Articles tagged with Metabolism
Researchers at the University of Wisconsin-Madison have identified a critical step in how cancer cells shift their metabolism, leading them down a cancerous path. By inhibiting a specific protein modification, the study reveals a potential therapeutic target to reverse several hallmarks of cancer.
Apixaban is a new oral anticoagulant with good bioavailability, independent of patient sex and age. The drug has a short half-life, wide therapeutic window, and low number of drug interactions, making it suitable for patients with bleeding or surgical conditions.
A study found that consuming high sugar diets increases fat levels in the blood and liver, raising cardiovascular health risks. Healthy men with low liver fat showed similar changes after consuming a high sugar diet, highlighting the importance of sugar intake regulation.
Researchers discover nerve-associated macrophages that become inflamed with age and disrupt fat cell function. Lowering inflammation in these cells restores normal fat metabolism in older mice.
DNA damage accelerates aging in nematode worms, showing surprising similarities with aged humans. The study reveals comprehensive connections between metabolism, DNA preservation, and signaling pathways.
Increases in bone marrow fat are associated with a decline in bone density after gastric bypass surgery, while improvements in blood sugar control are linked to reduced marrow fat levels. The study suggests that weight loss and blood sugar metabolism may influence bone health through changes in bone marrow fat.
A new study suggests that India's planned 'smart' cities could have a detrimental impact on the environment if adequate infrastructure is not provided. The study analyzed the environmental implications of medium-rise housing replaced with high-rise towers, predicting significant extra demands on resources and increased waste output.
A recent study by UMass Amherst researchers found that certain beneficial gut bacteria can grow when fed a carbohydrate in cranberries, exhibiting a special nontypical metabolism. The findings could lead to new supplements or food products with potential health benefits.
Despite being hailed as the key regulator of leanness, leptin's function in humans remains uncharacterized. Researchers call for experimental evidence to demonstrate its mechanism of action, highlighting a crucial gap in our understanding of metabolism and obesity.
A comprehensive review highlights the most effective treatment options for co-managing type 2 diabetes and osteoporosis. Researchers suggest using medications like Metformin and DPP-4 inhibitors to protect bone health. Meanwhile, insulin therapy is recommended for achieving glycemic control in patients with T2D and fractures.
Researchers at Kanazawa University found that transcranial direct current stimulation (tDCS) on the lateral occipito-temporal cortex (LOTC) improved mental manipulation of body part imagery. This improvement was observed in healthy adults, indicating potential benefits for exercise learning and rehabilitation outcomes.
A recent study found that delayed eating patterns, compared to daytime eating, can lead to increased weight, insulin, cholesterol, and triglyceride levels, negatively affecting fat metabolism. Eating earlier in the day may help prevent overeating in the evening and at night.
A new study from the University of Illinois suggests that simple metabolic functions were the precursor to the emergence of life on Earth. The research analyzed gene ontology data and constructed a tree tracing the evolutionary path of molecular functions over time.
A team of scientists has discovered that breast cancer cells rely on a different nutrient metabolism to produce energy than normal cells and non-metastasizing cancer cells. Inhibiting this process reduces metastases by over 60% in mouse models.
A two-week high-intensity interval training (HIIT) program improved glucose metabolism in muscles of people with type 2 diabetes. HIIT surpassed traditional moderate intensity continuous training in its benefits, with significant improvements in insulin sensitivity and endurance noted.
Researchers found metreleptin treatment improved liver function and reduced fatty liver disease progression in patients with partial lipodystrophy. Patients with lower baseline leptin levels showed higher response rates to the treatment.
Climate change research needs to focus on how changing population structures will affect future human wellbeing. Global scenarios already include demographic data, but this is not being fully utilized. A new conceptual model, 'demographic metabolism,' can account for the replacement of generations and their impact on vulnerability.
Researchers found that cancer cells rely on metabolic processes, specifically the use of intermediates for energy production, to drive growth and division. A specific variant of STAT5, which cannot detect a marker indicating a full energy supply, prevents sustained activation necessary for leukemia development.
A pilot study conducted by the University of California, Los Angeles, has shown that consuming grapes twice a day for six months can prevent metabolic decline in Alzheimer-related areas of the brain. Participants who followed a grape-enriched diet demonstrated improved attention and memory performance compared to those on a placebo diet.
A recent study found that metformin treatment inhibits abnormal mitochondrial metabolism and activates anti-proliferation signaling in individuals with Li-Fraumeni syndrome. This inhibition leads to lower rates of tumor formation and increased survival time, suggesting metformin as a potential strategy for cancer prevention.
Researchers found a 'cross-talk' between the immune system, gut bacteria, and glucose metabolism, with implications for type 2 diabetes and metabolic syndrome. The gut bacteria Akkermansia muciniphila plays a critical role in regulating glucose metabolism.
Researchers found a link between necrotizing enterocolitis and mitochondrial metabolism, which generates energy for cells. The study suggests a genetic deficiency may trigger the disease, which affects up to 10% of premature infants and is fatal 25-35% of the time.
Researchers have found that impaired insulin metabolism affects neighboring cells involved in wound healing, leading to slow and incomplete healing. This discovery opens up new possibilities for treating wounds in diabetics, with local treatment targeting insulin metabolism.
Researchers discovered a metabolic enzyme that acts as a gatekeeper for the innate immune system, triggering strong inflammatory responses against harmful bacteria. This finding may help explain why obesity, Type 2 diabetes, and coronary artery disease are often accompanied by inflammation.
A new therapy has been developed to replace essential steroids in the body, which could help people with conditions like Addison's disease and congenital adrenal hyperplasia. The treatment uses corticosterone instead of cortisol, resulting in fewer side effects on fat cells.
Researchers at TUM discovered that brain cells, specifically astrocytes, regulate sugar intake and adjust metabolism in response to hormones like insulin and leptin. This paradigm shift could lead to new treatments for diabetes and obesity by targeting multiple cell types involved in metabolic processes.
Researchers created a liver on a chip that accurately replicates the metabolic variations found throughout the organ. The microfluidic device allows for fine control over liver cell metabolism, enabling the study of the effects of toxins and new drugs on the liver.
Researchers developed an index to predict bone loss in women during menopause by considering both bone formation and breakdown. The Bone Balance Index was found to be a stronger predictor of bone loss than a measurement of bone breakdown alone.
A study found that a cellular sorting protein called SORLA disrupts fat metabolism by recycling molecular receptors for insulin. This causes fat cells to become overly sensitive to insulin, leading to excessive fat deposits and obesity. The researchers discovered this link in human samples, mouse models, and cell cultures.
Research by Thomas Willnow found that SORLA regulates insulin signaling, leading to increased fat accumulation and obesity in mice. Reducing SORLA levels protected against diet-induced obesity.
Researchers at Mayo Clinic have identified CD38 as the key enzyme responsible for decreased nicotinamide adenine dinucleotide (NAD) levels during aging. This decline is associated with age-related metabolic decline and conditions like obesity and diabetes. Increasing NAD levels may be achieved by inhibiting CD38 function.
A review of physical employment standards aims to improve age- and sex-neutrality and address nutritional health, hydration, protective clothing, and load carriage. The special issue consolidates international perspectives on best practices in employment standards.
A new study finds that EU-15 citizens increasingly identify as European, with the proportion rising to 61% in 2013. The study also shows that younger cohorts are more likely to have multiple identities, which will continue to increase as they replace older generations.
Researchers discovered that a protein called methylation controlled J (MCJ) can be altered to boost the immune system's response to the flu. MCJ acts as a braking system in mitochondria, slowing down energy production and preventing overactive cells from killing healthy ones.
A study published in mSystems found that Burkholderia multivorans bacteria evolve and adapt in bursts to survive in the lungs of cystic fibrosis patients. The bacteria target adherence, metabolism, and changes to the cell envelope to evade antibiotics and persist in the host.
A new study found that bright light exposure increases insulin resistance compared to dim light exposure in both the morning and evening. This could lead to excess blood glucose, weight gain, and a higher risk of diabetes over time. The study suggests that lighting impacts health outcomes.
Researchers have identified six newly discovered proteins that may help prevent diabetes, Alzheimer's disease, cancer, and other age-related illnesses. The tiny proteins are produced in the mitochondria of cells and play a significant role in metabolism and cell survival.
A new study published in Cerebral Cortex found that brain metabolism is a significant predictor of fluid intelligence in young adults. The research used magnetic resonance spectroscopy to measure concentrations of the molecule N-acetyl aspartate in different regions of the brain, revealing a link between NAA levels and fluid intelligence.
A recent study suggests that decreased dietary diversity leads to reduced gut microbiota richness, which is associated with various metabolic disorders. The researchers emphasize the importance of dietary diversity for maintaining a healthy gastrointestinal microbiome.
Researchers developed a new laboratory method to study the function of GABA in brain processes controlling appetite and metabolism. The study found that mice lacking GABA in their hypothalamus, a key brain area regulating appetite, experienced significant weight loss and improved glucose tolerance.
A new study led by TSRI scientists has found that oxygen sensing in the brain plays a role in metabolism and internal state sensing. The research discovered a connection between oxygen levels and fat reserves in animal models, suggesting a possible mechanism for regulating metabolism in humans.
Vitamin B6 plays a crucial role in nitrogen metabolism, informing plants of their ammonium content and helping regulate its use. This discovery could lead to the development of new methods to prevent overuse of nitrogen-containing fertilizers, which harm the environment.
A recent study published in Cell reveals how eggs store fuel for embryo development by accumulating sugars during the final stages of maturation. Insulin signaling is inactivated, leading to reduced mitochondrial activity and sugar buildup.
Researchers designed synthetic microbes to learn what drives the bacterial circadian clock and how it might be manipulated. The findings indicate that the cyanobacteria's clock can synchronize to metabolism outside of photosynthesis, suggesting potential applications in engineered microbes.
Researchers link flibanserin-induced decreases in female brain metabolism to increased pair bonding and grooming behavior in common marmosets. The study provides insight into how the drug may work in women's brains, but highlights room for improvement in treatment and safety.
Researchers at the Buck Institute discover that dysfunctional mitochondria induce a unique type of senescence, characterized by a distinct secretory phenotype. This finding provides an alternative explanation for the free-radical theory of aging and highlights a new role for mitochondria in affecting physiology.
Research reveals that dietary restriction enhances the expression of circadian clock genes in fruit flies, improving fat metabolism and extending lifespan. The study suggests a potential target for drug development to promote healthy aging.
Researchers from Tohoku University created a modified DNA sequence that increases sucrose levels in tomatoes without limiting growth. The technology also affects amino acid metabolism, resulting in higher levels of several key compounds.
Researchers found that well-trained seniors can expend as much energy as elite athletes during maximal physical exertion. The study, conducted by the University of Copenhagen, revealed that seniors can perform at near-maximum rates for longer periods than expected.
Scientists at the University of Illinois have developed a process to track the movement of lycopene, a cancer-fighting compound found in tomatoes, in the human body. The study used plant biofactories to produce heavier versions of lycopene, which can be easily tracked in the body.
A Kansas State University researcher is gathering large-scale biological information on rivers across the US and Mongolia. The study aims to understand how climate change affects river systems, including oxygen production and consumption from bacteria, algae, plants, and animals.
A team of researchers from Caltech analyzed eggshells from sauropod dinosaurs, bird-like oviraptorid dinosaurs, and Titanosaurs to determine their body temperatures. The results showed that smaller dinosaurs had lower basal metabolisms, while larger ones maintained warm temperatures similar to modern mammals.
Researchers at Osaka University found that smoking habits change the levels of α-klotho and FGF-21 in blood serum, which are linked to aging. These changes suggest a metabolic disorder and may contribute to accelerated aging in smokers.
Researchers have developed a sticky gel that helps stem cells adhere to and restore their metabolism in rat hearts, improving cardiac function after simulated heart attacks. The gel, which combines serum and hyaluronic acid, has been shown to retain up to 73% of transplanted cells in the heart.
Early-career cell biologists Clifford Brangwynne, Ahmet Yildiz, and Meng Wang have won the ASCB-Gibco Emerging Leaders Prizes for their groundbreaking research in cell biology. Their work has launched new research fields at the interface of biology and physics.
A University of Missouri study found that female mice exposed to endocrine disruptors like BPA and EE showed decreased physical activity in their daughters, which can predispose them to obesity and other metabolic disorders. The chemicals can affect metabolism, energy expenditure, and voluntary exercise patterns.
A mathematical calculation platform predicts how patients respond to modified diets depending on their gut microbiome composition. The study reveals that individuals with low-diversity gut microbiomes experience improved blood chemistry when following a weight loss diet.
A study published in JAMA Neurology found insulin resistance associated with reduced global and regional brain glucose metabolism in late middle-age adults at risk for Alzheimer's disease. Lower glucose metabolism was linked to poorer performance in immediate memory tasks.
A new special issue in ecancermedicalscience explores the complex relationship between diet, metabolism, and cancer. Researchers investigate the role of antioxidants, obesity, and biomarkers in cancer development and prevention.
Researchers have found that altered cholesterol metabolism in certain immune cells may help some people with HIV naturally control disease progression. This discovery was made possible by using 30 years of data and biologic specimens collected through the NIH-funded Multicenter AIDS Cohort Study.