomass due to the increased expression of genes involved in photosynthesis and starch metabolism during the day. This connection between circadian clock regulators and growth vigor could lead to new methods for increasing biomass crops for biofuels and improving food yields.
A new study published in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism found that dose-dependent growth hormone treatment increased final height in children with short stature who are not GH deficient. Children from parents of normal height responded better to treatment than those from short parents.
Research on ethanol-induced gastric mucosa injury reveals the critical role of oxidative stress in energy metabolism disturbance. Elevated ethanol exposure time increases malondialdehyde content, damaging mitochondria ultrastructure.
A large study has found a significant increase in fracture rates among HIV-infected patients compared to non-infected controls. The study, published in the Journal of Clinical Endocrinology and Metabolism, reveals that nearly 3% of HIV patients experienced fractures, with risks increasing with age.
Researchers at the University of Georgia discovered that 25% of genes in Neurospora crassa are under control of the biological clock, a much higher rate than previously reported. This finding has significant implications for understanding various biological processes, including cell cycling and ribosome biogenesis.
Two new studies found a connection between the circadian clock and metabolism through the protein SIRT1, which regulates energy levels throughout the day. The findings suggest that drugs targeting SIRT1 could help treat circadian sleep disturbances.
A study by the University of Bonn and Karolinska Institute found that a specific gene variant in women's endorphin metabolism is altered more often in female alcoholics than in healthy women. In mice, endorphins play a crucial role in ethanol consumption, particularly among females.
A study by the University of Southern California suggests that abdominal fat releases lipids directly to the liver at night, leading to insulin resistance and increasing the risk of type 2 diabetes. The findings highlight the importance of abdominal obesity in the pathogenesis of the disease.
A human clinical study by Montana Center for Work Physiology and Exercise Metabolism found that wildland firefighters who consumed a yeast-based antioxidant supplement, Wellmune WGP¹, had significantly fewer upper respiratory tract infections compared to a placebo group. The study showed a strong statistical trend of 23% fewer infectio...
Mark Friedman, a leading researcher in eating behavior, has received a Guggenheim Fellowship to study the effects of diet on obesity. His work aims to elucidate the mechanisms driving diet-induced obesity, with a focus on the interaction between dietary fat and carbohydrate.
A new genetic analysis by Yale School of Medicine researchers suggests that a genetic variant in East Asian populations may have protected residents from becoming alcoholics. The study found that this variant became widespread through natural selection in specific Hmong- and Altaic-speaking groups, hinting at an environmental factor.
A recent study suggests that cocaine's impact on brain metabolism may be a key factor in its addictive nature. The research, conducted at Brookhaven National Laboratory, found that the drug had significant effects on brain metabolism beyond just dopamine, even in mice lacking the gene for dopamine transporters.
Uppsala University scientists have developed a method to analyze genetic regulation and identified genes that govern fat levels and energy conversion. This breakthrough provides new understanding of the causes of disturbed metabolism, including familial combined hyperlipidemia.
Researchers have mapped gut microbes to better understand their role in human metabolism and disease. The study identifies key bug species involved in metabolic processes, paving the way for new treatments.
Researchers at UT-Houston have discovered an association between genes regulating glucose metabolism and spina bifida, a birth defect that affects the spine. The study found variants in three glucose metabolism genes were linked to an increased risk of spina bifida.
Researchers found that high-fat diets can shift mice's activity patterns, causing them to eat more during the day and altering molecular components of the circadian clock. The study suggests that metabolic processes, like nutrient status, may influence the internal body clock.
Researchers developed a mouse model to predict the loss of orally administered drugs due to CYP3A metabolism. The study found that mice with human CYP3A expression in the intestine had higher docetaxol levels, while those with liver expression showed only slight decreases.
A new study suggests that narcolepsy patients are more likely to be overweight due to lower metabolism and changes in eating behavior. The study found that narcoleptic patients had lower body mass index (BMI) scores than healthy controls, indicating a positive energy balance.
A study published in JCI Journals reveals that disturbances in sphingolipid metabolism may be a key factor in early pregnancy loss. Sphingosine kinase 1 (Sphk1) and Sphk2 proteins play a crucial role in metabolizing these fats, which are essential for placental development.
A diet rich in choline, found in red meat, eggs, poultry, and dairy products, may increase the risk of colorectal polyps. Research suggests that higher intake of choline is associated with an elevated risk, contradicting previous expectations.
Researchers at the University of Warwick discovered a glycation process that creates a metabolic memory in diabetes, persisting even after glucose levels are corrected. The study suggests early tight control of glucose and antioxidant use can mitigate complications, but long-term antioxidants may have health problems.
Researchers at the University of Pennsylvania School of Medicine have discovered a potential new target for treating type 2 diabetes, a protein that regulates fat metabolism. The study found that insulin stimulates the addition of a phosphate group to this protein, preventing the activation of genes involved in fat metabolism.
Eduardo Slatopolsky has been recognized for his pioneering experimental research in mineral metabolism, leading to improved treatment of patients with renal failure worldwide. He was awarded the ISN Amgen International Prize for Therapeutic Advancement in Nephrology in 2007.
Researchers discovered Dap1, which controls the activity of enzymes involved in cholesterol synthesis and drug metabolism. The study found that genetic variations in Dap1 may influence how people react to certain drugs.
A team of researchers at Penn State has discovered a master regulator that controls metabolic responses to essential amino acid deficiency, leading to profound effects on fat metabolism. The discovery may lead to new treatments for obesity and protein malnutrition, particularly in underdeveloped nations where malnutrition is prevalent.
A study found associations between two genes involved in choline metabolism and the risk of spina bifida. The link was discovered independently of maternal dietary choline intake during pregnancy.
A new study found that even low levels of heavy metal pollution can harm oysters, while high temperatures exacerbate the damage. The combined effect can lead to fatal weakness and disease in oysters.
A recent study found that mice lacking the GBA2 protein exhibit decreased fertility due to abnormal sperm morphology and reduced motility. The discovery may shed light on the mechanism behind certain treatments for Gaucher's disease, which can also impact fertility.
Researchers found that seals can dive to over 1,000 meters and for more than an hour without shivering, allowing their bodies to cool and reduce oxygen demand. This adaptation helps seals conserve oxygen and minimize brain damage caused by hypoxia during long dives.
A new UCLA study shows that chemotherapy causes persistent changes in brain function, leading to cognitive symptoms like forgetfulness and confusion. PET scans reveal a link between chemo-brain symptoms and lower brain metabolism, suggesting that monitoring brain activity could help prevent these effects.
Researchers at Thomas Jefferson University have found that cyclin D1 inhibits the size and activity of mitochondria in cancer cells, shifting their metabolism from energy production to proliferation. This discovery may lead to new treatments targeting cancer cell metabolism.
Researchers created the first 'encyclopedia' of nuclear receptors, revealing their role in regulating reproduction and nutrient metabolism. The study found that certain receptors form networks to control processes such as diet-derived lipid use for energy.